• Clinical and Experimental Pediatrics
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• 제57권11호
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• pp.472-478
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• 2014

Kawasaki disease (KD), an acute vasculitis that primarily affects young children, is the most common acquired paediatric cardiovascular disease in developed countries. While sequelae of arterial inflammation in the acute phase of KD are well documented, its late effects on vascular health are increasingly unveiled. Late vascular dysfunction is characterized by structural alterations and functional impairment in term of arterial stiffening and endothelial dysfunction and shown to involve both coronary and systemic arteries. Further evidence suggests that continuous low grade inflammation and ongoing active remodeling of coronary arterial lesions occur late after acute illness and may play a role in structural and functional alterations of the arteries. Potential importance of genetic modulation on vascular health late after KD is implicated by associations between mannose binding lectin and inflammatory gene polymorphisms with severity of peripheral arterial stiffening and carotid intima-media thickening. The changes in cholesterol and lipoproteins levels late after KD further appear similar to those proposed to be atherogenic. While data on adverse vascular health are less controversial in patients with persistent or regressed coronary arterial aneurysms, data appear conflicting in individuals with no coronary arterial involvements or only transient coronary ectasia. Notwithstanding, concerns have been raised with regard to predisposition of KD in childhood to accelerated atherosclerosis in adulthood. Until further evidence-based data are available, however, it remains important to assess and monitor cardiovascular risk factors and to promote cardiovascular health in children with a history of KD in the long term.

• 한국도로학회논문집
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• 제14권4호
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• pp.1-8
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• 2012

PURPOSES : Skid resistance on pavements plays an important role in reducing the risk of vehicle skidding on wet surface particularly. Almost 9.3 percent of traffic accidents were occurred under rainy condition and these are over-represented in terms of the severity of the crashes. Recently, unusual weather conditions referred widely as the intensified rainfalls justify the need of a systematic management of skid resistance. In this context, the study carried out the observational study on the skid resistance characteristics of different types of pavement with the time passage. METHODS : This study measured the skid resistance with Pavement Friction Tester at three times within five years. The skid resistance measurement has followed the method suggested by ASTM. RESULTS : As the main results under the scope of this study, skid resistance of asphalt concrete has not nearly reduced with time. On the contrary, skid resistance of cement concrete has been rapidly reduced with time though the highest resistance was gained at the early observation. Porous asphalt concrete shows a steady decrease of skid resistance with time, anyway, the reduction rate according to the increase of measurement speeds is relatively lower than the others. CONCLUSIONS : Based on our study, skid resistance of the pavement should be regarded as one of the pavement management system, so periodic measurement should be made to assure road safety as a whole.

• Journal of Chest Surgery
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• 제16권1호
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• pp.40-48
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• 1983

Tetralogy of Fallot is characterized by the interventricular septal defect associated with obstruction of the right ventricular outflow. The importance of the latter anatomic malformation was clinically evaluated according to the angiographic measurements of the pulmonary arteries along with the pulmonary valve annulus. Seventy of a total 76 patients operated on during a whole year of 1981 were the patients for clinical evaluation. Fifteen patients died within 1 month after operation with the operative mortality of 21.4%. The young age and the severity of pulmonary arterial hypoplasia were ones among the surgical risk factors at a total corrective surgery of tetralogy. Preoperative angiographic measurements of the pulmonary arteries to speculate the expected postoperative ratio between the left ventricular and the right ventricular pressures were retrospectively calculated according to the formula. The predicted values of P RV/LV greater than 0.5 carried apparenliy higher complication and mortality rates than the group of P RV/LV less then 0.5. The selection of the candidates for either a total correction or the staged operation In tetralogy of Fallot can be evaluated on the preoperative angiographic measurements and the expected Improvements of the clinical results were discussed.

• 한국방재학회 논문집
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• 제10권6호
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• pp.89-97
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• 2010

본 연구에서는 현재 및 미래기후에서의 가뭄심도-영향면적-지속기간 곡선의 비교를 통하여 극한 가뭄사상의 시공간적 거동에 대한 기후변화의 영향을 살펴보았다. 미래기후는 CGCM3.1-T63과 CSIRO-MK3.0으로부터 획득되었다. 분석 결과 CGCM3.1-T63의 경우에는 미래가뭄이 현재와 비슷할 것으로 예측되었으나, CSIRO-MK3.0의 경우에는 연강수량 총량의 변화가 거의 없음에도 불구하고 미래가뭄이 현재보다 더 극심해질 것으로 예측되었다. 이에 따라 현재의 수자원 공급 시스템에 대한 기후변화 취약성 평가가 시급함을 제시하고 있다.

• 대한한의학회지
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• 제38권1호
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• pp.8-20
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• 2017

Objectives: Traditional oriental herbal medicine is used in cancer care to alleviate symptoms. Anorexia is a symptom which is frequently observed in patients with cancer and impairs their quality of life. The objective of this systematic review is to summarize current available evidence to evaluate the effect of traditional oriental herbal medicine on anorexia in cancer patients. Methods: The review evaluated randomized controlled trials (RCTs) measuring the effect of any types of herbal medicine on anorexia in cancer patients within 4 electronic databases and manual search up to December 2015. The Cochrane risk of bias tool (ROB) was used to assess the quality of RCTs. Results: In total, 11 RCTs met the inclusion criteria. All of the studies reported the rate or severity of anorexia improved after treatment in herbal-conventional medicine combined group compared to conventional medicine group. 7 of 11 studies showed between-group statistical differences. The methodological quality of RCTs was insufficient with unclear and high ROB. Conclusions: Traditional oriental herbal medicine may have a potential to improve anorexia in patients with cancer. To confirm the clinical recommendation, further researches with rigorous study design are required to support the effects of herbal medicine.

