Browse > Article

Bacterial Reverse Mutation Test of 1,2,4-trimethylbenzene  

Kim, Soo-Jin (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute)
Cho, Hae-Won (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute)
Rim, Kyung-Taek (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute)
Maeng, Seung-Hee (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute)
Kim, Hyeon-Yeong (Toxicological Research Team, Chemical Safety&Health Center, Occupational Safety & Health Research Institute)
Publication Information
Environmental Analysis Health and Toxicology / v.21, no.4, 2006 , pp. 317-322 More about this Journal
Abstract
We have investigated the genotoxicity of 1,2,4-trimethylbenzene using Ames reverse mutation test. In Ames reverse mutation test, 1,2,4-trimethylbenzene treatment at the dose of 100, 50, 25, 12.5, $6.25{\mu}g/plate$ did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and in Escherichia coli WP2uvrA with and without metabolic activation. These results indicate that 1,2,4-trimethylbenzene has no mutagenic potential under the rendition in this study.
Keywords
reverse mutation; 1,2,4-trimethylbenzene;
Citations & Related Records
연도 인용수 순위
  • Reference
1 국립환경과학원. 고시 제2006-4호 '화학물질유해성시험연구기관의 지정 등에 관한 규정', 2006
2 Maron DM and Ames BN. Revised Methods for the Salmonella Mutagenicity Test, Mutation Res 1983; 113: 173-215   DOI
3 US Environmental Protection Agency. Chemicals in the Environment: OPPT chemical fact sheets, 2006; EPA 749-F-94-022. http://www.epa.gov/chemfact
4 노동부. 고시 제2002-8호 '화학물질 및 물리적인자의 노출기준', 2002
5 산업안전보건법 제38조 [제조 등의 허가], 2006
6 산업보건기준에 관한 규칙 '제11장 관리대상유해물질에 의한 건강장해 예방', 2003
7 한국산업안전공단. 1, 2, 4-trimethylbenzene의 물질안전보건자료 (MSDS), 안전보건정보서비스 (KOSHANET), 2006. http://www.kosha.net/shdb/msds/main.jsp
8 National Institute of Occupational Safety and Health. Registry of Toxic Effects of Chemical Substances 1998; DHHS(NIOSH) Publication No. 97-119
9 National Library of Medicine. Specialized Information Services, 2004. http://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp
10 Organisation for Economic Co-operation and Development (1997). OECD Guidelines for the Testing of Chemicals TG471. Bacterial Reverse Mutation Test. 1997
11 노동부. 화학물질별 취급 제조업체 현황, 2004
12 산업안전보건법 제37조 [제조 등의 금지], 2006