• Biomolecules & Therapeutics
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• v.27 no.3
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• pp.318-326
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• 2019

Sphingosine 1-phosphate (S1P) levels are often found to be elevated in serum, bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and experimental mouse models. Although the roles of sphingosine kinase 1 and S1P receptors have been implicated in fibrosis, the underlying mechanism of fibrosis via Sphingosine 1-phosphate receptor 2 ($S1P_2$) has not been fully investigated. Therefore, in this study, the roles of $S1P_2$ in lung inflammation and fibrosis was investigated by means of a bleomycin-induced lung fibrosis model and lung epithelial cells. Bleomycin was found to induce lung inflammation on day 7 and fibrosis on day 28 of treatment. On the $7^{th}$ day after bleomycin administration, $S1P_2$ deficient mice exhibited significantly less pulmonary inflammation, including cell infiltration and pro-inflammatory cytokine induction, than the wild type mice. On the $28^{th}$ day after bleomycin treatment, severe inflammation and fibrosis were observed in lung tissues from wild type mice, while lung tissues from $S1P_2$ deficient mice showed less inflammation and fibrosis. Increase in TGF-${\beta}1$-induced extracellular matrix accumulation and epithelial-mesenchymal transition were inhibited by JTE-013, a $S1P_2$ antagonist, in A549 lung epithelial cells. Taken together, pro-inflammatory and pro-fibrotic functions of $S1P_2$ were elucidated using a bleomycin-induced fibrosis model. Notably, $S1P_2$ was found to mediate epithelial-mesenchymal transition in fibrotic responses. Therefore, the results of this study indicate that $S1P_2$ could be a promising therapeutic target for the treatment of pulmonary fibrosis.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2014.11a
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• pp.289-290
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• 2014

Single layer $MoS_2$가 가지고 있는 전기적 특성, 광특성 등을 이용하기 위해 본 연구에서는 $O_2$ plasma를 이용해 경제적이며 효과적인 방법을 제시하고자 한다. 미세 etching을 통해 linear하게 thickness가 변화하는 것을 확인하고, pristine과 비슷하거나, 더 향상된 $MoS_2$를 제작하였다.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.325-325
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• 2019

본 연구에서는 안동댐 유역을 대상으로 Soil and Water Assessment Tool(SWAT) 모형을 이용해 하천단면 특성을 고려하여 유량 및 수질(SS, TN, DO)을 모의하였다. 안동댐 유역 내 위치한 도산 및 안동댐 관측소의 실측 유량 자료를 이용하였으며, 낙본B 관측소의 수질 측정 자료를 이용하였다. 본 연구에서는 항공사진을 통해서 안동댐 유역 내 각각의 소유역에 대하여 평균 하천폭과 홍수터폭 자료를 구축하였으며, 이를 실측 자료로 가정하였다. 또한 하천단면 실측 자료를 기반으로 상류 유역 면적에 대한 하천폭 및 홍수터폭 회귀식을 개발하였다. 이렇게 개발된 회귀식을 통해 산정된 하천폭과 홍수터폭을 SWAT 모형에 적용하여 유량 및 수질 모의를 모의하였으며, 하천단면 특성을 고려하기 이전(Scenario 1, S1)과 이후(Scenario 2, S2)의 모의 결과를 비교하여 하천단면 특성 고려에 따른 모의 결과의 차이에 대하여 분석하였다. S1와 S2의 하천폭과 홍수터폭을 비교한 결과 S1이 하천폭과 홍수터폭을 과대 산정하는 것으로 나타났으며, S1의 유속은 S2보다 작게 나타났다. 유량 모의 결과와 실측 자료에 대한 $R^2$와 NSE를 산정한 결과 S1과 S2의 결과는 큰 차이를 나타내지 않았으나, S2가 S1에 비해 상대적으로 첨두유량을 높게 모의하는 경향이 나타났다. 유량 모의 결과와 달리 수질 모의 결과에서는 S1과 S2의 차이가 뚜렷하게 나타났다. SS, TN, DO 모의 결과 모두에서 S2가 S1보다 높은 모의 정확도를 나타내었다. 결론적으로 하천단면 특성이 유량 및 수질 모의 정확도에 영향을 주는 것으로 나타났으며, 특히 하천단면과 관련한 변수들은 수질 모의에 있어서 민감하게 영향을 주는 것으로 판단되었다. 하지만 본 연구는 단일 유역에 대해서만 진행되었기 때문에 연구 결과의 신뢰성을 확보하기 위해서는 본 연구의 연구대상 유역과 다른 유역 특성을 가진 유역들을 대상으로 본 연구의 결과에 대한 재검토가 필요하다.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.10 no.6
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• pp.773-783
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• 1998

