• 한국식품위생안전성학회지
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• 제23권3호
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• pp.206-211
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• 2008

식품의약품안전청 제2007-22호로 고시된 PSL-TL 검지법의 적용 가능성을 확인하기 위하여 국내에서 방사선 조사가 허가되어 있는 복합조미식품과 향신료를 대상으로 실시한 결과, 향신료의 조사되지 않은 1개 시료가 PSL 분석결과 중간시료로 분류되어 추가적으로 TL 분석을 실시한 결과 방사선 조사되지 않은 것으로 판단되었고, 나머지 조사되지 않은 시료들은 PSL 분석결과 음성시료로 판정되어 방사선 조사되지 않은 것으로 판단되었다. 방사선이 조사된 시료들은 PSL 분석에서 양성시료로 분류되어 추가적으로 TL 분석을 실시하여 glow curve가 나타나는 온도범위와 glow curve의 형태를 확인하고 TL ratio를 구한 결과, 방사선이 조사된 시료는 $150{\sim}250^{\circ}C$ 사이에서 아주 강한 강도의 glow curve를 보여주었고, TL ratio가 0.29이상을 나타내어 방사선 조사된 것으로 판단하였다. 따라서 PSL-TL 검지법의 적용가능성이 확인되었다.

• 해양환경안전학회지
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• 제23권5호
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• pp.447-454
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• 2017

해상에서 두 척의 대형 해양경찰 함정을 이용하여 충돌 가능성이 높은 네 가지 조우방위각($000^{\circ}$, $045^{\circ}$, $090^{\circ}$, $135^{\circ}$)을 설정하여 피험자인 30명의 해양경찰관을 대상으로 조우방위별 거리 3해리(Nautical Mile: NM)에서부터 0.25 NM까지 근접하며 상대거리가 점차 감소될 때 피험자들이 상대선박을 보며 지각한 충돌위험도(Perceived Ship Collision Risk, PSCR)를 측정(0.25 NM 간격으로 기록)하는 실험을 하였고 획득된 데이터를 이용하여 특징을 통계적으로 분석하였다. 본 연구의 목적은 인적오류 예방을 위하여 실선 실험한 선박 조우방위별 상대거리 3 NM에서 0.25 NM까지의 열두 구간에서 획득한 충돌위험도 값을 적정 다항식으로 곡선 근사(Curve Fitting)하여 분포곡선으로 나타내고 특징을 분석하여 항해당직자들이 지각한 충돌위험도의 변화가 최대인 거리를 제시하기 위한 것이다. 분석결과, 각 조우방위에서 거리 구간별 최적의 회귀방정식을 도출하였으며 거리 1.25 1 NM 구간에서 충돌위험도 평균값의 편차가 가장 크게 변화되었고, 특히 1 NM에서 충돌위험도 값이 가장 크게 나타나 실선 실험결과 항해당직자가 지각(Perception)한 충돌위험도의 변화 값이 최대인 거리가 1 NM임을 도출 및 검증하였으며 이는 선박 충돌가능성이 높은 근접상황에서 인적오류 예방 자료로 유용할 것으로 기대된다.

• 응용통계연구
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• 제31권3호
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• pp.329-342
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• 2018

노모그램은 질병의 위험 요인과 예측 확률을 쉽게 이해할 수 있도록 시각적으로 표현하는 통계적 도구이다. 본 논문은 만성 폐쇄성 폐질환(chronic obstructive pulmonary disease)의 위험 요인을 이용하여 로지스틱 회귀모형과 순수 베이지안 분류기 모형의 노모그램을 구축하고 이를 비교하였다. 분석 데이터는 국민건강영양조사 6기(2013-2015)를 이용하여 진행하였다. 총 6개의 위험 요인을 이용하였다. 그리고 로지스틱 회귀모형, 순수 베이지안 분류기 모형과 각각의 구축 방법을 이용하여 만성 폐쇄성 폐질환의 노모그램을 제시하였다. 또한, 구축된 두 노모그램을 비교하여 유용성을 살펴보았다. 마지막으로 ROC curve와 Calibration plot을 통하여 각 노모그램을 검증하였다.

