• 동의신경정신과학회지
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• 제15권1호
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• pp.87-99
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• 2004

This experiment was designed to investigate the effect of Coptis japonica Makino(CJM) on the Alzheimer's disease. The effects of CJM extract on $IL-1{\beta}$, IL-6, amyloid precursor proteins (APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$ and AChE activity of PC-12 cell lysate treated by $A{\beta}$ plus $rIL-1{\beta}$ and behavior of memory deficit rats induced by scopolamine and mice glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine were investigated, respectively. The results were summarized as follows ; 1. CJM extract suppressed $IL-1{\beta}$, IL-6 mRNA in PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$ 2. CJM extract suppressed APP, AChE, GFAP mRNA in PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$ 3. CJM extract suppressed AChE activity in cell lysate of PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$ 4. CJM extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. 5. CJM extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. According to the above results, it is suggested that CJM extract might be usefully applied for prevention and treatment of Alzheimer's disease and memory deficit symptom.

• 한국초지조사료학회지
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• 제31권3호
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• pp.243-250
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• 2011

본시험은 2모작 작부체계적응 다수성이며 조숙성인 헤어리베치의 품종을 선발하기 위하여 실시하였다. 생산력검정은 조생종 Cold green, Haymaker plus, Cappello와 중만생종 Cheong pa, Challenger, Hungvillosa 및 Latigo의 생육특성, 건물수량, 사초품질을 평가하기 위하여 경북성주에서 2009년부터 2011년까지 수행되었다. 시험설계는 품종을 처리로 7처리 3반복의 난괴법으로 배치하였다. 파종은 2009년 9월 26일과 2010년 10월 11일에 하였으며 수확은 2010년과 2011년 공히 4월 30일에 실시하였다. 내한성은 울리포드베치인 Haymaker plus와 Cappello가 다른 헤어리베치품종에 비해 약간 낮았다. 50% 개화기는 Cold green이 4월 23일로 가장 빨랐으며, Haymaker plus와 Cappello가 각각 4월 26일과 4월 24일로 비슷했으며, Cheong pa와 Challenger는 5월 13일로 같았고, Hungvillosa 5월 17일, Latigo 5월 22일이었다. 1년차 시험에서 건물수량은 Cold green이 Haymaker plus를 제외하고 제일 높았으며 (P<0.05), Haymaker plus는 다른 품종들 보다 높았으며(P<0.05), Cappello, Cheong pa, Challenger는 Hungvillosa와 Latigo 보다 높았다(P<0.05). 2년차 시험에서 Cold green이 가장 높았으며 (P<0.05), Haymaker plus는 다른 품종들 보다 높았고(P<0.05), Cappello는 Hungvillosa와 Latigo 보다 높았고(P<0.05), Cheong pa와 Challenger는 Latigo 보다 높았다(P<0.05). 베치의 CP 함량은 높았고 ADF 함량은 낮았다. 본 시험의 결과에 의하면 가을파종베치의 품종은 조생품종이 양호했으며 차선으로 중만생품종중에서 선택할 경우 개화기가 빠른 품종이 좋은 것으로 생각된다.

• 동국한의학연구소논문집
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• 제3권
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• pp.207-222
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• 1994

