• Title/Summary/Keyword: S109

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Association of Leptin Receptor Lys109Arg and Gln223Arg Polymorphisms with Increased Risk of Clear Cell Renal Cell Carcinoma

  • Mu, Hui-Jun;Zou, Jian;Xie, Ping;Xu, Zhuo-Qun;Ruan, Jun;Yang, Shu-Dong;Yin, Ying
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.10
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    • pp.4211-4215
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    • 2014

  • Background: Although roles of genetic polymorphisms of leptin receptor (LEPR) gene in several cancers have been documented, the association between polymorphisms of LEPR and clear cell renal cell carcinoma (CC-RCC) remains unknown. The aim of this study was to explore any relation. Materials and Methods: The study population consisted of 77 patients with CC-RCC and 161 healthy control subjects. Polymorphism analyses of Lys109Arg and Gln223Arg were performed by direct DNA sequencing and PCR-restriction fragment length polymorphism approaches respectively. Results: Comparisons of allelic and genotypic frequencies in Lys109Arg and Gln223Arg showed no significant difference between the cases and controls. However, when evaluating the combined genotype of Lys109Arg and Gln223Arg, risk with GG/GG was increased (OR=1.85, 95%CI=1.04-3.30) and with GA/GG or GG/GA was decreased (OR=0.07, 95%CI=0.01-0.54; OR and 95%CI of the latter could not be calculated for a value of zero). Furthermore, the G-G haplotype frequency of Lys109Arg and Gln223Arg in the cases was higher (OR=1.68; 95%CI=1.02-2.76). In contrast, the A-G and G-A haplotype frequencies in the cases were lower than those in the controls (OR=0.06; 95%CI=0.01 to 0.47; OR and 95%CI of the latter could not be calculated for a value of zero). In addition, the Lys109Arg A allele was in LD with the Gln223Arg A allele (d'=0.9399) in the CC-RCC subjects, but not in the controls. Conclusions: Our data suggest that the GG/GG combined genotype and G-G haplotype of Lys109Arg and Gln223Arg can act as evaluating factors for CC-RCC risk.

  • https://doi.org/10.7314/APJCP.2014.15.10.4211 인용 PDF KSCI

VALIDATION OF TRANSITION FLOW PREDICTION AND WIND TUNNEL RESULTS FOR KU109C ROTOR AIRFOIL (로터 익형 KU109C 풍동시험 및 천이유동 해석결과의 검증)

  • Jeon, S.E.;Sa, J.H.;Park, S.H.;Kim, C.J.;Kang, H.J.;Kim, S.B.;Kim, S.H.
    • Journal of computational fluids engineering
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    • v.17 no.1
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    • pp.54-60
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    • 2012

  • Transition prediction results are validated with experimental data obtained from a transonic wind tunnel for the KU109C airfoil. A Reynolds-Averaged Navier-Stokes code is simultaneously coupled with the transition transport model of Langtry and Menter and applied to the numerical prediction of aerodynamic performance of the KU109C airfoil. Drag coefficients from the experiment are better correlated to the numerical prediction results using a transition transport model rather than the fully turbulent simulation results. Maximum lift coefficient and drag divergence at the zero-lift condition with Mach number are investigated. Through the present validation procedure, the accuracy and usefulness of both the experiment and the numerical prediction are assessed.

  • https://doi.org/10.6112/kscfe.2012.17.1.054 인용 PDF KSCI