• 대한건축학회논문집:계획계
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• 제34권11호
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• pp.95-104
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• 2018

Healthcare technology has been growing and fostering cooperation between industry, university and hospitals as growth engines in korea. So, the medibio research institutes in hospital have been constructed to promote research and industrialization centering on healthcare technology. The purpose of this study is to investigate the cases of research institutes in hospitals, and search the characteristics of building organization of medibio research laboratory facilities. Case study is investigated by floor plan, homepage and site visits about five research institutes selected in research-driven hospitals. The facility title and size of research laboratory is originated from site area and research building location. The building function include not only the research lab and business office reflecting on the development platform, and but assembly and meeting room in the ground level. Laboratory floor plans have three types, rectangular, rectangular+linear and linear type, one is traditional and efficient, the others are people and friendly. And building core types are correlated with lab space unit modules, single and double side core are shown in rectangular type. All the laboratories are open lab, composed with laboratory bench and research note writing desk facing the lab service and enclosed lab-support area. And they have communication space looking as warm and cozy common area for the innovation, convergence and collaboration. As the high risk of contamination and high standard for safety and security, equipment and facilities are well managed with biological environment including BSC, fume hood, PCR classification, eye washing and emergency shower.

• 비만대사연구학술지
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• 제1권2호
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• pp.78-82
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• 2022

Liraglutide (Saxenda^R) is prescribed to induce and sustain weight loss in obese patients. The starting dose of liraglutide is 0.6 mg/day for 1 week, which is increased by 0.6 mg/day every week until the full maintenance dose of 3 mg/day is achieved. Such dose titration is needed to prevent side effects, which primarily include gastrointestinal problems such as nausea, diarrhea, constipation, vomiting, dyspepsia, and abdominal pain. A 35-year-old, reportedly healthy obese man receiving liraglutide treatment for obesity visited the emergency room complaining of generalized weakness and dizziness accompanied by repeated diarrhea and vomiting. He reported over 20 episodes of diarrhea starting the day after liraglutide dose escalation from 1.2 mg/day to 1.8 mg/day. Laboratory findings suggested pre-renal acute kidney injury, including serum creatinine 4.77 mg/dl, blood urea nitrogen (BUN) 37 mg/dl, estimated glomerular filtration rate (eGFR) 15 ml/min/1.73 m², and Fractional excretion of sodium 0.08. After volume repletion therapy, his renal function recovered to a normal range with laboratory values of creatinine 1.08 mg/dl, BUN 14 mg/dl, and eGFR 88 ml/min/1.73 m². This case emphasizes the need for caution when prescribing glucagon-like peptide-1 receptor agonists, including liraglutide, given the risk of serious renal impairments induced by volume depletion and dehydration through severe-grade diarrhea and vomiting.

• 한국정보통신학회논문지
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• 제25권5호
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• pp.667-676
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• 2021

최근 우리나라의 청소년들은 스마트폰 과사용, 많은 학습량에 따른 신체활동 부족 등으로 인하여 자세 불균형의 위험에 노출되어있다. 또한 코로나 19로 인해 효과적인 비대면 운동 서비스에 대한 니즈가 증가하고 있는 추세이다. 이에 착안해 본 연구에서는 청소년들을 대상으로 둥근 어깨 개선의 효과를 제공하면서 비대면 서비스의 한계를 극복하기 위해 근전도 센서를 활용한 운동 서비스를 제안하고자 한다. 둥근 어깨를 개선할 수 있는 운동 프로그램을 구성하고, 효과적으로 운동할 수 있도록 근전도 센서를 연동한 어플리케이션을 구현하였다. 운동 프로그램은 4주 동안 타깃 근육 부위를 번갈아 가며 운동할 수 있도록 구성했고, 이에 따라 변화하는 근전도 수치를 측정하여 피드백을 제공할 수 있는 기능을 부가했다. 본 연구를 통하여 운동 기반의 자세 교정 디지털 서비스의 바탕을 제공하고, 이를 통하여 불균형한 신체를 개선함으로써 건강 증진의 가능성을 도모하고자 한다.

