• Journal of Chest Surgery
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• 제47권3호
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• pp.275-279
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• 2014

A 13-year-old girl, who had undergone the total correction of partial atrioventricular septal defect at the age of 4 years, was admitted with severe tricuspid regurgitation in echocardiography. She had received one-and-a-half ventricle repair during follow-up. Her right ventricle showed global akinesia, and the ejection fraction of the left ventricle was 25% with paradoxical interventricular septal motion. We performed right ventricular exclusion adjunct to the Fontan procedure. She is doing well two years after the operation without complications.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권3호
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• pp.256-264
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• 2021

Purpose: Data on the relationship between gastroesophageal reflux (GER) and brief resolved unexplained events (BRUE) in infants is scarce. The aim of this study was to identify the characteristics of combined multichannel intraluminal impedance-pH (MII-pH) monitoring in infants who have experienced BRUE. Methods: We conducted a prospective study of infants who were hospitalized on account of BRUE and required 24-hour MII-pH monitoring. Results: Twenty-one infants (mean age, 4.7 months; range, 0.9-8.9 months; male/female, 11/10) participated in this study. BRUE symptoms associated with GER were found in 10 infants (47.6%). Based on the RI on pH-metry alone, only 7 (33.3%) infants were diagnosed with GERD. More than 100 GER episodes detected by MII were found in 10 (47.6%) infants. Nineteen percent of infants were diagnosed with GERD based on both pH and MII. Conclusion: Both acid and non-acid reflux seem to play a significant role in the pathogenesis of GER-related BRUE in infants.

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• 제3권1호
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• pp.47-53
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• 2022

The escape behavior of prey fish to predator attack is directly linked to the survival of the fish. In this study, I explored the escape behavior of Medaka fish to bird attacks. To simulate the attack, I designed a model triangular-shaped bird to slide along a fishing line connected between rods at both ends of the tank. The triangular shape was set to 10×15 (S=1), 15×20 (S=2), and 20×25 cm (S=3) with base×height. The slope (θ) of the fishing line, which determines the attack speed of the model bird, was set to values of 15° (θ=1), 30° (θ=2), and 45° (θ=3). The escape behavior was characterized using five variables: escape speed (ν), escape acceleration (α), responsiveness (γ), branch length similarity entropy (ε), and alignment (ϕ). The experimental results showed when (S, θ)=(fixed, varied), the change in values of the five variables were not significant. Thus, the fish respond more sensitively to S than to θ In contrast, when (S, θ)=(varied, fixed), ν, α, and γ showed increasing trends but ε and ϕ did not change much. This indicates the nature of fish escape behavior irrespective of the threat is inherent in ε and ϕ. I found that fish escape behavior can be divided into two types for the five physical quantities. In particular, the analysis showed that the type was mainly determined by the size of the model bird.

• 한국미생물·생명공학회지
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• 제33권4호
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• pp.308-314
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• 2005

상용 복막투석액에 함유된 고농도의 포도당과 포도당 분해산물(glucose degradation products: CDP)이 복막의 비후, 복막 투과성의 증가 및 한외여과 부전과 같은 복막의 구조적, 기능적 변화를 초래하리라 추정되고 있다. 본 연구에서는 CDP성분이 사람 복막중피세포 활성화에 미치는 영향을 검색하였고 또 이때 ROS와 PKC가 관여하는지를 검색하였다. 혈청이 배제된 M199 배양액으로 성장을 동일화시킨 사람 복막중피세포를 GDP인 methylglyoxal(MGO), acetaldehyde, 그리고 3,4-dioxyglucosone-3-ene(3,4-DGE)으로 48시 간 동안 자극하였고, 복막의 투과성에 대한 지표로서 혈관내피성장인자(vascular endothelial growth factor VEGF)를, 섬유화의 지표로서 fibronectin과 heat shock protein 47(hsp47)의 단백을 정량하였다. 활성산소족(reactive oxygen species:ROS)과 protein kinase C(PKC)의 관여여부는 각각 항산화제 N-acetylcystein(NAC)과 PKC 억제제 calphostin C의 억제 효과로 검색하였다. MGO는 대조군과 비교하여 VEGF 분비를 1.9배, fibronectin분비를 1.5배 그리고 hsp47 표현을 1.3배로 유의하게 증가시켰다(p<0.05). MGO에 의한 VEGF 상향 조절은 calphostin C와 NAC에 의하여 유의하게 억제되었다. 사람 복막중피세포에서 VEGF 분비는 acetaldehyde에 의하여 증가하였으나 3,4-DGE에 의하여 억제되었고, fibronectin 분비와 hsp47 표현은 acetaldehyde나 3,4-DGE에 의하여 영향을 받지 않았다. 이상을 종합할 때, ROS생산과 PKC활성화가 상용투석액내 함유된 MGO에 의한 점진적인 복막의 투과성 증가, 세포외기질 축적 그리고 복막 섬유화를 유발하는 주된 신호체계로서 이를 선택적으로 억제함으로써 복막의 기능을 유지할 수 있을 것으로 생각된다.

• 원예과학기술지
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• 제19권1호
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• pp.7-11
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• 2001

1998-1999년도에 걸쳐 총 238점의 고추 유전자원에 대하여 흰가루병에 대한 저항성을 검정한 결과, Capsicum baccatum에 속하는 KC604, 605, 606, 608, C. chinense에 속하는 KC616, C. pubescens에 속하는 KC638, 640, 641, 642, 643, 644가 발병하지 않을 정도로 고도의 저항성을 나타내었으며 C. annuum에 속하는 KC47-1(PI244670), KC319-1, KC545, KC320는 경미하게 발병하여 다소 저항성으로 나타났다. KC47-1, KC319-1, KC320은 Stemphylium spp.에 의한 고추 잎점무늬병에 저항성이며, 그 중 KC 47-1은 더뎅이병(Xanthomonas campestris pv. vesicatoria)에도 저항성이어서 이들 병에 복합저항성 육성도 가능할 것으로 기대된다.

