• 제목/요약/키워드: Right hand

검색결과 1,063건 처리시간 0.026초

Expression of Cytokines in Radiation Injured Brain at Acute Phase

  • Lee, Jang-Bo;Kim, Min-Ho;Chung, Yong-Gu;Park, Jung-Yul
    • Journal of Korean Neurosurgical Society
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    • 제42권3호
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    • pp.200-204
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    • 2007
  • Objective : Radiation therapy is an important treatment for brain tumor. However, serious complications such as radiation necrosis can occur and it may be secondary to the expression of acute phase genes, like cytokines. In particular, inflammatory cytokines (IL-$1{\beta}$, TNF-${\alpha}$) and other immunomodulatory cytokines (TNF-${\alpha}$, TGF-${\beta}1$) might be changed after irradiation (high single dose irradiation). Although it has been reported that IL-1 level is remarkably elevated within 8 week after the irradiation to the rat brain. the change of cytokines levels at acute phase (within 24 hours) has not been reported. In the present study, we examined TNF-${\alpha}$, TGF-${\beta}1$, and IL-$1{\beta}$ levels in acute phase to clarify the early effect of cytokines on the radiation-induced brain damage. Methods : Fifty Sprague-Dawley rats were used and these were divided into irradiation group and control group. After a burr-hole trephination on the right parietal area using a drill, a single 10Gy was irradiated at the trephined site. Their forebrains were extirpated at 30 min, 2 hr, 8 hr, 12 hr and 24 hr, respectively and examined for the expression of TNF-${\alpha}$, TGF-${\beta}1$, and IL-$1{\beta}$. Results : The expression of TNF-${\alpha}$ and TGF-${\beta}1$ were decreased until 12 hr after irradiation but elevated thereafter. The expression of IL-1 was peak at 8 hr and then decreased until 12 hr but elevated after this time window. The present study indicated that expression of cytokines (TNF-${\alpha}$, TGF-${\beta}1$ and IL-$1{\beta}$) were increased at 24 hr after the irradiation to the rat brain. IL-$1{\beta}$ level, on the other hand. reached peak at 8 hr after radiation injury. Conclusion : These findings indicate that IL-1, among various cytokines, may have a more important role in the inflammatory reaction by radiation injury at acute phase and provide some clues for better understanding of the pathogenesis of radiation injury.

기항지부(奇恒之腑)와 기경팔맥(奇經八脈)의 관련성 고찰 (A Study on The Association between Extraordinary Organs(奇恒之腑) and Eight Extra Meridians(奇經八脈))

  • 류정아;정창현
    • 대한한의학원전학회지
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    • 제27권2호
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    • pp.49-67
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    • 2014
  • Subject : The Association between Extraordinary Organs(奇恒之腑) and Eight Extra Meridians(奇經 八脈). Objectives : This study research some special aspects of Extraordinary Organs and Eight Extra Meridians which differentiated from ordinary Organs and Meridians, and the association between Extraordinary Organs and Eight Extra Meridians. Methods : First, researched classification standard and physiological characteristics of Extraordinary Organs through studying various chapters of HuangdiNeijing. Second, researched The Association between Extraordinary Organs and Eight Extra Meridians through studying on the origin of Eight Extra Meridians in HuangdiNeijing. Third, from accompanying researching the subject of Cheon-gye(天癸) and human body shape, draw synthetic hypothesis on the relationship among ordinary Meridians and Organs, muscles and skins of body shape, Extraordinary Organs and Eight Extra Meridians. Results & Conclusions : The following conclusions could be drawn. 1. Extraordinary Organs afford background for shaping human body. This is same as the properties of the earth which afford background for shaping all creations. The physiological characteristics of Extraordinary Organs is intermediation and regulation between Ki(氣) of Five Viscera & six Bowels and shape of muscles & skins in human body. 2. The origin of Eight Extra Meridians could be found in HuangdiNeijing. The collateral Meridians of the Uterus and Epiglottis Meridian are specifically formulated to supplying for the Uterus or Epiglottis. From this we can draw The Association between Extraordinary Organs and Eight Extra Meridians, that is Eight Extra Meridians are specifically formulated to supplying for Extraordinary Organs. 3. The Cheon-gye(天癸) is doing significant function in Eight Extra Meridians supplying for Extraordinary Organs. Cheon-gye concerned to growth, secondary sexual characters, generative function, aging process. Theses are all concerned with the changing of human body shape. Cheon-gye urge to change the body shape with following the human life cycle. 4. Human body has vertical symmetry because preserve its shape from the gravitational force. Eight Extra Meridians place at the middle or flank axis of human body, thus do physiological function that assistant human body have vertical symmetry shape. The purpose of shaping vertical symmetry is securing space what the inner Twelve Regular Meridians and Five Viscera & six Bowels create there own physical changes. On the other hand the inner changes need deviation between left and right because of mobility and circulation of force. But human body change the shape in the process of growth, reproduction, aging. Eight Extra Meridians play role at time of these processing, thus they deeply concerned to human's life cycle and reproduction. 5. Eight Extra Meridians and Extraordinary Organs were named 'Extra' because of some special aspects which differentiated from ordinary Meridians and Organs. All they play role to have vertical symmetry shape of human body and maintain the shape, thus they deeply concerned to the change of human life cycle. These shaping maintaining and the change of human life cycle are very special aspects of human body. So they needed to differently cognize separate to the ordinary changes of Five Viscera & six Bowels and Twelve Meridians at inner space.