• 대한조선학회논문집
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• 제57권6호
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• pp.322-330
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• 2020

This study deals with underwater explosion (UNDEX) characteristics of various non-explosive underwater shock sources for the development of non-explosive underwater shock testing devices. UNDEX can neutralize ships' structure and the equipment onboard causing serious damage to combat and survivability. The shock proof performance of naval ships has been for a long time studied through simulations, but full-scale Live Fire Test and Evaluation (LFT&E) using real explosives have been limited due to the high risk and cost. For this reason, many researches have been tried to develop full scale ship shock tests without using actual explosives. In this study, experiments were conducted to find the characteristics of the underwater shock waves from actual explosive and non-explosive shock sources such as the airbag inflators and Vaporizing Foil Actuator (VFA). In order to derive the empirical equation for the maximum pressure value of the underwater shock wave generated by the non-explosive impact source, repeated experiments were conducted according to the number and distance. In addition, a Shock Response Spectrum (SRS) technique, which is a frequency-based function, was used to compare the response of floating bodies generated by underwater shock waves from each explosion source. In order to compare the magnitude of the underwater shock waves generated by each explosion source, Keel Shock Factor (KSF), which is a measure for estimating the amount of shock experienced by a naval ship from an underwater explosionan, was used.

• 한국정보통신학회논문지
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• 제24권4호
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• pp.546-552
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• 2020

원격제어서버와 작동기가 무선네트워크를 통해 연결되어 동작하는 원격제어시스템은 그 편의성이 큰 만큼 잠재된 위험성도 크다. 신뢰할 수 없는 무선 채널로 인해 제어명령이 유실될 수 있기 때문이다. 지능형원격제어시스템은 작동기에 제어명령을 유추할 수 있는 기능을 추가하여 제어명령을 수신하지 못하는 경우에도 동작하도록 해주는 시스템이다. 본 논문에서는 지능형원격제어시스템 테스트베드를 구현하여 원격제어시스템에서 발생할 수 있는 문제 상황들을 실험을 통해 확인하고 지능형원격제어시스템이 문제를 해결하는 것을 검증하였다. 지능형원격제어시스템은 일반적인 원격제어시스템이 높은 통신오버헤드를 감수해야 달성할 수 있는 성능을 더 적은 통신오버헤드만으로도 달성할 수 있음을 확인하였다.

• Journal of Information Science Theory and Practice
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• 제10권2호
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• pp.30-44
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• 2022

The primary function of an electronic records management system (ERMS) is to support organisations in providing effective records management services by enabling efficient remote access to the organisations' records. This helps the organisation to continue running during emergency events, such as the COVID-19 pandemic. The need to study ERMS for accessing records remotely has increased dramatically, due to the increase in daily use. The situation arising from the COVID-19 pandemic has increased the need for implementing proper digital systems, such as ERMS, to enable efficient work processes and enhance business continuity. An ERMS has the potential to allow organisations to create records and workflows off-site. During a pandemic, the ability to structure processes digitally helps in maintaining operations remotely. This study aims to provide a narrative review of the ERMS literature with an emphasis on explaining the primary components of ERMS that act as enablers for the implementation of the system in the oil and gas sector of developing countries. The current study proposes ERMS roles and responsibilities that could enhance business continuity. The authors use a qualitative narrative review and analyse the literature related to this study and its findings. The results show that, in cases of risk or crises, staff members need to have easy access to their records and documents to remain productive. An ERMS allows professionals to remain active and work off-site. Thus, ERMS play a significant role in protecting an organisation's content through the monitoring and control over who has authorisation to access its records.

• Molecules and Cells
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• 제45권4호
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• pp.202-215
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• 2022

The androgen receptor (AR) is an important therapeutic target for treating prostate cancer (PCa). Moreover, there is an increasing need for understanding the AR-independent progression of tumor cells such as neuroendocrine prostate cancer (NEPC). Menin, which is encoded by multiple endocrine neoplasia type 1 (MEN1), serves as a direct link between AR and the mixed-lineage leukemia (MLL) complex in PCa development by activating AR target genes through histone H3 lysine 4 methylation. Although menin is a critical component of AR signaling, its tumorigenic role in AR-independent PCa cells remains unknown. Here, we compared the role of menin in AR-positive and AR-negative PCa cells via RNAi-mediated or pharmacological inhibition of menin. We demonstrated that menin was involved in tumor cell growth and metastasis in PCa cells with low or deficient levels of AR. The inhibition of menin significantly diminished the growth of PCa cells and induced apoptosis, regardless of the presence of AR. Additionally, transcriptome analysis showed that the expression of many metastasis-associated genes was perturbed by menin inhibition in AR-negative DU145 cells. Furthermore, wound-healing assay results showed that menin promoted cell migration in AR-independent cellular contexts. Overall, these findings suggest a critical function of menin in tumorigenesis and provide a rationale for drug development against menin toward targeting high-risk metastatic PCa, especially those independent of AR.

