• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
• /
• pp.151.2-152
• /
• 2000

• 생명과학회지
• /
• 제21권1호
• /
• pp.96-101
• /
• 2011

ATP와 L-methionine으로부터 SAM synthetase (MetK)에 의해 생합성 되는 S-adenosylmethionine (SAM)은 세포내 메틸화에 필요한 메틸기를 제공하는 중심적인 공급체의 역할을 할뿐만 아니라 방선균에서는 일차 및 이차대사산물의 생산 조절에 관여하고 있다는 사실이 밝혀졌다. 이에 논 연구에서는 산업적으로 매우 중요한 항진균성 항생물질인 natamycin을 생산하는 S. natalensis로부터 SAM synthetase 코드하는 metK 유전자를 클로닝하고 동정하였다. S. natalensis에서 클로닝된 metK는 1,209 bp의 염기를 가진 유전자로써 아미노산서열에서 S. pristinaespiralis ATCC 25486과 S. peucetius ATCC 27952의 MetK와 96%, S. violaceusniger Tu 4113과 95% 일치하는 매우 높은 상동성을 보였다. 또 pSET152ET 벡터를 이용해 구축한 metK 고발현용 재조합 플라스미드 pCD1를 S. lividans TK24의 genomic DNA에 도입하여 actinorhodin 생산 유도를 시도해 본 결과 R5 고체배지에서 pCD1이 도입되지 않은 균주에서는 actinorhodin 생산을 전혀 확인할 수 없었지만 pCD1이 도입된 형질전환체에서는 actinorhodin 생산이 강하게 유도되었으며 R4 액체배지에서는 actinorhodin 생산량이 10배 증가되었다. 따라서 본 연구를 통해 클로닝된 S. natalensis 유래 metK 유전자는 방선균에서 이차대사산물의 생산을 유도할 수 있음을 확인할 수 있었다.

• Progress in Superconductivity
• /
• 제5권2호
• /
• pp.149-152
• /
• 2004

The design and the fabrication of a 1 MVA single-phase HTS transformer are presented in this paper, The rated voltages are 22.9 ㎸ for primary and 6.6 ㎸ for secondary, and the rated currents are 44 A and 152 A respectively. The transformer has HTS double pancake type windings. This type of winding has many advantages such as ease of fabrication and maintenance, good distribution of surge voltage and insulation of windings. Single HTS wire was used for primary winding and four HTS parallel wires were used for secondary winding. These windings are arranged reciprocally with the shell type iron core. An FRP cryostat with room temperature bore was fabricated to isolate the iron core from the coolant. The winding will be cooled down to 65 K with sub-cooled liquid nitrogen using a GM-cryocooler. The sub-cooled liquid nitrogen has advantages of good insulation because of no bubbles as well as increased current capacity of HTS wire.

• 한국간호교육학회지
• /
• 제17권2호
• /
• pp.296-305
• /
• 2011

Purpose: This study was done to develop an educational needs scale for cell phone use, to investigate the scope of cell phone use in children and their parents' perception, and to compare the educational needs for children and parents regarding children's cell phone use. Method: The participants were 152 children and 152 parents in two cities. Data were collected through self-report questionnaires, and analyzed using the SPSS program. Result: Ten items regarding the educational needs for cell phone use were selected for the final scale, and categorized into 2 factors (cell phone use and cell phone addiction). The scope of cell phone use in children is different from their parents' perception. The educational needs of parents were higher than those of children. Conclusion: The findings indicate that the scope of cell phone use and the educational needs of children were different from their parents' perception and needs. Further research would be required to identify the educational needs for children and parents regarding children's cell phone use and related factors. In addition, development and effects of the educational programs for cell phone use in children and parents will be required.

• 농촌의학ㆍ지역보건
• /
• 제41권3호
• /
• pp.152-161
• /
• 2016

Objective: The purpose of this study was to develop a motivation-enhancing self-management program and apply to rural aged with hypertension to evaluate the applicability of the Program. Methods: The motivation-enhancing self-management program was on the evidence of Orem's self-care theory and Ford's Motivational system theory which consists of group education and tele-coaching conducted 12-week. The program evaluation was done by structured questionnaires of motivation (self-efficacy, perceived benefit, perceived barrier and emotional salience), self-care and blood pressure. There were totally 31 aged with hypertension in 2 rural areas enrolled in the program. Results: There was only perceived benefit statistically significant between the intervention and control group (t=2.05, p=.04) and self-care level was no difference between the two groups (t=0.21, p=.84) after program. But there are statistically significant differences of systolic blood pressure between the intervention and control group(t=-2.62, p=.01). Conclusion: The motivation-enhancing self-management program is necessary for the rural aged with hypertension, but it's needed modify and revise in the future study.

• Nuclear Engineering and Technology
• /
• 제51권7호
• /
• pp.1805-1815
• /
• 2019

While nickel-based alloys have been widely used for power plants due to corrosion resistance and good mechanical properties, during the last couple of decades, failures of nuclear components increased gradually. One of main degradation mechanisms was primary water stress corrosion cracking at dissimilar metal welds of piping and reactor head penetrations. In this context, precise estimation of welding effects became an important issue for ensuring reliability of them. The present study deals with a series of finite element analyses and crack growth rate evaluation of Alloys 690/152. Firstly, variation of residual stresses and equivalent plastic strains was simulated taking into account welding of a cylindrical block. Subsequently, extraction and pre-cracking of compact tension (CT) specimens were considered from different locations of the block. Finally, crack growth curves of the alloys and heat affected zone were developed based on analyses results combined with experimental data in references. Characteristics of crack growth behaviors were also discussed in relation to mechanical and fracture parameters.