• Earthquakes and Structures
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• 제16권6호
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• pp.705-714
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• 2019

Seismic assessment of underground structures is one of the challenging problems in engineering design. This is because there are usually many sources of uncertainties in rocks and probable earthquake characteristics. Therefore, for decreasing of the uncertainties, seismic response of underground structures should be evaluated by sufficient number of earthquake records which is scarcely possible in common seismic assessment of underground structures. In the present study, a practical risk-based approach was performed for seismic risk assessment of an unsupported tunnel. For this purpose, Incremental Dynamic Analysis (IDA) was used to evaluate the seismic response of a tunnel in south-west railway of Iran and different analyses were conducted using 15 real records of earthquakes which were chosen from the PEER ground motion database. All of the selected records were scaled to different intensity levels (PGA=0.1-1.7 g) and applied to the numerical models. Based on the numerical modeling results, seismic fragility curves of the tunnel under study were derived from the IDA curves. In the next, seismic risk curve of the tunnel were determined by convolving the hazard and fragility curves. On the basis of the tunnel fragility curves, an earthquake with PGA equal to 0.35 g may lead to severe damage or collapse of the tunnel with only 3% probability and the probability of moderate damage to the tunnel is 12%.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
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• pp.1426-1431
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• 2011

A study on the standardization of design fire HRR(heat release rate) curve was conducted for various railcar from the fire simulation or the fire tests. These standard curves are listed on the tunnel fire safety manual which will be used for the QRA(quantitative risk analysis) process of the long railway tunnels. The design fire curve is based with four simple factor representing the key of fire curve characteristics. Flashover time, maximum HRR and burn out time are the key factors of the design fire curve. Specially total heat release is decided by the burnable material amount in the car.

• 해양환경안전학회지
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• 제19권2호
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• pp.145-154
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• 2013

유류를 포함한 위험 유해물질(Hazardous and Noxious Substances : HNS, 이하 HNS)의 물동량이 증가하는 추세에 있음에도 불구하고 우리나라에서는 HNS 해상운송 중에 일어난 사고의 분석과 위험에 관한 연구가 미진하다. HNS는 형태와 종류가 다양하고, 사고발생 시 피해가 심각하게 나타나기 때문에 사고에 대한 위험도 분석과 저감방안 모색이 필요하다. 본 연구는 ETA를 통해 국내에서 발생하고 있는 HNS 해상운송사고의 전개과정을 분석하여 사고유형과 특징을 고찰하고, 시나리오별 확률과 인명피해를 산출하여 F-N curve로 표현함으로써 위험도를 평가한다. 또한 Risk Matrix를 이용하여 고위험군 시나리오를 선정하여 국내에 적용 가능한 현실적인 사고 저감방안을 모색한다. 연구의 결과는 충돌사고의 발생확률이 가장 높은 반면 인명위험도는 발생확률이 낮은 질식, 침몰, 폭발의 사고유형이 높은 것으로 나타났다. 이러한 인명피해를 줄이기 위해서는 기본적으로 선내에서 안전수칙 및 작업절차를 준수하는 것으로도 효과를 얻을 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6327-6330
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• 2013

Haematuria is a common presentation of bladder cancer and requires a full urologic evaluation. This study aimed to develop a scoring system capable of stratifying patients with haematuria into high or low risk groups for having bladder cancer to help clinicians decide which patients need more urgent assessment. This cross-sectional study included all adult patients referred for haematuria and subsequently undergoing full urological evaluation in the years 2001 to 2011. Risk factors with strong association with bladder cancer in the study population were used to design the scoring system. Accuracy was determined by the area under the receiver operating characteristic (ROC) curve. A total of 325 patients with haematuria were included, out of which 70 (21.5%) were diagnosed to have bladder cancer. Significant risk factors associated with bladder cancer were male gender, a history of cigarette smoking and the presence of gross haematuria. A scoring system using 4 clinical parameters as variables was created. The scores ranged between 6 to 14, and a score of 10 and above indicated high risk for having bladder cancer. It was found to have good accuracy with an area under the ROC curve of 80.4%, while the sensitivity and specificity were 90.0% and 55.7%, respectively. The scoring system designed in this study has the potential to help clinicians stratify patients who present with haematuria into high or low r isk for having bladder cancer. This will enable high-risk patients to undergo urologic assessment earlier.

