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박완제;조양제;김영지;김제학;박관하;김유삼;함경수
- Biomolecules & Therapeutics
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- v.2 no.4
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- pp.326-330
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- 1994
The treatment of pseudomonal infection is a perplexed problem because of its modest susceptibility to most of the major antibiotics. A novel Pseudomonas vaccine(CFC-101) was prepared from the outer membrane protein fractions of several Pseudomonas strains. In this study, we examined CFC-101's effectiveness in both active and passive immunization models. CFC-101 in mice at 0.2 mg/kg, i.p., given three times at two-day intervals, completely prevented the death caused by Pseudomonas aeruginosa. Antibody titer, in accordance with the protective effect in this active immunization, was elevated to its peak level following three consecutive administrations of CFC-101. Thereafter, antibody titer stayed at a constantly high level. Each outer membrane protein fraction from the four CFC-101 producers, exhibited good cross-protective effects in mouse infection models against different Fisher types of P. aeruginosa. In the passive immunization model, 21~336 $\mu\textrm{g}$/kg of anti-rabbit IgG to CFC-101, when mice being infected with a challenge strain, prevented the Pseudomonhas-induced death up to 60%. Therefore, the preventive effect of CFC-101 was verified in both the active and passive immunization models.
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Jang, In-Seong;Lee, Chung-Ho;Kim, Min-Su
- Proceedings of the Korean Institute of Navigation and Port Research Conference
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- 2014.10a
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- pp.239-241
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- 2014
최근 S-100 표준을 기반으로 웹 상에서 표준화된 전자해도 및 항행정보의 융합 서비스를 제공하기 위한 연구가 활발히 진행되고 있다. 그러나, S-101의 전자해도, S-102의 해저지형 등과 같은 데이터 표준들은 어느 정도 완성이 되어 제시되고 있으나, 선박과 선박, 선박과 항만, 또는 선박/항만과 대국민 사이에 항행정보의 웹 서비스 또는 클라우드 서비스를 가능하게 하는 서비스 표준들은 매우 부족한 상황이다. 이에 본 연구에서는 ISO 19100과 OGC의 공간정보 표준을 참고하여 개발되고 있는 S-100 표준의 상황을 고려하여 S-101의 전자해도 표준과 공간정보의 WMS, WMTS 등의 웹 서비스 표준을 수용하는 On-Shore 항행정보 서비스 플랫폼에 대하여 제시하고자 한다. 제안된 On-Shore 항행정보 서비스 플랫폼은 전자해도, 공간정보, 날씨, AIS 정보 등의 융합 서비스가 가능하며, WebApp 서비스 또는 앱 지원을 통하여 스마트 폰 등의 모바일 기기에서도 손쉽게 항행정보 서비스를 제공받을 수 있다.
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송미경;우석규;장정순;김중학;김화영;홍성길;이병욱;박미현;정건섭
- Microbiology and Biotechnology Letters
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- v.31 no.4
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- pp.355-361
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- 2003
Immunostimulating effects of lactic acid bacteria as biological response modifier is a subject of growing interest, but the knowledge of these focused on some bacteria as Lactobacillus and Bifidobacterium. In this study, we investigated the effects of Pediococcus pentosaceus EROM101 on the immunostimulating and anti-cancer activity in murine model. P. pentosaceus was mainly found in Kimchi and fermented sea food and is facultatively anaerobic, catalase-netative, gram-positive cocci arranged in pairs, tetrads and clusters. The immunostimulating effects of P. pentosaceus EROM101 were evaluated using IgA production assay of Peyer's patch and proliferation assay of exudated immune cells of Balb/C mice fed P. pentosaceus EROM101 for 3 weeks. The macrophage and splenocyte proliferation were enhanced by orally administrated of P. pentosaceus EROM101. Also, IgA production in Peyer's patch increased by P. pentosaceus EROM101. Anti-cancer activity of P. pentosaceus EROM101 was appeared in Sarcoma 180 tumor-bearing ICR mice. However, this bacterium lysate itself appeared to have noncytotoxic substance against Sarcoma 180 cell in vitro. These results suggested that P. pentosaceus EROM101 reinforce immune system and therefore was revealed to be anti-cancer activity in mice.
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Bae, Y.Z.;Kim, K.U.
- Korean Journal of Weed Science
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- v.8 no.2
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- pp.182-186
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- 1988
This study was conducted to level up the tolerance of tobacco plant against bialaphos herbicide through tissue culture. The relatively good shoot regeneration from the subcultured calli treated with bialaphos at 0.5 ppm was observed in old the tobacco varieties tested such as NC 82, BY 4 and KA 101. However, at the treatment of bialaphos 1.0 ppm, shoot regeneration was only made in KA 101 variety, showing better regeneration than that of untreated one, When these shoots were transfered to the medium containing of bialaphos 10.0 ppm, the percentage of living shoots (i.e. tolerant plant) was very low, showing 2.43% in NC 82, 2.76% in KA 101 and 0.78% BY 4. Calli were induced and multiplied from leaf petiole of the above tolerant plants even under 2.5ppm of bialaphos, showing an average of 9% in NC 82 and 16% in KA 101 as compared with the untreated control. No calli were induced from tolerant plants as bialaphos concentration increased up to 5.0 ppm. Direct shooting from leaves of the above tolerant plants, that is selected at 10.0ppm of bialaphos treatment, was observed even under 10.0ppm of bialaphos treatment both in NC 82 and in KA 101 varieties, indicating that tolerance of tobacco plants against bialaphos can be greatly increased.
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