• YAKHAK HOEJI
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• v.54 no.6
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• pp.529-534
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• 2010

Alzheimer's disease (AD) is characterized pathologically by the presence of intracellular neurofibrillary tangles and deposition of ${\beta}$-amyloid ($A{\beta}$) peptides, which are generated by processing of amyloid precursor protein (APP). It is urgent to develop effective therapies for the treatment of AD, since our society rapidly accelerate aging. $A{\beta}$ peptides have been believed to be neurotoxic and now are also considered to have effects on the mechanism of memory formation. Recently, we investigated that a quinoline compound from natural product reduced the secretion of $A{\beta}$ from the neuroblastoma N2a cells (NL/N cell line) overexpressing APPswe. In this study, 3-phenyl-1-isoquinolinamine, a synthetic isoquinoline compound was analyzed to determine its effects on the metabolism of APP. It inhibited the secretion of $A{\beta}$ peptides from the N2a NL/N cell line. Beta-site APP cleaving enzyme (BACE) fluorescence resonance energy transfer (FRET) assay revealed that it inhibited BACE activity in a dose dependent manner. Immunoblotting study showed that it inhibited APP stabilization and expression and it slightly increased the stablization and the expression of ${\gamma}$-secreatase component from the N2a NL/N cell line. We suggest that 3-phenyl-1-isoquinolinamine inhibits APP metabolism and $A{\beta}$ generation by the means of BACE inhibitory mechanism. This is the first report that 3-phenyl-1-isoquinolinamine inhibits the secretion of $A{\beta}$ peptides from neuroblastoma cells.

• Journal of Korean Library and Information Science Society
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• v.25
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• pp.501-527
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• 1996

This study attempts to provide the foundation that KINITI and industrial su n.0, pporting organizations can be strong information analysis centers if they fortify their information analysis activities. The following conclusions are resulted from the analysis in the state-of-the-art-report covered in national information flow system, service methods and their publications of the information analysis activities provided by the KINITI and industrial su n.0, pporting organizations. First, the KINITI and industrial su n.0, pporting organizations have not be acquiring enough information materials. The services for bibliographic information should guarantee the uses of original documents. Second, the number of organizations providing on-line information services has been increasing, but the provided materials are not sufficiently suited for user's requests. Third, the speedy information provision and efficient information dissemination for the end users in the long distance may be possible through on-line service, but it requires information analysis procedure to select the necessary information in our industrial environment. Forth, the information activities provided by the libraries of industrial su n.0, pporting organizations should be fortified.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2001.11a
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• pp.152-156
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• 2001

본 논문에서는 단일 DGS의 전송특성을 ABCD 파라미터로 모델링하여 연속한 N개의 DGS 분석 및 설계를 용이 하게 하였다. 모델링된 식의 검증을 위해 연속된 N개의 주기적 DGS에서 전송특성을 이론, 회로 시뮬레이션, EM 시뮬레이션을 비교하였다. 또한 응용 예로서, 능동안테나의 불요 고조파가 방사하는 것을 저지하기 위한 DGS를 설계 및 시뮬레이션하여 제시된 방법론의 타당성을 검증하였다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.17 no.9
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• pp.972-981
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• 1992

In this paper, the performance of linear and hard-limiting correlation receivers for DS/SSMA BPSK power line communication system is analyzed. Strong impulsive noise of power line is modeled with Chan's noise model, and the performance of both receivers is analyzed in terms of parameters such as ratio of power spectrum density of impulsive noise to that background noise, ratio in impulsive noise width th that of data bit, and interarrival time of impulsive noise. And also multiple access capacity is evaluated with Gaussian approximation of multiple access interference. The results of this analysis reveal that the performance of linear correlation receiver is superior to that of hard-limiting correlation receiver when $N_1/N_b$ is small and is close to 1. But the BER and the multiple access capacity of hard-limiting correlation receiver becomes better in comparison with linear correlation receiver as $N_1/N_b$ increases.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.453-453
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• 2000

This paper presented Fuzzy logic application to Electrical power system analysis for fault location estimation in distribution lines and apply the Power system theory to be fuzzy logic database. The case study referred to the Overhead distribution line of the Provincial Electricity Authority (PEA.), Thailand which mostly the distribution line of PEA. are Radial schemes. These benefits include reduced outage time, help in locating momentary faults, enhance safety to the line crews and provide notification of an outage without receiving calls from the consumer, Which these benefits also increase Reliability, Stability and Efficiency.