In order to find out the effect of Anti-Histamine of the Sungmagalkuntang and Sungmagalkuntang-plus-samultang I've investigated the effect of the time to death, the peripheral vascular Pemeability, the amount of secretion of Gastric Juice, the total Acidity of Gastric Juice, the contraction of Intestine Tube by Histamine and the effect of the Skin-Reaction by the decrease of DNCB. These results are following ; 1. The effect of Mice's time to death by Histamine was that the injection group of sungmagalkungtang and the injection group of sungmagalkungtang-plus-samultang both have had the effect of the extention of the time to death, which indicated a statistical significance in comparison with comparative group. 2. The effect of the increased vascular permeability by Histamine was that the injection group of sungmagalkuntang and the injection group of sungmagalkuntang-plus-samultang both have had the effect of the restraint of the increased vascular permeability, which indicated a statistical significance in comparison with comparative group. 3. The effect of the the amount of the secretion of Gastric Juice by Histamine stimulus was that the injection group of sungmagalkuntang-plus-samultang only has had the effect of restraint of the increased of the secretion of Gastric Juice, which indicated a statistical significance in comparison with comparative group. 4. The effect of the change of total Acidity of Gastric Juice by Histamine's stimulus was that the injection group of sungmagalkuntang-plus-samultang only has had the effect of the restraint of the increase of total Acidity of Gastric Juice, which indicated a statistical significance in comparison with comparative group. 5. The effect of the contraction of Intestine Tube by Histamine was that sungmagalkuntang and sungmagalkuntang-plus-samultang both have had the effect of the contraction and the restraint. According to the increase of the density, the effect of the restraint was more clear. But the difference of the effects between two substances had little. 6. The effect of the reaction of skin by the decrease of DNCB was that the injection group of sungmagalkuntang and the injection group of sungmagalkuntang-plus-samultang have had the decreased effect of the Skin-Reaction in comparison with comparative group. sungmagalkuntang-plus-samultang aws more effective. In these results shown above, both sungmagalkuntang and sungmagalkuntang-plus-samultang was shown as more effective one.

• 한국수학사학회지
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• 제11권1호
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• pp.52-57
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• 1998

Since cluster analysis encompasses many diverse techniques for discovering structure within complex bodies of data, it has been employed as an effective tool in scientific inquiry. Recent works on cluster analysis softwares carried out by SAS, SPSS, S-PLUS and BMDP are briefly summarized and investigated in this paper. The inferred statistical package for windows executing a nay for data analysis in modern statistical techniques has several merits superior to other packages. Especially, S-PLUS can be designed and tried out much faster than other statistical packages. S-PLUS provides a graphic which is interactive, informative, flexible ways of looking at data. Also, if a statistical computation time is long and programs are complex, these can be shorten by providing interfaces to the UNIX systems (or C, Fortran).

• Advances in Traditional Medicine
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• 제7권2호
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• pp.128-132
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• 2007

Diarun plus, a polyherbal formulation containing herbal ingredients of folkloric Antidiabetic effect, was investigated for its effect on glycemic status in rats and mice. In contrast to conventional chemical induced diabetic animal models, changes in glycemic states were induced by physiological maneuvers. Results revealed that in euglycemic animals Diarun plus elicited little change (-10 to +10%), which was insignificant. In food deprivation/swim exercise induced hypoglycemia, Diarun plus reduced the degree of hypoglycemia in both rats and mice (from 38% to 27% in rats and 45% to 32% in mice). Similarly, the marked hyperglycemia induced by dextrose (70% in rats and 95% in mice) was reduced markedly to 8% and 25% respectively. The findings of the present study suggests that the ingredients of Diarun plus have the unique property of maintaining near euglycemic state irrespective of the altered glycemic state, and that have no significant effect in euglycemic condition.

• 동의신경정신과학회지
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• 제34권4호
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• pp.421-431
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• 2023

Objectives: The purpose of this study was to report the effect of complex Korean medicine treatments on Essential Tremor Plus (ET plus) patient aggravated by a traffic accident. Methods: We treated an ET plus patient with complex Korean medicine. The patient's resting tremor and kinetic tremor in both hands intensified after experiencing a traffic accident, with tremor in the left hand being worse than that in the right hand. Effect of complex Korean medicine treatment was evaluated using Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS), Numerical Rating Scale (NRS), and Beck Anxiety Inventory (BAI). Results: After 26 weeks of treatments (acupuncture, pharmacupuncture, cupping, Iigyeungbyunqi-therapy, and herbal medicine), the FTMTRS decreased from 38 to 15. NRS of Lt. upper limb pain decreased from NRS 9 to 0. BAI score also decreased from 31 to 17. Conclusions: Complex Korean medicine could be used to treat patients with ET plus aggravated by a traffic accident.

