• 화약ㆍ발파
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• 제15권3호
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• pp.14-19
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• 1997

Koreans have emphasized education as the primary means to reconstruct our country means to reconstruct our country after two catastrophic events-the Japanese occupation and the Korean War(1950-1953). A Strong belief- in education coupled with sheer deter-mination spurred the period of industrial and eeonomic development that started in the early 1970-'s. The "can-do" attitude of the general public was matched and aided by small S & T communities. Scientists and engineers provided the neeessary expertise to manufacture goods and process the many raw materials imported from overseas. After nearly three decades of reconst-ructing our completely devastated country, Korea has become a modern, cosmo-politan, fast-paced and dynamic country. In order to further increaser our manufac- turing capabilities and double the per-capita income by the beginning of the 21st century, we must improve productivitiy and encourage creatitivity in all sectors of our country. The S & T community's efforts in research and development. education, and interna-tional cooperation will be invaluable in determining our direction and reaching these goals. The general public is eager to peacefully unite our foreign powers since 1945. Toward that end. members of the S & T community are willing to coope-rate with our north Korean counterparts in all areas of S & T with the exception of defense related endeavors. Establi-shing scientific ties with north Korea will result in mutual economic benefit and greater regional stability in East Asia. In particular. scientists and manu-facturers in each province are eager to initiate cordial and professional relation-ships with north Korea in the hopes of securing these benefits. The Korean Federation of Science and Technology Societies(KOFST) has played an important role both in developing S & T policies, and in gostering the frowty of S & T societies. A non-governmental umbrella organization composed of over 251 professional societies, KOFST facili-tates the transfer of research outcomes and technology from research institutions to the various industries. KOFST also seeks to increase cooperation between the countries of the Pacific Rim. As evidence of that, we have pursued joint research and industrial ventures with China. Established projects include those on environmental conditions in the Yellow Sea, and improvement of aircraft manufacturing, telecommunica-tion equipment, and agricultural produ-cts. Increased cooperation between the Pacific Rim countries, particularly in S & T, would foster social and economic development for the region as a whole.

• 한국건설관리학회논문집
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• 제10권3호
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• pp.139-147
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• 2009

Accurate construction cost estimation in the initial stage of building project plays a key role for project success and for mitigation of disputes. Total construction cost(TCC) estimation of apartment projects in Vietnam has become more important because those projects increasingly rise in quantity with the urbanization and population growth. This paper presents the application of artificial neural networks(ANNs) in estimating TCC of apartment projects. Ninety-one questionnaires were collected to identify input variables. Fourteen data sets of completed apartment projects were obtained and processed for training and generalizing the neural network(NN). MATLAB software was used to train the NN. A program was constructed using Visual C++ in order to apply the neural network to realistic projects. The results suggest that this model is reasonable in predicting TCCs for apartment projects and reinforce the reliability of using neural networks to cost models. Although the proposed model is not validated in a rigorous way, the ANN-based model may be useful for both practitioners and researchers. It facilitates systematic predictions in early phases of construction projects. Practitioners are more proactive in estimating construction costs and making consistent decisions in initial phases of apartment projects. Researchers should benefit from exploring insights into its implementation in the real world. The findings are useful not only to researchers and practitioners in the Vietnam Construction Industry(VCI) but also to participants in other developing countries in South East Asia. Since Korea has emerged as the first largest foreign investor in Vietnam, the results of this study may be also useful to participants in Korea.

• 디지털콘텐츠학회 논문지
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• 제19권7호
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• pp.1381-1387
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• 2018

본 연구는 전세계적으로 여성암 발병률 1위로 꼽히는 유방암 검진을 활성화하여 질병을 예방하고 조기에 발견할 수 있는 인식 개선 방안을 살펴보기 위해 진행되었다. 유방암 관련 인식을 살펴보기 위해 건강신념모형(HBM)을 활용하였다. 질병 위험 지각, 질병 예방 행동 평가가 질병 관련 정보 추구에 긍정적인 영향을 주고 이러한 정보 추구 행동이 결과적으로 유방암 건강 검진 의도를 강화할 것이라고 추측하였다. 여기에 개인의 가치와 관심에 의한 스스로의 행위 조절을 뜻하는 '자율적 동기'를 추가적으로 살펴보았다. 연구 결과, 유방암을 위험하다고 지각할수록 유방암과 관련한 정보를 보다 적극적으로 찾고 있었다. 유방암 검진을 수행함으로써 얻을 수 있는 이익을 높게 지각할수록 관련 정보를 추구하는 행동 역시 높게 나타났다. 또한 스스로의 행위 조절에 적극적일수록, 즉 자율적 동기가 높을수록 유방암 관련 정보 추구 행동이 강하게 나타났다. 이러한 정보 추구 행동은 다시 건강 검진 의도에 긍정적인 영향을 미쳤다. 즉 유방암 관련 정보를 많이 찾아볼수록 검진을 하겠다는 의도가 높아짐을 확인할 수 있었다.

