• Reproductive and Developmental Biology
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• 제34권2호
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• pp.81-88
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• 2010

Our objective of current study was to investigate the development of bone and heart in association with diabetes mellitus (DM). DM was induced by administering an intraperitoneal injection of streptozotocin (STZ; 60 mg/kg) to 4-week-old Sprague-Dawley rats. Body weight and blood glucose were monitored, and rats were sacrificed after 2 or 5 weeks. The left ventricle (LV), including the interventricular septum, was weighed, and body weight and tibial bone length were assessed. Young diabetic rats showed reduced growth in terms of tibial length and body weight compared to controls. Moreover, diabetic males showed more significant growth suppression and reduced LV size than diabetic females. Morphometric analysis of tibiae from diabetic rats revealed suppressed bone growth at 2 and 5 weeks, with no difference between genders. STZ-induced diabetes decreased bone growth and retarded pre-pubertal heart development. As a result, diabetes may increase cardiovascular risk factors and lead to eventual heart failure. Therefore, new therapeutic approaches are required for diabetic children exhibiting growth retardation. Heart growth factor, exercise, and cardiopulmonary physical therapy may be required to promote heart development and physiological function.

• Archives of Reconstructive Microsurgery
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• 제13권1호
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• pp.1-6
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• 2004

Advances in microvascular techniques and refinements in microsurgical tissue transfers have enabled surgeons to combine different tissue components and reconstruction into a single-stage operation in extensive or composite defect following injury. Some problems and consideration for extensive or composite defects are form, shape, function, and dimension of the defect sites. Therefore combination of two or more flaps is required to reconstruct extensive or composite defect. This paper presents our clinical experience of four cases of combined free flaps with or without sequential microanastomosis in reconstruction of upper extremity based on peroneal flowthrough, thoracodorsal, and dorsalis pedis vascular system. Satisfactory results were obtained without flap loss and complications. The free flaps were combined in th following fashion; two cases by bridge fashion, one by chimeric microanastomosis and one by simple chimeric fashion. The median follow-up time on all patients was 21.7 months. Donor site morbidity was minimal. Extensive soft tissue or composite defects can be effectively covered by various combined flaps. Even though the risk for complication exists, the options of combination with or without sequential microanastomosis can add a functional or sensory dimension to reconstruction of complex wounds.

• 대한안전경영과학회지
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• 제6권3호
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• pp.249-273
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• 2004

Finding an optimal solution in MADN[(Multi-Attribute Decision-Making) problems is difficult, when the number of alternatives, or that of attributes is relatively large Most of the existing mathematical approaches arrive at a final solution on the basis of many unrealistic assumptions, without reflecting the decision-maker's preference structure exactly. In this paper we suggest a model that helps us find a group consensus without assessing these parameters in specific cardinal values. Therefore, This research provides a comprehensive Decision Making of the theory and methods applicable to the analysis of decisions that involve risk and multiple criteria attributes. after, The emphasis of the procedure will be on developments from the fields of decisions analysis and utility theory of Taguchi Method. This theoretical development will be illustrated through the discussion of several real-world application and a case study. When the multiple number of decision makers are involved in the decision making procedure, the problem of uncertainties invariably occurs, because of the different views between them. In this paper, New decision making model using Taguchi Method is applied to effectively model the multi-attribute-decision making(MADM) procedure in the uncertainties dominated two area(quantitative and qualitative factors), Quantitative factors evaluation is used Loss Function of Taguchi, qualitative factors evaluation is used 50 ratio by each specialist. thus it can be used for aiding of preferable alternative. as a result, We will be proved efficiency about New decision making model of applied Taguchi Method with Analytical presentation of all the expecting outcomes when a specific strategy or an alternative plan is selected under expecting future environment.

• 대한기관식도과학회지
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• 제13권1호
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• pp.23-28
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• 2007

Background and Objectives: Since intractable aspiration in patients with impaired protective function of the larynx often results in multiple episode of aspiration pneumonia, repeated hospitalizations and expensive nursing care. The authors reported the preliminary results of laryngotracheal separation(LTS) in patient with chronic intractable aspiration. The purpose of this study was to report the follow up results of patient outcome with the LTS. Materials and Methods: A retrospective review of 15 patients who underwent LTS between 1996 and 2006 was conducted. Ages ranged from 3 to 72 years. Results: Eight patients had morbid aspiration as a consequence of acquired neurologic injuries and seven patients with congenital neurologic injuries. Two patients had a postoperative fistula, which was well controlled with local wound care. Following LTS, aspiration was effectively controlled in all patients and eight were able to tolerate a regular diet. Conclusion: LTS is a low-risk, successful, definitive procedure which decreases the potential for aspiration, pulmonary complications, duration of hospitalizations and increases quality of life, especially in patent with irreversible upper airway dysfunction and poor speech potential.

