• KSCE Journal of Civil and Environmental Engineering Research
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• v.12 no.2
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• pp.123-130
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• 1992

We check up on whether the one-dimensional station precipitation model of Geogakakos and Bras is suitable to the storm model for Chonju station or not. The fundamental variables of the physically based model consists of the pressure at the cloud top, the hight-averaged updraft velocity(HAUV), and the inverse of the average diameter of the hydrometeors(ADH) at cloud base. And they are parameterized by input variables. The parameters are eastimated by the direct search algorithm of Hooke and Jeeves in this paper. The results show that HAUV and ADH are dominant factors to minimize root mean square error between the calculated and the observed rainfall. In this numerical analysis, the deviation between the calculated and the total observed rainfall is small, otherwise the gap for the time distribution is quite big.

• Journal of Sasang Constitutional Medicine
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• v.20 no.2
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• pp.53-57
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• 2008

1. Objectives When we give Jowiseungcheong-tang to Taeumin patients, analyzing a change of their autonomic nervous system. It is measured by the heart rate variability(HRV) analyzer. 2. Methods We give Jowiseungcheong-tang to ten Taeumin patients for three days and examine the HRV at first time and three days later. 3. Results and Conclusions We compared two HRV results. The value of RRNN(average of normal RR intervals), SDNN(the standard deviation of all normal RR intervals), RMSSD(the root mean square of successive differences between the normal heart beats) have a downward tendency. Norm HF(normalized high frequency power) have a upward tendency. norm LF (normalized low frequency power) and LHR(LF/HF ratio) have a downward tendency. It means hypofunction of autonomic nervous system. But all results are not significant. We think that restudy is needed with more patients and longer periods afterward.

• Bulletin of the Korean Chemical Society
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• v.34 no.4
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• pp.1043-1046
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• 2013

Prediction of physicochemical properties of organic molecules is an important process in chemistry and chemical engineering. The MSEP approach developed in our lab calculates the molecular surface electrostatic potential (ESP) on van der Waals (vdW) surfaces of molecules. This approach includes geometry optimization and frequency calculation using hybrid density functional theory, B3LYP, at the 6-31G(d) basis set to find minima on the potential energy surface, and is known to give satisfactory QSPR results for various properties of organic molecules. However, this MSEP method is not applicable to screen large database because geometry optimization and frequency calculation require considerable computing time. To develop a fast but yet reliable approach, we have re-examined our previous work on organic molecules using two semi-empirical methods, AM1 and PM3. This new approach can be an efficient protocol in designing new molecules with improved properties.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2002.11a
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• pp.97-117
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• 2002

A chemoinfometrical method for quantitative determination of crystal content of indomethacin (IMC) polymorphs based on fourie-transformed near-infrared (FT-NIR) spectroscopy was established. A direct comparison of the data with the ones collected from using the conventional powder X-ray diffraction method was performed. Pure $\alpha$ and ${\gamma}$ forms of IMC were prepared using published methods. Powder X-ray diffraction profiles and NIR spectra were recorded for six kinds of standard materials with various content of ${\gamma}$ form IMC. The principal component regression (PCR) analyses were performed based on normalized NIR spectra sets of standard samples of known content of IMC ${\gamma}$ form. A calibration equation was determined to minimize the root mean square error of the prediction. The predicted ${\gamma}$ form content values were reproducible and had a relatively small standard deviation. The values of ${\gamma}$ form content predicted by two methods were in close agreement. The results were indicated that NIR spectroscopy provides for an accurate quantitative analysis of crystallinity in polymorphs compared with the results obtained by conventional powder X-ray diffractometry.

• Bulletin of the Korean Chemical Society
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• v.28 no.2
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• pp.200-206
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• 2007

Pharmacophore models for lymphocyte-specific protein tyrosine kinase (P56 LCK) were developed using CATALYST HypoGen with a training set comprising of 25 different P56 LCK inhibitors. The best quantitative pharmacophore hypothesis comprises of one hydrogen bond acceptor, one hydrogen bond donor, one hydrophobic aliphatic and one ring aromatic features with correlation coefficient of 0.941, root mean square deviation (RMSD) of 0.933 and cost difference (null cost-total cost) of 66.23. The pharmacophore model was validated by two methods and the validated model was further used to search databases for new compounds with good estimated LCK inhibitory activity. These compounds were evaluated for their binding properties at the active site by molecular docking studies using GOLD software. The compounds with good estimated activity and docking scores were evaluated for physiological properties based on Lipinski's rules. Finally 68 compounds satisfied all the properties required to be a successful inhibitor candidate.

