• 한국산학기술학회논문지
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• 제19권12호
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• pp.918-923
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• 2018

항공기용 연료탱크는 평상시에는 연료저장 등의 단순한 기능을 한다. 그러나, 항공기 추락과 같은 긴급 상황에서는 연료탱크 구조건전성은 승무원의 생존과 직결되므로, 관련 성능의 보유 여부를 충돌충격시험을 통해 입증하도록 규정되어 있다. 충돌충격시험은 높은 충격하중으로 실패 위험이 높기 때문에 설계 초기 실물시험에서의 시행착오 가능성을 최소화하기 위한 노력이 진행되어 왔다. 실제 시험 전에 수행하는 수치해석도 그러한 노력의 일환이다. 하지만, 수치해석 결과가 설계에 반영되기 위해서는 수치해석의 신뢰성 확보가 필요하다. 본 연구에서는 회전익항공기 연료탱크의 충돌충격시험 수치해석의 신뢰성 확보를 위해 수치해석 결과와 시험 데이타 간의 비교를 수행하였다. 수치해석은 충돌전용 소프트웨어인 LS-DYNA을 사용하였고, 해석방법은 유체-구조연성해석 방법 중 ALE(arbitary lagrangian eulerian) 방법을 적용하였다. 시험데이터 확보를 위해 연료탱크 금속 피팅부에 변형률게이지를 설치하고 데이터 획득장비와 연동시켰다. 수치해석 결과로써 연료탱크 피팅부의 변형률과 응력을 계산하였다. 그리고, 실물 연료탱크로 수행한 충돌충격시험을 통하여 확보한 상부피팅의 변형률 측정값과 수치해석으로 계산된 변형률과의 오차를 평가함으로써 수치해석의 신뢰성을 제고하였다.

• 해양환경안전학회지
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• 제27권2호
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• pp.238-246
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• 2021

어선과 같은 소형선박의 충돌사고는 큰 인명피해를 초래한다. 본 연구 이전에 선행된 연구에서는 충돌위험을 판단하고 경보를 발생시키는 소형선박 충돌예방 알고리즘을 개발하였다. 하지만 충돌경보와 같이 안전을 위해 제공되는 서비스는 위험을 예방할 뿐 아니라 이용자의 만족도 또한 어느 정도 수반되어야 효과적으로 기능할 수 있다. 본 연구에서는 소형선박 충돌예방 알고리즘의 실용성 향상을 위해 알고리즘을 개선하고, 알고리즘을 실제로 적용하여 개선결과 및 효과를 확인하고자 하였다. 충돌경보 서비스를 사용한 소형선박 운항자들을 대상으로 설문조사를 수행한 결과, 충돌경보의 정확도 향상과 경보 횟수 및 음량에 대한 사용자들의 요구사항이 확인되었다. 이에 따라 본 연구에서는 사용자 만족도 향상을 위해 알고리즘을 개선하였으며 실제 해상환경에서 개선된 알고리즘을 적용한 실선실험을 수행하였다. 그 결과 개선 전보다 경보 발생 빈도가 감소하였지만, 위험한 상황에서는 경보가 비교적 꾸준히 발생하였으며, 충돌경보의 정확성과 실용성이 향상된 것으로 분석되었다. 추후에는 개선된 알고리즘의 적정성에 대한 근거자료를 마련하여 알고리즘의 실용성과 신뢰성을 확보한다면 소형선박 충돌사고 예방에 효과적으로 기여할 수 있을 것이다.

• Molecules and Cells
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• 제44권1호
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• pp.38-49
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• 2021

Airway mucus secretion is an essential innate immune response for host protection. However, overproduction and hypersecretion of mucus, mainly composed of the gel-forming MUC5AC protein, are significant risk factors for patients with asthma and chronic obstructive pulmonary disease (COPD). The transforming growth factor β (TGFβ) signaling pathway negatively regulates MUC5AC expression; however, the underlying molecular mechanism is not fully understood. Here, we showed that TGFβ significantly reduces the expression of MUC5AC mRNA and its protein in NCI-H292 cells, a human mucoepidermoid carcinoma cell line. This reduced MUC5AC expression was restored by a TGFβ receptor inhibitor (SB431542), but not by the inhibition of NF-κB (BAY11-7082 or Triptolide) or PI3K (LY294002) activities. TGFβ-activated Smad3 dose-dependently bound to MUC5AC promoter. Notably, TGFβ-activated Smad3 recruited HDAC2 and facilitated nuclear translocation of HDAC2, thereby inducing the deacetylation of NF-κB at K310, which is essential for a reduction in NF-κB transcriptional activity. Both TGFβ-induced nuclear translocation of Smad3/HDAC2 and deacetylation of NF-κB at K310 were suppressed by a Smad3 inhibitor (SIS3). These results suggest that the TGFβ-activated Smad3/HDAC2 complex is an essential negative regulator for MUC5AC expression and an epigenetic regulator for NF-κB acetylation. Therefore, these results collectively suggest that modulation of the TGFβ1/Smad3/HDAC2/NF-κB pathway axis can be a promising way to improve lung function as a treatment strategy for asthma and COPD.

