• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제9권2호
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• pp.129-138
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• 2006

Lots of cases relating Helicobacter pylori infection to iron-deficiency anemia have been described in the literature and H. pylori infection has emerged as a cause of refractory iron-deficiency anemia which is unresponsive to oral iron therapy. H. pylori-associated iron-deficiency anemia can be treated by H. pylori eradication. It is not thought to be attributable to gastrointestinal blood loss, such as duodenal ulcer. The mechanism by which H. pylori infection contributes to iron-deficiency anemia remains unclear. However, four possible explanations can be posited for this relationship; occult blood loss secondary to chronic gastritis, reduced iron absorption due to hypo- or achlorhydria, increased iron consumption by H. pylori, and iron sequestration in gastric mucosa. H. pylori-associated iron-deficiency anemia seems to develop in populations at increased risk for iron depletion. When pubescent girls, including athletes, are found to have iron-deficiency anemia refractory to iron administration, they should be evaluated for H. pylori infection.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1247-1251
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• 2012

Background: Helicobacter pylori is an important gastrointestinal pathogen related to the development of not only atrophic gastritis and peptic ulcer, but also gastric cancer. Human leukocyte antigens (HLA) may play particular roles in host immune responses to bacterial antigens. This study aimed to investigate the association between HLA-DQA1 and DQB1 genotypes and haplotypes vs H. pylori infection in an Indonesian population. Methods: We selected 294 healthy participants in Mataram, Lombok Island, Indonesia. H. pylori infection was determined by urea breath test (UBT). We analyzed HLA-DQA1 and DQB1 genotypes by PCR-RFLP and constructed haplotypes of HLA-DQA1 and DQB1 genes. Multiple comparisons were conducted according to the Bonferroni method. Results: The H. pylori infection rate was 11.2% in this Indonesian population. The DQB1*0401 genotype was noted to be associated with a high risk of H. pylori infection, compared with the DQB1*0301 genotype. None of the HLA-DQA1 or DQB1 haplotypes were related to the risk of H. pylori infection. Conclusions: The study suggests that HLADQB1 genes play important roles in H. pylori infection, but there was no statistically significant association between HLA-DQA1 or DQB1 haplotypes and H.pylori infection in our Lombok Indonesian population.

• Journal of Chest Surgery
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• 제35권5호
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• pp.375-380
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• 2002

배경: 개심술후 발생하는 흉골감염은 심각한 합병증일 뿐만 아니라 술후 사망률을 높이는 한 요인이 된다. 저자들은 1999년 7월 집중치료실 및 수술장 이전을 계기로 이를 전후로한 환자들의 흉골감염 발생현황을 비교 분석함으로써 집중치료실 및 수술장 개선이 흉골감염에 미치는 영향을 알고자 하였다. 대상 및 방법: 집중치료실 및 수술장 이전 시점을 전후로 하여 1997년 1월 1일부터 1998년 12월 31일까지 개심술을 시행받은 환자 237명을 Group I으로, 2000년 1월 1일부터 2001년 7월 31일까지 개심술을 시행받은 환자 216명을 Group II로 분류하여 총 453명을 대상으로 하였다. 만 15세 이상의 성인 환자에서 정중흉골절개술 및 심폐바이패스를 시행한 경우만을 포함하였고 흉골감염 이외의 원인으로 사망한 예는 포함하지 않았다. 결과: 흉골감염은 GroupI에서 18례(8.0%), Group II에서 1례(0.49%) 발생하였다. 흉골감염에 영향을 미치는 것으로 알려진 위험인자 중에서 응급수술여부, 심폐바이패스시간, 수술시간, 수혈량, 기관절개술유무, 재수술여부 등이 유의한 연관성이 있었으며, 이들을 대상으로 시행한 로지스틱 회귀분석에서 집중치료실과 수술장의 이전이 흉골감염에 유의한 영향을 미치는 것으로 나타났다.(p=0.029, 95% 신뢰구간 0.011∼0.788). 결론: 개심술후 흉골감염에 영향을 주는 여러 인자들이 알려져 있지만 집중치료실 및 수술장의 개선이 흉골감염의 발생을 줄일 수 있는 하나의 방법으로 생각된다.

