• Biomolecules & Therapeutics
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• v.4 no.3
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• pp.224-231
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• 1996

DA-5018, a non-narcotic analgesic agent, was examined for mutagenicity in the reverse mutation test on bacteria, chromosomal aberration test on cultured mammalian cells and micronucleus test on mice. The reverse mutation test was performed by a plate incorporation method with or without a metabolic activation system(S9 mix) using Salmonella typhimurium strain TA100, TA1535, TA98 and TA1537. DA-5018 did not significantly increase revertant colonies in any of the test strains under any conditions at concentrations ranging from 0.0049 to 1.25 mg/plate, compared with the vehicle control. In the chromosomal aberration test using cultured Chinese Hamster Lung(CHL) cells, DA-5018 did not increase the number of aberrant cells in the presence or absence of S9 mix at concentrations of 0.016 mM/plate to 0.25 mM/plate, compared with the vehicle control. In the micronucleus test, male ICR mice were given DA-5018 intraperitoneally at a dose level of 0.55, 1.10 and 2.20 mg/kg. The incidence of bone marrow micronucleated polychromatic erythrocytes in the DA-5018 treated mice was not significantly different from that of the vehicle control. These results indicate that DA-5018 does not have mutagenic potential under the present test conditions.

• Nuclear Engineering and Technology
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• v.54 no.8
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• pp.3140-3153
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• 2022

A numerical feasibility study was conducted to investigate the thermal-hydraulic characteristics of a steam generator with corrugated plates for a small modular reactor. Accordingly, a one-dimensional thermal-hydraulic analysis code was developed based on the existing state-of-the-art thermal-hydraulic models and correlations for corrugated plate heat exchangers. Subsequently, the pressure loss, heat transfer, and instability characteristics of the steam generator with corrugated plates were investigated according to the chevron angle and mass flux. Additionally, the characteristics of rectangular and disk-type corrugated plate steam generators with equivalent heat transfer areas were analyzed. The steam generator with disk-type corrugated plates exhibited better performance in terms of pressure loss and heat transfer rate than the rectangular type. In addition, when the mass flux decreased from the onset of boiling points, reverse gradients of the total pressure change were observed in both types. Thus, it was confirmed that Ledinegg instability could occur in the steam generator with corrugated plates. However, it was dependent on the chevron angle, and the optimal chevron angle to minimize instability was 45° under the conditions of the present analysis.

• The Pure and Applied Mathematics
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• v.17 no.4
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• pp.321-332
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• 2010

In this paper, we experiment image warping and morphing. In image warping, we use radial basis functions : Thin Plate Spline, Multi-quadratic and Gaussian. Then we obtain the fact that Thin Plate Spline interpolation of the displacement with reverse mapping is the efficient means of image warping. Reflecting the result of image warping, we generate two examples of image morphing.

• Journal of Mechanical Science and Technology
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• v.19 no.11
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• pp.2061-2067
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• 2005

In this study, we focus on the submerged plate built into the Very Large Floating Structure with the partial openings of Sm long, which enables the reverse flow of incident wave to generate the wave breaking. The purpose of this study is to investigate the characteristics of wave exciting forces acting on the submerged plate and the fore part of VLFS. Firstly, we have carried out the extensive experiments to understand the characteristics of the wave exciting forces. Then we have performed the numerical simulations by applying the Marker and Cell method (MAC method) and compared with the experimental results. We discuss the validity of MAC method and the effects of the submerged plate on the motion of VLFS. As a result, we get the conclusion that the submerged plate is useful for reducing the wave exciting forces acting on the structure behind the submerged plate.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.20 no.12
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• pp.775-780
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• 2008

A dynamic model to simulate LNG reliquefaction process has been developed. The model was applied to two candidate cycles for LNG reliquefaction process, which are Reverse Brayton and Claude cycles. The simulation was intended to simulate the pilot plant under construction for operation of the two cycles and evaluate their feasibility. According to the simulation results, both satisfy control requirements for safe operation of brazed aluminum plate-fin type heat exchangers. In view of energy consumption, the Reverse Brayton cycle is more efficient than the Claude cycle. The latter has an expansion valve in addition to the common facilities sharing with the Reverse Brayton cycle. The expansion valve is a main cause to the efficiency loss. It generates a significant amount of entropy associated with its throttling and increases circulation flow rates of the refrigerant and power consumption caused by its leaking resulting in lowered pressure ratio. It is concluded that the Reverse Brayton cycle is more efficient and simpler in control and construction than the Claude cycle.

