• 제목/요약/키워드: S/I Ratio

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Screening of Precancerous Gastric Lesions by Serum Pepsinogen, Gastrin-17, Anti-Helicobacter Pylori and Anti-Caga Antibodies in Dyspeptic Patients over 50 years Old in Guilan Province, North of Iran

  • Mansour-Ghanaei, Fariborz;Joukar, Farahnaz;Rajpout, Yaghoub;Hasandokht, Tolou
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권18호
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    • pp.7635-7638
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    • 2014
  • Background: The aim of this study was to investigate the value of serum gastric markers to differentiate between patients with precancerous lesions and nonatrophic chronic gastritis. Materials and Methods: Serum samples of 128 patients with dyspepsia who were candidates for endoscopic examination were tested for pepsinogen (PG I and PG II), PG I/II ratio, gastrin 17(G-17), anti-Helicobacter pylori (anti-H pylori ) and anti-CagA antibodies. Two sample t-tests, chi-square tests and Pearson's correlation analyses were used for analysis using SPSS (version 20). Results: PGI, PG I/II ratio values were decreased significantly in the precancerous lesion group (0.05, 0.001 respectively). The frequency of H pylori infection was significantly (p=0.03) different between the two groups ofthe study. Conclusions: We suggest PGI and the PG I/II ratio as valuable markers for screening of premalignant gastric lesions.

고강도와 보통 강도 콘크리트를 사용한 보-기둥 접합부의 휨강성화에 따른 이력거동 (The Effect of The Flexural Strength Ratio on Beam-Column Joint with High and Low Strength Concrete)

  • 신성우;안종문;문정일;김대근;이광수;박희민;이승훈;오정근
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 1992년도 가을 학술발표회 논문집
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    • pp.185-190
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    • 1992
  • ACI318-89 Recommended that when the specified compressive strength of concrete in a column is greater than1.4 times that specified for a floor system, top surface of the column concrete shall extend 2ft(600mm)into the slab from the face of column to avoid unexpected brittle failure. The major variables are extension distance, flexural strength ratio(Mr), and shear reinforcement ratio(Vs). Test results are as follows ; (1) The failure modes of specimens under cyclic loading were concentrated at critical region from beam-column joint face. (2) Ductility index($\mu$f) were increased with increasing of shear confinement ratio and flexural strength ratio. (3)The specimens with 2ft extension distance showed more ductility than the specimens with 1ft extension distance.

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소아 특발성 혈소판 감소증에서 항-HLA Class I항체의 임상적 의미 (Clinical Significance of Antibodies Against Platelet HLA Class I in Children with Idiopathic Thrombocytopenic Purpura)

  • 이홍준;염정숙;박지숙;박은실;서지현;임재영;박찬후;우향옥;윤희상
    • 대한수혈학회지
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    • 제24권3호
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    • pp.233-240
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    • 2013
  • 배경: 수혈의 기왕력이 항HLA항체의 형성과 연관이 있다는 사실은 잘 알려져 있다. 하지만, 특발성 혈소판 감소성 자반증의 주 표적은 혈소판의 당단백이며, 당단백 항체와 항 HLA class I 항체의 형성기전은 완전히 다른 것이다. 이번 연구의 목적은 특발성 혈소판 감소성 자반증 환아의 항HLA class I 항체의 임상적 의미를 찾아 보고자 함에 있다. 방법: 1990년부터 2010년까지 경상대학교병원을 방문한 48명의 대조군과 48명의 특발성 혈소판감소성자반증 환아들을 대상으로 하였다. 각각의 환자들의 혈청을 Modified Antigen Capture Enzyme-linked immunosorbent assay (MACE) kit를 이용하여 항 당단백 항체와 항 HLA class I 항체를 검사하였다. 결과: 두 그룹간의 항 HLA class I항체의 양성률은 의미 있는 차이를 보였으며[36/39 (92.3%) vs 29/46 (63.0%)][혈소판감소성자반증 환자군 vs 정상대조군] (P=0.002), 항HLA class I 평균항체 S/C ratio 또한 의미 있는 차이를 보였다(3.55 vs 1.51) [혈소판감소성자반증 환자군 vs 정상대조군] (P=0.0000). 하지만 혈소판 감소성 자반증 환자군에서 수혈을 받은 환자들과 수혈을 받지 않은 환자들 간의 항HLA항체 양성률은 의미 있는 차이를 보이지 않았으며[12/12 (100%) vs 24/27 (88%)][수혈을 받은 환자군 vs 비수혈 환자군](P=0.22), 평균 항체 S/C ratio 또한 통계적으로 의미 있는 차이를 보이지 않았다(4.30 vs 3.25)[수혈을 받은 환자군 vs 비수혈 환자군](P=0.22). 수혈 이후에 추적검사를 위해 채혈을 했던 환아들의 샘플을 이용한 항체 양성률 및 항체가 검사에서도 의미 있는 차이는 없는 것으로 나타났다. 결론: 항 HLA class I 항체는 혈소판 감소성 자반증과 연관이 있을 수 있으나, 수혈은 혈소판 감소성 자반증 환아의 임상적 경과에 영향을 미치지 못한다.