The heating system for apartment complex may be classified as old systems including central system with steam boiler(S1), gas engine driven heat pump system(S2), system using waste heat(S3) and new systems including mechanical vapor re-compression system with flashing heat exchangers(S4), system using methanol(S5), system using metal hydride (S6). The purpose of the present study is to suggest optimal heating system by technically, economically and environmentally evaluating old and new heating systems of apartment complex from 500 to 3,000 households. Economic evaluation based on the technical evaluation results which estimated heat transfer area of heat exchangers and capacity of equipments was estimated initial investment cost, annual operating cost and relative payback period by considering annual increasing rates of energy cost and interest. Environmental evaluation provided annual generation rate of carbon dioxide. Initial investment cost was cheap in the order of S6, S5, S3, S2, S4, S1, annual operating cost was cheap in the order of S1, S2, S4, S5 and relative payback period was short in the order of S6, S5, S2, S3 and S4. Relative payback period was within 8 years for all scenarios of 3,000 households, and was increased as annual increasing rates of energy cost and interest were increased. As transportation pipe length was increased twice, payback period was increased by 1.4~2.6 time. The effect of temperatures of waste gas and waste water on the relative payback period was small within 0.8 years. The annual generation rate of carbon dioxide was big in the order of S4, S2 and S1. S4 was the most economic system among whole scenarios when S1 was replaced with other scenarios.

• Journal of Bio-Environment Control
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• v.23 no.2
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• pp.144-147
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• 2014

It was intended to closely examine an effect that a change in the concentration of culture medium had on the potato(Solanum tuberosum L.) plantlet growth in the microponic system so as to mass-produce the virus-free plant of new variety 'Saebong' for potato processing. The adjusted concentration of potato culture medium was 0.2, 0.6, 1.0, 1.4, 1.8, and $14.0dS{\cdot}m^{-1}$. And potato seedling was cut into pieces of 1.5 cm in length, which included 2 growth points and leaves. And each was explanted in glass vial of 50 mL. And experiments were carried out twice for 18 days or 21days. Culture medium of 2ml was put in the container respectively. And 1 mL was added after 10 days. And in terms of cultivation environment, the experiment was carried out at the day length of 16 hours at the temperature of $23{\pm}1^{\circ}C$ under the white LED light of $40{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$. The concentration of culture medium in the experiment I was EC 0.2, 1.0, $14dS{\cdot}m^{-1}$ and was adjusted to 0.6, 1.0, 1.4, $1.8dS{\cdot}m^{-1}$ in the experiment II. The results showed that the survival rate of plantlet was 90% at $0.2dS^2m^{-1}$, 100% at $0.6dS^2m^{-1}$, 100% at $1.0dS^2m^{-1}$. 0% at $1.4dS{\cdot}m^{-1}$, 0% at $1.8dS{\cdot}m^{-1}$. and 0% at $14.0dS{\cdot}m^{-1}$ after 7 days. With regard to the explanted potato seedling, in case of the treatment where the electrical conductivity of culture medium was adjusted to $1.0dS{\cdot}m^{-1}$, root developed 2 days after transplantation. And the plantlet vigorously grew into strong plant that had 7 leaves, length of 5cm, and fresh weight of 0.5 g after 18 days. In case of the treatment where the concentration of culture medium was adjusted to $0.6dS{\cdot}m^{-1}$, the root plantlets developed 4 days after transplantation. And those grew into plant that had 7 leaves and fresh weight of 0.2 g after 21 days. Therefore, we found that it is effective to control potato culture medium by adjusting its electrical conductivity to $0.6{\sim}1.0dS{\cdot}m^{-1}$ for the mass production of virus-free potato seedling in the microponic system.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.27 no.5
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• pp.643-658
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• 1994

