• 한국임상약학회지
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• 제25권1호
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• pp.56-58
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• 2015

Summary: We report the first hepatic adverse effect of tosufloxacin tosylate in a muscle invasive bladder cancer patient with normal liver functions and with scheduling to undergo a surgical operation for a neobladder. Tosufloxacin tosylate 150 mg was administered to a 57-year-old man who maintained transurethral resection of bladder tumor (TUR-BT) postoperative multiple medications. His labs presented significant increases in alanine amino transferase (ALT) and aspartate amino transferase (AST) levels with 2-week compliance of 150 mg tablet three times a day. After discontinuing tosufloxacin tosylate, the levels slowly decreased and completely returned to normal ranges without any intervention in a few weeks. The Naranjo Causality Algorithm indicates a probable relationship between increased ALT and tosufloxacin. The patient was to have the second surgical operation as scheduled after getting normal range of ATL level. Therefore, tosufloxacin should be avoided in patients at risk for having liver dysfunctions or diseases if the patients have a schedule for any operation. Background: Tosufloxacin tosylate has been shown to have favorable benefits as an antibiotic. Tosufloxacin tosylate may be considered to have the adverse effects such as nauseas, vomiting, diarrhea, abdominal pain, stomatitis, tendonitis, tendon rupture, headache, dizziness, drowsiness, insomnia, weakness, agitation including hemolysis in the event of glucose-6-phosphate dehydrogenase deficiency as other fluoroquinolones. More severe adverse reactions of tosufloxacin tosylate over the above common adverse effects of fluoroquinolones were thrombocytopenia and nephritis. It also is not well known that tosufloxacin can cause hepatic problem. Here the study reports the first hepatic reaction from tosufloxacin and might arouse heath care providers' attention to appropriate drug choice for patients.

• 한국융합학회논문지
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• 제8권5호
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• pp.45-52
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• 2017

본 연구는 가스 안전 작업 관리 모바일 앱의 개발을 위하여 다음과 같은 사항을 연구하였다. 기 연구된 초기 연구에 의해 모바일 앱의 시나리오 설계 및 1, 2차 이미지 도출이 완료된 후 후속 연구로 이루어 진 본 연구에서는 1) 가스 작업의 유형별 분류를 형태별 분류와 위험도 별 분류로 나누어 제안 2) 투핸드 작업의 많은 산업현장에서 모바일 앱과 작업자의 효과적인 연동을 위한 인터랙션 방안의 연구 및 제안이 이루어졌다. 특히 가스 작업뿐 아니라 각 산업현장 영역에서 이를 관리하는 메인 시스템과 상호작용하는 모바일 앱의 개발은 국내 최초의 시도라 할 수 있으며, 다양한 인터랙션 방안을 통해 작업자가 자유롭고 안전하게 작업할 수 있도록 도왔다.

• 구강회복응용과학지
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• 제27권4호
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• pp.423-436
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• 2011

교합성 외상은 과도하거나 비정상적인 교합력으로 인한 치아의 주위에 발생하는 병적 변화를 말한다. 교합성 외상과 치주질환과의 관계에 대한 다양한 논쟁이 있었지만 위험요소임은 확실하기 때문에 교합조정을 하는 것이 치주치료의 결과를 개선시킬 수 있다. 정상적인 치주조직을 가진사람이라도 저작양태와 교합양상 및 전치피개의 양상에 따라 교합외상이 발생할 가능성이 있다. 치주질환으로 인해 이차적인 교합외상이 있으면 다양한 문제점을 유발할 가능성이 있는데 특히 구치가 상실되면 교합의 안정을 위협받게 된다. 상실된 구치를 수복하지 않아도 된다는 개념부터 반드시 회복시켜야 한다는 극단적인 주장이 있지만 양쪽의 주장 모두 교합의 안정성을 최우선의 목표로 한다는 점에서는 일치한다. 또한 구치가 상실되면 대합치의 변위나 정출 뿐 아니라 전치의 변위까지도 유발할 수 있기 때문에 교합성 외상을 제거하고 교합의 안정성을 확보하기 위한 치료가 필수적이다.