Angle씨 II급 1류 부정교합아동의 발음에 관한 음향학적 연구 (AN ACOUSTIC ANALYSIS OF PRONUNCIATION IN CHILDREN WITH ANGLE'S CLASS II DIV. 1 MALOCCLUSION)

  • 박윤정;이상훈;손동수
    • 대한소아치과학회지
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    • 제24권1호
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    • pp.95-111
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    • 1997
  • The human speech organ consists of respiration system (lung, larynx), phonation system (vocal cord), articulation system (esophagus, pharynx, uvula, teeth, gingiva, palate, tongue, lip) and resonating system(oral cavity, nasal cavity, paranasal sinus). Because teeth are components of the articulation system, it has been reported that the persons with abnormally positioned teeth generally have abnormal occlusion and pronunciation. In this study, using /ㅅ(s)/, the most commonly mispronunced consonant in children with malocclusion, and the seven single vowels, /사(sa), 서($s\delta$), 소(so), 수(su), 스($s\omega$), 시(si), 세(se)/ and / ㅏ(a), ㅓ($\delta$), ㅗ(o), ㅜ(u), ㅡ($\omega$), 1(i), ㅔ(e)/ were recorded and analyzed using speech analysis program on computer by measuring formants and compared them for investigating the differences in pronunciation in children with Angle's class I occlusions and those with Angle's class II div.1 malocclusion. The result were as follows: 1. In the Angle's Class II div.1 group, there were no significant differences in F1 of all recorded sounds as compared with Angle's Class I group(p>0.05). 2. In the consonants, there were significant differences in F2 of /스($s\omega$)/ and F2/F1 ratio of /사(sa), 서($s\delta$), 시(si)/ between the two group(p<0.05). 3. In the vowels, there were significant differences F2/F1 ratio of /ㅓ($\delta$)/(p<0.05) and no significant differences in F2/F1 ratio between two group(p>0.05). 4. In the consonants, there were significant differences in F2 and F2/F1 ratio when succeeding vowels were high or low, and F2/F1 ratio when front in accordance with tongue position (p<0.05). 5. In the vowels, there were no significant differences in formant in accordance with tongue position(p>0.05)

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ELA 기판을 사용한 NVM 소자의 전기적 특성 분석 (Analysis on the Characteristics of NVM Device using ELA on Glass Substrate)

  • 오창건;이정인;이준신
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2007년도 추계학술대회 논문집
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    • pp.149-150
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    • 2007
  • ONO(Oxide-Nitride-Oxide)구조는 기억소자의 전하보유 능력을 향상시키기 위해 도입된 게이트 절연막이다. 본 연구에서는 ELA(Excimer Laser Annealing)방법으로 비정질 실리콘을 결정화 시켜서 그 위에 NVM(Nonvolatile Memory)소자를 만들어 전기적 특성을 측정하여 결과를 나타내었다. 실험 결과 같은 크기의 $V_D$에서 $V_G$를 조절함으로써 $I_D$의 크기를 조절할 수 있었다. $V_G-I_D$ Graph에서는 $I_{on}$$I_{off}$, 그리고 Threshold Voltage를 알 수 있었다. $I_{on}/I_{off}$ Ratio는 $10^3-10^4$이다. $V_G-I_D$ Graph에서는 게이트에 인가하는 Bias의 양을 통해서 Threshold Voltage의 크기를 조절할 수 있었다. 이는 Trap되는 Charge의 양을 임의로 조절할 수 있다는 것을 의미하며, 이러한 Programming과 Erasing의 특성을 이용하여 기억소자로서의 역할을 수행하게 된다.