2겹 판재 멀티포밍 장치에 관한 연구 (A study of Double Sheet Multi-forming Equipment)

  • 윤재웅;손옥종
    • 한국산학기술학회논문지
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    • 제18권3호
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    • pp.49-55
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    • 2017
  • 대부분의 모터 케이스는 방수기능과동심도, 직각도 품질 등이 우수한딥드로잉 제품을 채택하고 있으며 그외 방수기능이 필요없는 블로우모터, 시트모터 등 실내에 장착되는 모터 케이스는 멀티포밍 제조방법을 채택하고 있다. 딥드로잉 공정은 드로잉 성형, 트리밍 및 피어싱 등 약 12공정을 소화할수 있는 고가의 트랜스퍼 프레스가 필요하다. 하지만 멀티포밍 공법은 멀티포밍기 1대 또는 멀티포밍기 1대와 프레스 1대의 구성으로 이루어지기 때문에 저렴한 투자로도 완제품 생산이 가능하다. 멀티포밍기는 대부분 수입이 되는 고가설비 이고 국내 중소기업이 개발한 굽힘/전단가공 일체형 멀티포밍기는 생산원가를 줄이는데 부족하여 굽힘/전단 분리형 멀티포밍기를 본 연구를 통해 개발하였다. 일체형 멀티포밍기는 비교적 얇고 작은소형 제품을 제한적인 작업 방법으로 사용된다. 크고 소재가 두꺼운 제품은 전단 하중이 높아 단발 크랭크 프레스를 이용하고 블랭킹 후 멀티포밍기로 이동 작업자가 수작업으로 소재를 공급한다. 멀티포밍기에서 벤딩 작업이 이루어지면 다시 프레스로 이송해 치수를 교정한다. 이러한 작업공정 분산은 생산성 저하, 품질이슈 및 과도한 인원 투입으로 원가경쟁력 저하를 가져왔다 이에 굽힘/전단가공 공정분리와 설비자동화를 통하여 안정되고 원가가 절감되는 생산체계를 갖추고자 하는게 본 연구의 목적이다.

API J55강의 미세조직과 기계적 특성에 미치는 열처리 및 합금원소(B, Ti)의 영향 (Microstructures and Mechanical Properties of API J55 steel with Heat treatment conditions and Alloying elements(B, Ti))

