• YAKHAK HOEJI
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• v.45 no.4
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• pp.378-386
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• 2001

A purified histone Hl protein, p961, which plays a role in mediating the condensation of DNA into chromatin, was recently proved as an arthritis-suppressing agent in the mouse CIA model. The pharmacokinetics of p961 was carried out in rats and rabbits. The rat's blood, bile and urine samples were serially collected from the femoral vein, common bile duct, and bladder respectively, after bolus i.v. injection at low (10 mg/kg) and high (30 mg/mg) doses. The rabbit's blood samples were also collected from the marginal ear vein after bolus i.v. injection at a dose 10 mg/kg. p961 and its major metabolite in the physiological samples were analyzed by reverse-phase HPLC using a Yydac C4 protein column and a multistep water-acetonitrile gradient containing 0.24% trifluoroacetic acid. The major pharmacokinetic parameters (AUC, $C_{max}$, MRT, $t_{1}$2/, $V_{ss}$ and Cl) were estimated from the time course of plasma p961 and metabolite concentrations using WinNonlin. A two-compartment model was chosen for p961 as the most appropriate pharmacokinetic model. After i.v. injection of p961 at doses of 10 mg/kg and 30 mg/kg, more than 80% of p961 was removed rapidly from the plasma within 15 min. The plasma half-life of p961 in rats and rabbits was found not to exceed 12 min. p961 (22448.9 mol wt) was rapidly cleaved to 21612 mot wt fragment and the breakdown product appeared rapidly in the circulation with no lag phase. p961 and metabolite were not detected in rat urine and bile....

• Korean Journal of Agricultural Science
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• v.14 no.1
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• pp.191-195
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• 1987

The ductus arteriosus (Botallo's duct) is a vascular communication between the pulmonary artery near its bifurcation and the aorta distal to the origin of the left subclavian artery. A surgical operation was tried in the shepherd dog which was affected by patent ductus arteriosus. The patient was six months old and weighed about 11kg. Pentobarbital sodium, 26 mg/kg was used intravascularly for the anesthesia. And then a respirator was used for the patient. The thoracotomy incision was made over the fourth intercostal space on the left and the ductus arteriosus was ligated twice. But the patient revealed ventricular fibrillation at three minutes after ligations of ductus arteriosus. So the cardiac massage was done after incision of pericardium and then the defibrillator was used for the defibrillation. But the patient was not recovered without effect. It was considered that if there is complication or cyanosis, the adaptability of surgical operation should be specially considered. Histologically, chronic passive congestion of liver was observed.

• Journal of the Society of Naval Architects of Korea
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• v.28 no.2
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• pp.318-328
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• 1991

The present paper describes the experimental study on the fixed-type wave-energy conversion system, consisting of the OWC-type wave-energy absorbing chamber and the duct for the air turbine. For simplicity, a screen of wire mesh was employed in place of an air turbine in order to simulate its effects on OWC chamber. Experiments were performed at the towing tank in regular waves with the frequency range of 0.22-0.75Hz. Comparison wish the numerical prediction using a potential flow-based method [4] was made to validate the capability of numerical code. It was shown that the agreements between measured and calculated results are quite good, giving a confidence in prediction method. Simulation of air turbine using a wire-mesh screen was successful, at least in a qualitative sense, to investigate the inter action between the OWC chamber and an air turbine. Results also showed that the effects of a wire-mesh screen on chamber efficiency are negligible, and the present model can be effectively utilized for the practical use in ocean waves with the frequency range under 0.3Hz.

• Fire Science and Engineering
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• v.34 no.3
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• pp.28-34
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• 2020

In this study, an ISO 5660-1 cone calorimeter experiment was conducted to examine the effects of changes in flow and thermal thickness around solid combustibles on heat release rate characteristics. Polymethyl methacrylate (PMMA) is a solid combustible material that does not generate char during the combustion reaction. Hence, it was selected for the experiment, and the thermal penetration depth was calculated to distinguish the thermal thickness of PMMA. Furthermore, the thermal decomposition characteristics were analyzed by measuring the heat release rate measured during the combustion of PMMA. This was performed after generating the forced flow around the combustibles by setting the duct flow of the cone calorimeter to 12, 24, and 40 L/s. The results confirmed that the thermal release rate of the thermally thin combustible material was not significantly affected by the change in the surrounding flow. Hence, the thermally thick combustible material was significantly affected by the change in the flow rate.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2003.05a
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• pp.89-93
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• 2003