• 임상간호연구
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• 제26권2호
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• pp.265-273
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• 2020

Purpose: The purpose of this study was to test the predictive validity of the Fall Assessment Scale-Korean version (FAS-K) and to find the most appropriate cutoff score to screen high-risk fall groups in adult patients in general hospitals in Korea. Methods: We performed a prospective evaluation study in medical and surgical ward patients at two major general hospitals in Seoul. Data were collected from Nov. 1, 2018 to Feb. 28, 2019, nurses performed 651 observation series. The researcher measured the fall risk assessment score by applying FAS-K, MFS (Morse Fall Scale), and JHFRAT (Johns Hopkins Hospital Fall Risk Assessment tool) to the patients twice a week between 10 am and 12 noon. Data were analyzed using Pearson's corelation coefficients, and the sensitivity, specificity, predictive value, and the area under the curve (AUC) of the three tools. Results: The FAS-K was positively correlated with the MFS (r=.70, p<.001) and the JHFRAT (r=.82, p<.001). According to the receiver operating characteristics (ROC) curve analysis of the FAS-K, sensitivity, specificity, and positive and negative prediction values were 85.3%, 49.4%, 8.5%, and 98.4%, respectively, when the FAS-K score was 4. Therefore, the cut-off score of the FAS-K to identify groups with high fall risk was 4. Conclusion: The FAS-K is a valid tool for measuring fall risk in adult inpatients. In addition, the FAS-K score, 4, can be used to identify high-risk fall groups and know specific points in time to provide active interventions to prevent falls.

• 한국안전학회지
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• 제10권1호
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• pp.56-63
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• 1995

Two methods of the numerical method of CPQRA(Chemical Process Quantitative Risk Analysis) and the manual method of IAEA(International Atomic Energy Agency) were used to estimate the individual risk and societal risk around the chemical plant. Where, the CPQRA is introduced to verify the theoritical background of the manual of international atomic energy agency. The Gaussian plume model which has a weather stability class D with velocity of 5m/s was applied to calculate dispersion of hazard material. Also, 8-point method was employed to the effects of accidents for wind distribution. Furthermore, historical record, FTA(Fault Tree Analysis) and ETA(Event Tree Analysis) were used to estimate the probability or frequency of accidents. Eventually, the individual risk shows isorisk contour and the societal risk shows F-N curve around hazard facility, especially in chemical plants. Caulculated results, which both individual and societal risk, by using IAEA manual show simillar results to those of calculation by numerical method of CPQRA.

• Toxicological Research
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• 제6권2호
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• pp.205-213
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• 1990

The regulation of neurotoxicants has usually been based upon setting reference doses by dividing a no observed adverse effect level (NOAEL) by uncertainty factors that theoretically account for interspecies and intraspecies extraploation of experimental results in animals to humans. Recently, we have proposed a four-step alternative procedure which provides quantitative estimates of risk as a function of dose. The first step is to establish a mathematical relationship between a biological effect or biomarker and the dose of chemical administered. The second step is to determine the distribution (variability) of individual measurements of biological effects or their biomarkers about the dose response curve. The third step is to define an adverse or abnormal level of a biological effect or biomarker in an untreated population. The fourth and final step is to combine the information from the first three steps to estimate the risk (proportion of individuals exceeding on adverse or abnormal level of a biological effect or biomarker) as a function of dose. The primary purpose of this report is to enhance the certainty of the first step of this procedure by improving our understanding of the relationship between a biomarker and dose of administered chemical. Several factors which need to be considered include: 1) the pharmacokinetics of the parent chemical, 2) the target tissue concentrations of the parent chemical or its bioactivated proximate toxicant, 3) the uptake kinetics of the parent chemical or metabolite into the target cell(s) and/or membrane interactions, and 4) the interaction of the chemical or metabolite with presumed receptor site(s). Because these theoretical factors each contain a saturable step due to definitive amounts of required enzyme, reuptake or receptor site(s), a nonlinear, saturable dose-response curve would be predicted. In order to exemplify this process, effects of the neurotoxicant, methlenedioxymethamphetamine (MDMA), were reviewed and analyzed. Our results and those of others indicate that: 1) peak concentrations of MDMA and metabolites are ochieved in rat brain by 30 min and are negligible by 24 hr, 2) a metabolite of MDMA is probably responsible for its neurotoxic effects, and 3) pretreatment with monoamine uptake blockers prevents MDMA neurotoxicity. When data generated from rats administerde MDMA were plotted as bilolgical effect (decreases in hippocampal serotonin concentrations) versus dose, a saturation curve best described the observed relationship. These results support the hypothesis that at least one saturable step is involved in MDMA neurotoxicity. We conclude that the mathematical relationship between biological effect and dose of MDMA, the first step of our quantitative neurotoxicity risk assessment procedure, should reflect this biological model information generated from the whole of the dose-response curve.