  • 최종민
    • 한국산학기술학회논문지
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    • 제19권4호
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    • pp.69-76
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    • 2018
  • 본 연구에서는 유정용 강관의 열처리 조건 및 합금원소(B, Ti)에 따른 미세조직 및 기계적 성질을 조사하였다. 실험에는 J55, J55+B,Ti 강재를 사용하였고, 열처리 조건은 각각 오스테나이트 처리온도 ($880^{\circ}C$, $910^{\circ}C$, $940^{\circ}C$), 냉각방식 (수냉, 유냉), 템퍼링 온도 (미실시, $550^{\circ}C$, $650^{\circ}C$) 이다. 열처리 조건에 따라 얻어지는 미세조직을 예측하기 위해 J55, J55+B,Ti 강재의 화학적 성분을 기준으로 평형상태도와 CCT 곡선을 예측하였다. 시뮬레이션 결과 평형상태도는 A1, A3 온도가 약 $20^{\circ}C$ 감소하였고, CCT 곡선은 B, Ti이 첨가됨에 따라 ferrite와 bainite nose 부분이 오른쪽으로 이동하였다. J55, J55+B,Ti 강재의 CCT 곡선을 기준으로 냉각속도에 따른 martensite, bainite, ferrite등 예상되는 미세조직을 예측하였고, J55 강재의 미세조직 예측값은 실제 실험값과 유사한 양상을 나타내었지만. J55+B,Ti 강재의 예측값은 실제 실험값과는 차이가 있었다. 열처리 조건이 변화됨에 따라 martensite, bainite, ferrite 등 다양한 조직이 생성되었으며, 이는 경도, 강도 및 연신율에 밀접한 영향을 미쳤다. J55시편의 수냉의 경우 martensite 조직이 형성되었고, 유냉의 경우 bainite와 ferrite 조직이 형성되었지만, J55+B,Ti시편은 B의 첨가에 의한 경화능 향상으로 냉각방식에 관계없이 martensite 조직이 형성되었다. 전반적으로 B, Ti을 첨가하면서 기계적 성질은 향상되었고, quenching 이후의 시편보다 tempering 이후의 시편에서 크게 향상되었다. 이는 Ti의 첨가로 인해 생성된 미세한 석출물이 재결정시 결정립 성장을 억제하여 미세한 오스테나이트 결정립을 생성하였고, tempering 열처리 이후에도 결정립 미세화 효과가 큰 영향을 미친 것으로 판단된다.

롤러신발과 일반신발의 착용 후 보행 시 하지근의 근전도 비교 (The Effects of Wearing Roller Shoes on Muscle Activity in The Lower Extremity During Walking)

  • 채원식;임영태;이민형;김정자;김연정;장재익;박원균;진재흥
    • 한국운동역학회지
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    • 제16권3호
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    • pp.137-148
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    • 2006
  • The purpose of this study was to compare muscle activity in the lower extremity during walking wearing jogging and roller shoes. Twelve male middle school students (age: 15.0 yrs, height 173.7 cm, weight 587.7 N) who have no known musculoskeletal disorders were recruited as the subjects. Seven pairs of surface electrodes (QEMG8, Laxtha Korea, gain = 1,000, input impedance >$1012{\Omega}$, CMMR >100 dB) were attached to the right-hand side of the body to monitor the rectus femoris (RF), vastus medialis (VM), vastus lateralis (VL), biceps femoris (BF), tibialis anterior (TA), and medial (GM) and lateral gastrocnemius (GL) while subjects walked wearing roller and jogging shoes in random order at a speed of 1.1 m/s. An event sync unit with a bright LED light was used to synchronize the video and EMG recordings. EMG data were filtered using a 10 Hz to 350 Hz Butterworth band-passdigital filter and further normalized to the respective maximum voluntary isometric contraction EMG levels. For each trial being analyzed, five critical instants and four phases were identified from the recording. Averaged IEMG and peak IEMG were determined for each trial. For each dependent variable, paired t-test was performed to test if significant difference existed between shoe conditions (p<.05). The VM, TA, BF, and GM activities during the initial double limb stance and the initial single limb stance reduced significantly when going from jogging shoe to roller shoe condition. The decrease in EMG levels in those muscles indicated that the subjects locked the ankle and knee joints in an awkward fashion to compensate for the imbalance. Muscle activity in the GM for the roller shoe condition was significantly greater than the corresponding value for the jogging shoe condition during the terminal double limb stance and the terminal single limb stance. Because the subjects tried to keep their upper body weight in front of the hip to prevent falling backward, the GM activity for the roller shoe condition increased. It seems that there are differences in muscle activity between roller shoe and jogging shoe conditions. The differences in EMG pattern may be caused primarily by the altered position of ankle, knee, and center of mass throughout the walking cycle. Future studies should examine joint kinematics during walking with roller shoes.