The Korea Research Institute of Ships and Ocean Engineering (KRISO), the ocean engineering branch of KORDI, has designed and manufactured a model of an autonomous underwater vehicle (AUV) to test underwater docking. This paper introduces the AUV model, ASUM, equipped with a visual servo control system to dock into an underwater station with a camera and motion sensors. To make a visual servoing AUV, this paper implemented the visual servo control system designed with an augmented state equation, which was composed of the optical flow model of a camera and the equation of the AUV's motion. The system design and the hardware configuration of ASUM are presented in this paper. A small long baseline acoustic positioning system was developed to monitor and record the AUV's position for the experiment in the Ocean Engineering Basin of KRISO, KORDI. ASUM recognizes the target position by processing the captured image for the lights, which are installed around the end of the cone-type entrance of the duct. Unfortunately, experiments are not yet conducted when we write this article. The authors will present the results for the docking test of the AUV in near future.

• Journal of the Society of Naval Architects of Korea
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• v.59 no.1
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• pp.46-54
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• 2022

A magnetohydrodynamic (MHD) seawater propulsion thruster has been proposed to reduce propeller noise, propeller pitting, and vessel vibration originated from the propeller cavitation. The MHD thruster was also focused to overcome the limitation of propulsion velocity for the special purpose of marine ships. The research trends and key technologies in the worldwide leading countries are reviewed for the development of MHD propulsion thrusters in Korea. A small performance test device was developed firstly with a conventional solenoid magnet of ≤0.6 Tesla and a helical-type cylindrical duct(inner diameter of 5 cm) of thruster. The artificial seawater was fabricated by a salt solution including a conductivity of 5~6 S/m. The measured flow velocity of artificial seawater in the test device was 0.03~0.42 m/s (0.06~0.84 Knot) with a magnetic field strength of 0.6 Tesla and the applied currents of 10~80 A including the change of anode materials. It was found that the flow direction of seawater was reversed by the directional change of applied current in the solenoid magnet.

• Archives of Plastic Surgery
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• v.51 no.1
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• pp.130-134
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• 2024

Refractory chylous ascites can cause significant nutritional and immunologic morbidity, but no clear treatment has been established. This article introduces a case of a 22-year-old female patient with an underlying lymphatic anomaly who presented with refractory chylous ascites after laparoscopic adnexectomy for ovarian teratoma which aggravated after thoracic duct embolization. Ascites (>3,000 mL/d) had to be drained via a percutaneous catheter to relieve abdominal distention and consequent dyspnea, leading to significant cachexia and weight loss. Two sessions of hybrid lymphovenous anastomosis (LVA) surgery with intraoperative mesenteric lymphangiography guidance were performed to decompress the lymphatics. The first LVA was done between inferior mesenteric vein and left para-aortic enlarged lymphatics in a side-to-side manner. The daily drainage of chylous ascites significantly decreased to 130 mL/day immediately following surgery but increased 6 days later. An additional LVA was performed between right ovarian vein and enlarged lymphatics in aortocaval area in side-to-side and end-to-side manner. The chylous ascites resolved subsequently without any complications, and the patient was discharged after 2 weeks. The patient regained weight without ascites recurrence after 22 months of follow-up. This case shares a successful experience of treating refractory chylous ascites with lymphatic anomaly through LVA, reversing the patient's life-threatening weight loss. LVA was applied with a multidisciplinary approach using intraoperative mesenteric lipiodol, and results showed the possibility of expanding its use to challenging problems in the intraperitoneal cavity.