• IMMUNE NETWORK
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• 제24권1호
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• pp.4.1-4.19
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• 2024

TNF, a pleiotropic proinflammatory cytokine, is important for protective immunity and immunopathology during Mycobacterium tuberculosis (Mtb) infection, which causes tuberculosis (TB) in humans. TNF is produced primarily by phagocytes in the lungs during the early stages of Mtb infection and performs diverse physiological and pathological functions by binding to its receptors in a context-dependent manner. TNF is essential for granuloma formation, chronic infection prevention, and macrophage recruitment to and activation at the site of infection. In animal models, TNF, in cooperation with chemokines, contributes to the initiation, maintenance, and clearance of mycobacteria in granulomas. Although anti-TNF therapy is effective against immune diseases such as rheumatoid arthritis, it carries the risk of reactivating TB. Furthermore, TNF-associated inflammation contributes to cachexia in patients with TB. This review focuses on the multifaceted role of TNF in the pathogenesis and prevention of TB and underscores the importance of investigating the functions of TNF and its receptors in the establishment of protective immunity against and in the pathology of TB. Such investigations will facilitate the development of therapeutic strategies that target TNF signaling, which makes beneficial and detrimental contributions to the pathogenesis of TB.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.4953-4960
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• 2013

Primary liver cancer is one of the most common cancers at the global level, accounting for half of all cancers in some undeveloped countries. This disease tends to occur in livers damaged through alcohol abuse, or chronic infection with hepatitis B and C, on a background of cirrhosis. Various cancer-causing substances are associated with primary liver cancer, including certain pesticides and such chemicals as vinyl chloride and arsenic. The strong association between HBV infection and liver cancer is well documented in epidemiological studies. It is generally acknowledged that the virus is involved through long term chronic infection, frequently associated with cirrhosis, suggesting a nonspecific mechanism triggered by the immune response. Chronic inflammation of liver, continuous cell death, abnormal cell growth, would increase the occurrence rate of genetic alterations and risk of disease. However, the statistics indicated that only about one fifth of HBV carries would develop HCC in lifetime, suggesting that individual variation in genome would also influence the susceptibility of HCC. The goal of this review is to highlight present level of knowledge on the role of viral infection and genetic variation in the development of liver cancer.

• 대한기관식도과학회지
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• 제11권1호
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• pp.37-41
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• 2005

Deep neck infections mean infection in the potential spaces and facial planes of the neck, either abscess formation or cellulitis. Deep neck infections are caused by dental, salivary gland, pharyngeal and tonsillar infections. Sometimes, deep neck infection may be caused by tuberculosis in case of immunodefiecient patients. Acquired immunodeficiency syndrome(AIDS) is a disease associated with defective cell-mediated immunity after infected with human immunodeficiency virus(HIV). The chance of opportunistic infection in patients of AIDS increases as the level of immunodeficienty progresses. Human immunodeficiency virus infection is the most single significant risk factor for progression of pulmonary tuberculosis to extrapulmonary sites. In patients infected with HIV, the rate of extrapulomonary tuberculosis rises upto $60\%$. We report a case of a 47 year old male patient with AIDS associated with deep neck infection by tuberculosis.

• Clinical and Experimental Pediatrics
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• 제54권5호
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• pp.197-200
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• 2011

Respiratory syncytial virus (RSV) is a major cause of respiratory infection in children. Most of the pediatric population have RSV infection before the age of 2, and recurrent infections are common even within one season. Chronic lung disease, prematurity, along with congenital heart disease (CHD) are major risk factors in severe lower respiratory infection. In hemo-dynamically significant CHD patients with RSV infection, hospitalization is usually needed and the possibility of treatment in intensive care unit and the use of mechanical ventilator support are known to increase. Therefore the prevention of RSV infection in CHD patients is mandatory. The current standard for RSV prevention is immunoprophylaxis by palivizumab. Immunoprophylaxis is recommended monthly in hemodynamically significant CHD patients, up to 5 months. Motabizumab, a second generation drug and newly developing RSV vaccines are also expected to play a key role in RSV prevention in the future. The prophylaxis of RSV infection in CHD patients is cost-effective in both the medical aspect of the patients as well as the socio-economic aspect. Therefore an effort to promote prevention should be made by not only the family of the patients but also by the government.