건측(健測) 취혈(取穴) 다종(多種) 침자법(鍼刺法)이 백서(白鼠)의 신경병리성(神經病理性) 동통(疼痛)에 미치는 영향 (Effects of Acupuncture, Electro-acupuncture, Low Level He-Ne Laser Therapy at Oe-gwan($TE_5$) ${\cdot}$ Chogimup ($GB_{41}$) on L5 Spinal Nerve Ligation Model in Rats)

  • 정정희;조명래;위통순;류충열
    • Journal of Acupuncture Research
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    • 제24권5호
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    • pp.137-150
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    • 2007
  • Objectives : To find effects of acupuncture, electro-acupuncture, low level He-Ne laser therapy(LLLT) at $TE_5$, $GB_{41}$ in the neuropathic pain. We made experiment on rats ligated L5 spinal nerve like general herniation of nucleus pulposus(HNP). Methods : A model of neuropathic pain was made by isolating Left 5th lumbar spinal nerve of rats. Three days after the neuropathic surgery, acupuncture and LLLT, electro-acupuncture was injected at $TE_5$, $GB_{41}$ one time a day for a week. Each group was divided two. one is opposite side performed the surgery which is right, another is left side performed the surgery. After that, the author examined the withdrawal response of neuropathic rats' legs by van Frey filament and acetone stimulation. And also the author examined c-Fos, Nociceptin and KOR-3 in the midbrain central gray of neuropathic rats. Results : As we have observed the effect of mechanical allodynia, LT-R group were diminished on 6th day compared with control group, EA-L group, EA-R group and LT-L group were diminished on 7th day compared with control group. As we have observed the effect of cold allodynia, EA-R group were diminished on 6th day, 7th day compared with control group. As we have observed the effect of activity of c-Fos in the central gray part, EA-R group and LT-R group were diminished compared with control group. As we have observed the effect of activity of Nociceptin in the central gray part, EA-R group were a little increased compared with control group but it is not reliability. As we have observed the effect of activity of KOR-3 in the central gray part, EA-R group were significantly increased compared with control group. Conclusions : We have noticed that effect of acupuncture at opposite side of sickness and powerful stimulation could be more effective, because of EA-R group have more controllable effect all test we have done on the other hand EA-L group have only effect on mechanical allodynia. This study can be used in clinical therapy for neuropathic pain. But it is not reliability that Nociceptin have effectively to control pain. Therefore We have to follow up about that.

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온병(溫病)의 증상(症狀) 중(中) 반진(斑疹)에 관(關)한 문헌적(文獻的) 고찰(考察) (The Literature Study on Macula among the Symptoms of Warm Factor Disease)

  • 장윤정;류상채;김정순;전호성;유동희;김난영;정명수;이기남
    • 대한의료기공학회지
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    • 제11권1호
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    • pp.80-116
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    • 2009
  • It studies into viewpoints of 7 doctors of Wenbing studies on macula. The results concerning characteristics, remedy and prevention of macula are as follows; Macule does not protrude on the surface of skin and does not have any color change for external stimulus, but rash out on the surface and becomes white when pushed. It becomes macule when the blood leaks beneath skin as stomach-heat of yangming enters into blood system and damages it. On the other hand, when heat enters lung meridian, penetrates beneath the skin and congeals inside the vessel, it becomes rash. When you combine symptoms of body and pulse with numbers, color, shape and distribution status of macula, you can diagnose the depth of rash, seriousness, the possibility of treatment and prognosis of macula. The remedy for macule consists of cooling heat of yaming, removing heat from the blood and relieving feverish rash, and the one for rash consists of facilitating meridian with aroma, expelling pathogenic factors from muscles with drugs of pungent flavor and cool nature and clearing away heat from the blood systems. It relieves the inhibited functional activities of lung-Ki, and helps extermination of rash as well as clearing heat of the vessel. Also, it is the most important to preserve resin of stomach for every treatment. It is good to avoid expelling pathogenic factors with drugs of pungent flavor and warm nature, raising drugs and invigorating drugs during treating macula. Moreover, the patients should not over dose cold-natured drugs and purgative therapy. There are common clinical symptoms of macula in advance, so right recognition of symptoms can contribute to prevention of macula.

