• The korean journal of orthodontics
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• v.31 no.5 s.88
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• pp.479-487
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• 2001

The perception of facial esthetics is critically important to orthodontists. A viewpoint to facial esthetics is influenced by various factors and dependent on the perception of observer. The purpose of this study was to examine the differences regarding esthetic viewpoints among orthodontists, to identify attractive profiles preferred to orthodontists and to present the characteristic aspects of attractive profiles upon the degree of facial convexity. 35 persons whose faces were judged as attractive one by S orthodontists were selected out of 133 young Korean women. Soft tissue profiles Identified as a good-profile group were measured and analyzed. And then according to the facial convexity, good-profile group was subdivided to convex (G-Sn-Pg$9^{\circ}$) and straight (G-Sn-Pg<$9^{\circ}$) groups for the purpose of this study. There were statistically no significant differences regarding esthetic viewpoints among S orthodontists(p<0.05), even if there exists prevailing concept that the standard for facial esthetics is substantially subjective. N-Pg-Sn and N-Pg-Pn, measured for determining anteroposterior relationship of midfacial convexity, showed significant differences statistically between 2 subgroups (P

• Journal of Fashion Business
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• v.11 no.1
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• pp.1-14
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• 2007

This study was aimed at giving help to the people intending to change their own hair color design and also providing the guide line to the cosmetic circles for developing new hair color design and promoting sales by statistically analyzing seasonal changes of hair colors puplished on women's magazines(Vogue Korea, Estetica Korea, Woman Chosun, Ce.ci) from 2003 to 2006. The researching methods were as follows; (1) hair colors published on women's magazines from september 2003 to August 2006 were measured by N.C.S. color reader(4 magazines $\times$10 main hair colors/magazine $\times$ 12 months $\times$ 3 years = 1,440 colors). (2) N.C.S. tone is made of percentage, so measured values and chromas were statistically analyzed by mean, standard deviation, and seasonal deferences were statistically analyzed by t-test and specified on high significant values. But hues were not made of percentage, so these were statistically analyzed by cross tabulation analysis, $x^2$ -test and specified on high significant values. These all had been analyzed by SPSS program(ver. 11.0). The results were as follows; (1) Usually seasonal changes of hair values were significant, specially in foreign licensed magazines, and bright values appeared in S/S and dark values in F/W. (2) Seasonal changes of hair hues were significant only on foreign women's magazines. Therefore seasonal changes of korean hair colors were not significant compared by foreign hair colors because of hardness of color changes of dark black hair and hair damages by hair tints and bleaches and trends of well being and hair care. But hair color changes have been developed gradually and will developed furthermore. So korean hair cosmetic circles have to present hair color trends deferenciated by seasons. And S/S hair values have to be brignt and F/W have to be dark. And new seasonal hair hues matched by korean have to be developed and presented.

• Clinical and Experimental Pediatrics
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• v.64 no.7
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• pp.355-363
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• 2021

Background: Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, children with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes, suggesting molecular heterogeneity. Purpose: This study aimed to explore the molecular responses of podocytes to nephrotic plasma to identify specific genes and signaling pathways differentiating various clinical NS groups as well as biological processes that drive injury in normal podocytes. Methods: Transcriptome profiles from immortalized human podocyte cell line exposed to the plasma of 8 subjects (steroid-sensitive nephrotic syndrome [SSNS], n=4; steroid-resistant nephrotic syndrome [SRNS], n=2; and healthy adult individuals [control], n=2) were generated using microarray analysis. Results: Unsupervised hierarchical clustering of global gene expression data was broadly correlated with the clinical classification of NS. Differential gene expression (DGE) analysis of diseased groups (SSNS or SRNS) versus healthy controls identified 105 genes (58 up-regulated, 47 down-regulated) in SSNS and 139 genes (78 up-regulated, 61 down-regulated) in SRNS with 55 common to SSNS and SRNS, while the rest were unique (50 in SSNS, 84 genes in SRNS). Pathway analysis of the significant (P≤0.05, -1≤ log2 FC ≥1) differentially expressed genes identified the transforming growth factor-β and Janus kinase-signal transducer and activator of transcription pathways to be involved in both SSNS and SRNS. DGE analysis of SSNS versus SRNS identified 2,350 genes with values of P≤0.05, and a heatmap of corresponding expression values of these genes in each subject showed clear differences in SSNS and SRNS. Conclusion: Our study observations indicate that, although podocyte injury follows similar pathways in different clinical subgroups, the pathways are modulated differently as evidenced by the heatmap. Such transcriptome profiling with a larger cohort can stratify patients into intrinsic subtypes and provide insight into the molecular mechanisms of podocyte injury.