• Toxicological Research
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• v.35 no.3
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• pp.215-224
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• 2019

As various populations are rapidly becoming an aging society worldwide and interest in health issues has increased, demand for functional foods including herbal products has increased markedly to maintain a healthy state which has led to safety issues about their intake as an inevitable result. The objective of this study was to identify the safety profile of a Korean red ginseng and Salvia plebeia R. Br. extract mixture (KGC-03-PS) which is a valuable ingredient that can be used as a functional food. In the present study, the subacute oral toxicity and bacterial reverse mutagenicity of KGC-03-PS were evaluated. Sprague Dawley rats were administered KGC-03-PS orally for 28 days by gavage. Daily KGC-03-PS dose concentrations were 0, 500, 1,000, or 2,000 mg/kg body weight (bw) per day. Bacterial reverse mutation test with KGC-03-PS dose levels ranging from 312.5 to $5,000{\mu}g/plate$ was carried out by OECD test guideline No. 471. Five bacterial strains (Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli WP2) were tested in the presence or absence of metabolic activation by plate incorporation method. There were no toxicological effects related with test substance in the clinical evaluation of subacute oral toxicity test including clinical signs, body weight, and food consumption. Moreover, no toxicological changes related to KGC-03-PS were observed in the hematological and serum biochemical characteristics as well as in the pathological examinations, which included organ weight measurements and in the gross- or histopathological findings. KGC-03-PS did not induce an increase in the number of revertant colonies in all bacterial strains of the bacterial reverse mutation test. The no-observed-adverse-effect level of KGC-03-PS is greater than 2,000 mg/kg bw/day, and KGC-03-PS did not induce genotoxicity related to bacterial reverse mutations under the conditions used in this study.

• Journal of Food Hygiene and Safety
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• v.14 no.3
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• pp.259-264
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• 1999

To evaluate the bacterial reverse mutation of xylooligosaccharide(XO)s the in vitro Ames test using Salmonella typhimurium (TA9S, TAIOO, TA1535, TA1537) and Escherichia coli (WP2 uvrA) was performed. XO was negative in Ames test with Salmonella typhimurium and Escherichia coli with and without rat liver microsomal enzyme (S-9 fraction). According to the results, XO does not cause bacterial reverse mutation.

• Journal of Welding and Joining
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• v.28 no.5
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• pp.64-68
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• 2010

The purpose of this study is to develop the control technology of global distortion in the deck of superstructures during manufacturing processes. The behavior of global distortion in the deck was evaluated by FEA and verified through comparing with the measured results by 3D measuring instrument. It was seen from the results that the principal factor inducing the global distortion is to be the bending moment associated with the longitudinal shrinkage force and transverse shrinkage caused by welding of stiffeners and flame heating to correct the excessive local out-of-plane distortion. Based on the results, the amount of reverse distortion in the thin deck plate was determined to control the global distortion in the deck plate. The proposed distortion control technology was verified by applying it to the actual structure.

• Environmental Analysis Health and Toxicology
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• v.21 no.4 s.55
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• pp.317-322
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• 2006

We have investigated the genotoxicity of 1,2,4-trimethylbenzene using Ames reverse mutation test. In Ames reverse mutation test, 1,2,4-trimethylbenzene treatment at the dose of 100, 50, 25, 12.5, $6.25{\mu}g/plate$ did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and in Escherichia coli WP2uvrA with and without metabolic activation. These results indicate that 1,2,4-trimethylbenzene has no mutagenic potential under the rendition in this study.

• International Journal of Air-Conditioning and Refrigeration
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• v.17 no.4
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• pp.135-140
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• 2009

A dynamic model to simulate LNG reliquefaction process has been developed. The model was applied to two candidate cycles for LNG reliquefaction process, which are Reverse Brayton and Claude cycles. The simulation was intended to simulate the pilot plant under construction for operation of the two cycles and evaluate their feasibility. According to the simulation results, both satisfy control requirements for safe operation of brazed aluminum plate-fin type heat exchangers. In view of energy consumption, the Reverse Brayton cycle is more efficient than the Claude cycle. The latter has an expansion valve in addition to the common facilities sharing with the Reverse Brayton cycle. The expansion valve is a main cause to the efficiency loss. It generates a significant amount of entropy associated with its throttling and increases circulation flow rates of the refrigerant and power consumption caused by its leaking resulting in lowered pressure ratio. It is concluded that the Reverse Brayton cycle is more efficient and simpler in control and construction than the Claude cycle.