과학동산 운영에 관한 질적 연구 (A Qualitative Study of Running질 Science Garden질)

  • 채동현;이수영
    • 한국초등과학교육학회지:초등과학교육
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    • 제21권2호
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    • pp.263-288
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    • 2002
  • 'Science Garden' is a science program that develops acquirements of science & technology at an early stage through experiential study and inspire the spirit of scientific inquiry by carrying out laboratory work, science movie, science lecture, scientific work, outdoor activities, computer classes and science experiment which is hard to do through the regular educational course. It is targeted grade 4,5,6 students during summer and winter vacation. 'Science Garden' is conducted by selective participation freely. It is a wholelistic activity that develops children's potential talents or creativities, improves interest and attitude toward science, and also gives opportunity for self-realization by extending capacity for inquiry to show each student's ability. This study is observed and is compared how it is conducted in elementary school using qualitative study. This study is used narrative observation, in-depth interview and document analysis. Objects of narrative observation are two elementary schools, each from Jellabukdo and Gyeonggido, and 7 teachers were interviewed in-depthly. Here are results of the study. 1 A teacher in school G never takes part in student activities, tends to be indifferent to classes, but focuses on observation and experiment in laboratory. And feedback or evaluation about student's activity is never done. On the other hand, a teacher in school S guides students to understand the principals of science on themselves, and wide variety forms of activities such as role playing, discussion, and games are being done. But an effort to evaluate student's activity is not being made properly. 2. Teachers set a high valuation on the need of 'Science Garden'. Observing the way of conducting 'Science Garden', usually teachers who is in charge of science for official work is selected as a teacher in charge, and groan under a heavy burden of conducting it without anyone's help. Participating students are selected by volunteering or teacher's recommendation, but because of low Participation rate, teachers have difficulty in conducting it. Plan for conducting ‘science Garden’ is made 20 days before it, after getting an official document from Office of Education, refering to booklets produced by National Jungang Science Institute, or data from Office of Education, and internet. Teachers evaluate rarely Most school principals have interest in 'Science Garden' but parents are not well aware of it, The budget is made at the same time with the plan, and scale is varied between 200,000∼500,000 won. Because of the improper way of selecting teacher in charge, difficulty in selecting students, heavy works caused by planning, conducting the program, as well as reporting teacher's work, and lack of parents' awareness, 'Science Garden' has been conducted formally and superficially. Next gives you direction to change, for the right way of conducting' Science Garden'. It is important to motivate competent teachers to instruct students actively. For students' active participation, They should publicize thoroughly beforehand, and develope 'Science Garden' program for teachers to be able to make better use of it. Evaluation of student activities and program should be done in the aspect of developing students’ faculties. Beside of school facilities, they need to put diverse local facilities and places to practical use for immediate natural experience. And not only separate schools but also associated form of schools to conduct it is necessary.

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전략적 적합성 및 협력관계가 협력기업의 성과에 미치는 영향: 삼성전자 협력사를 대상으로 (The Effect of Strategic Fit and Cooperative Relationships on the Small Suppliers' Performance)

