• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.323-335
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• 2016

Breast cancer risk assessment has developed during years and evaluation of genetic factor affecting risk of breast cancer is an important component of this risk assessment. The aim of this meta-analysis was to investigate the role of XRCC1 polymorphisms (Arg194Trp, Arg280His and Arg399Gln) in risk of breast cancer among different population and categories of menopausal status.PubMed, Medline, Web of Science, and PubMed Central were systematically searched to identify studies evaluating association between breast cancer and XRCC1 gene polymorphisms (Arg194Trp, Arg280His and Arg399Gln). Two authors independently extracted required information. Odds Ratios were pooled for four genetic inheritance models using both fixed and the DerSimonian and Laird random-effect models. Egger's test and contour-enhanced funnel plot was used to evaluate publication bias and small study effect. Additional subgroup analysis was performed for menopausal status, ethnicity, and source of controls. After evaluation and applying inclusion criteria on extracted studies, fifty three studies were included in this meta-analysis. For polymorphisms of Arg194Trp and Arg280His, no significant association was observed in all genetic models. Arg194Trp had a protective effect in post-menopausal status only in homozygote model (OR=0.57 [0.37-0.88]). Arg399Gln showed significant association with breast cancer in homozygote (OR=1.21 [1.10-1.34]), dominant (OR=1.09 [1.03-1.15]) and recessive (OR=1.21 [1.09- 1.35]) genetic models. Arg399Gln was associated with higher risk in post-menopausal status for homozygote and heterozygote models. Our findings suggest that XRCC1 gene polymorphisms modify breast cancer risk in different populations and different categories of menopausal status.

• 한국방재안전학회논문집
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• 제16권2호
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• pp.49-56
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• 2023

영향예보는 기존의 기상요소 중심의 예보에서 벗어나 기상상황에 따른 잠재적 사회경제적 위험도 정보를 함께 제공하는 것을 의미한다. 기상 선진국들은 영향정보 제공 및 확산을 위한 기술개발에 인력과 재정을 투입하고 있지만 국내에서는 영향예보에 대한 인식이 확산되어 있지 않다. 또한 영향예보 피해가 많이 발생하는 홍수, 태풍 등의 재난에 초점이 맞춰져 있으며 상대적으로 피해발생이 적은 교통 분야의 강풍으로 인한 차량 위험 영향 평가에 대한 연구는 부족한 실정이다. 국내에서는 강풍으로 인한 차량 전도에 대한 피해 사례는 많이 없지만 과거 피해 사례가 존재하며 연구에 대한 필요성이 높아지고 있다. 강풍으로 인한 차량의 위험(Risk) 평가를 위해서는 도로의 취약성(Vulnerability)이 필요하며 본 연구에서는 도로의 취약성 기준을 산정하는 것을 목적으로 하였다. 도로의 취약성 평가는 도로의 고도, 차선 수, 도로 유형으로 평가하였다. 분석결과 사고사례가 있던 지역의 취약성 지역을 잘 재현하는 것으로 나타났다. 본 연구의 성과를 이용하여 차량 운전자에게 잠재적 위험에 대한 객관적인 평가 마련에 대한 기준으로 활용할 수 있을 것이라 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3501-3505
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• 2012

Links between the CHEK2 1100delC heterozygote and breast cancer risk have been extensively explored. However, both positive and negative associations with this variant have been reported in individual studies. For a detailed assessment of the CHEK2 1100delC heterozygote and breast cancer risk, relevant studies published as recently as May 2012 were identified using PUBMED and EMBASE and selected using a priori defined criteria. The strength of the relationship between the CHEK2 1100delC variant and breast cancer risks was assessed by odds ratios (ORs) under the fixed effects model. A total of 29,154 cases and 37,064 controls from 25 case-control studies were identified in this meta-analysis. The CHEK2 1100delC heterozygote was more frequently detected in cases than in controls (1.34% versus 0.44%). A significant association was found between CHEK2 1100delC heterozygote and breast cancer risk (OR=2.75, 95% CI: [2.25, 3.36]). The ORs and CIs were 2.33 (95% CI: [1.79, 3.05]), 3.72 (95% CI: [2.61, 5.31]) and 2.78 (95% CI: [2.28, 3.39]) respectively in unselected, family, early-onset breast cancer subgroups. The CHEK2 1100delC variant could be a potential factor for increased breast cancer risk in Caucasians. However, more consideration is needed in order to apply it to allele screening or other clinical work.

