• Title/Summary/Keyword: Risk function

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Kushta Jast, a conventional herbo-mineral immunity booster tonic: potential use in COVID-19

  • Ahmad, Tasleem;Zakir, Mohammad;Fatma, Syeda Hajra;Kazmi, Munawwar Husain;Javed, Ghazala;Ali, Shakir
    • CELLMED
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    • v.10 no.3
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    • pp.24.1-24.6
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    • 2020
  • Kushta Jast (KJ) is a unique herbo-mineral preparation of the Unani System of Medicine (USM) which is prepared by taklis (calcination) and prescribed by the practitioners of USM for the treatment of various ailments, including the respiratory ailments. It is used as muqawwi (tonic) to boost the immunity (Muqawwi-i-badan), and can increase the phagocyte activity of the immune cells, thereby, promoting the growth and spread of lymphocytes and increasing circulating antibodies to neutralize a harmful pathogen and reduce humma or body fever (Dafi'-i-humma). Incidentally, the principal mineral component of KJ, zinc, has been widely acknowledged for its beneficial influence on the immune function, and decrease the risk of developing serious respiratory illnesses. In this manuscript, we provide a glimpse of the literature on KJ and postulate its potential beneficial effects in respiratory infections, including COVID-19.

Klebsiella pneumoniae liver abscess in an immunocompetent child

  • Kwon, Jang-Mi;Jung, Hye Lim;Shim, Jae Won;Kim, Deok Soo;Shim, Jung Yeon;Park, Moon Soo
    • Clinical and Experimental Pediatrics
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    • v.56 no.9
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    • pp.407-410
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    • 2013
  • Klebsiella pneumoniae has emerged as a leading pathogen that causes pyogenic liver abscesses (PLAs) in Korea. K. pneumoniae liver abscess (KLA) is potentially life threatening, and the diagnosis is difficult. In developed countries, PLA is rarely observed in children and is frequently associated with disorders of granulocyte function and previous abdominal infection. We observed a case of KLA in a healthy 12-year-old boy. To our knowledge, this is the first reported case of KLA in an immunocompetent child without an underlying disease in Korea. The patient was treated with percutaneous catheter drainage and antibiotics. The catheter was placed in the intrahepatic abscess for 3 weeks and parenteral antibiotics (ceftriaxone and amikacin) were administered for 4 weeks, followed by oral antibiotics (cefixime) for 2 weeks. We reported this case to raise awareness of KLA in immunocompetent children among physicians, and to review the diagnosis, risk factors, potential complications, and appropriate treatment of KLA.

Design of 3D Visualization Software Tool Based on VTK for Manual Brain Segmentation of MRI (뇌 MR영상 수동분할을 위한 VTK기반의 3차원 가시화 소프트웨어 툴 설계)

  • Yoon, Ho-Sung;Hewage, Nuwan;Moon, Chi Wong;Kim, Young-Hoon;Choi, Heung-Kook
    • Journal of Korea Multimedia Society
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    • v.18 no.2
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    • pp.120-127
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    • 2015
  • Mild Cognitive Impairment(MCI) is a prior step to Alzheimer's Disease(AD). It is different from AD which is seriously affecting daily life. Particularly, the hippocampus could be charged a crucial function for forming memory. MCI has a high risk about progress to AD. Our investigated research for a relationship between hippocampus and AD has been studied. The measurement of hippocampus volumetric is one of the most commonly used method. The three dimensional reconstructed medical images could be passible to interpret and its examination in various aspects but the cost of brain research with the medical equipment is very high. In this study, 3D visualization was performed from a series of brain Magnetic Resonance Images(MRI) and we have designed and implemented a competitive software tool based on the open libraries of Visualization ToolKit(VTK). Consequently, our visualization software tool could be useful to various medical fields and specially prognosis and diagnosis for MCI patients.