• Journal of the Korean Geophysical Society
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• v.6 no.3
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• pp.155-164
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• 2003

The validity and efficiency of the roll-along technique widely used in 2-D electrical resistivity survey are analyzed in case of the dipole-dipole and the Wenner-Schlumberger arrays by numerical modelling. The shallow anomalous resistivity bodies are successfully inverted both in the dipole-dipole and in the Wenner-Schlumberger arrays because the shallow data of pseudosection are not omitted by the roll-along technique. However, the deep anomalous resistivity bodies can not be well resolved due to the skip of observed data which is more significant in the Wenner-Schlumberger array having relatively poor horizontal coverage of obtaining data. Carrying out electrical survey adopting the dipole-dipole array, the skip of data is insignificant because it is unfeasible to expand the electrodes to the maximum electrode separation coefficient($n_max$) owing to low S/N ratio. In case of the Wenner-Schlumberger array, however, because it is generally feasible to expand the electrodes $n_max$ to the owing to high S/N ratio, it is highly possible that skip of data from the roll-along technique causes significant distortion of inversion results. Therefore, adopting the Wenner-Schlumberger array having deeper median depth(Edwards, 1977) than do the dipole-dipole array on condition of the same unit electrode spacing( ($a$) ) and $n_max$, it is recommended to determine $a$ based on not $n_max$but $n_prob$free from the skip of observing data and forward electrodes with keeping overlap interval 3/4 of the survey line length in order to reduce the distortion of resistivity structure and perform resistivity survey efficiently. These results are confirmed by numerical modelling.

• Journal of Advanced Marine Engineering and Technology
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• v.32 no.3
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• pp.430-436
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• 2008

Recently, there are many cases to use a ship's engine performance analyzer(SEPA) to measure pressure in cylinder and top dead center(TDC) of piston of engine, and analyze its performance such as fuel injection time and horsepower as well as wear of piston ring. But, SEPA needs TDC pulses($T(1){\sim}T(n)$) generated when pistons of engine are located to the TDC position ($TDC(1){\sim}TDC(n)$), these pulses are gathered from sensors connected to gear wheel of the propeller shaft in the remote distance from the measurement point. Therefore, operators need a long wire cable(WRC) to TDC detecting sensor to get these pulses, but this method is a very uncomfortable and expensive in case of installation, and it might decrease user's purchase desire. In this paper, we design and fabricate a small and inexpensive MODEM cable(M0C) so that it may be available to transmit TDC pulse generated from sensor in propeller shaft through existing power line. We also verify the facts that this MOC can be applied to SEPA and the effectiveness of the system through the experiments.

• Economic and Environmental Geology
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• v.17 no.4
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• pp.273-282
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• 1984

The Buncheon manganese ore deposits occur in vein along the fault of $N20^{\circ}E$, cutting the foliation of Yulri Series. The deposits consist of primary manganese silicate ores in the deeper part and superficial manganese oxide ores near the surface. The spatial distribution of manganese oxide ores with respect to the manganese silicate ores suggests that the manganese oxide ores are the supergene oxidation product of the manganese silicate ores. Manganese silicate ores consist mainly of fine-to coarse-grained pyroxmangite with minor rhodochrosite, quartz, sulfides and chlorite. Manganese oxide ores are composed of supergene manganese oxides such as nsutite, birnessite, manganite and todorokite, and other associated minerals. Paragenetic sequence of formation of the manganese minerals are as follows: $\array{{rhodochrosite{_{\rightarrow}^o}todorokite{_{\searro}^o}}\\pyroxmangite{_{\line(10){90}}^o}{\nearro}}birnessite{_{\rightarrow}^o}nsutite{_{\rightarrow}^s}manganite$ In order to elucidate the mineralogy of the manganese minerals, microscopic, X-ray, IR spectroscopic, and thermal studies were made for manganese and associated minerals.

• Journal of the Korean Magnetics Society
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• v.4 no.4
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• pp.335-339
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• 1994

The crystallograpic and magnetic properties of $Eu(Fe_{1-x}In_{x})O_{3}$ (x=0, 0.03과 0.05) have been studied by the methods of X-ray diffraction, $M\"{o}ssbauer$ spectroscopy, and magnetic hysteresis measurement at room temperature. The X-ray results show that the samples have a crystal structure of orthorhombic and unit cell volume of the crystal with the exception of the sample of x=0 increases as increasing the In concentration. In the analysis assuming two sets of six-line of $M\"{o}ssbauer$ spectra, it is found that the magnetic hyperfine field in each of sets decreases increasing x. The linewidth of the absorption lines for the samples increased as increasing x. This implies that the data involve a sum of several hyperfine patterns which have intensity being proportional to $_{n}P_{z}(x)$, the probability of an environment with z such Fe neighbors. The magnetic hysteresis curves show decrease of $M_{s}$ and increase of $H_{c}$ of the samples with increasing x.

