• Title/Summary/Keyword: Rhabdomyolysis

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Acute Compartment Syndrome Induced by Rhabdomyolysis Due to Antipsychotic Drug Overuse (항정신병 약물 과량 복용 후 발생한 횡문근융해증으로 인한 급성 구획증후군)

  • Hwang, Seok-Ha;Hong, Sung-Ha;Suh, Seung-Pyo;Kim, Joo-Young
    • Journal of the Korean Orthopaedic Association
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    • v.55 no.3
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    • pp.276-280
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    • 2020
  • A 49-year-old male was found unconscious at his accommodation and visited the emergency room. He was on antipsychotic and antidepressant drugs (vortioxetine hydrobromide, mirtazapine, sertraline hydrochloride, quetiapine, and alprazolam) for schizophrenia and major depression. At the time of discovery there were signs of overdose of the drugs around the patient. A physical examination revealed, pain, pallor, and edema in the left buttocks and lateral thigh. Active ankle movements below the left ankle were not possible and sensations in the tibia and peroneal nerves were lost. The pressure in the buttock compartment was measured at 42 mmHg. Magnetic resonance imaging revealed edema and high intensity signals in the left hip muscles and surrounding soft tissue. An emergency fasciotomy was performed and partial restoration of the lower extremity sensation and muscle strength were achieved after 24 hours.

Toxicological Profiles of Poisonous, Edible, and Medicinal Mushrooms

  • Jo, Woo-Sik;Hossain, Md. Akil;Park, Seung-Chun
    • Mycobiology
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    • v.42 no.3
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    • pp.215-220
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    • 2014
  • Mushrooms are a recognized component of the human diet, with versatile medicinal properties. Some mushrooms are popular worldwide for their nutritional and therapeutic properties. However, some species are dangerous because they cause toxicity. There are many reports explaining the medicinal and/or toxic effects of these fungal species. Cases of serious human poisoning generally caused by the improper identification of toxic mushroom species are reported every year. Different substances responsible for the fatal signs and symptoms of mushroom toxicity have been identified from various poisonous mushrooms. Toxicity studies of mushroom species have demonstrated that mushroom poisoning can cause adverse effects such as liver failure, bradycardia, chest pain, seizures, gastroenteritis, intestinal fibrosis, renal failure, erythromelalgia, and rhabdomyolysis. Correct categorization and better understanding are essential for the safe and healthy consumption of mushrooms as functional foods as well as for their medicinal use.

$^{99m}Tc-MDP$ Scan in Rhabdomyolysis (횡문근융해증의 골스캔)

  • Zeon, Seok-Kil;Lee, Hee-Jung;Lee, Jae-Tae;Lee, Kyu-Bo
    • The Korean Journal of Nuclear Medicine
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    • v.26 no.1
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    • pp.106-110
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    • 1992
  • 외상, 만성간질환, 화상 및 전신성경련등의 원인으로 발생한 횡문근융해증 9예의 $^{99m}Tc-MDP$ 골스캔을 분석하여 다음과 같은 성적을 얻었다. 동통부위보다 넓은 전신성 병변이 44%에서 확인되었으며 나머지 56%는 국소 동통부위의 근육에만 Bone-seeking agent가 침착되는 것이 확인되있고, 골스캔만으로도 44%에서 신부전증이 동반되었음을 확인할 수 있었다. 전신성 병변은 원인과는 관계없이 출현하였고, 신부전증도 원인질환에는 관계없이 발생하였다. 1예에서 실시한 CT는 국소성 병변만을 보여 주었으나골스캔은 전신성 병변을 나타내어 주었다. 따라서 횡문근융해증의 진단에는 골스캔이 중요함을 확인해주었다.