• 치과방사선
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• 제27권1호
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• pp.55-71
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• 1997

Digora/sup (R)/ an intraoral digital radiography system utilizing image plate (IP) - has a dynamic range of exposure time which allows it to decrease the patient's exposure time and to increase diagnostic ability through image processing, transmission and storage. The purpose of this study was to evaluate the Digora/sup (R)/ system by assessing the effects of various exposure times on the detectability on the tip of the endodontic file. Examining the root canals of 45 extracted sound premolars, K -files No. 10, 15, and 20 were placed at slightly varying distances from the apex. The teeth were glued onto resin-plaster blocks. Five exposure times varying between 0.01 seconds and 0.25 seconds were used. Four observers were asked to measure the distance between the tip of the file and a reduction of crown portion, and obtained mean errors (subtracting true file length from the measured file length), comparing Digora/sup (R)/ monitors with E-plus films, which were both obtained under the same geometrical positions. The results were as follows : 1. Comparing E-plus film with Digora/sup (R)/ at 0.01 seconds, the mean errors in E-plus film showed -4.453 nun, -4.497 nun, and -3.857 nun, while the mean errors in Digora/sup (R)/ showed 0.065 nun, 0.607 nun, and 0.719 mm according to the file groups. Therefore there was a significant difference between E-plus film and Digora/sup (R)/(p<0.05). 2. By comparison of mean errors according to the various exposure times in the Digora/sup (R)/ system, the mean error at 0.01 seconds was significantly lower than that at 0.12 and 0.25 seconds in the No. 10 file group(p<0.05). And the standard deviation was the highest at 0.01 seconds. 3. Comparing E-plus film at 0.25 seconds with the Digora/sup (R)/ system, the mean errors showed a significant difference between E-plus film at 0.25 seconds and the Digora/sup (R)/ system at 0.25 seconds in No. 10 and 20 file groups(p<0.05). 4. Comparing E -plus film at 0.25 seconds with other exposure times, the mean errors showed a significant difference between E-plus film at 0.25 seconds and E-plus film at 0 .. 01 and 0.03 seconds in 10 file group(p<0.05). In the No. 15 and 20 file groups, there was a significant difference between E-plus film at 0.25 seconds and E-plus film at 0.01 seconds(p<0.05). In conclusion, Digora/sup (R)/ was better than E-plus film in detectability on the tip of the file at the exposure time of 0.01 seconds in all file groups. And we concluded that Digora/sup (R)/ can shorten exposure times up to 4％ of 0.25 seconds (0.01 sec), which is adequate exposure time for premolar in E-plus film using No. 15 and 20 files.

• 대한한방소아과학회지
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• 제16권1호
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• pp.81-103
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• 2002