Study on Substitution Effect caused by Application of BIM Simulation System to Mock-up Site (시공단계 현장 Mock-up의 BIM 기반 시뮬레이션 기법 적용에 의한 기대효과 분석 연구)

  • Jang, Se-Jun;Yun, Seok-Heon;Paek, Joon-Hong
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2008.05a
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    • pp.147-151
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    • 2008
  • Construction project is completed through several stages and problems of each stage affect directly not only now but also next. Defect of 2D drawings influence in construction phase, and it make many loss on project. Nowadays we practically use real Mock-up test in construction sites to solve the problems. But it also has many problems which are waste much money and time. Therefore, this study tries to analyze effect that is occurred by appling BIM Mock-up simulation instead of real Mock-up execution. These analysis is conducted by comparing two construction building site. These have same shape but one is made for BIM Mock-up, and another is real Mock-up. Comparison points of view are cost, time and operator's satisfaction. It is expect that BIM Mock-up is more effective at low cost and on shorter time. But our analysis show that each are conducted different part of function. So new Mock-up type is required. Hybrid Mock-up is combine real mock-up with BIM simulation and it can minimize risk of project.

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System Engineering Interfaces of Reliability Engineering in Development of Launch Vehicle (우주발사체 개발사업에서 신뢰성공학의 시스템엔지니어링 인터페이스)

  • Shin, Myoung Ho;Cho, Sang Yeon;Joh, Miok
    • Journal of the Korean Society of Systems Engineering
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    • v.2 no.1
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    • pp.31-36
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    • 2006
  • Development of launch vehicle needs a large-scale and complicated System Engineering discipline interfacing to small-quantity production with special manufacturing processes. In general, the System Engineering discipline of launch vehicle has its relationship with Production, Operations, Product Assurance and Management disciplines and its internal partitions into the functions of System Engineering Integration & Control, Requirements Engineering, Analysis, Design and Configuration and Verification. As a function of Product Assurance, reliability of launch vehicle plays an significant role in risk management, system safety, flight safety and launch certification through design assurance. Moreover, major functions of systems engineering are integrated by means of reliability in the phases of design and verification. Therefore, derailed identification of system engineering interfaces of reliability, and execution of tasks for reliability assurance is required for successful development of launch vehicle. This paper identifies specific pattern and mechanism of the interfaces between reliability and system engineering.

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Modified Kolmogorov-Smirnov Statistic for Credit Evaluation (신용평가를 위한 Kolmogorov-Smirnov 수정통계량)

  • Hong, C.S.;Bang, G.
    • The Korean Journal of Applied Statistics
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    • v.21 no.6
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    • pp.1065-1075
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    • 2008
  • For the model validation of credit rating models, Kolmogorov-Smirnov(K-S) statistic has been widely used as a testing method of discriminatory power from the probabilities of default for default and non-default. For the credit rating works, K-S statistics are to test two identical distribution functions which are partitioned from a distribution. In this paper under the assumption that the distribution is known, modified K-S statistic which is formulated by using known distributions is proposed and compared K-S statistic.

Sequestration of Organic Pollutants in the Environments: Implications on Bioavailability and Bioremediation

  • Nam, Kyoungphile
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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    • 2000.11a
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    • pp.107-118
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    • 2000
  • For the last several decades, the fate of organic pollutants has been extensively studied in natural environments with emphasis on sorption and desorption phenomena. Although the mechanisms involved are not clear yet there is a consensus about the existence of hysteresis in the sorption and desorption of organic pollutants. Furthermore, it is found that hysteresis is the outcome of slow nonequilibrium sorption of organic pollutants, which results in the formation of desorption-resistant fractions of the pollutants. Desorption-resistant fractions may increase as a function of the residence time of the pollutants in the environments. Field monitoring data show a slow but continuous decline of chemicals applied to soil, followed by little or no subsequent disappearance. One plausible explanation for such resistance to biodegradation, desorption, or extraction can be attributed the gradual movement of organic pollutants to less accessible remote sites inside the matrix with time. This phenomenon has been termed sequestration or aging. The fact that some pollutants are sequestered in soil with time may have a great impact on bioremediation and risk assessment, Some portion of the resistant pollutants may still be present in the environments after bioremediation. It requires vigorous means to completely remove the aged portion that may not be further bioavailable. However, precaution should be taken since aging is not always evident. Aging seems to be soil and chemical specific.