• 구강회복응용과학지
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• 제34권3호
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• pp.225-231
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• 2018

다운증후군 환자는 일반적으로 구강 관리에 대한 인식과 수행능력의 부족으로 구강위생상태가 불량하며, 치아 상실의 위험이 높다. 또한 작고 불규칙한 치아, 부분 무치증의 구강 내 특징으로 보철 치료에 어려움이 있다. 본 증례는 다운증후군 환자에서 상악 무치악 부위의 임플란트 하이브리드 보철 치료에 대한 케이스를 보고하고자 한다. 최종보철물의 외형은 하악 잔존치와 인공치를 조화롭게 설정하여 결정하였고, 위생관리가 용이하도록 가공치부위를 수정하였다. 결과적으로 심미적, 기능적으로 만족스러운 결과를 얻었기에 이를 보고하고자 한다.

• 대한치과보철학회지
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• 제54권4호
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• pp.401-406
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• 2016

임플란트 피개의치는 전통적인 총의치에 비해 높은 유지력 및 저작능력, 환자의 만족도를 보인다. 특히 골흡수가 심한 하악 무치악 환자의 치료에서는 우선되는 치료방법으로 고려된다. 임플란트 피개의치를 위한 attachment에는 임플란트간 연결된 bar type과 연결되어있지 않은 solitary type으로 구분할 수 있다. 최근 임상에서 많이 사용하는 solitary type의 경우 임플란트간의 평행관계가 중요하며, 임플란트간의 평행관계가 불량한 경우 attachment의 마모 및 유지력 감소로 유지관리를 내원횟수가 증가할 수 있다. 본 증례는 평행하지 못한 두 개의 하악 임플란트 식립 환자에서 milled bar를 이용하여 제작한 임플란트 피개의치로 만족할 만한 결과를 얻었기에 이를 보고하고자 한다.

• Journal of Korean Biological Nursing Science
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• 제18권4호
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• pp.305-317
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• 2016

Purpose: Recent studies demonstrated disruption of the circadian clock gene is associated with the development of obesity and metabolic syndrome. Obesity is often caused by the high calorie intake, In addition, the chronic stress tends to contribute to the increased risk for obesity. To evaluate the molecular mechanisms, we examined the expression of circadian clock genes in high fat diet-induced mice models with the chronic stress. Methods: C57BL/6J mice were fed with a 45% or 60% high fat diet for 8 weeks. Daily immobilization stress was applied to mice fed with a 45% high fat for 16 weeks. We compared body weight, food consumption, hormone levels and metabolic variables in blood. mRNA expression levels of metabolic and circadian clock genes in both fat and liver were determined by quantitative RT-PCR. Results: The higher fat content induced more severe hyperglycemia, hyperlipidemia and hyperinsulinemia, and these results correlated with their relevant gene expressions in fat and liver tissues. Chronic stress had only minimal effects on metabolic variables, but it altered the expression patterns of metabolic and circadian clock genes. Conclusion: These results suggest that the fat metabolism regulates the function of the circadian clock genes in peripheral tissues, and stress hormones may contribute to its regulation.

• 대한한방소아과학회지
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• 제22권2호
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• pp.217-225
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• 2008

Objectives : Prevalence of night eating habit associated with substance use and obesity is increasing rapidly in children and adolescents. Further, staying up late and eating snacks late at night were known as leading health risk behaviors for children, suggesting the potential adverse effect of night-eating habit on children. However, only few reports had been issued on the effect of night-eating habit on gastrointestinal symptom and SUI-TAI(水滯) symptom of children. Therefore, we aimed to investigate clinical characteristics of children by night-eating symptom status. Methods : Parents were asked to give a detailed answer to a systemized medical history questionnaire concerning night-eating habit, gastrointestinal symptom and SUI-TAI symptom of their children. Medical records of 28 children treated in the Department of Pediatrics, Hospital of Oriental Medicine, were the subject of this study. Clinical characteristics of two groups of children who with no night-eating habit and frequent night-eating group(eating at night more than 3 times per week) were analysed. In addition, the correlation analysis between clinical characteristics were performed. Results : Children with frequent night-eating habit(n=7, more than 3 days of night-eating a week) were observed to have more aggravated gastrointestinal symptom and SUI-TAI symptom compared with those without night-eating habit(n=13). In parallel, the association of gastrointestinal symptom and SUI-TAI symptom was demonstrated(n=28). Conclusions : It is notable that deranged gastrointestinal function and aggravated SUI-TAI symptom were observed among children generally regarded as healthy. Therefore, endeavors to correct night-eating habit as well as to treat aggravated gastrointestinal and SUI-TAI symptoms are needed for the promotion of health of children.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권1호
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• pp.1-14
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• 2020