This present study was carried out to investigate the effect of Saengjingamrotang and Saengjingamrotang plus Radix Trichosanthis in streptozotocin induced hyperglycemic rats. Body weigh, serum levels of glucose, insulin, total cholesterol, triglyceride and urine levels of volume, glucose, protein were measured in streptozotocin induced hyperglycemic rats orally receiving extracts of Sanengjingamrotang and Saengjingamrotang plus Radix Trichosanthis for 4 days. The results were as follows: 1. The change of body weight, the medication group of Saengjingamrotang plus Radix Trichosanthis concentration has the notable increase, the medication group of Saengjingamrotang concentration has no notable change, as compared to control group. 2. The change of the content on serum glucose, the medication group of Saengjingamrotang conctntration have notable decrease, as compared to control group. 3. The change of the content on serum insulin, the medication group of Saengjingamrotang plus Radix Trichosanthis concentration has the notable increase, the medication group of Saengjingamrotang concentration has no notable change, as compared to control group. 4. The change of the content on serum total cholesterol, the medication group of saengjingamrotang concentration and the medication group of Saengjingamrotang plus Radix Trichosanthis concentration have notable decrease, as compared to control group. 5. The change of the content on serum triglyceride, the medication group of Saengjingamrotang concentration and the medication group of Saengjingamrotang plus Radix Trichosanthis Concentration have notable decrease, as compared to control group. 6. The change of urine volume, the medication group of Saengjingamrotang plus Radix Trichosanthis concentration has the notable decrease, the medication group of Saengjingamrotang concentration has no notable change, as compared to control group. 7. The change of the content on urine glucose, the medication group of Saengjingamrotang concentration and the medication group of Saengjingamrotang plus Radix Trichosanthis concentration have notable decrease, as compared to control group. 8. The Change of the content of serum protein, the medication group of Saengjingamrotang concentration and the medication group of Saengjingamrotang plus Radix Trichosanthis concentration have notable decrease, s compared to control group. 9. The change of body weight, serum insulin and urine volume, the medication group of saenfjingamrotang plus Radix Trichosanthis concentration has more notable change than the medication group of Saengjingamrotang concentration, as compared to control group. According to above mentioned results, Saengjingamrotang and Saenfjingamrotang plus Radix Trichosanthis have the effect of decreased blood sugar, serum lipid levels and urine volume, protein, glucose in streptozotocin induced hyperglycemic rats, and so they were expected to be appled to the treatment of diabetes mellitus.

• Journal of Microbiology and Biotechnology
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• 제27권10호
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• pp.1744-1752
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• 2017

Myeolchi jeotgals (MJs) were prepared with purified salt (PS), solar salt aged for 1 year (SS), and bamboo salt (BS) melted 3 times at 10% and 20% (w/w) concentrations, and fermented for 28 weeks at $15^{\circ}C$. BS MJ showed higher pH and lower titratable acidities than the other samples because of the alkalinity of bamboo salt. Lactic acid bacteria counts increased until 4-6 weeks and then decreased gradually, and were not detected after 20 weeks from MJs with 10% salt. Yeast counts of PS MJs were higher than those of BS and SS MJs. Bacilli were detected in relatively higher numbers throughout the 28 weeks, like marine bacteria, but archae were detected in lower numbers during the first 10 weeks. When 16S rRNA genes were amplified from total DNA from PS MJ (10% salt) at 12 weeks, Tetragenococcus halophilus was the major species. However, Staphylococcus epidermidis was the dominant species for BS MJ at the same time point. In SS MJ, T. halophilus was the dominant species and S. epidermidis was the next dominant species. BS and SS MJs showed higher amino-type nitrogen, ammonia-type nitrogen, and volatile basic nitrogen contents than PS MJs. SS and BS were better than PS for the production of high-quality MJs.

• 한국시뮬레이션학회논문지
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• 제28권3호
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• pp.65-74
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• 2019

분기-접합 생산시스템은 오랜 기간 동안 연구되어왔지만, 개별 또는 공유 유한 버퍼를 갖고 일반공정시간 분포를 따르는 시스템에 대한 분석은 제한적이다. 일반적으로 대기행렬 이론적 분석법은 유한 버퍼를 갖는 시스템에 대한 분석에는 어려움이 있다. 본 연구에서는 max-plus 대수적 분석법을 활용하여 일반 공정시간을 갖는 버퍼 공유 분기-접합 생산시스템을 분석하였다. 하지만, 이러한 분석법은 특성치 계산의 관점에서는 적절한 방법을 제공하지 못하기 때문에 max-plus 대수로 도출된 표현식과 @RISK 소프트웨어를 활용하여 스프레드시트 시뮬레이션 모형을 개발하였다. 시뮬레이션 실험을 통해 유한 버퍼와 두 가지 차단규칙인 BBS(통신차단)과 BAS(제조차단) 하에서 시스템 대기시간에 대한 몇몇 특성을 비교 분석하였다.