• Radiation Oncology Journal
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• 제37권1호
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• pp.43-50
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• 2019

Purpose: The aim of this retrospective study was to investigate the use of a radiopaque tissue fiducial marker (TFM) in the treatment of prostate cancer patients who undergo post-prostatectomy radiotherapy (PPRT). TFM safety, its role and benefit in quantifying the set-up uncertainties in patients undergoing PPRT image-guided radiotherapy were assessed. Materials and Methods: A total of 45 consecutive PPRT patients underwent transperineal implantation of TFM at the level of vesicourethral anastomosis in the retrovesical tissue prior to intensity-modulated radiotherapy. Prostate bed motion was calculated by measuring the position of the TFM relative to the pelvic bony anatomy on daily cone-beam computed tomography. The stability and visibility of the TFM were assessed in the initial 10 patients. Results: No postoperative complications were recorded. A total of 3,500 images were analysed. The calculated prostate bed motion for bony landmark matching relative to TFM were 2.25 mm in the left-right, 5.89 mm in the superior-inferior, and 6.59 mm in the anterior-posterior directions. A significant 36% reduction in the mean volume of rectum receiving 70 Gy (rV₇₀) was achieved for a uniform planning target volume (PTV) margin of 7 mm compared with the Australian and New Zealand Faculty of Radiation Oncology Genito-Urinary Group recommended PTV margin of 10 mm. Conclusion: The use of TFM was safe and can potentially eliminate set-up errors associated with bony landmark matching, thereby allowing for tighter PTV margins and a consequent favourable reduction in dose delivered to the bladder and rectum, with potential improvements in toxicities.

• Communications for Statistical Applications and Methods
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• 제24권6호
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• pp.561-581
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• 2017

Bayesian statistics can play a key role in the design and analysis of clinical trials and this has been demonstrated for medical device trials. By 1995 Bayesian statistics had been well developed and the revolution in computing powers and Markov chain Monte Carlo development made calculation of posterior distributions within computational reach. The Food and Drug Administration (FDA) initiative of Bayesian statistics in medical device clinical trials, which began almost 20 years ago, is reviewed in detail along with some of the key decisions that were made along the way. Both Bayesian hierarchical modeling using data from previous studies and Bayesian adaptive designs, usually with a non-informative prior, are discussed. The leveraging of prior study data has been accomplished through Bayesian hierarchical modeling. An enormous advantage of Bayesian adaptive designs is achieved when it is accompanied by modeling of the primary endpoint to produce the predictive posterior distribution. Simulations are crucial to providing the operating characteristics of the Bayesian design, especially for a complex adaptive design. The 2010 FDA Bayesian guidance for medical device trials addressed both approaches as well as exchangeability, Type I error, and sample size. Treatment response adaptive randomization using the famous extracorporeal membrane oxygenation example is discussed. An interesting real example of a Bayesian analysis using a failed trial with an interesting subgroup as prior information is presented. The implications of the likelihood principle are considered. A recent exciting area using Bayesian hierarchical modeling has been the pediatric extrapolation using adult data in clinical trials. Historical control information from previous trials is an underused area that lends itself easily to Bayesian methods. The future including recent trends, decision theoretic trials, Bayesian benefit-risk, virtual patients, and the appalling lack of penetration of Bayesian clinical trials in the medical literature are discussed.

• Journal of Microbiology
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• 제43권6호
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• pp.529-536
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• 2005

Viral infection causes stress to the endoplasmic reticulum (ER). The response to endoplasmic reticulum stress, known as the unfolded protein response (UPR), is designed to eliminate misfolded proteins and allow the cell to recover. The role of hepatitis C virus (HCV) non-structural protein NS4B, a component of the HCV replicons that induce UPR, is incompletely understood. We demonstrate that HCV NS4B could induce activating transcription factor (ATF6) and inositol-requiring enzyme 1 (IRE1), to favor the HCV subreplicon and HCV viral replication. HCV NS4B activated the IRE1 pathway, as indicated by splicing of X box-binding protein (Xbp-1) mRNA. However, transcriptional activation of the XBP-1 target gene, EDEM (ER degradation-enhancing $\alpha-mannosidase-like$ protein, a protein degradation factor), was inhibited. These results imply that NS4B might induce UPR through ATF6 and IRE1-XBP1 pathways, but might also modify the outcome to benefit HCV or HCV subreplicon replication.