The sedimentary records of anthropogenic metal loads in the Suyeong Bay, Pusan were determined by combining the Pb-210 dating technique with the measurements of heavy metals in the sediment cores. The sedimentation rates of sediment particles ranged from $0.12\;to\;0.20\;g/m^2/yr\;or\;2.4{\sim}4.0\;mm/yr$ in accumulation rates. The lowest sedimentation rate was observed at station S3 which was characterized by a bottom with relatively low organic matter contents(e.g. TIL and TOC). Heavy metals showed generally higher concentrations at station S1 and S2 near the mouth of the Suyeong River than at station S3 and the outmost station S4. The contents of copper, lead and zinc in the sediment cores especially from station S1 and S2 began to increase around 1930, and were at their highest levels in the $1960{\sim}1970$ period as a result of increasing industrial activities. Concentrations of these heavy metals have slightly decreased since 1970, probably due to regulation of pollution discharge. The natural background levels of copper, lead and zinc in the sediments of this bay ranged $18{\pm}4ppm,\;28{\pm}6ppm\;and\;74{\pm}9ppm$, respectively, by averaging the contents in the sediment depths corresponding to periods between about 1900 and 1920 at the four stations. The total amounts of anthropogenic loads deposited in the sediments since about 1930 were estimated to be $9{\sim}291{mu}g/cm^2$ for lead, $165{\sim}1122{mu}g/cm^2$ for zinc and $20{\sim}208{mu}g/cm^2$ for copper. These values were remarkably high at stations S1 and S2 relative to the other two stations. At stations S1 and S2, the anthropogenic loads of lead, copper and zinc constituted $29{\sim}30\%,\;32{\sim}42\%\;and\;28{\sim}35\%$ of the total sedimentary inventories at the present day, respectively. These metal contents have a good correlation(r>0.7) with each other and cadmium measurements also show a positive linear relation with nickel or total organic nitrogen.

• The Journal of the Korea Contents Association
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• v.2 no.3
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• pp.146-151
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• 2002

The $Ca_{1-x}$Sr$_{x}$S:CuCl TFEL devices were fabricated by electron-beam deposition system and luminescent characteristics of the TFEL devices were studied. The SrS and CaS powders were mixed to form $Ca_{1-x}$Sr$_{x}$S host materials and 0.2 at% of CuCl was added as the activator. The luminance(lao) and peak emission wavelength of CaS:CuCl TFEL devices were 9.5 cd/m$^2$ and 492 nm, respectively. The luminance(L$_{30}$) and peak emission wavelength of SrS:CuCl TFEL devices were 633 cd/m$^2$ and 500 nm, respectively. It seems that the addition of CaS into the SrS host material generates blue shift of the EL emission characteristics but reduces the luminance and the luminous efficiency of the $Ca_{1-x}$Sr$_{x}$S:CuCl TFEL devices drastically.

• Journal of the Korean institute of surface engineering
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• v.25 no.5
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• pp.215-221
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• 1992

This research is aimed at developing(110) preferred TiS2 cathode films and glass typed solid electro-lytes which have high ionic migrations and low electron conductivities for thin secondary solid batteries. To obtain preferred oriented TiS2 thin films on a substrate by CVD method using TiCl4 and H2S gases three factors of heating temperature, inner pressure of furnace and TiCl4/H2S gas mole fraction were ex-amined systematically. To obtain solid films of Li2O-B2O3-SiO2 electrolytes by r.f. sputtering for thin proto-type batteries of Li/Li2O-B2O3-SiO2TiS2, sputtering conditions were examined. TiS2 cathode films showed columnar structure, namely c axis oriented parallely. At low pressure of reaction chamber and low heating temperature, surface of smooth TiS2 films couldd be obtained. Ionic conductivity of Li2O-B2O3-SiO2 films manufactured by r.f. magnetron sputtering were 3$\times$10-7$\Omega$-1cm-1 and electron conductivities were 10-11$\Omega$-1cm-1. Open cell voltage of thin lithium batteries were 2.32V with a designed prototype cell.