• 대한기관식도과학회지
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• 제19권1호
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• pp.19-24
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• 2013

Objective The objective was to evaluate changes in swallow safety and dietary status after the transcutaneous injection of botulinum toxin into the upper esophageal sphincter in a series of outpatients with dysphagia. Methods Patients who were at risk for aspiration and who had an unsuccessful trial of swallowing therapy were admitted to the study. All patients showed significant pooling of fluids in the pyriform sinus. All patients were treated in the office; none had previous esophageal dilatation. The upper border of the cricoid cartilage was identified using standard electromyogram procedures and botulinum toxin was injected. Outcomes were assessed using the penetration-aspiration scale, NIH swallowiwng safety score, patients' short-term and long-term subjective impressions of their ability to swallow, and change in dietary status. Results Ten patients underwent an instrumental evaluation of swallowing function. Of the 10 patients, 9 showed an overall improvement in their ability to take an oral diet safely. The penetration-aspiration scale, NIH swallowiwng safety score, patients' short-term and long-term subjective impressions of their ability to swallow, and change in dietary status were significantly improved after office-based botox injection. Conclusion Office-based EMG guided botox injection to the cricopharyngeus muscle is a simple, safe, and effective tool for dysphagia patients. Injection of Botox in the office should be considered when the dysphagia pattern is aspiration after swallow.

• Corrosion Science and Technology
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• 제11권3호
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• pp.77-81
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• 2012

Cathodic protection(CP) is widely used as a means of protecting corrosion for not only marine structures like ship hulls and offshore drilling facilities, but also underground structures like buried pipelines and oil storage tanks. The principle of CP is that the anodic dissolution of metal can be protected by supplying electrons to the cathode metal. When unprotected structures are nearby to CP systems, interference problems between unprotected and protected structures may be happened. The stray current interference can accelerate the corrosion of nearby structures. So far many efforts have been made to reduce the interference in the electric railway systems adjacent to the underground metal structures like buried pipelines and gas/oil tanks. During recent few decades the protection technologies against stray current induced corrosion have been significantly improved and a number of techniques have been developed. However, there is very limited information an marine environments. Some complex harbor structures are protected by two cathodic protection systems, i.e. sacrificial anode cathodic protection(SACP) and impressed current cathodic protection(ICCP). In this case, when the protection current from sacrificial anodes returns to the cathode through electrolyte, it passes through nearby other low resistance metal structures. In many cases the stray current of ICCP systems influences the function of SACP. In this study, the risk of stray current from the SACP system to adjacent reinforced concrete structures has been verified through laboratory experiments. Concrete and steel pile structures modeled a part of bridge have been investigated in terms of CP potential and current between the two. The variation of stray current according to the magnitude of ICCP/SACP has been studied to mitigate it and to suggest the proper protection criteria.

• 한국철도학회논문집
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• 제12권4호
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• pp.443-449
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• 2009

국가에서는 철도운영 및 시설기관에 산재되어 있는 철도안전정보를 수집하여 분석할 수 있는 철도안전정보 종합관리시스템을 구축하야 철도안전관리를 효율적으로 수행하기 위하여 노력하고 있다. 매년 철도안전도를 평가하기 위하여 철도사고 자료를 분석하여 사망자 및 부상자 수를 산출하고 있으며 사고 원인 및 위험발생 경위를 규명하여 사고를 최소화 할 수 있도록 여러 안잔정책 및 안전관리방안을 시행하고 있다. 따라서 보다 선진적인 안전정책 수립 및 안전관리를 위해 철도안전도를 입체적으로 그리고 정량적으로 표현할 수 있는 방안이 필요하며 이를 위해서는 안전에 대한 주요 영향요소가 무엇인지를 파악해야 하며 선정된 개발적 요소들에 대한 정량적 철도안전지수(Railway Safety Index)를 개발해야 한다. 본 연구에서는 철도안전도를 정량적으로 평가할 수 있는 안전도 평가지표를 개발하여 안전목표 수립 및 관리 등 철도안전향상를 위한 전략적 방향 및 정책수립 과정에서 활용할 수 있는 모델을 제공하고자 한다.