• 한국컴퓨터그래픽스학회논문지
• /
• 제28권1호
• /
• pp.1-9
• /
• 2022

비소세포폐암(NSCLC)은 전체 폐암 중 85%의 높은 비중을 차지하며 사망률(22.7%)이 다른 암에 비해 현저히 높은 암으로 비소세포폐암 환자의 수술 후 예후에 대한 예측은 매우 중요하다. 본 연구에서는 종양을 관심영역으로 갖는 비소세포폐암 환자의 수술 전 흉부 CT 영상 패치의 종류를 종양 관련 정보에 따라 총 다섯 가지로 다양화하고, 이를 입력데이터로 갖는 사전 학습 된 ResNet 과 EfficientNet CNN 네트워크를 사용하여 단일 모델과 간접 투표 방식을 이용한 앙상블 모델, 그리고 3 개의 입력 채널을 활용한 앙상블 모델에서의 실험 결과 및 성능을 오분류의 사례와 Grad-CAM 시각화를 통해 비교 분석한다. 실험 결과, 종양 주변부 패치를 학습한 ResNet152 단일 모델과 EfficientNet-b7 단일 모델은 각각 87.93%와 81.03%의 정확도를 보였다. 또한 ResNet152 에서 총 3 개의 입력 채널에 각각 영상 패치, 종양 주변부 패치, 형상 집중 종양 내부 패치를 넣어 앙상블 모델을 구성한 경우에는 정확도 87.93%를, EfficientNet-b7 에서 간접 투표 방식으로 영상 패치와 종양 주변부 패치 학습 모델을 앙상블 한 경우에는 정확도 84.48%를 도출하며 안정적인 성능을 보였다.

• Clinical and Experimental Reproductive Medicine
• /
• 제25권2호
• /
• pp.217-231
• /
• 1998

The effectiveness of intrauterine insemination (IUI) combined with controlled ovanan hyperstimulation (COH) in the treatment of infertility with various etiologies was compared in a total of 152 cycles. Patients received a maximum of three IUI cycles for the treatment. Severe male ($<2\times10^6$ motile sperm) or age factor (> 39 y) patients were excluded in this study. Pregnancy was classified as clinical if a gestational sac was seen on ultrasound. The overall clinical pregnancy rate was 7.9% per cycle (12/152) and 9.7% per patient (12/124). The pregnancy rates were 0% in unstimulated natural (0/18), 7.5% in CC (3/40), 8.2% in CC+hMG (4/49), 5.9% in GnRH-a ultrashort (1/17), 5.9% in GnRH-a long (1/17) and 27.3% in dual suppression cycles (3/11), respectively. The pregnancy rate was higher in dual suppression cycle than other stimulated cycles, but this was not significant. The multiple pregnancy rates were 25.0% (2 twins and 1 triplet). No patient developed ovarian hyperstimulation. Abortion rates were 66.7% in CC (2/3) and 100% in ultrashort cycles (1/1). The livebirth rate was 5.9% per cycle (9/152) and 7.3% per patient (9/124). There were no differences in age, duration of infertility, follicle size, total ampules of gonadotropins and days of stimulation between pregnant and non-pregnant groups. However, significant(P<0.05) differences were observed in the level of estradiol $(E_2)$ on the day of hCG injection ($3,266.6{\pm}214.2$ vs $2,202.7{\pm}139.4$ pg/ml) and total motile sperm count ($212.1{\pm}63.4$ vs $105.1{\pm}9.9\times10^6$) between pregnant group and non-pregnant group. These results suggest that IUI combined with successful ovarian stimulation tends to improve the chance of pregnancy as compared to IUI without COH and a total motile sperm count may be considered predictive of the success for pregnancy.

• 산업경영시스템학회지
• /
• 제20권42호
• /
• pp.131-141
• /
• 1997

The purpose of this study is to certify the actual state of JIT(Just-in-Time) production system's implementation of Korean manufacturing industries and to exhibit the appropriate JIT system considering the company's characteristics, for attain the superior competitiveness. To understand the current situations of JIT system's implementation a questionnaire study is performed. Total 152 valid questionnaires are collected by personal visit and mailing method. All the data is statistically analyzed by SPSS PC+ and SAS program and reviewed to develop a strategy for JIT implementation of Korean manufacturing companies.

• 한국전자파학회:학술대회논문집
• /
• 한국전자파학회 2001년도 종합학술발표회 논문집 Vol.11 No.1
• /
• pp.152-156
• /
• 2001

본 논문에서는 단일 DGS의 전송특성을 ABCD 파라미터로 모델링하여 연속한 N개의 DGS 분석 및 설계를 용이 하게 하였다. 모델링된 식의 검증을 위해 연속된 N개의 주기적 DGS에서 전송특성을 이론, 회로 시뮬레이션, EM 시뮬레이션을 비교하였다. 또한 응용 예로서, 능동안테나의 불요 고조파가 방사하는 것을 저지하기 위한 DGS를 설계 및 시뮬레이션하여 제시된 방법론의 타당성을 검증하였다.