• Journal of Microbiology and Biotechnology
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• 제33권6호
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• pp.840-847
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• 2023

Korean ginseng (Panax ginseng C. A. Meyer), a member of the Araliaceae family, is known as a traditional medicinal plant to have a wide range of health properties. Polysaccharides constitute a major component of Korean ginseng, and its berries exhibit immune-modulating properties. The purpose of this study was to investigate the immune effects of crude polysaccharide (GBPC) extracted from Korean ginseng berry on peritoneal macrophages in mice with cyclophosphamide (CY)- induced immunosuppression. BALB/c mice were divided into eight groups: normal control, normal control + CY, levamisole + CY, ginseng + CY, and four concentrations of 50, 100, 250, and 500 mg/kg BW/day of GBPC + CY. Mice were orally administered with samples for 10 days. Immunosuppression was established by treating mice with CY (80 mg/kg BW/day) through intraperitoneal injection on days 4 to 6. The immune function of peritoneal macrophages was then evaluated. Oral administration of 500 mg/kg BW/day GBPC resulted in proliferation, NO production, and phagocytosis at 100%, 88%, and 91%, respectively, close to the levels of the normal group (100%) of peritoneal macrophages. In CY-treated mice, GBPC of 50-500 mg/kg BW/day also dose-dependently stimulated the proliferation, NO production, and phagocytosis at 56-100%, 47-88%, and 53-91%, respectively, with expression levels of immune-associated genes, such as iNOS, COX-2, IL-1β, IL-6, and TNF-α, of about 0.32 to 2.87-fold, compared to those in the CY group. GBPC could be a potential immunomodulatory material to control peritoneal macrophages under an immunosuppressive condition.

• 한국광학회지
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• 제9권3호
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• pp.175-180
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• 1998

고체 레이저매질로 가장 널리 쓰이는 Nd:YAG 단결정을 Czochralski 방법으로 육성하였다. 자체 제작한 Czochralski 결정 육성로 및 자동 결정 적경제어 장치를 써서 유효 직경 50mm, 길이 100mm의 Nd3+ 이온농도가 0.9at%이고 <111>방향의 단결정을 육성하였다. 단결정 육성시 융액의 수직방향에 대한 온도구배가 중용한 변수인 것이 확인되었으며, 결정 직경은 자동 제어가 가능하도록 컴퓨터 프로그램을 제작하였다. 육성된 단결정을 절단, 가공, 연마, 코팅 과정을 거쳐서 레이저 발진용 Nd:YAG막대를 제작하고 흡수 스펙트럼, 형과 스펙트럼 분석을 통하여 정확한 Nd:YAG의 레이저 발진특성을 확인하였다. 자체 가공된 레이저 막대로부터 발진된 CW 레이저의 최대 출력은 70W이었고, 발진문턱값과 효율은 각각 1.3kW, 1.64%이었다.

• 드라이브 ㆍ 컨트롤
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• 제15권1호
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• pp.10-15
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• 2018

The hydraulic cylinder seals are used not only to protect leakage of the working fluids but also to prevent incoming of foreign particles into the system. Chromium plating is generally applied to improve corrosion and wear resistance. It has been noticed that sealing surface damage occurs due to the hard foreign/wear particles contained in the hydraulic oil. In this study, a three-bodied sliding contact problem related with a PTFE seal, a spherical particle and chrome-plated steel substrate is modeled to investigate the relations to wear mechanism. Using the nonlinear finite element software, MARC/MENTAT, the deformed shapes, the von Mises and first principal stress distributions with plating thickness were compared. The sealing surface was mainly abraded by hard particles embedded in the seal. The plastic deformation of the steel substrate decreased with thicker plating. Hence it could be more effective to coat the sealing surface of a hydraulic cylinder with a hard material such as TiN, TiC and DLC.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part2
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• pp.1276-1277
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• 2006

The ever increasing requirements on today's compacts with regard to their geometry and precision call for flexible high-precision and most capable production systems. DORST Technologies has coped with these requirements by developing the new HP series for pressing forces between 1600 kN and 16000 kN and the new HS series for pressing forces between 150 kN and 1200 kN. These fully hydraulic presses featuring upper ram, lower ram, core rod, filler, up to 4 lower tool levels and up to 4 upper tool levels with closed-loop controlled movements. Thanks to latest servo technology and an electronic bus system it is possible to have all movements closed-loop controlled in the desired relation to each other. Thus, today's hydraulic presses provide high stroke rates, low energy consumption and a user-friendly interface. The input of data is carried out via clearly arranged screen masks on a touch-screen. The innovative DORST $IPG^{(R)}$ (Intelligent Program Generator) has been designed to support the set-up staff in preparing and optimizing the toolprogram. The combination of the machine type with the hydraulic unit determines the productivity in consideration of the specific application and the part to be pressed. Thanks to the closed-loop control circuits, DORST hydraulic automatic presses of the latest generation ensure unmatched precision and repeatability - and consequently process reliability - often without necessitating subsequent machining steps.