• 대한한의학회지
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• 제30권1호
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• pp.150-162
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• 2009

Objectives: Inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 ($PGE_2$) and pro-inflammatory cytokines, TNF-${\alpha}$ and IL-$1{\beta}$ playa critical role in inflammatory immune response. Therefore, intervention of inflammatory mediator production promises therapeutic benefit for treatment of many chronic inflammatory diseases, such as allergic asthma, rheumatoid arthritis, multiple sclerosis, septic shock and neurodegenerative diseases. In this study, the pharmacological effects of the flower MeOH extract Panax notoginseng (Notoginseng Flos; NF) on inflammation were investigated to address potential therapeutic or toxic effects. Methods: RA W264.7 cells were treated with different concentrations of NF methanol (NF-M) extract in the presence or absence of LPS ($1{\mu}g/m{\ell}$). Results: NF-M extract significantly inhibited LPS-induced production of NO, $PGE_2$ and pro-inflammatory cytokines, TNF-${\alpha}$ and IL-$1{\beta}$ in a dose-dependent manner. In addition, NF-M extract suppressed mRNA expressions and protein levels of iNOS, COX-2 and pro-inflammatory cytokines in LPS-stimulated RA W264.7 cells. Conclusion: These results indicated that NF-M extract inhibits LPS-induced production of inflammatory mediators in macrophages and demonstrated that NF-M extract possesses anti-inflammatory properties in vitro.

• 자원ㆍ환경경제연구
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• 제29권2호
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• pp.247-270
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• 2020

통계적 생명가치는 환경정책의 편익 산정에 있어 매우 중요한 역할을 한다. 예를 들어 대기오염물질의 감소에 따른 건강 편익의 최종적인 화폐가치화 단위로 활용되며 이는 비용편익 분석의 기초가 된다. 통계적 생명가치는 사망위험 감소를 위해 사회의 구성원이 지불하고자 하는 화폐적 가치로 정의될 수 있다 따라서 통계적 생명가치는 각 사회를 구성하고 있는 구성원의 특성에 따라 결정된다. 본 연구는 웹 설문조사를 통해 수집된 총 3,081명의 응답자를 질문의 형태에 따라 두 개의 표본으로 분리하여 선택실험법을 적용하였다. 추정결과 총 1,528명의 표본 집단의 자료를 통해 도출된 약 13억 원의 통계적 생명가치가 가장 적절한 것으로 나타났으며, 이는 국내 선행연구를 활용한 메타분석의 결과와 유사하다. 또한 응답자들은 사망위험을 감소시키기 위해 정부의 정책비용에 대한 지불보다는 개인 차원의 예방에 비용을 지불하는 것을 선호하는 것으로 나타났다.

• 통상정보연구
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• 제17권1호
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• pp.265-285
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• 2015

다자간 무역기구인 WTO는 전통적 교역 분야 이외에 회원국의 국내 정책까지 관여하여 지역 정부의 역할과 자주성을 위협함에 따라 최근에는 양자간 FTA 체결이 증가하고 있다. 이와 같은 통상 환경 변화를 활용하기 위하여 한국과 중국은 FTA 체결을 위한 실질적인 합의에 도달하였다. 일반적으로 자동차 분야는 우리나라가 국제 경쟁력을 지닌 주력 산업으로 분류되어 한 중 FTA의 수혜 업종으로 기대되었으며, 실제로 분석 결과 한국의 자동차 산업이 중국에 비해 세계 시장에서 비교우위를 지닌 것으로 나타났다. 그러나 한 중 FTA 관세 철폐 계획에서 자동차는 양허 대상 품목에서 제외되어 우리가 기대했던 관세 철폐를 통한 한국산 자동차의 가격 경쟁력을 누릴 수 없게 되었다. 이에 따라 우리 자동차 업계는 중국의 비관세 장벽 철폐 등 투자 환경 개선을 통해 효율적인 대중국 투자 환경을 조성해야 하고 한 중 FTA상 자동차의 양허 편입에 대비하여 중국 내 세계 유수 자동차 업체의 대한국 수출 확대 가능성 방지를 위한 엄격한 원산지 규정안을 마련해야 한다. 또한 중국 내 브랜드 전략을 더욱 강화하며 친환경 차량 개발 지원을 통해 중국의 환경 정책에 부응하면서 관련 시장을 창출 확대해야 한다.

• Journal of Gastric Cancer
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• 제17권2호
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• pp.186-191
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• 2017

The role of nodal station No. 14v (along the superior mesenteric vein) in lymphadenectomy for distal gastric cancer remains elusive. A 73-year-old woman underwent endoscopic submucosal dissection for gastric cancer, and was referred to our division for additional surgery because of pathologically non-curative resection. A laparoscopic distal gastrectomy with D1+ dissection was performed, with a final diagnosis of pT1bN1M0, Stage IB (2 nodal metastases to No. 6). Four months post-surgery, abdominal computed tomography revealed a 14-mm solitary nodule along the superior mesenteric vein. The lesion was excised and pathologically identified as a lymph node metastasis. Adjuvant chemotherapy with tegafur-gimeracil-oteracil potassium (S-1) was administered for the metastasis. Presently the patient survives without recurrence, 5.5 years after the second operation. Our findings suggest that there is lymphatic flow from the No. 6 to the No. 14v nodal station. Some patients with a No. 6 metastasis may benefit from a No. 14v lymphadenectomy, even in early-staged disease.