  • 이장우;김민재
    • 기업가정신과 벤처연구
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    • 제19권3호
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    • pp.57-74
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    • 2016
  • 본 연구는 부품공급 중소기업의 전략적 적합성과 대기업과의 협력관계가 부품공급 중소기업의 성과에 미치는 영향에 대해 조사하고자 한다. 이를 위해, 삼성전자의 1차 협력사 90개 기업을 대상으로 대기업과 전략적 적합성 및 대기업과의 협력관계가 중소기업의 기업성과에 미치는 영향을 분석하였다. 실증분석 결과, 전략적 적합성은 중소기업의 경영성과와 혁신성과 모두에 긍정적인 영향을 미치는 것으로 나타났다. 따라서 중소기업이 경쟁력을 제고시키기 위해서는 환경에 적합한 전략을 추구해야 한다는 기존 이론적 주장을 뒷받침한다. 둘째, 대기업과의 협력에 있어 기술 및 인력 협력과 협력의 질이 부품공급 중소기업의 경영성과와 혁신 성과 모두에 긍정적인 영향을 미치는 것으로 나타났다. 즉, 대기업과의 기술 및 인력 협력을 통해 부품공급 중소기업의 생산성 및 효율성을 제고시켜 경영성과를 높일 수 있을 뿐만 아니라, 혁신성과 역시 달성할 수 있음을 보여준다. 셋째, 대기업과의 기술 및 인력 협력과 협력의 질이 전략적 적합성과 혁신성과 간의 관계에서 상호작용 효과가 있는 것으로 나타났다. 이는 부품공급 중소기업이 환경의 불확실성이 높은 경우 차별화 전략을 추구하고 원청 대기업과 장기 지향적이고 상생적인 형태 협력을 수행함으로써, 더 많은 특허출원과 같은 혁신성과를 달성할 수 있음을 보여준다. 반면, 환경의 불확실성이 낮은 경우에는 원가우위 전략을 추구하고 원청 대기업과 기술 및 인력 협력을 수행함으로써, 더욱 큰 혁신성과를 달성할 수 있음을 시사한다. 본 연구는 이러한 연구결과를 토대로 부품공급 중소기업이 경쟁력을 창출하기 위해서는 환경에 적합한 경쟁전략의 선택과 실천뿐만 아니라, 원청 대기업과의 기술 및 인력 협력 강도와 협력의 질이 중요한 영향을 미침을 주장한다. 이러한 주장은 중소기업의 경쟁력 제고를 위해 경쟁과 협력이 모두 중요함을 시사한다.

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DITI를 이용한 갱년기 환자의 체열분포 양상 (Using DITI to examine the pattern of subcutaneous heat of the climacteric patients)

  • 김로사;최정은;김용석;이경섭
    • 대한한방체열의학회지
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    • 제1권1호
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    • pp.38-46
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    • 2002
  • 1. Objectives Among many symptoms that the climacteric patients complain of, the major subjective symptom is both heat in the upper part and cold in the lower part of the body(e.g foot, knee, and leg). We use DITI as a method to prove the symptoms of climacteric patients such as both heat in the upper part and cold in the lower part of the body, diagnose these symptoms, and follow up the progress of the clinical treatments. 2. Subjects and Methods We compare the subcutaneous heat of the climacteric patients with the symptom of heat in the upper part and cold in the lower part of the body with young women without any specific disease. The age distribution of the experimental group is 28 patients in 40's, and 22 in 50's. The mean age of the experimental group is $48.5{\pm}4.25$. The age distribution of the control group is 17 patients in teen, 26 in 20's, 7 in 30's. The mean age of the control group is $23.31{\pm}6.45$. We measure the subcutaneous heat on the cheeks, upper arms, palms, thighs, knees, dorsum pedis, lower back, hip, upper abdomen, lower abdomen of both groups and analyse the results. 3. Statistical methods All the results are statiscally analysed using student T-test of Microsoft Exel program. Statistically significant value by the analysis of variance procedure is P<0.05. 4. Results 1. The subcutaneous heat of the whole body of the experimental group shows hypothermia compared with control group, and the hypothermic pattern gets severe on the periphery. ${\Delta}T$ between the right and left side of the body in experimental group is larger than that of control group. 2. ${\Delta}T$ between the cheeks and the hypogastric in the experimental group is significantly larger than that of the control group, which shows cold face. 3. ${\Delta}T$ between the upper arms and the palms in the experimental group is significantly larger than that of the control group, which shows cold hand. 4. ${\Delta}T$ between the thighs and the knees in the experimental group is significantly larger than that of the control group, which shows cold knee. 5. ${\Delta}T$ between the thighs and the feet in the experimental group is significantly larger than that of the control group, which shows cold foot. 6. ${\Delta}T$ between the hip and the lower back in the experimental group is significantly larger than that of the control group. That shows the Lower back is warmer than the hip. 7. ${\Delta}T$ between the upper and the lower abdomen in the experimental group is significantly larger than that of the control group, which shows cold hypogastric.

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