• Nuclear Engineering and Technology
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• 제53권10호
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• pp.3264-3274
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• 2021

In a severe accident of light water reactor (LWR), molten core material (corium) can be released into the wet cavity, and a fuel-coolant interaction (FCI) can occur. The molten jet with high speed is broken and fragmented into small debris, which may cause a steam explosion or a molten core concrete interaction (MCCI). Since the premixing stage where the jet breakup occurs has a large impact on the severe accident progression, the understanding and evaluation of the jet breakup phenomenon are highly important. Therefore, in this study, the jet breakup simulations were performed using the Smoothed Particle Hydrodynamics (SPH) method which is a particle-based Lagrangian numerical method. For the multi-fluid system, the normalized density approach and improved surface tension model (CSF) were applied to the in-house SPH code (single GPU-based SOPHIA code) to improve the calculation accuracy at the interface of fluids. The jet breakup simulations were conducted in two cases: (1) jet breakup without structures, and (2) jet breakup with structures (control rod guide tubes). The penetration depth of the jet and jet breakup length were compared with those of the reference experiments, and these SPH simulation results are qualitatively and quantitatively consistent with the experiments.

• Nuclear Engineering and Technology
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• 제55권4호
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• pp.1563-1570
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• 2023

In this study, a DeCART/MIG uncertainty quantification (UQ) analysis code system with a multicorrelated cross section stochastic sampling (S.S.) module was established and verified through the UAM (Uncertainty Analysis in Modeling) and the BEAVRS (Benchmark for Evaluation And Validation of Reactor Simulations) benchmark calculations. For the S.S. calculations, a sample of 500 DeCART multigroup cross section sets for two major actinides, i.e., ²³⁵U and ²³⁸U, were generated by the MIG code and covariance data from the ENDF/B-VII.1 evaluated nuclear data library. In the three pin problems (i.e. TMI-1, PB2, and Koz-6) from the UAM benchmark, the uncertainties in k_inf by the DeCART/MIG S.S. calculations agreed very well with the sensitivity and uncertainty (S/U) perturbation results by DeCART/MUSAD and the S/U direct subtraction (S/U-DS) results by the DeCART/MIG. From these results, it was concluded that the multi-group cross section sampling module of the MIG code works correctly and accurately. In the BEAVRS whole benchmark problems, the uncertainties in the control rod bank worth, isothermal temperature coefficient, power distribution, and critical boron concentration due to cross section uncertainties were calculated by the DeCART/MIG code system. Overall, the uncertainties in these design parameters were less than the general design review criteria of a typical pressurized water reactor start-up case. This newly-developed DeCART/MIG UQ analysis code system by the S.S. method can be widely utilized as uncertainty analysis and margin estimation tools for developing and designing new advanced nuclear reactors.

• Nuclear Engineering and Technology
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• 제54권2호
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• pp.608-616
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• 2022

Power peaking factors (PPF) is an important parameter for safe and efficient reactor operation. There are several methods to calculate the PPF at TRIGA research reactors such as MCNP and TRIGLAV codes. However, these methods are time-consuming and required high specifications of a computer system. To overcome these limitations, artificial intelligence was introduced for parameter prediction. Previous studies applied the neural network method to predict the PPF, but the publications using the ANFIS method are not well developed yet. In this paper, the prediction of PPF using the ANFIS was conducted. Two input variables, control rod position, and neutron flux were collected while the PPF was calculated using TRIGLAV code as the data output. These input-output datasets were used for ANFIS model generation, training, and testing. In this study, four ANFIS model with two types of input space partitioning methods shows good predictive performances with R² values in the range of 96%-97%, reveals the strong relationship between the predicted and actual PPF values. The RMSE calculated also near zero. From this statistical analysis, it is proven that the ANFIS could predict the PPF accurately and can be used as an alternative method to develop a real-time monitoring system at TRIGA research reactors.