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뮤코다당증의 장기 치료 효과와 한계점 극복을 위한 노력

  • Son, Yeong-Bae
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.14 no.1
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    • pp.29-36
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    • 2014
  • Mucopolysaccharidoses (MPSs) are a group of rare inherited metabolic diseases caused by deficiency of lysosomal enzymes. MPSs are clinically heterogeneous and characterized by progressive deterioration in visceral, skeletal and neurological functions. The aim of this article is to review the treatment of MPSs, the unmet needs of current treatments and vision for the future including recent clinical trials. Until recently, supportive care was the only option available for the management of MPSs. Hematopoietic stem cell transplantation (HSCT), another potentially curative treatment, is not routinely advocated in clinical practice due to its high risk profile and lack of evidence for efficacy. From the early 2000s, enzyme replacement therapy (ERT) was approved and available for the treatment of MPS I, II and VI. ERT is effective for the treatment of many somatic symptoms, particularly walking ability and respiratory function, and remains the mainstay of MPS treatment. However, no benefit was found in the neurological symptoms because the enzymes do not readily cross the blood-brain barrier (BBB). In recent years, intrathecal (IT) ERT, substrate reduction therapy (SRT) and gene therapy have been rapidly gaining greater recognition as potential therapeutic avenues. Although still under investigation, IT ERT, SRT and gene therapy are promising MPS treatments that may prevent the neurodegeneration not improved by ERT.

Outcome of Open Reduction Via Retromandibular Approach for Mandibular Subcondyle Fracture (하악골 과두경부 골절에 있어서 후하악부 절개법을 이용한 관혈적 정복술의 유용성)

  • Lee, Hyung Chul;Kang, Dong Hee;Koo, Sang Hwan;Park, Seung Ha
    • Archives of Plastic Surgery
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    • v.32 no.6
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    • pp.739-743
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    • 2005
  • Subcondylar fractures have generally been treated by intermaxillary fixation except in cases where there is an absolute indication for open reduction. The reason behind a less aggressive surgical approach lies on the inherent difficulties in manipulating fragments in such a small area at the risk of damaging facial nerves or vessels such as the internal maxillary artery. However, long-term follow-up studies showed that conservative treatment of subcondylar fractures results in disturbances of occlusal function, deviation of the mandible, internal derangement of the temporomandibular joint, and ankylosis of the joint. We carried out open reduction of dislocated subcondylar fractures in 14 patients from 2000 to 2004 by a retromandibular approach. After the reduction of fractured bone, two H-shaped miniplates with 6 holes were fixed with screws at the anterior and posterior surfaces of the subcondyle. The retromandibular approach allowed good access and easy manipulation of the subcondyle. Immediate relief from malocclusion and correction of mandibular midline shifting were observed in all patients. Late temporomandibular dysfunction and ankylosis were not observed. Open reduction with plate osteosynthesis made it possible to avoid IMF in 7 of the 14 patients. The present study shows that open reduction through this retromandibular approach can produce good outcome in adult patients with subcondylar fracture.

Evolutional Process of Economic Integration In The U. S. Broiler Industry (미국브로일러산업의 경제통합전개과정)

  • 박영인
    • Korean Journal of Poultry Science
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    • v.12 no.2
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    • pp.119-126
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    • 1985
  • The purpose of the study is to review the evolutional process of the U.S. broiler industry into the integrated production and marketing systems and to examine the factors influenced such a structural change over the Past half a century. The study is also carried out under the consideration that the experience gained by the integrated U.S. broiler industry could be utilized in applying the system to any non-integrated broiler industries like one in Korea. The U.S. broiler industry has been prevailed in the typical independent operation of all stages, from factor supply through growing to dressing and marketing until such time as growers began to suffer from financial difficulties right after the end of the World Wat II due mainly to lowered price of broilers stemmed from whopping decrease of the demand, which eventually reflected to the allied agribusiness sectors. The feed business field was the first reactor to this situation so that a kind of measures was taken to cope with the problems faced in such a way to provide extended credit on feeds first and help obtain chicks or sell broilers later. This trend has been practiced for broiler related agribusiness through late 1940's to work together with growers by coordinating its function between two or more stages involved in broiler production and marketing process as a means of spreading risk and sharing profit between stages Participated. The integrated system and contract farming thus became Popular across the country through mid 1950's.

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