• Explosives and Blasting
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• v.16 no.3
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• pp.16-24
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• 1998

Methods of Rock fragmentation are used rock of housing repair development at KU-SAN DONG area in seoul Youn-Pyong Ku. So, Theorical analyses of the effect of vibration and frequency on structural damage around old housed also discussed. The results can be summarized as follows: 1. A area(Rock area not more than 15m Ku-San Mention) Some Empirical equations were obtained $V=K\{{\frac{D}{W}}1/3\}^{-n}$ where the values for n and K are estimated to be -1.64 and 94 respectively, this values were obtained only theorical analyses. If we have 125g charge this area is impossible blasting operation, so this area must be worked by SRS(Super Rock Splitter) method. 2. B area(Rock area from 15m to 25m in a boundary line from Ku-San Mention) This area charge is about 125g in a delay time by some empirical equation s. So, this area can be blasting operations by small charge. 3. C area(Rock area from 25m to 35m in a boundary line from Ku-San Mention) This area charge is about 500g in delay time by some empirical equation s. So, this area can be blasting operations by middle charge. 4. D area(Rock area more then 35m in a boundary line from Ku-San Mention) This area charge is about 1000g in a delay time by some empirical equation s. So, this area can be blasting operations by middle charge.

• Horticultural Science & Technology
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• v.33 no.1
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• pp.83-92
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• 2015

xBrassicoraphanus line BB#5, a new synthetic intergeneric hybrid between Brassica rapa L. ssp. pekinensis and Raphanus sativus L. var. rafiphera induced by N-methyl-N-nitroso-urethane mutagenesis in microspore culture, shows high seed fertility and morphological uniformity. Dual-color fluorescence in situ hybridization (FISH) using 5S and 45S rDNA probes and genomic in situ hybridization (GISH) using B. rapa genomic DNA probe were carried out to analyze the chromosome composition and the meiosis pairing pattern compared to its parental lines. The somatic chromosome complement is 2n = 38, which consists of 17 metacentric and two submetacentric chromosomes with lengths of 2.18 to $5.01{\mu}m$. FISH karyotype analysis showed five and eight pairs of 5S and 45S rDNA loci. GISH meiosis pairing analysis showed that 19 complete bivalents were most frequent and accounted for 42% of the 100 pollen mother cells examined. Based on chromosome number, size, morphology, rDNA distribution, and meiosis pairing pattern, both parental genomes of B. rapa and R. sativus appear to exist in xBrassicoraphanus line BB#5, demonstrating its genome integrity. Such stable chromosome constitutions and meiotic pairing patterns in somatic and meiotic cells are very rare in natural and synthetic intergeneric hybrids. Chromosomal studies and genetic and phenotypic changes in allopolyploids a re discussed. The results p resented h erein will b e usef ul f or f urther g enomic s tudy o f xBrassicoraphanus lines and their improvement as promising new breeding varieties.

• 한국전산유체공학회:학술대회논문집
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• 2004.03a
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• pp.202-207
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• 2004

In the present study a mesh generation program has been developed by using DXF file. The program consists of DXF file reading and mapping algorithm, which projects the 2-D mesh point onto the triangular surface constructed by nearest three points. The present program has been tested for mesh generations for the road tunnel ventilation analysis and analysis of lava movement in mountain area.

• Proceedings of the KIEE Conference
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• 2004.11b
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• pp.36-38
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• 2004

In many countries, including Korea, in order to transmit the more electric power, the higher transmission line voltage is inevitable. So, a rapid reclosing scheme is important for UHV transmission lines to ensure requirements for high reliability of main lines. But, because of the high voltage and long span of UHV lines, the secondary arc current flows across the fault point even after the interruption of the fault current. i.e. A critical aspect of reclosing operation is the extinction of the secondary arc since it must extinguish before successful reclosure can occur. In Korea transmission lines, it is scheduled to energize 765kV single transmission line(79km) between Sin-Ansung S/S and Sin-Gapyeong S/S at June 2006. Therefore this paper analyzes characteristics of the secondary arc extinction on 765kV single transmission line using EMTP. Simulation results shows that the average value of the secondary arc is $30A_{rms}$ and the auto-extinction time of it is longer at closer point to Sin-Gapyeong S/S.

• Proceedings of the KIEE Conference
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• 2001.07c
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• pp.1738-1740
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• 2001

The occurrence of fires under transmission lines is responsible for a great number of power line outages. In this paper, the ac flashover voltages and the corona onset voltages of a model transmission line in the presence of flame were investigated. We found that the corona onset voltages and the flashover voltages were varied with the position of flames. Flashover voltages of vertical arranged electrodes with flame appeared to decrease 43[%] lower than those of same conditions with no flame.