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Immunostimulating and Anti-cancer Effects of Pediococcus pentosaceus EROM101 Isolated from Korea.  

송미경 ((주)이롬라이프 생명과학연구원)
우석규 ((주)이롬라이프 생명과학연구원)
장정순 ((주)이롬라이프 생명과학연구원)
김중학 ((주)이롬라이프 생명과학연구원)
김화영 ((주)이롬라이프 생명과학연구원)
홍성길 ((주)이롬라이프 생명과학연구원)
이병욱 ((주)이롬라이프 생명과학연구원)
박미현 ((주)이롬라이프 생명과학연구원)
정건섭 (연세대학교 생물자원공학과)
Publication Information
Microbiology and Biotechnology Letters / v.31, no.4, 2003 , pp. 355-361 More about this Journal
Abstract
Immunostimulating effects of lactic acid bacteria as biological response modifier is a subject of growing interest, but the knowledge of these focused on some bacteria as Lactobacillus and Bifidobacterium. In this study, we investigated the effects of Pediococcus pentosaceus EROM101 on the immunostimulating and anti-cancer activity in murine model. P. pentosaceus was mainly found in Kimchi and fermented sea food and is facultatively anaerobic, catalase-netative, gram-positive cocci arranged in pairs, tetrads and clusters. The immunostimulating effects of P. pentosaceus EROM101 were evaluated using IgA production assay of Peyer's patch and proliferation assay of exudated immune cells of Balb/C mice fed P. pentosaceus EROM101 for 3 weeks. The macrophage and splenocyte proliferation were enhanced by orally administrated of P. pentosaceus EROM101. Also, IgA production in Peyer's patch increased by P. pentosaceus EROM101. Anti-cancer activity of P. pentosaceus EROM101 was appeared in Sarcoma 180 tumor-bearing ICR mice. However, this bacterium lysate itself appeared to have noncytotoxic substance against Sarcoma 180 cell in vitro. These results suggested that P. pentosaceus EROM101 reinforce immune system and therefore was revealed to be anti-cancer activity in mice.
Keywords
Pediococcus pentosaceus; immunostimulant; anti-cancer; lactic acid bacteria;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 2
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