• Tuberculosis and Respiratory Diseases
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• 제71권3호
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• pp.172-179
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• 2011

Background: Statins can regulate the production of pro-inflammatory cytokines and inhibit MMP production or activation in a variety of types of cells. This study evaluated whether statins would inhibit MMP release from human lung fibroblasts, which play a major role in remodeling processes. Methods: This study, using an in-vitro model (three-dimensional collagen gel contraction system), evaluated the effect of cytokines (tumor necrosis factor-${\alpha}$, TNF-a and interleukin-$1{\beta}$, IL-1b) on the MMP release and MMP activation from human lung fibroblasts. Collagen degradation induced by cytokines and neutrophil elastase (NE) was evaluated by quantifying hydroxyproline. Results: In three-dimensional collagen gel cultures (3D cultures) where cytokines (TNF-a and IL-1b) can induce the production of MMPs by fibroblasts, it was found that simvastatin inhibited MMP release. In 3D cultures, cytokines together with NE induced collagen degradation and can lead to activation of the MMP, which was inhibited by simvastatin. Conclusion: Simvastatin may play a role in regulating human lung fibroblast functions in repair and remodeling processes by inhibiting MMP release and the conversion from the latent to the active form of MMP.

• 대한안전경영과학회지
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• 제17권4호
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• pp.275-286
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• 2015

Global interests in RFID are increased and Korean government and companies make an active effort to propagate and spread RFID. Due to the overwhelming advantages of RFID system in comparison with existing bar code system, ripple effects on logistics sector among the utilizing fields of RFID technology are expected to be great, but application of RFID system is lowly progressed unlike the expectation of several experts. Therefore, this research extracts precedent studies on theoretical background, applying fields, promotion condition and domestic/foreign parts of RFID system, factors for operating domestic RFID system and effects and considers the effects of RFID's external variables on easiness and effectiveness of TAM. It confirms the relations of RFID applying effects for companies applying and utilizing RFID and verifies the relations among the effects for application of RFID system, accepting intention of RFID system and applying effects. Based on the results of analysis, it should play a role of good guide for all of companies and institution who will introduce RFID system to all of Korean logistics fields, make policies and systems which promote RFID acceptance nationally and socially and play a role of guide making confident climate for RFID technolog

• Animal Bioscience
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• 제37권2_spc호
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• pp.323-336
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• 2024

Molecular hydrogen (H₂) and formate (HCOO^-) are metabolic end products of many primary fermenters in the rumen ecosystem. Both play a vital role in fermentation where they are electron sinks for individual microbes in an anaerobic environment that lacks external electron acceptors. If H₂ and/or formate accumulate within the rumen, the ability of primary fermenters to regenerate electron carriers may be inhibited and microbial metabolism and growth disrupted. Consequently, H₂- and/or formate-consuming microbes such as methanogens and possibly homoacetogens play a key role in maintaining the metabolic efficiency of primary fermenters. There is increasing interest in identifying approaches to manipulate the rumen ecosystem for the benefit of the host and the environment. As H₂ and formate are important mediators of interspecies interactions, an understanding of their production and utilization could be a significant starting point for the development of successful interventions aimed at redirecting electron flow and reducing methane emissions. We conclude by discussing in brief ruminant methane mitigation approaches as a model to help understand the fate of H₂ and formate in the rumen ecosystem.

• KEPCO Journal on Electric Power and Energy
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• 제2권3호
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• pp.409-413
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• 2016

The 500 MW rated steam turbine model in coal fired power plant is developed to be used for validation and verification of controller rather than for the education of operator. The valve, steam turbine, reheater and generator are modeled and integrated into the simulator. And the data from the plant heat balance diagram are used for estimation of the model parameters together with actual operating data. It is found that the outputs of model such as pressure, temperature and speed are similar to the operating ones. So, it is expected that the developed model will play a very big role in controller development.

• 한국수학사학회지
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• 제27권1호
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• pp.47-57
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• 2014

This paper aims to evaluate works of Frege and G$\ddot{o}$del, who play the trigger role in development of logic, by Knowledge Change Model. It identifies where their positions are in the model respectively. For this purpose I suggest types of knowledge change and their criteria for the evaluation. Knowledge change are classified into five types according to the degree of its change: improvement, weak glorious revolution, glorious revolution, strong glorious revolution, and total revolution. Criteria to evaluate the change are its contents, influence, pervasive effects, and so forth. The Knowledge Change Model consists of the types and the criteria. I argue that in the model Frege belongs to the total revolution and G$\ddot{o}$del to the weak glorious revolution. If we accept that the revolution in logic initiated by Frege was completed by G$\ddot{o}$del, it is a natural conclusion.