• 응용통계연구
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• 제13권2호
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• pp.247-263
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• 2000

자연재해(Natural Catastrophe)는 태풍, 홍수, 호우, 폭풍, 해일, 폭설, 가뭄, 지진 등과 같이 자연현상으로 인하여 발생하는 피해를 말한다. 자연재해는 한번 발생하면 엄청난 피해를 가져오므로 거대위험으로 분류된다. 현재 우리나라에서는 일반화재보험에서 풍수재위험과 지진위험을 담보하는 약관과 요율이 적용되고 있으나 이러한 풍수재담보와 지진담보에 대한 약관 및 요율은 외국에서 가져온 것(구득요율)이므로 우리나라 현실을 전혀 반영하지 못한 것이다. 이러한 연유로 보험계약자의 권익을 보호하기 위해 현재까지 우리나라 손해보험에서 사용하지 않은 통계적 방법을 이용하여 태풍과 풍수재에 대한 손해액 분포를 결정하고 그에 따른 적정보험료를 산출하였다.

• 한국병원경영학회지
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• 제18권2호
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• pp.81-103
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• 2013

This study is to research cost accounting practice and to analyze propriety of patients' medical payment in artificiality kidney center. The researched cost datum of the year 2012 are as follows. - Hemodialysis medical treatment was reimbursed as much as 158,001 won in case of health insured patients, but payed-off as much as 135,810 won. - The average figure of the total hospitals and clinic center is 1,603,303 won, and one time cost of hemodialysis treatment is 154,487 won. Optimal treatment pay are suggested as follows. First, Regardless of the notified classification from MOHW(Ministry of Health and Welfare), 136,000 won of fixed price payment classification needs to be reclassified by patients, severity and tobe rearranged by fixed price payment system of hospitals. Second, Fixed payment code notified by the Ministry of Health and Welfare is recommended to be simplifies and to reflect according to contents of the medical treatment rendered to patients. Third, Establishment of artificial kidney center has to be risk managed because of its huge investment. Fourth, Cost analysis model has to be maintained as basis together with appropriate application of conversion index model mixed with SGR model.

• Tuberculosis and Respiratory Diseases
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• 제70권5호
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• pp.384-389
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• 2011

The prevention of and the controlling of symptoms, reductions in the frequency of exacerbations, and disease severity are central to the pharmacologic therapy of chronic obstructive pulmonary disease (COPD). COPD patients are inclined to be older, have more comorbidities, and use polypharmacy as a result. Long-acting inhaled muscarinic antagonists (LAMAs) is a preferred treatment modality. However, the cardiovascular (CV) safety of anti-cholinergics, including LAMA, has been an issue. In contrast, the results of the UPLIFT trial and a pooled analysis of data from 30 trials of tiotropium illustrates the association of tiotropium with reductions in the risk of all cause mortality, CV mortality and CV events. And, the UPLIFT trial provides clues regarding the additive advantages of tiotropium in COPD patients who already are using long-acting inhaled ${\beta}_2$ agonists and inhaled corticosteroids. Following the contribution of tiotropium as a first LAMA, new LAMAs such as aclidinium and glycopyrrolate (NVA-237) seem to be emerging.

• Journal of Communications and Networks
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• 제14권4호
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• pp.396-409
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• 2012

With the proliferation of diverse wireless devices, there is an increasing concern about the security of location information which can be spoofed or disrupted by adversaries. This paper investigates the characterization and detection of location spoofing attacks, specifically those which are attempting to falsify (degrade) the position estimate through signal strength based attacks. Since the physical-layer approach identifies and assesses the security risk of position information based solely on using received signal strength (RSS), it is applicable to nearly any practical wireless network. In this paper, we characterize the impact of signal strength and beamforming attacks on range estimates and the resulting position estimate. It is shown that such attacks can be characterized by a scaling factor that biases the individual range estimators either uniformly or selectively. We then identify the more severe types of attacks, and develop an attack detection approach which does not rely on a priori knowledge (either statistical or environmental). The resulting approach, which exploits the dissimilar behavior of two RSS-based estimators when under attack, is shown to be effective at detecting both types of attacks with the detection rate increasing with the severity of the induced location error.

• 생물정신의학
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• 제23권3호
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• pp.116-121
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• 2016

Objectives Experience of early childhood abuse elevates the risk of developing schizophrenia in later period of life, incidence of psychiatric comorbidity, symptomatic severity and complexity. In this context, we hypothesized that the pattern of psychotropic medication used would reflect this; those with childhood trauma will received more types and higher doses of psychotropic medication. Methods From our database of 102 outpatients diagnosed with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) schizophrenia, we analyzed experiences of childhood trauma measured by the Childhood Trauma Questionnaire-Short Form and types and dose of prescribed psychotropic medication. Results We found significant positive correlations between child sexual abuse and the number of psychotropic medications (p = 0.029) and between child emotional neglect and the number of psychotropic medications other than antipsychotics (p = 0.045). Conclusions This preliminary study suggests that the pattern of psychotropic use may be affected by types of childhood trauma. Further studies will have to shed light on mediating factors such as symptoms or comorbid conditions that lead to prescription of certain psychotropic class.