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플라즈마 디스플레이 판넬의 제작 및 특성 연구 (A Study on the Fabrication of Plasma Display Panel and It's Characteristics)

  • 김준식;최경철;신범재;황기웅
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 1990년도 추계학술대회 논문집 학회본부
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    • pp.157-160
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    • 1990
  • A dot matrix type DC Plasma Display Panel was fabricated and it's characteristics was investigated. Paschen curve and I-V curve of various gas mixture was given. Optimal gas mixing ratio, pressure and operating point was determined. The priming effect was observed and discharge delay time was measured with varing applied voltage, priming current, priming distance, duty ratio.

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대구지역 셰일의 점재하지수 특성 및 일축압축강도와의 상관성 (The Point Load Index of the Daegu Shale and its Relation to the Uniaxial Compressive Strength)

  • 이영휘;윤찬호
    • 한국지반환경공학회 논문집
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    • 제10권3호
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    • pp.37-45
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    • 2009
  • 대구지역에 분포하는 고유이방성 셰일(shale)의 점재하지수 및 일축․압축강도 특성을 평가하기 위한 일련의 실험실 시험을 수행하였다. 또한 시험시편의 크기효과 및 형태효과를 조사하기 위하여 축방향 및 직경방향으로 점재하지수를 측정하였다. 일반적으로 직경방향의 점재하지수는 길이/직경(L/D)비가 대략 1.0 이상일때 일정한 값을 보이고 축방향 점재하 시험 결과 L/D비의 증가에 따라 평균 점재하지수가 약간 감소하는 경향을 보였으며 L/D비가 1.0 이상이면 corner파괴가 발생하였다. 최소의 점재하지수는 층리면이 연직과 이루는 각 ($\beta$)이 $15^{\circ}{\sim}30^{\circ}$에서 나타났고 ${\beta}=30^{\circ}$에서 최소의 일축압축강도가 얻어졌다. $\beta$ 값의 범위가 $0^{\circ}{\sim}90^{\circ}$인 시편의 점재하지수와 일축압축강도를 측정하여 이들의 상호관계를 회귀분석하였다. 층리면을 $0^{\circ}$에서 $90^{\circ}$까지 변화시키면서 측정한 점재하지수는 일축압축강도와 선형적인 관계인 ${\sigma}_c=25.0 I_{s(50)}$로 나타났다. 한편, 층리각($\beta$)를 90${^{\circ}}$로 고정시킨 상태에서의 이들의 상관성은 ${\sigma}_c=14.4 I_{s(50)}$로 나타났는데, 이는 ISRM(1985)에서 추천하는 층리가 없는 무결암 시료에 대한 일반적인 상관성, ${\sigma}_c=22 I_{s(50)}$과는 많은 차이가 있음을 확인하였다. 일축압축강도의 이방성 모형은 기존의 Ramamurthy(1993)이론에 지수 'n'을 도입하여 n= 3을 적용 했을때 측정결과와 잘 부합되는 결과를 얻었다.