• Smart Structures and Systems
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• v.6 no.7
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• pp.851-866
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• 2010

This paper presents a new concept of using PZT (lead zircornate titanate) transducers as a non-destructive testing (NDT) tool for evaluating quality of concrete. Detection of defects in concrete is very important in order to check the integrity of concrete structures. The electro-mechanical impedance (EMI) response of PZT transducers bonded onto a concrete specimen can be used for evaluating local condition of the specimen. Measurements are carried out by electrically exciting the bonded PZT transducers at high frequency range and taking response measurements of the transducers. In this study, the compression test results showed that concrete specimens without sufficient compaction are likely to fall below the desired strength. In addition, the strength of concrete was greatly reduced as the voids in concrete were increased. It was found that the root mean square deviation (RMSD) values yielded between the EMI signatures for concrete specimens in dry and saturated states showed good agreement with the specimens' compressive strength and permeable voids. A quality metric was introduced for predicting the quality of concrete based on the dry-saturated state of concrete specimens. The simplicity of the method and the current development towards low cost and portable impedance measuring system, offer an advantage over other NDE methods for evaluating concrete quality.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.2
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• pp.209-217
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• 2000

The solubility and miscibility measurement apparatus was developed and used to obtain data for refrigerant/oil mixture. The solubility and miscibility data for R-410A/68 ISO VG polyol ester (POE) oil mixture are obtained over the temperature range from -20 to $60^{circ}C\;with\;10^{\circ}C$ intervals and the oil concentration range from 0 to 90 wt%. Using the experimental data, an empirical model was developed to predict the solubility relations for R-410A/POE oil mixture at equilibrium. In the R-410A/Solest 68 oil mixture, the average root-mean-square deviation between measured data and calculated results from the empirical model is 3.4% and in the R-4104/EMKARATE RL 68H oil mixture, that is 2.86%. For R-410A/68 ISO VG POE oil mixture immiscibility was usually observed at the low oil concentrations(5~30 wt%) over the all experimental temperature range($-20~60^{circ}C$) and at the high oil concentrations(50~90 wt%) over the low experimental temperature range($-2O~0^{circ}C$).

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.6
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• pp.589-598
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• 2000

The vapor-liquid equilibrium and miscibility measurement apparatus was developed and used to obtain data for refrigerant/oil mixture. The vapor-liquid equilibrium and miscibility data for R-410a/POE32 and R-410A/POE46 oil mixtures are obtained over the temperature range from -20 to $60^{\circ}C\;with\;10^{\circ}C$ intervals and the oil concentration range from 0 to 90 wt%. Using the experimental data, an empirical model is developed to predict the temperature-pressure-concentration relations for R-410A/POE oil mixtures at equilibrium. In the R-410A/POE32 oil mixture, the average root-mean-square deviation between measured data and calculated results from the empirical model is 2.00% and in the R-410a/POE46 oil mixture, that is 3.69%. Flory-Huggins theory is also used to predict refrigerant/oil mixture behavior. Miscibility for R-410A/POE32 oil mixture was observed all over the experimental conditions. Immiscibility for R-410A/POE46 oil mixture was observed at the low oil concentrations(10~30 wt%).

• Nuclear Engineering and Technology
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• v.39 no.1
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• pp.43-50
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• 2007

A partial flow blockage in an assembly of a liquid metal reactor could result in a cooling deficiency of the core. To develop a partial blockage detection system, we have studied the changes of the temperature fluctuation characteristics in the upper plenum according to changes of the t10w blockage conditions in an assembly. We analyzed the temperature fluctuation in the upper plenum with the Large Eddy Simulation (LES) turbulence model in the CFX code and evaluated its statistical parameters. Based on the results of the statistical analyses, we developed a neural network model for detecting a partial flow blockage in an assembly. The neural network model can retrieve the size and the location of a flow blockage in an assembly from a change of the root mean square, the standard deviation, and the skewness in the temperature fluctuation data. The neural network model was found to be a possible alternative by which to identify a flow blockage in an assembly of a liquid metal reactor through learning and validating various flow blockage conditions.

• Journal of the Korean Society for Nondestructive Testing
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• v.27 no.6
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• pp.501-508
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• 2007

This paper presents the feasibility of using electromechanical impedance based active sensing technique for nondestructive strength gain monitoring of early-age concrete by employing piezoelectric lead-zirconate-titanate (PZT) patches on concrete surface. The strength development of early age concrete is actively monitored by performing a series of experiments on concrete specimens under moist curing condition. The electrical admittance signatures are acquired for five different curing ages and compared with each other. The resonant frequency shifts of PZT patches with increasing days is observed which is on account of additional stiffening due to strength gain of concrete during curing and level of stiffening being related to strength obtained from compression tests on companion cylinder specimens. The proposed approach is found to be suitable for monitoring the development of compressive strength in early-age concrete. It is also observed in this study that root mean square deviation (RMSD) in admittance signatures of the PZT patches can also be used as an indicator of concrete strength development.