• Journal of Korean Neurosurgical Society
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• 제64권1호
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• pp.120-124
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• 2021

Objective : Infection is one of most devastating complications in ventriculoperitoneal (VP) shunt surgery. Preoperative hair removal has traditionally been performed to reduce infectious complications. We performed VP shunt surgeries and evaluated the prevalence of infection in patients who were shaved and those who were unshaven. Methods : A retrospective analysis was conducted of 82 patients with hydrocephalus of various pathologies who underwent VP shunt surgery, with or without having the head shaved, between March 2010 and March 2017. For patients in the non-shaved group (n=36), absorbable suture materials were used for wound closure, and Nylon sutures or staples were used in the shaved group (n=46). We evaluated the infection outcomes of patients in the two groups. Results : There was no difference in the average age of patients in the two groups. In the non-shaved group, there were no infections, while two patients in the shaved group required revision because of shunt infection. Conclusion : Non-shaved shunt surgery may be safe and effective, with no increase of infection rate. We recommend that shunt procedures could be performed without shaving the hair, which may increase patients' satisfaction without increasing infection risk.

• 한국치위생학회지
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• 제21권5호
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• pp.675-683
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• 2021

Objectives: This study aimed to verify the relations of COVID-19 infection-related knowledge, dental infection control performance, and psychosocial health of dental hygienists. Methods: From the data was analyzed through the frequency analysis, t-test, one way ANOVA, and pearson's correlation analysis with a total of 198 dental hygienists using SPSS Statistics 21.0. Results: The correct answer rate for knowledge about COVID-19 was higher with a bachelor's degree or higher. Thus, when the level of education was higher, the performance was also high (p<0.01). COVID-19 infection control performance was highly shown in case of high age (4.43) (p<0.05) and the married (4.42) (p<0.01). Infection control performance was high when they had an educational experience of COVID-19 infection control (4.46), and when the infection control guidebooks were equipped in their workplaces (p<0.001). Degree of psychosocial health of research subjects was shown in the order of potential stress (60.6%), high-risk stress (23.7%), and healthy (15.7%). Infection control performance was higher, the psychosocial health was healthy. Conclusions: For the response to COVID-19 infectious disease and the preparation for mutated viruses and new infectious diseases in the future, it would be necessary to establish the concrete measures for establishing the strict infection control system for dental clinics and also enhancing the psychosocial health of dental hygienists.

• Journal of Ecology and Environment
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• 제47권2호
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• pp.35-41
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• 2023

Background: Several species of amphibians in agricultural areas are often infected with ranaviruses; however, the biological or ecological factors that cause this infection are not well understood. In this study, we investigated whether local tadpole density, Gosner developmental stage, and weather conditions affected ranavirus infection in Dryophytes japonicus tadpoles in rice paddies over three months. Results: During the study, eight samplings were undertaken between June 6 and August 21, 2022. No die-off of tadpoles occurred, but 20 of 110 tadpoles (18.8%) were found to be infected with ranavirus. The tadpole density at the sampling site and Gosner stage of the sampled tadpoles were not related to the daily ranavirus infection rate. The mean daily highest temperature during the two weeks prior to the sampling date and the mean daily lowest and highest temperatures during the week prior to the sampling date were negatively related to the daily infection rate. Conclusions: Our results suggest that low and extreme temperatures caused by flooding and draining of paddy fields or climate change in summer could be a significant risk factor for ranavirus infection in summer-breeding frogs in agricultural areas.