• 한국화재소방학회논문지
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• 제24권4호
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• pp.116-122
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• 2010

원자력발전소는 심층화재방어 개념에 따라 화재 발생시 발전소 외부로 방사능의 누출을 억제하고, 발전소의 안전정지 기능이 유지될 수 있도록 설계, 건설, 운영되어야 한다. 해외의 원전건설 국가는 이러한 원자력발전소의 안전정지 기능의 목적을 달성하기 위하여 원자력발전소에 대한 통합된 화재방호 규제요건을 가지고 있으나, 우리나라의 경우, 원자력발전소의 화재방호계통을 적용하기 위한 강제 요건으로서 소방관계법과 원자력법을 동시에 적용하는 비합리적인 규제지침을 가지고 있다. 화재방호설비에 관하여 원자력발전소 운영에 오랜 경험을 가진 미국, 캐나다 및 일본의 기술적으로 단일화된 원자력발전소의 화재방호 규제체계를 제시하였고, 우리나라도 화재방호설비는 원자력법에 의한 화재하중에 따른 화재위험도분석 결과를 설계에 반영하여 소방관계법에서는 예외조항으로 인정받을 수 있어야 함을 제안하였다.

• 한국화재소방학회논문지
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• 제30권5호
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• pp.108-115
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• 2016

화재감지기는 화재를 조기에 감지하여 관계인에 통보함으로써 자산보호 및 인명안전에 중요한 역할을 한다. 따라서 화재를 조기에 탐지할 수 있는 성능과 비화재보를 발생하지 않는 신뢰성이 중요하다. 최근 공동주택 오피스텔 숙박시설 노유자시설 의료시설 등과 같이 취침, 숙박, 입원 등 이와 유사한 용도로 사용되는 거실에는 조기화재 감지를 위한 연기감지기를 설치하도록 국가 화재안전기준이 개정되어 연기감지기의 적용이 증가되고 있다. 반면 현재 비화재보를 예방하기 위한 연구가 부족하다. 본 연구는 아날로그 광전식 연기감지기의 순간적으로 발생되는 먼지 등으로 인해 발생되는 비화재보를 예방하기 위한 알고리즘 개선과 감지기의 자기보상기능을 통해 감지기의 오염과 화재신호를 구분할 수 있도록 개선하였다. 본 연구를 통해 최근 수요가 증가하는 아날로그 광전식 연기감지기의 비화재보 개선으로 제품의 신뢰성을 확보하여 비화재보로 인한 경제적 손실을 예방할 것으로 기대된다.

• Clinical and Experimental Pediatrics
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• 제62권11호
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• pp.422-427
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• 2019

Background: Polyomavirus BK (BKV) infection is an important cause of graft loss in kidney transplant patients. Purpose: The purpose of this study was to evaluate clinical findings and risk factors for BKV in pediatric patients after kidney transplantation. Methods: This retrospective single-center study included 31 pediatric kidney transplant recipients from January 2002 to December 2017. Two patients received 2 transplantations during the study period, and each transplant was analyzed independently. Total number of cases is 33 cases with 31 patients. BKV infection was confirmed from blood samples via periodic quantitative polymerase chain reaction. Results: The mean age at kidney transplantation was 11.0±4.7 years, and the male-to-female ratio was 2.7:1. Three patients had a past medical history of high-dose chemotherapy and autologous stem-cell transplantation for solid tumors. Nine patients (27.3%) developed BKV infection. The median period from kidney transplantation to BKV detection in blood was 5.6 months. There was no statistically significant difference in estimated glomerular filtration rate between patients with and those without BKV infection. Among 9 patients with BKV viremia, 7 were treated by reducing their immunosuppressant dose, and BKV was cleared in 6 of these 7 patients. In the other 2 BKV-positive patients, viremia improved without immunosuppressant reduction. Conclusion: BKV infection is common in children with kidney transplantation and might not have affected short-term renal function in our patient sample due to early immunosuppressant reduction at the time of BKV detection.