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랫드에서 담도폐쇄에 의한 지질과산화와 간섬유화(경화) 촉진에 관한 연구 (Bile Duct Obstruction Stimulates Lipid Peroxidation and Liver Fibrosis (Cirrhosis) in Rat)

  • 김기영;서의석;임진아
    • Toxicological Research
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    • 제17권3호
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    • pp.187-194
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    • 2001
  • The oxidative stress causes the cell damage and death and thereby, stimulates membrane lipid peroxidation. In this study, the correlation between the lipid peroxidation product and the parameter of liver fibrosis (cirrhosis) was investigated in cholestasis induced rats. The Sprague-Dawley rats were divided into 3 groups (sham: sham operation, BDL/S-I and BDL/S-II : bile duct ligation/scission) and were observed for 2 or 4 weeks. After observation period, the organs were weighed and the ratio of organ weight/body weight was calculated. Sera and liver tissue were used for the measurement of malondealdehyde (MDA), parameter of clinical biochemistry, total collagen content and the staining. The ratio of organ weight/body weight in BDL/S-I and BDL/S-II was significantly increased compared to sham operated group. Serological parameters (Alanine transaminase, Aspartate transaminase, Alkaline phosphatase and Total bilirubin) in BDL/S-I and BDL/S-II group were significantly higher than those in sham operated group. Concentration of MDA in BDL/S-I (261%) and BDL/S-II(790%) was significantly increased compared to MDA in sham operated group. And the content of hydroxyproline (hyp) in BDL/S-I and BDL/S-II group was significantly increased 2~4 times than in sham operated group. The good correlations between hyp in liver tissue and MDA in sera of sham operated group and all operated group were found (r=0.825). The significantly higher value of MDA, hyp and serological parameters in BDL/S-I and BDL/S-II group suggests the stimulation of lipid peroxidation and chronic liver damage. Especially the activation of lipid peroxidation and the stimulation of liver fibrosis was stronger in BDL/S-II group than in BDL/S-I group. The stronger fibrosis, portal-portal septum formation, the more massive bile duct proliferation in portal triads and stroma, and hepatocytes swelling were observed in liver tissue of and BDL/S-II group compared to BDL/S-I group. Conclusively, a good correlation between MDA as a lipid peroxidation marker and hyp as a liver fibrotic parameter could be connected with the process of liver fibrosis. Moreover, cholestasis condition may cause jaundice, activation of lipid peroxidation, and collagen accumulation in liver. Additionally, optimal observation period of bile duct obstruction for the screening of antioxidant and antifibrotic effect in rats would be four weeks.

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Corrosion Fatigue Cracking of Low Alloy Steel in High Temperature Water

  • Lee, S.G.;Kim, I.S.;Jang, C.H.;Jeong, I.S.
    • Corrosion Science and Technology
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    • 제2권2호
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    • pp.93-97
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    • 2003
  • Fatigue crack growth test or low alloy steel was performed in high temperature water. Test parameters were dissolved oxygen content. loading frequency and R-ratio ($P_{min}/P_{max}$). Since the sulfur content or the steel was low, there were no environmentally assisted cracks (EAC) in low dissolved oxygen(DO) water. At high DO, the crack growth rate at R = 0.5 tests was much increased due to environmental effects and the crack growth rate depended on loading frequency and maximized at a critical frequency. On the other hand, R = 0.7 test results showed an anomalous decrease of the crack growth rate as much different behavior from the R = 0.5. The main reason of the decrease may be related to the crack tip closure effect. All the data could be qualitatively understood by effects of oxide rupture and anion activity at crack tip.

페로센을 이용한 비대칭 유기합성용 금속 촉매의 개발 (Development of Ferrocene-Containing Metal Catalysts for Asymmetric Synthesis)

  • 오영희;최미진
    • 공업화학
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    • 제10권5호
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    • pp.804-807
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    • 1999
  • 페로센 카르복시알데히드와 1,2-diaminocyclohexane을 2:1로 반응시켜 키랄 리간드 L(L=N,N'-cyclohexane bis(ferrocenylmethylene)amine)을 합성하고 이를 구리와 반응시켜 새로운 구리 착물을 합성하였다. 이 착물들을 확인하고 비대칭 유기 합성반응에 촉매로 사용하였다. 구리(II) 착물들은 스티렌과 에틸디아조아세테이트와의 시클로프로판화 반응에서 촉매작용을 하지 않았으나 구리(I)화합물, Cu(I)LOTf (OTf=trifluoromethanesulfonate)는 시클로프로판 생성물 trans:cis의 비율에 있어 80:20 이상의 높은 regioselectivity를 보였다.

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