• Archives of Pharmacal Research
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• v.28 no.4
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• pp.443-450
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• 2005

In the present study, we have characterized the choline transport system and examined the influence of various amine drugs on the choline transporter using a conditionally immortalized rat brain capillary endothelial cell line (TR-BBB) in vitro. The cell-to-medium (C/M) ratio of $[^3{H}]choline$ in TR-BBB cells increased time-dependently. The initial uptake rate of $[^3{H}]choline$ was concentration-dependent with a Michaelis-Menten value, $K_{m}$, of $26.2\pm2.7{\mu}M$. The $[^3{H}]choline$ uptake into TR-BBB was $Na^{+}-independent$, but was membrane potential-dependent. The $[^3{H}]choline$ uptake was susceptible to inhibition by hemicholinium-3, and tetraethy-lammonium (TEA), which are organic cation transporter substrates. Also, the uptake of $[^3{H}]choline$ was competitively inhibited with $K_{i}$ values of $274 {\mu}M, 251 {\mu}M and 180 {\mu}M$ in the presence of donepezil hydrochloride, tacrine and $\alpha-phenyl-n-tert-butyl nitrone$ (PBN), respectively. These characteristics of choline transport are consistent with those of the organic cation transporter (OCT). OCT2 mRNA was expressed in TR-BBB cells, while the expression of OCT3 or choline transporter (CHT) was not detected. Accordingly, these results suggest that OCT2 is a candidate for choline transport at the BBB and may influence the BBB permeability of amine drugs.

• Journal of Pharmacopuncture
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• v.22 no.3
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• pp.176-183
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• 2019

Objective: In the current work, we investigated the cytotoxic and apoptotic effects of Thymoquinone (TQ), an active compound of Nigella sativa (N. sativa) and Cis-platinum, on normal renal epithelial (GP-293) and human renal adenocarcinoma cell lines (ACHN). Methods: GP-293 and ACHN cell lines were cultured in Dulbecco's modified Eagle's medium (DMEM) with 10% Fetal bovine serum (FBS) and 1% penicillin plus streptomycin antibiotic. The MTT assay was used for cellular viability assessment. Viability of cells was observed using inverted light microscope 24, 48 and 72 h after exposure of the cells to various concentrations of TQ (1, 2.5, 5, 10, 50 and $100{\mu}g/ml$) and Cis-platinum (0.5, 1, 1.5, 2, 3, 6 and $12.5{\mu}g/ml$). Moreover, apoptosis was analyzed with a flow-cytometry method. The untreated cells were considered as control group. Results: Morphological changes such as reduced cell number and increased intercellular distance and reduced cell viability in ACHN and GP-293cell lines were observed in both TQ and Cis- platinum groups; however, Cis-platinum had greater effect on ACHN cell line than GP-293 cell line. In addition, GP-293 cell line was more sensitive to TQ compared to ACHN cell line. Furthermore, TQ and Cis-platinum had apoptotic effects on both ACHN and GP-293 cell lines. Conclusion: Our findings demonstrated that TQ and Cis-platinum had cytotoxic and apoptotic effects on both cell lines, However, GP-293 cell line was more sensitive to TQ. Additionally, Cis-platinum was more effective on ACHN cell line than on GP-293 cell line.

• Journal of Acupuncture Research
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• v.19 no.5
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• pp.136-148
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• 2002

본 연구는 osteoblastic cells에서 estogen 의 생합성을 유도하는 aromatase의 activity에 대한 봉독(蜂毒)작용을 측정하여, 봉독치료시 Arthritis의 진행 억제 및 estogen의 의한 bone formation의 효과여부를 검증하기 위해 실행하였다. 사용된 세포주로는 Osteoblastic phenotype으로 분화가 유도되는 Human leukaemic cell line FLG 29.1 및 the primary first-passage osteoblastic cells (hOB cells)이며, 이들을 각각 배양하고 각각의 RNA를 isolation한 뒤 PCR 증폭을 하였다. Aromatase에 대한 활성인자인 TPA와 TGF-${\beta}1$ 및 봉독을 이용하여 aromatase의 expression 및 activity에 대해 미치는 영향을 측정한 바, aromatase expression은 FLG 29.1 cell와 hoB cells에서, 50nM TPA 24시간 처리, 봉독 2 ~ 4시간 처리와 TGF-${\beta}1$ 3시간 처리로 유도한 결과 TPA와 TGF-${\beta}1$의 경우는 서로 유사하였고, 봉독에서 상대적으로 높게 나타났다. Aromatase activity는 FLG 29.1 cell, hoB cells에서 24시간 incubation한 결과, 모든 실험에서 일정하게 선상증가를 보였다. $5{\mu}{\ell}/m{\ell}$ BV에서 TPA와 TGF-${\beta}1$보다 뚜렷하게 증가하였으며, 0.5mM Bt2-cAMP, 50nM dexametasone처리에서는 유의성이 없었다. Estrogen 생합성을 촉매하는 aromatase activity BV가 처리에서 현저하게 증가하였기에, Rheumatis arthritis의 bone destruction에 대해 BV가 효과적인 역할을 할 것으로 보여진다.