• 재활치료과학
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• 제10권3호
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• pp.43-56
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• 2021

목적 : 본 연구에서는 허약노인의 정의를 정리하고, 허약노인 선별 시 사용되는 도구들을 분석함으로써 허약의 구성 요소를 제시하고자 한다. 연구방법 : 고령자에게 허약 선별 평가가 실시된 문헌을 검색하기 위해 CINAHL, Embase, Medline Complete, PubMed를 사용하였다. 검색어는 "assess" AND "frailty" AND "screening" AND ("frail elderly" OR "elderly")를 사용하였다. 결과 : 검색 결과로 얻은 539편의 문헌 중 선정기준에 부합하는 11편의 연구가 최종적으로 도출되었다. 본 고찰을 통해 허약은 다차원적 요인의 기능 저하로 인해 발생하며, 허약노인은 '건강 악화·기능손상·장애 발생의 가능성이 높고, 생명에 대한 위협 수준이 높은 사람'으로 정의되었다. 11편의 문헌 중 허약 선별 평가도구는 총 7종류로 Phenotype of frailty가 5편(45.4%)으로 가장 많이 사용되었다. 7개의 선별 평가도구에서 제시된 허약의 구성 요소는 신체적 요소(신체적 기능), 활동참여(일상생활활동, 수단적 일상생활활동), 영양상태(체중감소, 체질량 지수), 정신적 요소(인지, 정서), 사회적 요소(사회적 상호작용, 사회적지지, 사회적 환경), 전반적 건강 및 나이로 나타났다. 결론 : 본 연구를 통해 허약의 정의 및 구성 요소를 제시하였다. 이는 향후 허약노인 선별을 위한 표준화된 선별 평가도구 및 중재 프로그램 개발에 대한 기초자료가 될 것으로 사료된다.

• Journal of Korean Neurosurgical Society
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• 제64권5호
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• pp.791-798
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• 2021

Objective : The period of mechanical ventilator (MV)-dependent respiratory failure after cervical spinal cord injury (CSCI) varies from patient to patient. This study aimed to identify predictors of MV at hospital discharge (MVDC) due to prolonged respiratory failure among patients with MV after CSCI. Methods : Two hundred forty-three patients with CSCI were admitted to our institution between May 2006 and April 2018. Their medical records and radiographic data were retrospectively reviewed. Level and completeness of injury were defined according to the American Spinal Injury Association (ASIA) standards. Respiratory failure was defined as the requirement for definitive airway and assistance of MV. We also evaluated magnetic resonance imaging characteristics of the cervical spine. These characteristics included : maximum canal compromise (MCC); intramedullary hematoma or cord transection; and integrity of the disco-ligamentous complex for assessment of the Subaxial Cervical Spine Injury Classification (SLIC) scoring. The inclusion criteria were patients with CSCI who underwent decompression surgery within 48 hours after trauma with respiratory failure during hospital stay. Patients with Glasgow coma scale 12 or lower, major fatal trauma of vital organs, or stroke caused by vertebral artery injury were excluded from the study. Results : Out of 243 patients with CSCI, 30 required MV during their hospital stay, and 27 met the inclusion criteria. Among them, 48.1% (13/27) of patients had MVDC with greater than 30 days MV or death caused by aspiration pneumonia. In total, 51.9% (14/27) of patients could be weaned from MV during 30 days or less of hospital stay (MV days : MVDC 38.23±20.79 vs. MV weaning, 13.57±8.40; p<0.001). Vital signs at hospital arrival, smoking, the American Society of Anesthesiologists classification, Associated injury with Injury Severity Score, SLIC score, and length of cord edema did not differ between the MVDC and MV weaning groups. The ASIA impairment scale, level of injury within C3 to C6, and MCC significantly affected MVDC. The MCC significantly correlated with MVDC, and the optimal cutoff value was 51.40%, with 76.9% sensitivity and 78.6% specificity. In multivariate logistic regression analysis, MCC >51.4% was a significant risk factor for MVDC (odds ratio, 7.574; p=0.039). Conclusion : As a method of predicting which patients would be able to undergo weaning from MV early, the MCC is a valid factor. If the MCC exceeds 51.4%, prognosis of respiratory function becomes poor and the probability of MVDC is increased.