• 한국시뮬레이션학회논문지
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• 제25권4호
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• pp.127-135
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• 2016

선박에 현대화된 다양한 항해장비들이 설치됨에도 불구하고 여전히 해양사고가 자주 일어나는데, 이런 사고의 주요 형태 중 하나가 충돌 사고이다. 우리나라 해양사고의 약 1/4이 충돌에 의한 사고이고, 이 중 대부분이 인적오류가 원인인 것으로 알려져 있다. 따라서, 항해사의 의사결정을 도울 수 있는 지능적인 지원 도구가 필요한데, 이와 관련하여 충돌위험을 추정하는 다양한 방식들이 꾸준히 소개되어 왔으며 충돌위험 상황에 대해 사람에게 친숙한 언어적 표현을 반영하여 추론하기 위해 퍼지를 활용한 연구 결과들이 많다. 이런 기존 연구들의 충돌위험도는 현재시점에서 선박들의 속도나 방향 상태가 유지되는 것을 기준으로 충돌위험도를 추정한다. 그러나, 실제 선박에서는 충분히 피항 가능 상황임에도 불구하고 충돌 위험으로 판단되어 잦은 경고를 울리는 시스템들에 대해 항해사들이 느끼는 불편함이 적지 않아 보조 장치들의 알람 기능을 꺼놓은 경우도 많은 것으로 알려져 있다. 이 연구는 선박들의 일반적인 피항 패턴을 반영한 가까운 미래 시점의 충돌위험도 예측에 관한 것으로서, 퍼지추론과 DEVS 형식론에 기반한 충돌 위험 예측 모델을 제안한다.

• 대한한방소아과학회지
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• 제35권3호
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• pp.28-42
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• 2021

Objectives The purpose of this study is to investigate the effect of Tuina treatment for children with Autism Spectrum Disorder (ASD), and to propose guidance to future studies or application in clinical setting. Methods The articles published from year 2000 to May 2021 by China National Knowledge Infrastructure (CNKI) were searched by setting up field as '中醫學', '中藥', '中西醫結合' and by setting up keyword as '小儿自閉症', '儿童自閉症', '自閉症譜系障碍', 'Autism', 'Autism spectrum disorder' that corresponds to participant and '推拿', '導引', '按摩', 'Tuina', 'massage'. Results Nine selected articles were analyzed and summarized by authors and year published, characteristics, diagnostic criteria, treatment methods and contents, treatment duration, evaluation criteria and results of the study. The articles were also reviewed by reported side effects, and evaluated the quality of the study according to Cochrane Handbook's Risk of Bias 2 (RoB 2) assessment of the Randomized Control Trial (RCT) articles. All studies used Tuina treatment to achieve effective results for pediatric autism spectrum disorder. Conclusion Pediatric Tuina treatment (TM) is a non-invasive treatment that does not stimulate patients with unstable ASD but increase patient adherence, and can be safely and simply operated. Therefore, pediatric Tuina treatment is worth utilizing as a clinical basis for further development of ASD treatment.

• 한국국방기술학회 논문지
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• 제5권2호
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• pp.23-30
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• 2023

TRA(Technology Readiness Assessment)는 현재의 국내 기술수준을 정량적으로 평가하여 국내 연구개발 가능성에 대한 판단과 위험관리를 위한 핵심도구로 활용되고 있다. 하지만 현재의 TRA는 하드웨어 중심의 TRL(Technology Readiness Level)을 활용하기 때문에 개별기술의 독립적 평가에는 적합하나 체계관점의 평가에는 한계가 있다. 또한 체크리스트 방식의 평가는 주관적 평가 개입 가능성이 크다. 본 연구는 체계공학의 시스템통합 관점에서 TRA 절차와 기준을 재정의하여 개선된 TRA 프레임워크를 제안한다. 현재의 TRL과 TRA가 가진 한계를 극복하고 좀더 쉽고 직관적인 평가가 가능한 프레임워크 개발에 중점을 두었다. 제안 프레임워크는 HW, SW 및 인터페이스 관점에서 TE(Technology Element)와 CTE(Critical Technology Element)를 구분하고 TRL을 재정의 한다. TRA는 위 3가지 관점에서 재정의된 TRL에 따라 수행되고 위험관리를 고려하여 가장 낮은 평가결과를 시스템 수준의 성숙도로 활용한다. 제안된 CTE 선정방법은 주요 ROC(Required Operational Capability)의 정량목표, 개발난이도 및 COTS(Common Off The Shelf) 기술의 적용여부를 활용하여 평가자 주관의 개입을 최소화 한다. 본 프레임워크는 TSS(Target Surveillance System) 체계의 Case Study를 통해 실효성을 확인하였다. 본 연구를 시작으로 프레임워크 차원의 연구가 활성화 되어 TRA 제도 개선에 기여하길 바란다.

