Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Statin-Induced Autoimmune Necrotizing Myopathy Responsive to Immunosuppressive Therapy

면역억제치료에 반응하는 statin에 의한 자가면역성 괴사성 근병증

  • Park, Young-Eun (Department of Neurology, Pusan National University School of Medicine) ;
  • Seo, Jae-Deuk (Department of Neurology, Pusan National University School of Medicine) ;
  • Kim, Dae-Seong (Department of Neurology, Pusan National University School of Medicine)
  • 박영은 (부산대학교 의학전문대학원 신경과학교실) ;
  • 서재득 (부산대학교 의학전문대학원 신경과학교실) ;
  • 김대성 (부산대학교 의학전문대학원 신경과학교실)
  • Received : 2012.08.01
  • Accepted : 2012.10.23
  • Published : 2012.12.30
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Abstract

Statin is commonly used for lowering cholesterols and can be myotoxic to cause drug-induced necrotizing myopathy. Statin-induced myopathy ranges from asymptomatic hyperCKemia to lethal rhabdomyolysis but is usually reversed by withdrawal of causative drugs. The patient in this study presented with statin-induced necrotizing myopathy, which was finally improved with immunosuppressive therapy, but not just with drug withdrawal. Since statin can induce myopathy through autoimmune processes, we should consider using immunomodulating agents in cases with statin-induced myopathy, which is refractory to drug withdrawal.

Keywords

References

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