• Advances in pediatric surgery
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• v.2 no.2
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• pp.119-128
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• 1996

The survey on branchial anomalies was conducted by Korean Association of Pediatric Surgeons. A total of 173 cases were reported, which were managed by 36 members and cooperators during the three years from January 1, 1993 through December 31, 1995. The following results were obtained by retrospective analysis of the 173 cases of branchial anomalies. The presenting symptoms were cervical mass in 101 cases, pit with or without discharge in 71, cervical abscess in 47 and respiratory difficulty in 3. The average age of the patients with cervical abscess was 52 months. Seventy(79%) of 89 patients with branchial anomalies and a cystic mass had their first clinical manifestations by 1 year of age, while 40(51%) of 78 patients with only a branchial cyst had their first clinical manifestation in first year of life. Radiologic studies were carried out in 77 patients (43%). The preferred diagnostic modalities were ultrasonography(47 patients), simple neck radiogram(19) and CT scan(17). Preoperative diagnosis was correctly made in 156(91%) of 173 patients. Seventeen patients were incorrectly diagnosed as thyroglossal duct cyst in 5 patients, cystic hygroma in 4, dermoid cyst in 3, and lymphadenopathy in 3. There were no remarkable difference in sex and laterality of presentation but bilateral lesions were found in 9(5%) patients and unusual locations of the anomalies were the manubrium, left subclavicular area, median cervial area, preauricular and parotid area. There were 78(45%) patients with cyst, 52(30%) patients with sinus, 35(20%) patients with fistula and 8(5%) patient with skin tag. Embryological classification was possible in only 64(37%) patients. The 2nd branchial anomaly was present in 50(78%), the 1st branchial anomaly in 10(18%), and the 3rd or 4th branchial anomaly in 4(6%). Histopathological study of the lining epithelium(N=134) is recorded that 45% were lined with squamous epithelium, 17% with respiratory epithelium, 6% with. squamous and respiratory epithelium, 14% with inflammatory change. Lymphoid tissue was common(62%) in the wall of the lesions. Twelve(7%) of 158 patients had postoperative complications including wound complication, recurrence and facial nerve palsy.

• Korean Journal of Poultry Science
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• v.33 no.1
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• pp.57-63
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• 2006

This study was conducted to investigate the effect of ventilating system of environmental controlled broiler house on broiler production. Three hundred eighty four broiler chicks (Hubbard, mean live weight of $44.5{\pm}2.0g/bird$) were reared for 2 wk. The results of the present study were summarized as follows : 1. Ammonia gas production was lower in the second and the third floors of cages compared with first floor of cages 13.5 and 13.5 vs 14.6 ppm, respectively). The observations of ammonia production in the morning and afternoon were similar. The production of carbon dioxide was not different between morning and afternoon, but it was tended to decrease in the forth floor of cages due to a fresh air 2. A wind velocity in the enclosed house was similar across lower, middle and upper section (0.57m/sec, 0.22m/sec and 0.04msec, respectively). In order to maintain an optimal air flow velocity in the cages, the duct entrance was punched, and then the air flow was full-round in the overall space in the cage. 3. Daily liveweight gain, feed intakes, and feed efficiency were not significant differences among treatments during whole experimental period (P>0.05). Therefore, the present results showed that temperature, moisture and atmosphere controlling were desirable, and air flew evenly in the cage.

• Journal of Korean Tunnelling and Underground Space Association
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• v.19 no.6
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• pp.845-856
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• 2017

In the long railway tunnel, in order to secure safety in case of fire, it is required a emergency station. However, there is no standard or research results on smoke exhaust method and exhaust flow rate in emergency station, so it is necessary to study the smoke exhaust system for emergency station. In this study, we are created a numerical analysis model for emergency station where the evacuation cross passage connected to the service tunnel or the relative tunnel was installed at regular intervals (40 m intervals). And the fire analysis are carried out by varying the fire intensity (15, 30MW), the smoke exhaust method (only air supply, forced air supply and exhaust, forced air exhaust only), and the air flow rate (7, 14, $40m^3/s$). From the results of fire analysis, temperature and CO concentration are analyzed and ASET based on the limit temperature are compared at various condition. As a result, in the case with fire intensity of 15 MW, it is shown that a sufficiently safe evacuation environment can be ensured by applying forced air supply and exhaust method or forced air exhaust only method when the air flow rate is $7m^3/s$ above. In case of fire intensity of 30 MW, it is impossible to maintain the safety evacuation environment for more than 900 seconds when the exhaust air volume is below $14m^3/s$. And when the air flow rate is $40m^3/s$, the exhaust port is disposed at the side portion of the upper duct, which is most advantageous for securing the temperature-based safety.