The latest definition of a prebiotic is "a substrate that is selectively utilized by host microorganisms conferring a health benefit"; it now includes non-food elements and is applicable to extra-intestinal tissues. Prebiotics are recognized as a promising tool in the promotion of general health and in the prevention and treatment of numerous juvenile diseases. Prebiotics are considered an immunoactive agent, with the potential for long-lasting effects extending past active administration of the prebiotic. Because of its extremely low risk of serious adverse effects, ease of administration, and strong potential for influencing the composition and function of the microbiota in the gut and beyond, the beneficial clinical applications of prebiotics are expanding. Prebiotics are the third largest component of human breast milk. Preparations including galactooligosaccharides (GOS), fructooligosaccharides (FOS), 2'-fucosyllactose, lacto-N-neo-tetraose are examples of commonly used and studied products for supplementation in baby formula. In particular, the GOS/FOS combination is the most studied. Maintaining a healthy microbiome is essential to promote homeostasis of the gut and other organs. With more than 1,000 different microbial species in the gut, it is likely more feasible to modify the gut microbiota through the use of certain prebiotic mixtures rather than supplementing with a particular probiotic strain. In this review, we discuss the latest clinical evidence regarding prebiotics and its role in gut immunity, allergy, infections, inflammation, and functional gastrointestinal disorders.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1783-1789
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• 2014

Background: The EMSY gene encodes a BRCA2-binding partner protein that represses the DNA repair function of BRCA2 in non-hereditary breast cancer. Although amplification of EMSY gene has been proposed to have prognostic value in breast cancer, no data have been available concerning EMSY tissue expression patterns and its associations with clinicopathological features. Materials and Methods: In the current study, we examined the expression and localization pattern of EMSY protein by immunohistochemistry and assessed its prognostic value in a well-characterized series of 116 unselected breast carcinomas with a mean follow up of 47 months using tissue microarray technique. Results: Immunohistochemical expression of EMSY protein was detected in 76% of primary breast tumors, localized in nuclear (18%), cytoplasmic (35%) or both cytoplasmic and nuclear sites (23%). Univariate analysis revealed a significant positive association between EMSY expression and lymph node metastasis (p value=0.045) and larger tumor size (p value=0.027), as well as a non-significant relation with increased risk of recurrence (p value=0.088), whereas no association with patients' survival (log rank test, p value=0.482), tumor grade or type was observed. Conclusions: Herein, we demonstrated for the first time the immunostaining pattern of EMSY protein in breast tumors. Our data imply that EMSY protein may have impact on clinicipathological parameters and could be considered as a potential target for breast cancer treatment.

• 전자공학회논문지
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• 제50권8호
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• pp.171-179
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• 2013

내비게이션은 차량 운전자에게 경로탐색과 길안내 서비스의 제공을 기본으로 한다. 그러나 현재의 경로탐색에서는 운전자의 안전을 지키기 위해 다양한 도로 상황을 고려하지 않고, 안전운전 DB만을 이용하여 최단경로를 찾는 서비스만을 제공하고 있다. 따라서 안전운전을 위해서는 단순한 최단경로 검색 서비스를 벗어나, 위험지역이나 위험시간대를 고려한 경로탐색이 필요하다. 본 논문에서는 A* 알고리즘을 이용하여 안전운전을 위해 위험지역을 회피할 수 있는 경로탐색 방법을 제안한다. 이 경로탐색에서 탐색노드의 경로 적합 도를 측정할 때 위험지역 종류별로 서로 다른 휴리스틱 가중치를 적용하였다. 특히 경로 탐색에서 회피할 위험지역으로는 사고가 자주 발생하는 사고 다발구간, 어린이 보호구역, 교차로지역, 그리고 위험시간대를 고려하여 동적으로 위험지역별 가중치를 부여하였다. 컴퓨터 시뮬레이션 결과, 안전운전을 위해 위험지역을 회피할 수 있는 경로탐색 서비스를 제공할 수 있는 가능성을 확인하였다.