• 스마트미디어저널
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• 제9권4호
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• pp.176-186
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• 2020

농작물들의 크기와 형태는 매우 다양하며 생육 환경도 각기 다르다. 따라서 드론을 활용하여 농약을 살포할 때에는 각 농작물에 대한 재배 환경과 특성이 고려되어야 하며, 이에 따라 드론의 비행고도, 전진속도 등 비행 조건이 달라져야 한다. 실제로 비행 조건에 따라 농약의 액적 유동이 크게 영향을 받게 되며, 살포 영역에 큰 변화가 발생하고 이로 인해 불균일한 액적 분포가 후류에 형성되어 농약의 전달 효율성이 떨어질 수 있을 뿐만 아니라 비산에 대한 위험성이 존재하게 된다. 본 논문에서는 농업용 드론을 사용하여 특성이 다른 3가지 농작물을 선정하고 드론의 비행 조건을 각각 다르게 하여 농약을 살포했을 때 후류에서의 노즐 유동을 수치해석을 통하여 분석하였으며, 전달되는 액체의 비율을 확률 밀도 함수의 평균 제곱근을 나눈 새로운 성능지수를 이용하여 비교함으로써 작물의 특성에 따른 드론의 농약 살포 가이드라인을 구축하고자 한다.

• 한국환경복원기술학회지
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• 제25권1호
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• pp.41-55
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• 2022

Social interest in the fine particulate matter has increased significantly since the 2010s, and various efforts have been made to reduce it through environmental plans and policies. To support such environmental planning, in this study, spatial cluster characteristics of fine particulate matter (PM2.5) concentrations were analyzed in the metropolitan area to identify high-risk areas spatially, and the correlation with local environmental characteristics was also confirmed. The PM2.5 concentration for the recent 5 years (2016-2020) was targeted, and representative spatial statistical methods Getis-Ord Gi^* and Local Moran's I were applied. As a result of the analysis, the cluster form was different in Getis-Ord Gi^* and Local Moran's I, but they show high similarity in direction, therefore complementary results could be obtained. In the high concentration period, the hotspot concentration of the Getis-Ord Gi* method increased, but in Local Moran's I, the HH region, the high concentration cluster, showed a decreasing trend. Hotspots of the Getis-Ord Gi^* technique were prominent in the Pyeongtaek-Hwaseong and Yeoju-Icheon regions, and the HH cluster of Local Moran's I was located in the southwest, and the LL cluster was located in the northeast. As in the case of the metropolitan area, in the results of Seoul, there was a phenomenon of division between the northeast and southwest regions. The PM2.5 concentration showed a high correlation with the elevation, vegetation greenness and the industrial area ratio. During the high concentration period, the relation with vegetation greenness increased, and the elevation and industrial area ratio increased in the case of the annual average. This suggests that the function of vegetation can be maximized at a high concentration period, and the influence of topography and industrial areas is large on average. This characteristic was also confirmed in the basic statistics for each major cluster. The spatial clustering characteristics of PM2.5 can be considered in the national land and environmental plan at the metropolitan level. In particular, it will be effective to utilize the clustering characteristics based on the annual average concentration, which contributes to domestic emissions.

• 적정기술학회지
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• 제6권2호
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• pp.219-225
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• 2020

터치 장비와 스마트 러닝의 중요성이 높아짐에 따라 공공 기관 및 교육시설에서는 스마트 디바이스(smart device)를 업무 및 교육 환경에 적용하는 추세이다. 그러나 공공 스마트 디바이스 사용자들은 직·간접적 감염병 확산에 노출될 위험이 있다. 본 연구는 스마트 디바이스 사용자를 위해 손가락 끝을 감싸는 외골격 장치(Exo-finger)를 개발하였으며, 공용 장비에 활용 시 질병 예방 효과를 가지고자 한다. 활성화 재료인 카본 블랙(Carbon Black, CB)과 고분자 탄성중합체(elastomer)를 혼합한 2차 재료를 금형에 넣어 외골격 장치를 제작하였다. 이 장치는 CB 함량이 0.030 wt.% 이상일 때, 터치 기능이 있는 것으로 확인되었으며 탄성중합체의 함량을 변화시켜 사람이 스마트 디바이스를 터치할 때와 유사한 마찰력(마찰계수 2.5)를 가질 수 있도록 하였다. 실험을 통하여 CB의 함유량은 마찰 계수에 주는 영향이 거의 없음을 확인하였다. 완성된 시제품을 스마트 디바이스에 테스트한 결과, 개발된 외골격 장치는 보호 장구를 착용하여 터치가 불가능한 경우 또는 감염병 확산을 막기 위해 장갑 등의 장비를 사용하는 경우에 유용하게 활용할 수 있음을 확인하였다.