• IMMUNE NETWORK
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• 제20권6호
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• pp.47.1-47.13
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• 2020

Tetracyclines, which have long been used as broad-spectrum antibiotics, also exhibit a variety of nonantibiotic activities including anti-inflammatory and immunomodulatory properties. Tetracyclines bind to the 30S ribosome of the bacteria and inhibit protein synthesis. Unlike antimicrobial activity, the primary molecular target for the nonantibiotic activity of tetracycline remains to be clarified. Nonetheless, the therapeutic efficacies of tetracyclines, particularly minocycline and doxycycline, have been demonstrated in various animal models of autoimmune disorders, such as multiple sclerosis, rheumatoid arthritis, and asthma. In this study, we summarized the anti-inflammatory and immunomodulatory activities of tetracyclines, focusing on the mechanisms underlying these activities. In addition, we highlighted the on-going or completed clinical trials with reported outcomes.

• 대한환경공학회지
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• 제28권8호
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• pp.829-835
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• 2006

PBDEs의 조성, 발생원 및 지역적 농도 분포를 확인하기 위해 국내의 여러지역(서울, 안성, 청주, 울산, 대구, 부산, 파도리)에서 자생하는 소나무 잎을 채취하였다. Hepta-BDE부터 deca-BDE까지의 동족체(homologs) 농도는 총 PBDEs의 농도와 매우 유의한 상관성(Pearson 상관계수 r>0.96, p<0.001)을 보였다. Deca-BDE는 다른 homologs에 비해 모든 시료에서 최대농도를 나타내었다. PBDE 함유 제품(Bromkal 70-5DE, DE-71)과 소나무 중 침착된 PBDE 동질체(congeners) 사이의 상관성이 높게 나타나 PBDE 함유 제품이 본 채취지점에서 발생원으로 평가되었다. 또한 BDE-47, -99, -100, -206, -207 및 -209는 모든 소나무 잎에서 주된 성분을 나타내었는데 이는 전세계적으로 다량 사용된 penta-BDE와 deca-BDE 함유 제품이 국내에도 다량으로 사용되었기 때문으로 판단된다. 그러나 BDE-209와 BDE-47, -99, -100간의 상관성은 유의하지 않았는데 이는 tetra-BDE와 penta-BDE는 대기-토양 분배와 같은 2차 발생원에 영향이 지배적인 반면 deca-BDE는 여전히 1차 발생원의 영향이 2차 발생원의 영향보다 지배적이었기 때문으로 판단된다.

• 한국토양비료학회지
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• 제47권2호
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• pp.71-79
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• 2014

Climate change has been social and environmental issues, it typically indicates the trend changes of not only temperature but also rainfall. There is a need to consider climate changes in a long-term soil erosion estimation since soil loss in a watershed can be varied by the changes of rainfall intensity and frequency of torrential rainfall. The impacts of rainfall trend changes on soil loss, one of climate changes, were estimated using Sediment Assessment Tool for Effective Erosion Control (SATEEC) employing L module with current climate scenario and future climate scenario collected from the Korea Meteorological Administration. A 62 $km^2$ watershed was selected to explore the climate changes on soil loss. SATEEC provided an increasing trend of soil loss with the climate change scenarios, which were 182 ton/ha/year in 2010s, 169 ton/ha/year in 2020s, 192 ton/ha/year in 2030s,182 ton/ha/year in 2040s, and 218 ton/ha/year in 2050s. Moreover, it was found that approximately 90% of agricultural area in the watershed displayed the soil loss of 50 ton/ha/year which is exceeding the allow able soil loss regulation by the Ministry of Environment.

• Journal of Chest Surgery
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• 제47권5호
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• pp.494-496
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• 2014

The granular cell tumor (GCT) occurs extremely rarely in the mediastinum. Few mediastinal GCT cases have been reported in Japan or other countries. Here, we report a case of a 24-year-old man with superior mediastinal GCT. The mass was located just above the aortic arch. It was firm, oval in shape, and well encapsulated. The tumor was removed completely with video-assisted thoracoscopic surgery, but we had to resect the vagus nerve, which was already included in the tumor, along with the tumor. After the operation, the patient recovered without any specific complications except for a mild degree of hoarseness.

• 한국광학회지
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• 제11권4호
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• pp.294-298
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• 2000

반도체레이저로 단면 여기시킨 Nd:VAP 레이저의 내부공진기 제2고조파 출력특성을 조사하였다. 유도방출 단면적과 형광수명의 곱이 커 낮은 발진문턱 특성을 갖는 Nd:S-VAP 매질은 컴팩트한 마이크로칩 레이저에 적합하다. 내부공진기를 이용한 제2고조파 발진문턱에너지가 81 uJ로 측정되어 쉽게 발진됨을 확인하였다. 여기에너지 $2\mu\textrm{J}$에서 제2고조파 에너지 $126\mu\textrm{J}$을 얻었고, 내부공진기 제2고조파의 출력을 계산하여 이론적인 해석 근거를 제시하였다. Q-스위치된 제2고조파 출력은 펄스폭 26ns에 펄스당 에너지 $15\mu\textrm{J}$로 저출력에서도 시.공간적으로 깨끗한 펄스를 얻었으며, $M^2$도 1.47로 우수한 빔 특성을 나타내었다.