• Parasites, Hosts and Diseases
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• 제57권5호
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• pp.517-520
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• 2019

Echinococcosis is a disease caused by the Echinococcus species that parasitizes in humans. Alveolar echinococcosis (AE) which is caused by Echinococcus multilocularis is harmful to humans. AE mainly occurs in the liver and can be transferred to retroperitoneal lymph nodes, lung, brain, bone, spleen and other organs through lymphatic and blood vessels. Cholangiocarcinoma can occur in of the intrahepatic and extrahepatic bile ducts and is more common in the hilar. We reported a case of hilar bile duct alveolar echinococcosis which was originally misdiagnosed an cholangiocarcinoma.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.202-202
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• 1994

G009의 hepatic cirrhosis animal model중 bile duct ligation/scission (BDL/S) rat에서의 항섬유화 효과를 조사하였다. BDL/S 수술 후 4주간 투약군에는 G009 saline soln.(5mg/rat/day)을, 대조군에는 saline을 경구투여하였다. fibrosis가 최고에 달하는 4주후 rat를 도살하여, 혈청중 N-terminal procollagen type III peptide(PIIINP) level, 간 조직중 hydroxy proline content, serum biochemical value(ALT, AST, choleterol, total bilirubin, creatinine) 측정 및 간조직검사를 실시하였다. 그 결과 1) 혈청중 PIIINP의 경우, 투약군 BDL/S group(10.3ng/ml$\pm$2.2)이 대조군 (20.5ng/m1$\pm$3.9)에 비해 약 50%정도 유의성 있게 감소하였다(p<0,01). 2) 간 조직중 hydroxy proline치 측정 결과, 투약군 BDL/S group(471$\pm$160$\mu\textrm{g}$/g liver)이 대조군(566$\pm$42.9$\mu\textrm{g}$/g liver)에 비하여 약 13%정도 유의성있게 감소하였다(p<0.05). 3) 간조직검사 결과 투약군의 BDL/S op. group이 대조군보다 necrosis, inflammetion, bile duct proliferation, connective tissue 침착 등이 약화되었다. 위 실험을 종합한 결과 G009는 biliary cirrhosis model에서 antifibrotic effect가 있음이 사료된다.

• 약학회지
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• 제38권3호
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• pp.338-344
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• 1994

This study was carried out to investigate the antifibrotic effects of polysaccharides extracted from Garnoderma lucidum. The biliary cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats were dosed 5 mg/rat/day orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, serum procollagen type III peptide (PIIINP) levels, liver hydroxyproline contents, and light microscopical histology. The results obtained were as follows; 1) PIIINP levels in sera of treated BDL/S group were lowered to 50% of those of untreated BDL/S group. 2) Hydroxyproline contents in the liver of treated BDL/S group were also reduced to 83% of those of untreated BDL/S rats. 3) The hepatic damage such as hepatocellular necrosis, inflammation, bile duct proliferation and fibrosis was less severe in the livers of treated rats. These results suggest polysaccharides extracted from Garnoderma lucidum to be a promising agent for the inhibition of hepatic cirrhosis(fibrosis).

• 대한설비공학회지:설비저널
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• 제21권1호
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• pp.35-39
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• 1992

• Applied Microscopy
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• 제40권2호
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• pp.89-99
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• 2010

섬유모세포 (fibroblast)는 결합조직을 구성하는 세포의 한 종류로서, 결합조직 전체에 분포하는 것으로 알려져 있다. 섬유모세포는 주위환경에 따라 형태가 쉽게 변하며, 대부분 결합조직내에 고정되어 분포하고 있지만 염증이 일어났을 때나 조직배양중에는 세포들이 이동하기도 한다. 또한 조직이 손상되었을 때 상처부위로 이동하여 대량의 콜라겐 층을 형성함으로써 손상된 조직을 복구시키기도 한다. 미토콘드리아는 전자전달계(electron transport system)를 통해 세포대사에 필요한 ATP를 생산하는 것을 주 기능으로 한다. 미토콘드리아의 형태적 변이와 산화적 스트레스 그리고 전자전달효소 결핍으로 인한 세포내 활성산소의 증가 등의 기능이상으로 세포의 노화가 이루어지기도 하며, apoptosis의 주요 원인이 되기도 한다. 지금까지 간흡충 (Clonorchis sinensis)에 감염된 담관 조직으로부터 분리하여 배양된 섬유모세포에서 나타나는 세포질돌기의 증가와 같은 형태적인 변화양상과 배양중의 섬유모세포에 간흡충 분비배설물질을 첨가할 경우 섬유모세포의 형태와 세포분열양상의 변화가 이루어진다는 보고가 있었다. 하지만 간흡충의 감염이 미토콘드리아 효소의 분포에 미치는 영향에 대한 연구는 미흡하다. 따라서 이 연구에서는 간흡충 피낭유충을 실험쥐에 감염시킨 후 시간 경과에 따른 담관의 형태변화를 관찰하고, 간흡충에 감염된 담관과 담관으로부터 분리하여 배양한 섬유모세포의 미토콘드리아 전자전달효소 분포를 확인하여 간흡충에 감염된 담관에 존재하는 섬유모세포가 미토콘드리아 전자전달계 이상으로 인한 변이와 관련이 있는지 확인하였다. 간흡충에 감염된 담관에 분포하는 섬유모세포에서는 주변 섬유성조직에 의한 물리적 손상으로 세포질이 파괴되고, 소포체의 확장 및 미토콘드리아 내막의 손상이 관찰되었다. 미토콘드리아 전자전달 효소는 간흡충에 감염된 담관 조직과 담관 섬유모세포를 분리하여 배양하였을 경우에 정상대조군에 비해 ATPase, COXII, porin의 분포가 감소하였다. 간흡충에 감염된 담관은 충체의 자극으로 인해 결합조직의 섬유화가 이루어지고, 이러한 담관에 존재하는 섬유모세포는 섬유조직에 의한 물리적 상해로 세포가 파괴되었다. 감염된 담관으로 부터 분리된 섬유모세포는 간흡충 감염에 의한 화학적 손상으로 미토콘드리아 전자전달효소가 감소되었다. 그 결과, 섬유모세포는 미토콘드리아의 전자전달계 기능이상으로 인한 세포사멸이 유도될 것으로 추측된다. 따라서 간흡충의 감염은 물리적 자극에 의한 담관의 섬유화, 화학적 자극에 의한 섬유모세포 대사과정의 변이를 유발하며, 미토콘드리아의 경우 ATP 생성을 위한 섬유모세포의 전자전달효소의 분포를 감소시켜 정상 조직에 존재하는 섬유모세포와 같은 기능을 수행하지 못하고 담관의 섬유화가 유지되는 것으로 생각된다.