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Incidence level of abnormality in creatine phosphokinase by statin

  • Kim, Yoo-Ni;Bae, Kyun-Seop;Jung, Sun-Hoi;Lee, Seung-Mi;Yoon, Kyoung-Eun;Kim, Hwa-Young;Chae, Young-Moon;Park, Byung-Joo
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.237-237
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    • 2002
  • Creatine phosphokinase (CPK) was a marker in diagnosis of rhabdomyolysis. The CPK abnormality could be induced by intake of HMG CoA reductase inhibitors (statins). The objective of this study was to estimate the incidence rate of CPK abnormality by each statin. (omitted)

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Equine Polysaccharide Storage Myopathy in an American Paint Horse (American Paint Horse에서의 다당류저장성근질환)

  • Yong, Hwan-Yul;Kim, Dae-Young
    • Journal of Veterinary Clinics
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    • v.23 no.4
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    • pp.469-471
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    • 2006
  • A 4-year-old, American Paint horse gelding with recurrent episodes of exertional rhabdomyolysis was diagnosed with equine polysaccharide storage myopathy (EPSSM). The common clinical signs were muscle weakness, loss of muscle mass, exercise intolerance, difficulty holding up limbs for farrier, sensitivity of grooming, cramping with reluctance to move and the inability to rise. Through histological examination of skeletal muscle specimens, this case was confirmed of EPSSM.

Statin-Induced Autoimmune Necrotizing Myopathy Responsive to Immunosuppressive Therapy (면역억제치료에 반응하는 statin에 의한 자가면역성 괴사성 근병증)

  • Park, Young-Eun;Seo, Jae-Deuk;Kim, Dae-Seong
    • Annals of Clinical Neurophysiology
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    • v.14 no.2
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    • pp.76-79
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    • 2012
  • Statin is commonly used for lowering cholesterols and can be myotoxic to cause drug-induced necrotizing myopathy. Statin-induced myopathy ranges from asymptomatic hyperCKemia to lethal rhabdomyolysis but is usually reversed by withdrawal of causative drugs. The patient in this study presented with statin-induced necrotizing myopathy, which was finally improved with immunosuppressive therapy, but not just with drug withdrawal. Since statin can induce myopathy through autoimmune processes, we should consider using immunomodulating agents in cases with statin-induced myopathy, which is refractory to drug withdrawal.

Drug-Induced Nephrotoxicity and Its Biomarkers

  • Kim, Sun-Young;Moon, A-Ree
    • Biomolecules & Therapeutics
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    • v.20 no.3
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    • pp.268-272
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    • 2012
  • Nephrotoxicity occurs when kidney-specific detoxification and excretion do not work properly due to the damage or destruction of kidney function by exogenous or endogenous toxicants. Exposure to drugs often results in toxicity in kidney which represents the major control system maintaining homeostasis of body and thus is especially susceptible to xenobiotics. Understanding the toxic mechanisms for nephrotoxicity provides useful information on the development of drugs with therapeutic benefits with reduced side effects. Mechanisms for drug-induced nephrotoxicity include changes in glomerular hemodynamics, tubular cell toxicity, inflammation, crystal nephropathy, rhabdomyolysis, and thrombotic microangiopathy. Biomarkers have been identified for the assessment of nephrotoxicity. The discovery and development of novel biomarkers that can diagnose kidney damage earlier and more accurately are needed for effective prevention of drug-induced nephrotoxicity. Although some of them fail to confer specificity and sensitivity, several promising candidates of biomarkers were recently proved for assessment of nephrotoxicity. In this review, we summarize mechanisms of drug-induced nephrotoxicity and present the list of drugs that cause nephrotoxicity and biomarkers that can be used for early assessment of nephrotoxicity.