• Safety and Health at Work
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• 제13권2호
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• pp.240-247
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• 2022

Background: Although insomnia and constipation are highly prevalent worldwide, studies examining a possible association between them are lacking. We examined the relationship between insomnia and constipation in shift workers who have a high prevalence of insomnia and other diseases. Methods: This study had a multicenter cross-sectional design and conducted using health examination data including self-reported questionnaires. In total, 12,879 and 4,650 shift workers were enrolled in Severance Hospital and Wonju Severance Hospital, respectively, during 2015-2017. Multivariate logistic regression models and subgroup analysis were performed in each center with the same protocol, using a common data model. Results: The mean age of the total population was 44.35 (standard deviation = 8.75); the proportion of males was 56.9%. Female sex, being underweight and non-smoker were strongly associated with an increased risk of constipation symptom (p < 0.001). Pooled odds ratios (ORs) were calculated using ORs of both centers with weights; there was a significant dose-response relationship (sub-threshold 1.76 [95% confidence interval [CI] 1.62-1.91]; moderate 2.28 [95% CI 2.01-2.60]; severe 4.15 [95% CI 3.18-5.41] in the final model, p for trend < 0.001). Subgroup analysis performed by stratifying sex and pooled ORs showed a similar trend to that of the entire group. Conclusion: We observed a strong correlation between insomnia and constipation in this population. Our findings may help in formulating guidelines and policies to improve quality of life in shift workers through the management of sleep quality and proper bowel function. This study is the first to report this relationship among people working in shifts.

• 대한정형외과학회지
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• 제56권6호
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• pp.540-545
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• 2021

슬개골 횡골절은 수술이 필요한 전위된 슬개골 골절의 가장 흔한 형태이다. 이러한 슬개골 횡골절은 골절선을 지나 평행하게 삽입된 Kirschner-강선이나 나사못에 장력대 강선을 추가적으로 고정한 기법이 흔히 사용된다. 그러나 고식적인 고정 방법의 경우 삽입된 강선이나 핀의 돌출에 의한 합병증이 흔히 발생한다. 이러한 합병증은 내고정물의 제거를 위한 추가적인 수술을 필요로 하고, 의료비 상승 및 슬관절의 기능 제한을 일으킬 수 있다. 이에 슬개골 횡골절에 대해 안정적인 고정력을 제공하고 수술 시 연부조직 손상을 최소화하여 골절부 혈류를 보존하고 수술 후 통증을 감소시키며, 내고정물에 의한 자극과 그에 따른 통증을 감소시켜 관절 운동 제한 발생 위험을 감소 시키는 최소 침습 부하 분산 경피적 슬개건 봉합술을 이용하여 치료한 사례들을 수술 술기와 함께 보고하고자 한다.

• 한방재활의학과학회지
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• 제32권2호
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• pp.95-103
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• 2022

Objectives This study was conducted to assess the effect of chuna manual therapy after hip arthroplasty. Methods We searched across 9 electronic databases (PubMed, Cochrane Library, Wangfang data, China National Knowledge Infrastructure [CNKI], Oriental Medicine Advanced Searching Integrated System [OASIS], National Digital Science Library [NDSL], Korean Medical Database [KMBASE], Koreanstudies Information Service System [KISS], Research Information Sharing Service [RISS]) to find randomized controlled clinical trials for chuna manual therapy after hip arthroplasty. Results On inclusion criteria, 11 appropriate studies were included and analyzed. The deep vein thrombosis incidence of the chuna manual therapy group was statistically lower than the conventional treatment group (p=0.0002). Chuna manual therapy significantly improved the Harris hip score compared with conventional treatment (p<0.00001). Also, chuna manual therapy combined with herbal fumigation therapy significantly elevated the hip joint function score of Harris hip score compared with the conventional therapy group (p<0.00001). Conclusions The systematic review showed that chuna manual therapy had significant effects on hip arthroplasty. Nonetheless, considering the high risk of bias and geographic bias, further research with well-designed studies is required to support the effectiveness of chuna manual therapy.