• Journal of Dental Rehabilitation and Applied Science
• /
• v.27 no.4
• /
• pp.423-436
• /
• 2011

Trauma from occlusion (TFO) is a pathologic alterations which develop in the periodontium as a result of undue masticatory force. The purpose of this article is to review the controversies about TFO. There are evidences that TFO is a risk factor in the progression of periodontitis. Tooth mobility should be reduced by selective occlusal adjustment. TFO can be developed dependent on the masticatory pattern, occlusion and anterior overbite in sound periodontal conditions. Secondary TFO may aggravate unstable occlusion. If "loss of posterior support" was occur, the problems were worsen. Extrusion, migration, rotation and pathologic deviation can be resulted. Opposite contention is the "shortened dental arch" concept. However, these two concepts persue the occlusal stability together. To treat TFO adequately, exact diagnosis and multi-disciplinary treatment should be needed.

• Journal of Dental Rehabilitation and Applied Science
• /
• v.34 no.3
• /
• pp.225-231
• /
• 2018

Down syndrome patients generally have poor oral hygiene due to lack of awareness and ability to perform oral care, and there is a high risk of tooth loss. Also, they are characterized by small and irregular teeth and oligodontia, which makes it difficult to do prosthetic treatment. This article reports a case of implant hybrid prosthesis treatment of maxillary edentulous area in Down syndrome patient. The external shape of the final prosthesis was determined by using the mandibular artificial teeth to reflect the oligodontia of the mandible and the pontic areas were adjusted to facilitate oral hygiene care. As a result, aesthetically and functionally satisfactory results were obtained.

• The Journal of Korean Academy of Prosthodontics
• /
• v.54 no.4
• /
• pp.401-406
• /
• 2016

Implant overdenture exhibits higher retention, masticatory function, and patient's satisfaction compared to conventional dentures. Particularly, in treatment of severe alveolar bone resorption, implant overdenture can be considered as the first treatment option. The types of attachments used for implant overdenture can be classified into solitary type, which implants are not connected to each other, and bar type in which implants are connected. In the case of solitary type commonly used in clinical practice, parallel relationship is important. When it is not established, there is a higher risk of attachment wear, retention loss, and frequent visits for maintenance. In this case, satisfactory results have been obtained with implant overdentures using milled bar on two unparallel implants placed on the mandible.

• Journal of Korean Biological Nursing Science
• /
• v.18 no.4
• /
• pp.305-317
• /
• 2016

Purpose: Recent studies demonstrated disruption of the circadian clock gene is associated with the development of obesity and metabolic syndrome. Obesity is often caused by the high calorie intake, In addition, the chronic stress tends to contribute to the increased risk for obesity. To evaluate the molecular mechanisms, we examined the expression of circadian clock genes in high fat diet-induced mice models with the chronic stress. Methods: C57BL/6J mice were fed with a 45% or 60% high fat diet for 8 weeks. Daily immobilization stress was applied to mice fed with a 45% high fat for 16 weeks. We compared body weight, food consumption, hormone levels and metabolic variables in blood. mRNA expression levels of metabolic and circadian clock genes in both fat and liver were determined by quantitative RT-PCR. Results: The higher fat content induced more severe hyperglycemia, hyperlipidemia and hyperinsulinemia, and these results correlated with their relevant gene expressions in fat and liver tissues. Chronic stress had only minimal effects on metabolic variables, but it altered the expression patterns of metabolic and circadian clock genes. Conclusion: These results suggest that the fat metabolism regulates the function of the circadian clock genes in peripheral tissues, and stress hormones may contribute to its regulation.

• The Journal of Pediatrics of Korean Medicine
• /
• v.22 no.2
• /
• pp.217-225
• /
• 2008

Objectives : Prevalence of night eating habit associated with substance use and obesity is increasing rapidly in children and adolescents. Further, staying up late and eating snacks late at night were known as leading health risk behaviors for children, suggesting the potential adverse effect of night-eating habit on children. However, only few reports had been issued on the effect of night-eating habit on gastrointestinal symptom and SUI-TAI(水滯) symptom of children. Therefore, we aimed to investigate clinical characteristics of children by night-eating symptom status. Methods : Parents were asked to give a detailed answer to a systemized medical history questionnaire concerning night-eating habit, gastrointestinal symptom and SUI-TAI symptom of their children. Medical records of 28 children treated in the Department of Pediatrics, Hospital of Oriental Medicine, were the subject of this study. Clinical characteristics of two groups of children who with no night-eating habit and frequent night-eating group(eating at night more than 3 times per week) were analysed. In addition, the correlation analysis between clinical characteristics were performed. Results : Children with frequent night-eating habit(n=7, more than 3 days of night-eating a week) were observed to have more aggravated gastrointestinal symptom and SUI-TAI symptom compared with those without night-eating habit(n=13). In parallel, the association of gastrointestinal symptom and SUI-TAI symptom was demonstrated(n=28). Conclusions : It is notable that deranged gastrointestinal function and aggravated SUI-TAI symptom were observed among children generally regarded as healthy. Therefore, endeavors to correct night-eating habit as well as to treat aggravated gastrointestinal and SUI-TAI symptoms are needed for the promotion of health of children.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.23 no.1
• /
• pp.1-14
• /
• 2020