Delayed death after chlorfenapyr poisoning (클로르페나피르 중독 후 지연성 사망)

  • Lee, Jang Young
    • Journal of The Korean Society of Clinical Toxicology
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    • v.19 no.1
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    • pp.51-54
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    • 2021
  • Chlorfenapyr is a widely used insecticide, that is very lethal if ingested. It exhibits delayed toxicity in which there are few symptoms at first which suddenly worsen after a few days. A 66-year-old female patient ingested about 90 mL of chlorfenapyr liquid hydrating agent (Chlofenapyr 10%) and showed stable vital signs with no specific symptoms and findings other than a mild fever, vomiting, and nausea. From the 3rd day of ingestion, creatine kinase was high, and rhabdomyolysis was suspected. From the 4th day of ingestion, pancreatic enzymes began to gradually increase. A diffusion-weighted image showed a multifocal high signal intensity in the white matter and corpus callosum area. On the 8th day after ingestion, she suffered a high fever and a heart attack and died. Thus, if a patient is suspected of taking chlorfenapyr, he/she needs active treatment and monitoring even if he/she does not exhibit any symptoms.

Very Long Chain Acyl-coenzyme A Dehydrogenase Deficiency: A Review of Pathophysiology, Clinical Manifestations, Diagnosis, and Treatment (장쇄 수산화 아세틸코에이 탈수소효소 결핍증에 대한 고찰)

  • Kang, Seokjin
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.22 no.1
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    • pp.21-27
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    • 2022
  • Very long-chain acyl-coenzyme A dehydrogenase (VLCAD) deficiency (VLCADD) leads to a defective 𝛽-oxidation, specifically during prolonged fasting, infection, or exercise. Patients with VLCADD usually suffer from cardiomyopathy, hypoketotic hypoglycemia, hepatic dysfunction, exercise intolerance, muscle pain, and rhabdomyolysis, and sometimes succumb to sudden death. VLCADD is generally classified into three phenotypes: severe early-onset cardiac and multiorgan failure, hypoketotic hypoglycemia, and later-onset episodic myopathy. Diagnostic evaluation comprises acylcarnitine analysis, genetic analysis, and VLCAD activity assay. In the acylcarnitine analysis, the key metabolites are C14:1, C14:2, C14, and C12:1. A C14:1 level >1 mmol/L strongly suggests VLCADD. Various treatment recommendations are available for this condition. Dietary management includes decreasing fat content, increasing medium-chain triglyceride levels, and decreasing fasting periods. Supplementation with L-carnitine is controversial. Triheptanoin (a seven-carbon fatty acid triglyceride) treatment demonstrates improvement of cardiac functions. Bezafibrate may improve the quality of life of patients with VLCAD.

The Clinical Manifestations of Patients with Severe Alcoholic Ketoacidosis Treated at a Medical Intensive Care Unit (한 내과계 중환자실에서 치료하였던 중증 알코올성 케톤산증 환자들의 임상적 특성)

  • Lee, Kwang Ha;Lee, Sae Hwan;Oh, Yeon-Mok;Shim, Tae Sun;Lim, Chae-Man;Lee, Sang Do;Koh, Yoonsuck;Kim, Woo Sung;Kim, Dong Soon;Kim, Won Dong;Hong, Sang Bum
    • Tuberculosis and Respiratory Diseases
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    • v.60 no.5
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    • pp.548-553
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    • 2006
  • Background : Alcoholic ketoacidosis(AKA) is a metabolic disturbance that is caused by prolonged and excessive alcohol consumption. Though the prognosis is reportedly good, its outcome is unclear in some cases that are combined with multi-organ failure. There are few reports of an analysis of cases admitted to an intensive care unit(ICU) Method: Cases of AKA admitted to the ICU over the last 5 years were retrospectively analyzed. Severe AKA was characterized by multi-organ failure that required treatment in an ICU Results : All patients were males with a history of excessive alcohol consumption. Five of them (50%) mainly complained of gastrointestinal symptoms (nausea, vomiting, diarrhea), showing metabolic acidosis with an increased asmolar and anion gap. Rhabdomyolysis with acute renal failure was the most common combined organ failure. Mechanical ventilation was performed in 80%. Six patients died and 4 patients survived. In the surviving patients, the arterial blood gas analysis(ABGA) was normalized within 12 hours after admission. Conclusion : In severe AKA patients, rhabdomyolysis with acute renal failure was the most common complication. The mortality rate was high and death from shock occurred within 3 days.