• 한국물환경학회지
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• 제23권6호
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• pp.872-880
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• 2007

For effective management of sediment-related diffuse pollution, it is of utmost importance to estimate spatial variation of sediment transport processes within a catchment. A mathematical model can play a critical role in estimating sediment transport processes at the catchment scale provided that the model structure is appropriate for representing major sediment transport processes of the catchment of interest. This paper introduces a distributed catchment model River Basin Water Quality Simulator (RBWQS) and presents some results of its application to a small rural catchment in Korea. The model has been calibrated and validated for a wet period using hourly hydrographs and sediment concentrations observed at the catchment outlet. Based on the model simulation results, the spatial variation of sediment transport processes across the catchment and the effects of paddy fields and small reservoirs on hydrology and sediment transport have been analyzed at the catchment scale.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제17권3호
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• pp.209-219
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• 2013

The present paper deals with the extension of AUSMPW+ scheme into two-fluid model for multiphase flow. AUSMPW+ scheme is the improvement of a single-phase AUSM+ scheme by designing pressure-based weighting functions to prevent oscillations near a wall and shock instability after a strong shock. Recently, Kitamura and Liou assessed a family of AUSM-type schemes with two-fluid model governing equations [K. Kitamura and M.-S. Liou, Comparative study of AUSM-Family schemes in compressible multi-phase flow simulations, ICCFD7-3702 (2012)]. It was observed that the direct application of the single-phase AUSMPW+ did not provide satisfactory results for most of numerical test cases, which motivates the current study. It turns out that, by designing pressure-based weighting functions, which play a key role in controlling numerical diffusion for two-fluid model, problems reported in can be overcome. Various numerical experiments validate the proposed modification of AUSMPW+ scheme is accurate and robust to solve multiphase flow within the framework of two-fluid model.

• 국제학술발표논문집
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• The 5th International Conference on Construction Engineering and Project Management
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• pp.433-436
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• 2013

This study suggests IFC-based bridge information modeling methods and its application model in BIM environment. Data model extension for bridge structure was achieved using user-defined property sets based on IFC framework. First, identification information was added. Bridge members are identified through physical and spatial semantic information added as property sets. Instances for semantic information were assigned according to standardized rules. Second, CO2 related factors were added for application information model. It can play a role to calculate and manage the quantity of CO2 emission. Third, properties for temporary structure to estimate and manage the construction cost were added. Finally, we investigated proposed methods through implementing the application information model of bridges.

• Journal of Korea Trade
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• 제27권2호
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• pp.61-76
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• 2023

Purpose - The digital service trade has become an important driver of the global service trade. The main purpose of this study is to explore the influencing factors of digital service exports from China and Korea to RCEP sample countries respectively, and to comprehensively study the export potential of China and Korea to RCEP countries, so as to provide theoretical guidance and a decision-making reference to promote digital service trade exports and digital economy development in China and Korea. Design/methodology - First, the stochastic frontier gravity model was improved by introducing nonefficiency factors affecting digital services trade, extending the gravity model of traditional services trade exports to digital services trade exports. Secondly, the panel data of China and Korea for the eight sample countries of RCEP from 2011 to 2021 were adopted for the empirical analysis of digital service export potential by a stochastic frontier model. Findings - China's economic growth plays a role in increasing China's digital service trade exports, while Korea's economic growth does not play a significant role in increasing Korea's digital service trade exports. However, the economic growth of trading partner countries can play a significant role in boosting the digital service trade in both China and Korea, and comparison shows that Korea has higher resilience in the digital services trade than China. In addition, the market size of target countries plays a positive role in promoting the digital service trade exports of both China and Korea, and the increase in the value-added share of services in target countries will lead to a decrease in the digital service trade exports of both China and Korea. Originality/value - This study is innovative in terms of research perspective and method. Academic research on the export potential of international trade has been extensive, but most studies are based on the perspective of the goods trade, fewer studies are based on the perspective of the service trade, and there are almost no studies based on the perspective of digital service trade. There is a gap based on the comparative analysis of the export potential of the digital service trade between China and Korea. This study extends the gravitational model of traditional service trade exports to digital service trade exports to comparatively analyze the export potential of China and Korea to RCEP countries. This study addresses this limitation by analyzing a comparative analysis of the digital service trade export potential of China and Korea.

• 복식문화연구
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• 제20권4호
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• pp.604-615
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• 2012

Despite the increasing recognition of the value of emotions and younger consumers in luxury market segments, little research has focused on the role consumer characteristics and emotions play in younger consumers' commitment to luxury brands. Drawing on the identity-motivation model and the idea of self-construal, this study identifies the contributing factors of younger consumers' commitment to luxury fashion brands. Specifically, this study examines the role of consumer characteristics (i.e., self-construal), the self-expressiveness of brands, and emotional factors (i.e., brand love and brand attachment) in developing consumer-brand relationships. The proposed model was tested with college students in the U.S., which supplied a representative group of younger consumers of luxury fashion brands. The data were collected using web-based surveys and analyzed using structural equation modeling method. The results showed that consumers who were characterized with interdependent self-construal had positive perceptions of self-expressive luxury fashion brands. Furthermore, the perception of self-expressive brands promotes the consumers' brand love of and brand attachmentto luxury fashion brands. Also, while both improved brand commitment, brand attachment had a greater impact on brand commitment than brand love. This study contributes to the literature by identifying driving forces of younger consumers' brand commitment. It also provides managerial implications for luxury fashion brands.