• 보건교육건강증진학회지
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• 제28권3호
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• pp.31-42
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• 2011

Objectives: Busan had the highest mortality and the shortest life expectancy at birth among 16 provinces in Korea in 2008 and there were considerable health inequalities within the region. This study was performed to build up a priority setting framework in Healthy City Busan project. Methods: Analytic hierarchy process was used to determine the relative priority weight for different strategic and program dimensions along with the consistency of response. An on-site workshop-based meeting (calculating importance) and online survey (calculating risk) were conducted to obtain data from 8 experts. Results: The results showed that in strategic criteria "active health promotion & diseases prevention" and "building infrastructure for the Health City project" were two most important factors. In program criteria, considering both importance and risk scores, "making a healthy community" and "building community health centers" in disadvantaged areas were a top priority group. In addition, "enacting an ordinance for the Healthy City", "building the infrastructure for health impact assessment" and "making health care safety net for vulnerable population" were also higher priorities group. Conclusions: Our findings suggest that the Healthy City project in Busan should be focused on strengthening health equity and building infrastructure for sustainability of the project.

• Safety and Health at Work
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• 제9권2호
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• pp.133-139
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• 2018

Background: Selecting priority occupational carcinogens is important for cancer prevention efforts; however, standardized selection methods are not available. The objective of this paper was to describe the methods used by CAREX Canada in 2015 to establish priorities for preventing occupational cancer, with a focus on exposure estimation and descriptive profiles. Methods: Four criteria were used in an expert assessment process to guide carcinogen prioritization: (1) the likelihood of presence and/or use in Canadian workplaces; (2) toxicity of the substance (strength of evidence for carcinogenicity and other health effects); (3) feasibility of producing a carcinogen profile and/or an occupational estimate; and (4) special interest from the public/scientific community. Carcinogens were ranked as high, medium or low priority based on specific conditions regarding these criteria, and stakeholder input was incorporated. Priorities were set separately for the creation of new carcinogen profiles and for new occupational exposure estimates. Results: Overall, 246 agents were reviewed for inclusion in the occupational priorities list. For carcinogen profile generation, 103 were prioritized (11 high, 33 medium, and 59 low priority), and 36 carcinogens were deemed priorities for occupational exposure estimation (13 high, 17 medium, and 6 low priority). Conclusion: Prioritizing and ranking occupational carcinogens is required for a variety of purposes, including research, resource allocation at different jurisdictional levels, calculations of occupational cancer burden, and planning of CAREX-type projects in different countries. This paper outlines how this process was achieved in Canada; this may provide a model for other countries and jurisdictions as a part of occupational cancer prevention efforts.

• Journal of Korean Biological Nursing Science
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• 제13권1호
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• pp.53-60
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• 2011

Purpose: The purpose of the present study was to investigate the prevalence and lifestyle factors related to the metabolic syndrome in Korean elderly. Methods: A total number of 122 elderly over 60 yr were recruited from a community elderly center. Elderly were classified into young old (60-74 yr) and old (75-84 yr). Metabolic syndrome was defined by third report of the national cholesterol education program (NCEP) expert panel on Adult Treatment Panel III (ATP III). Abdominal obesity was determined by Korean society for the study of Obesity criteria. The nutritional status was measured by mini nutritional assessment (MNA). Results: The prevalence of the metabolic syndrome was significantly higher in the old than young old elderly (p<0.05, respectively). Abdominal obesity and hypertension were the most common risk factors. The related factors to metabolic syndrome were high Body mass Index (BMI) and currently not participating in exercise. Abdominal obesity, low HDL cholesterol and hypertension were associated with specific nutrient intakes. Conclusion: A strategy to decrease the metabolic syndrome in the elderly is urgently needed particularly so for the old elderly. A nutritional and exercise program for young old elders may be helpful reducing the prevalence of metabolic syndrome in later stage.

• 대한물리의학회지
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• 제12권3호
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• pp.49-58
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• 2017

PURPOSE: To summarize the evaluation tools of balance [Berg Balance Scale (BBS), timed up and Go (TUG), forward reaching test (FRT)], gait [6 m walking Test (6MWT)], and strength [Chair Stand Test (CST)] for patients with dementia. METHODS: The following databases were searched: Pub MED, Cochrane, Sciences Direct, and Web of Sciences. The inclusion criteria were as follows: 1) repeated measurement design, 2) subjects with dementia, 3) use of testing tools such as the BBS, TUG, FRT, 6MWT, and CST, 4) report the reliability. One reviewer performed the quality assessment of diagnostic accuracy study and two evaluators performed data extraction independently. RESULTS: Six articles and one letter were included. The interrater reliability of 6MWT, TUG, and CST, were acceptable (ICC>.90). However, FRT had unacceptable reliability. In test-retest reliability, only BBS has acceptable reliability (ICC>.90). Others had various reliabilities. The risk of interrater reliability bias was low in all studies. However, the risk of bias of intrarater reliability was low in five studies and moderate in two studies. CONCLUSION: The interrater reliability of the 6MWT, TUG, and CST were acceptable. However, in test-retest reliability, only BBS has acceptable reliability. Therefore, we suggest the use of BBS to test the balance of dementia patients. In addition, the study of tool reliability according to the subtype of dementia is needed in the future.