• 대한통합의학회지
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• 제9권3호
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• pp.37-45
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• 2021

Purpose : This study aimed to present normative data and cut-off points for older Korean adults completing the Montreal Cognitive Assessment - Korean (MoCA-K), which is used as a screening test for mild cognitive impairment in Korea. Methods : A total of 195 healthy adults ≥60 years were recruited. All participants completed the MoCA-K and the Korean - Mini-Mental State Examination (MMSE-K) to assess their cognitive function. Participants were divided into six groups based on their age: 60-64 years, 65~69 years, 70~74 years, 75~79 years, 80~84 years, and 85~89 years. Results : The results revealed that MoCA-K score decreased significantly with age (mean score ± standard deviation [SD]; 27.63±2.80 in subjects aged 60~64 years; 27.00±2.39 in subjects aged 65~69 years; 24.94±2.96 in subjects aged 70~74 years; 24.74±3.37 in subjects aged 75~79 years; 22.59±4.72 in subjects aged 80~84 years; and 18.83±5.38 in subjects aged 85~89 years; p<.001). Additionally, MoCA-K score also increased significantly with educational level (mean score±standard deviation [SD]; 19.95±4.78 in no formal education group; 24.95±2.22 in elementary school graduated group; 26.35±2.72 in middle school graduated group; 28.32±1.36 in high school graduated group; and 28.50±1.51 in more than college graduated group; p<.001). The optimal cut-off points were 24/25 for 60~69 years old group, 21/22 for 70~79 years old group, 17/18 for 80~84 years old group, and 13/14 for 85~89 years old group. The optimal cut-off points were 15/16 for individuals who were illiterate, 22/23 for individuals with 6 years of education, 22/24 for individuals with 9 years of education, and 26/27 for individuals with 12 or more years of education. Conclusions : This study presents normative data and cut-off points for the MoCA-K in older Korean adults. This data will facilitate more accurate detection and follow-up of the risk of mild cognitive impairment in this population, taking into consideration age and education. Future studies are required that should focus on the cut-off score on the level of education according to age.

• Ocean and Polar Research
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• 제44권2호
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• pp.147-160
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• 2022

SRFC (Sub-Regional Fisheries Commission) requested to the ITLOS (International Tribunal for the Law of the Sea) an advisory opinion relating to the IUU (Illegl, Unreported, and Unregulated) fishing (Case No-21 of the ITLOS). Since, in the UNCLOS, there is no article authorizing the jurisdiction of the ITLOS full court's Advisory opinion, so various scholarly opinion wad divided. But ITLOS delivered its Advisory opinion confirming its jurisdictional competence over the Advisory proceedings with its legal opinion about the IUU issues. It opens new possibility of the alternative dispute settlement mechanism of the ITLOS through the advisory procedures. In reality, there has been a view that ICJ (International Court of Justice) could take the part of a kind of dispute settlement through its Advisory procedures. But the advisory procedures of the ITLOS, with no definite clause in UNCLOS about the advisory procedures, which provides more allowances for the function of advisory opinion as the alternative dispute settlement mechanism. ITLOS accepted the requests of the advisory opinion by the State parties through international organization or themselves directly. And the advisory opinion of the ITLOS aims the interpretation and application into the special issues-specially IUU fishing in Case No. 21 of the ITLOS-. Those factors could enable more enhanced role of the ITLOS as an alternative dispute settlement mechanism. But those possibility has contain risk of excessive and unlimited advisory role of the ITLOS. So it is important to focus on the restriction on the role of the State parties in the request of the advisory opinion to the ITLOS. In this regard it is meaningful that the ITLOS has suggested a kind of legal standing in the advisory procedures in that only coastal States could request the Advisory opinion about the IUU in their EEZ. Furthermore the discretionary power of the ITLOS in the Article 138 of the Rules of the Tribunal could curtail the abuse of the Advisory opinion initiated by the States parties of the UNCLOS. Under this framework, Advisory opinion could broaden more alternative option to the disputes between State parties of the UNCLOS in that after being delivered detailed interpretation of the UNCLOS about the specific issues, States parties could devote themselves to searching for flexible solution for the disputes between State parties. It could obtain legal explanation about the dispute under the Article 297 and Article 298 by detouring the jurisdiction limits through advisory procedures.