• 한국전산유체공학회지
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• 제20권2호
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• pp.1-6
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• 2015

In this study, a numerical prediction on propulsive performance of a ducted propeller in open water condition was carried out by solving Reynolds averaged Navier-Stokes(RANS) equation using computational fluid dynamics(CFD). A configuration of propeller Ka-470 inside duct 19A was considered. Hexahedral grid system was generated by dividing whole computational domain into three separate regions; propeller, duct and outer flow region. A commercial CFD software, ANSYS-CFX was used for numerical simulations. Results were compared with experimental data and showed considerable improvement in accuracy, in comparison to those from surface panel method which is based on potential flow assumption. The results also exhibited the importance of grid system within the gap between the inner surface of duct and blade tip for accurate prediction of propulsive performance of ducted propeller.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2006년 제4회 한국유체공학학술대회 논문집
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• pp.213-216
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• 2006

This paper was a study about noise reduction through flow stabilization in duct using experimental method and numerical analysis at the same time. To determine the fan's type three kinds of fans(axial fan, centrifugal fan, and axial fan with centrifugal type blades) was examined to investigate the suitability for in-line duct. As a result, under the equal number of rotation 2000 RPM, performance of an axial fan with centrifugal type blades was the most superior by 55dBA at 4.3CMM among other fans. After this, analyzed the results of the numerical analysis to find out the optimum design of pitch angle such as $0^{\circ}$, $10^{\circ}$, $15^{\circ}$ and $20^{\circ}$. The intensity of turbulence was low when pitch angle was $15^{\circ}$ and air volume became peak by 5.08 CMM. It was observed that axis component of velocity increased gradually when pitch angle increased from $0^{\circ}$ to $20^{\circ}$, and embodied noise reduction and improvement of air flow rate through flow stabilization.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집B
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• pp.405-409
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• 2001

An experimental analysis of the flow inside the refrigeration compartment of a home refrigerator was conducted in order to achieve better performances in terms of uniform temperature distribution and cooling speed. 2D PIV and stereoscopic PIV were used for the experiments on an actual-size refrigerator at operating conditions. Two CCD cameras were employed for a wider field of view in the measurement of the shelf, and stereoscopic PIV was used to measure the three velocity components at the various cooling duct outlets and the mean velocity fields were area-integrated to calculate the flow-rates. 50 to 100 instantaneous velocity fields were time averaged for the mean velocity fields. With the result of this analysis, a new cooling duct system was developed, with the refrigerator's cooling performance increasing 11% in terms of cooling speed, and 25% in temperature uniformity.

• 한국소음진동공학회논문집
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• 제24권12호
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• pp.962-968
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• 2014

The lattice Boltzmann method(LBM) has attracted attention as an alternative numerical algorithm for solving fluid mechanics since the end of the 90's. In these days, its intrinsic unsteadiness and rapid increase in computing power make the LBM be more applicable for computing flow-induced noise as well as fluid dynamics. The lattice Boltzmann method is a weakly compressible scheme, so we can get information about both aerodynamics and aeroacoustics from single simulation. In this paper, numerical analysis on Aeolian tone noise generated by tandem-twin square cylinders in duct is performed using the LBM. For simplicity, laminar two-dimensional fluid models are used. To verify the validity and accuracy of the current numerical techniques, numerical results for the laminar duct and the cylinder flows are compared with the analytical solution and the measurement, respectively. Then, aerodynamic noise of the twin tandem square cylinders is investigated. It is shown that the aerodynamic noise from the twin tandem square cylinders can be reduced by controlling the distance between the cylinders.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2011년도 추계학술대회 초록집
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• pp.90.2-90.2
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• 2011

This paper describes performance enhancement of a fuel cell's blower by controlling flow path. Different duct diameter at the inlet and outlet of the blower is selected for reducing blower noise level and input power. Hole diameter and the number of hole at the check valve are tested to reduce the input power of the blower. Two types of blower, fuel pressurized blower and cathode blower, are considered in the present study. Throughout experimental measurements of the test blowers, it is found that duct diameter is effective to reduce noise level and input power in the fuel cell blower. Noise reduction due to the optimal duct diameter at the outlet is more effective when flow rate is relatively large. That is, cathode blower has larger noise reduction compared to fuel pressurized blower because of larger flower rate. Input power of the blower can be reduced by controlling the hole diameter and the number of hole at the check valve.