• Journal of the Korean Mathematical Society
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• v.42 no.3
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• pp.405-434
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• 2005

We establish appropriate $L^p$ estimates for a class of maximal operators $S_{\Omega}^{(\gamma)}$ on the product space $R^n\;\times\;R^m\;when\;\Omega$ lacks regularity and $1\;\le\;\gamma\;\le\;2.\;Also,\;when\;\gamma\;=\;2$, we prove the $L^p\;(2\;{\le}\;P\;<\;\infty)\;boundedness\;of\;S_{\Omega}^{(\gamma)}\;whenever\;\Omega$ is a function in a certain block space $B_q^{(0,0)}(S^{n-1}\;\times\;S^{m-1})$ (for some q > 1). Moreover, we show that the condition $\Omega\;{\in}\;B_q^{(0,0)}(S^{n-1}\;\times\;S^{m-1})$ is nearly optimal in the sense that the operator $S_{\Omega}^{(2)}$ may fail to be bounded on $L^2$ if the condition $\Omega\;{\in}\;B_q^{(0,0)}(S^{n-1}\;\times\;S^{m-1})$ is replaced by the weaker conditions $\Omega\;{\in}\;B_q^{(0,\varepsilon)}(S^{n-1}\;\times\;S^{m-1})\;for\;any\;-1\;<\;\varepsilon\;<\;0.$

• Bulletin of the Korean Chemical Society
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• v.24 no.5
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• pp.583-592
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• 2003

The gas phase identity nucleophilic substitution reactions of halide anions (X = F, Cl, Br) with cyclopentadienyl halides (1) are investigated at the B3LYP/6-311+G**, MP2/6-311+G** and G2(+)MP2 levels involving five reaction pathways: σ-attack $S_N2$, β-$S_N$2'-syn, β-$S_N$2'-anti, γ-$S_N$2'-syn and γ-$S_N$2'-anti paths. In addition, the halide exchange reactions at the saturated analogue, cyclopentyl halides (2), and the monohapto circumambulatory halide rearrangements in 1 are also studied at the same three levels of theory. In the σ-attack $S_N2$ transition state for 1 weak positive charge develops in the ring with X = F while negative charge develops with X = Cl and Br leading to a higher energy barrier with X = F but to lower energy barriers with X = Cl and Br than for the corresponding reactions of 2. The π-attack β-$S_N$2' transition states are stabilized by the strong $n_C-{\pi}^{*}_{C=C}$ charge transfer interactions, whereas the π-attack γ-$S_N$2' transition states are stabilized by the strong $n_C-{\sigma}^{*}_{C-X}$ interactions. For all types of reaction paths, the energy barriers are lower with X = F than Cl and Br due to the greater bond energy gain in the partial C-X bond formation with X = F. The β-$S_N$2' paths are favored over the γ-$S_N$2' paths only with X = F and the reverse holds with X = Cl and Br. The σ-attack $S_N2$ reaction provides the lowest energy barrier with X = Cl and Br, but that with X = F is the highest energy barrier path. Activation energies for the circumambulatory rearrangement processes are much higher (by more than 18 kcal $mol^{-1}$) than those for the corresponding $S_N2$ reaction path. Overall the gas-phase halide exchanges are predicted to proceed by the σ-attack $S_N2$ path with X = Cl and Br but by the β-$S_N$2'-anti path with X = F. The barriers to the gas-phase halide exchanges increase in the order X = F < Br < Cl, which is the same as that found for the gas-phase identity methyl transfer reactions.