The latest definition of a prebiotic is "a substrate that is selectively utilized by host microorganisms conferring a health benefit"; it now includes non-food elements and is applicable to extra-intestinal tissues. Prebiotics are recognized as a promising tool in the promotion of general health and in the prevention and treatment of numerous juvenile diseases. Prebiotics are considered an immunoactive agent, with the potential for long-lasting effects extending past active administration of the prebiotic. Because of its extremely low risk of serious adverse effects, ease of administration, and strong potential for influencing the composition and function of the microbiota in the gut and beyond, the beneficial clinical applications of prebiotics are expanding. Prebiotics are the third largest component of human breast milk. Preparations including galactooligosaccharides (GOS), fructooligosaccharides (FOS), 2'-fucosyllactose, lacto-N-neo-tetraose are examples of commonly used and studied products for supplementation in baby formula. In particular, the GOS/FOS combination is the most studied. Maintaining a healthy microbiome is essential to promote homeostasis of the gut and other organs. With more than 1,000 different microbial species in the gut, it is likely more feasible to modify the gut microbiota through the use of certain prebiotic mixtures rather than supplementing with a particular probiotic strain. In this review, we discuss the latest clinical evidence regarding prebiotics and its role in gut immunity, allergy, infections, inflammation, and functional gastrointestinal disorders.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.4
• /
• pp.1783-1789
• /
• 2014

Background: The EMSY gene encodes a BRCA2-binding partner protein that represses the DNA repair function of BRCA2 in non-hereditary breast cancer. Although amplification of EMSY gene has been proposed to have prognostic value in breast cancer, no data have been available concerning EMSY tissue expression patterns and its associations with clinicopathological features. Materials and Methods: In the current study, we examined the expression and localization pattern of EMSY protein by immunohistochemistry and assessed its prognostic value in a well-characterized series of 116 unselected breast carcinomas with a mean follow up of 47 months using tissue microarray technique. Results: Immunohistochemical expression of EMSY protein was detected in 76% of primary breast tumors, localized in nuclear (18%), cytoplasmic (35%) or both cytoplasmic and nuclear sites (23%). Univariate analysis revealed a significant positive association between EMSY expression and lymph node metastasis (p value=0.045) and larger tumor size (p value=0.027), as well as a non-significant relation with increased risk of recurrence (p value=0.088), whereas no association with patients' survival (log rank test, p value=0.482), tumor grade or type was observed. Conclusions: Herein, we demonstrated for the first time the immunostaining pattern of EMSY protein in breast tumors. Our data imply that EMSY protein may have impact on clinicipathological parameters and could be considered as a potential target for breast cancer treatment.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.50 no.8
• /
• pp.171-179
• /
• 2013

The primary function of navigation system is to provide route search and road guidance for safe driving for drivers. However, the existing route search system provides a simple service that looks up the shortest route using a safe driving DB without considering different road characteristics for the safety of the drivers. In order to maintain the safe driving, rather than searching the shortest path, a navigation system, in which the danger areas and/or the dangerous time zones have been considered, is required. Therefore, in this paper we propose a strategy of searching a navigation path to avoid danger areas for safe driving by using the A* algorithm. In the strategy, when evaluating the path-specific fitness of the navigation nodes, different heuristic weights were assigned to different types of risk areas. In particular, we considered three kinds of danger areas, such as accident-prone sections where accidents occur frequently, school zones, and intersection regions, as well as the time slots when the probability of danger is high. From computer simulation, the results demonstrate that the proposed scheme can provide the way to avoid danger areas on the route searching and confirm the possibility of providing the actual service.

• Journal of Fisheries and Marine Sciences Education
• /
• v.29 no.1
• /
• pp.137-147
• /
• 2017

An accident during pilotage may cause several problems such as crippling the harbour function, environmental disruption, loss of life. Since the pilot plays an important role in the safe operation of the port, securing their safety is directly connected to the vessel's safety coming into port in Korea. Pilotage service is offered on request without distinction of day and night. And traveling by helicopter and boarding/disembarking using a pilot ladder from and to a pilot boat have a high risk of falling into the sea. So, pilots can fall into the sea while boarding/disembarking from ship which can lead to serious injury by cardiac arrest. A number of pilots have died or severely injured due to fall from the pilot ladder during embarkation and disembarkation up to now. Current safety measures at embarkation and disembarkation required by pilotage act and IMO resolutions could not prevent all the pilot related accidents. Therefore, to prevent pilot accident during boarding/disembarking from ship, it is necessary to include safety training requirement for new pilots under the requirements for licensing of pilotage act. It is also necessary to compel pilots to take necessary personal protective equipment when they use a pilot ladder. In addition, the placement of emergency kit on pilot boats and first-aid training are required in order to deal with emergency situation promptly.

• Journal of Korean Medicine for Obesity Research
• /
• v.8 no.1
• /
• pp.63-70
• /
• 2008

Objectives Obesity is the major risk factor of the heart disease and the metabolic disease. The autonomic nervous system is a key contributor in the regulation of energy balance, so the blunted activity may contribute to the maintenance of the obese state. So we evaluated the function of the autonomic nervous system in young overweight and obese women with heart rate variability. Methods The subjects were 26 overweight and obese young women(BMI〉$23kg/m^2$) and 25 lean women who visited Kangnam Kyunghee hospital for obesity management from March 2006 to April 2008. Bioimpedance Analysis (BIA), short-term spectral analysis of heart rate variability (HRV) were performed. Results HRV of obese young group was lower than the lean young group, but there is no statistical significance. BMI had significantly a negative correlation with Low Frequency(LF) of HRV. LF power is mediated by sympathetic nervous system activity. These results indicate a decrease of sympathetic modulation in overweight and obese young women. Conclusions Overweight and obese young women have decreased sympathetic nervous system activity. In clinical practice, an assessement of HRV would be noninvasive and sensitive methods for sympathetic nervous system of young overweight and obese women.