• Nuclear Engineering and Technology
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• 제56권6호
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• pp.2002-2010
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• 2024

Korea Atomic Energy Research Institute (KAERI) has operated an integral effect test facility, the Advanced Thermal-Hydraulic Test Loop for Accident Simulation (ATLAS), with reference to the APR1400 (Advanced Power Reactor 1400) for tests for transient and design basis accidents simulation. A test for a loss of coolant accident (LOCA) at the top of the reactor pressure vessel (RPV) had been conducted at ATLAS to address the impact of the loss of safety injections (LSI) and to evaluate accident management (AM) actions during the postulated accident. The experimental data has been utilized to validate system analysis codes within a framework of the domestic standard problem program organized by KAERI in collaboration with Korea Institute of Nuclear Safety. In this study, the test has been analyzed by using thermal-hydraulic system analysis codes, MARS-KS 1.5 and TRACE 5.0 Patch 6, and a comparative analysis with experimental and calculation results has been performed. The main objective of this study is the investigation of the thermal-hydraulic phenomena during a small break LOCA at the RPV upper head with the LSI as well as the predictability of the system analysis codes after the AM actions during the test. The results from both codes reveal that overall physical behaviors during the accident are predicted by the codes, appropriately, including the excursion of the peak cladding temperature because of the LSI. It is also confirmed that the core integrity is maintained with the proposed AM action. Considering the break location, a sensitivity analysis for the nodalization of the upper head has been conducted. The sensitivity analysis indicates that the nodalization gave a significant impact on the analysis result. The result emphasizes the importance of the nodalization which should be performed with a consideration of the physical phenomena occurs during the transient.

• 약학회지
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• 제51권3호
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• pp.219-227
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• 2007

Ginsenoside Rgl (Rgl), the pharmacologically active constituent of ginseng (Panax ginseng C.A. Meyer), has a variety of biological activities. The present study was undertaken to evaluate a possibility of Rgl whether it can be used in treatment or prevention of stress disorders. Animals were stressed by immobilization for 2 hours or electroshocks for 20 minutes. The normal group was not exposed to any stress. Rgl was subcutaneously injected as dosages of 5 and 10 mg/kg and red ginseng (RG) was orally administered 200 mg/kg as the positive control. Animals were given supplements for 5 days without stress, and then were given supplements for 5 days with stress. We recorded stress-related behavioral changes of experimental animals using the Etho-vision system. Weight of adrenal gland and levels of corticosterone in plasma were measured and stress related behaviors (smelling, grooming, face washing, rearing) were observed. Rgl didn't make significant behavioral changes in total open field and elevated plus maze test. Rgl did not influence on behavioral changes induced by electroshock stress. Whereas, 10 mg/kg of Rgl alleviated the increment of the freezing and face washing time and the decrement of the smelling and rearing time induced by restraint stress. The administration of Rgl 10 mg/kg has significantly increased the endurance time on rotating rod and swimming pool tests compared to the control group. These results indicate that Rgl can alleviate the damage induced by physical stress. This result suggests that Rgl may bea new candidate for treating stress related disorder.

• Biomolecules & Therapeutics
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• 제13권3호
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• pp.165-173
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• 2005

The main aim of this study was to investigate stress related activities of ginsenosides and their action mechanism. Control group and ginsenoside supplemented groups were exposed to stress while no-stress group was not done. Animals of each group (n=$8\~10$) were orally administerd 100 mg red ginseng extract (R-G), or 10 mg ginsenosides/kg body weight once a day. Animals were given materials for 5 days without stress, and then were given supplements for 5 days with restraint and electroshock stress. Mice were given materials for 5 days for experiments on anti-fatigue effect. After loading final stress, stress-related behavioral changes of experimental animals were examined and plasma corticosterone levels were measured. R-G and ginsenoside $Rb_{1}$ supplementation partially blocked the stress effects on locomotion and elevated plus-maze test in rats and mice. They also partially blocked stress induced behavioral changes such as freezing, smelling, face-washing, rearing behavior in rats. R-G and $Rb_{1}$ decrease adrenal gland size and plasma corticosterone level, which were increased by stress in rats. R-G increased enduring time on the Rota rod, cold water and horizontal wire, but $Rb_{1}$ didn't. Effects of $Rb_{1}$ on plusmaze test were inhibited by administration of flumazenil. These results suggest that $Rb_{1}$ is the main antistress principle in ginseng and it's effect is modulated by GABAnergic nervous system.