• Journal of Korean Clinical Nursing Research
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• v.27 no.1
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• pp.54-65
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• 2021

Purpose: The purpose of this study was to identify influencing factors on vision-related quality of life in patients with retinal diseases receiving intravitreal injections by examining relationships among anxiety, depression, coping, eye health behaviors and vision-related quality of life. Methods: One hundred and five outpatients who were diagnosed with macular degeneration and diabetic retinopathy were recruited from one university hospital during August 16, 2019 to March 25, 2020. Data were analyzed using descriptive statistics (frequency and percentage, mean, standard deviation), and t-tests, ANOVA, Scheffé test, Pearson's correlations, and stepwise multiple regressions using the IBM SPSS Statistics 25.0. Results: The vision-related quality of life according to general characteristics of retinal disease patients with intravitreal injection showed significant differences in age (F=3.01, p=.034), subjective economic status (F=5.83, p=.004), types of retinal disease (t=2.62, p=.010), and disease in both eyes (t=-3.04, p=.003). The vision-related quality of life showed a significant positive correlation with age (r=.24, p=.012), and negative correlations with anxiety (r=-.66, p<.001), depression (r=-.48, p<.001), and emotion-focused coping (r=-.20, p=.036). The hierarchical regression analysis indicated that factors affecting vision-related quality of life in patients with retinal diseases were anxiety and subjective economic status, accounting for 47.0% of the variances of the vision-related quality of life. Conclusion: Based on our results, health professionals need to pay attention to patients with low socioeconomic status due to frequent treatments. Also, a program needs to be developed to decrease anxiety for outpatients receiving intravitreal injections to improve their vision-related quality of life.

• Current Optics and Photonics
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• v.8 no.2
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• pp.183-191
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• 2024

High-resolution retinal imaging based on adaptive optics (AO) is important for early diagnosis related to retinal diseases. However, in practical applications, closed-loop AO correction takes a relatively long time, and traditional open-loop correction methods have low accuracy in correction, leading to unsatisfactory imaging results. In this paper, a SH-U-net-based open-loop AO wavefront correction method is presented for a retinal AO imaging system. The SH-U-net builds a mathematical model of the entire AO system through data training, and the Root mean square (RMS) of the distorted wavefront is 0.08λ after correction in the simulation. Furthermore, it has been validated in experiments. The method improves the accuracy of wavefront correction and shortens the correction time.

• Journal of Biomedical Engineering Research
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• v.16 no.2
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• pp.121-128
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• 1995

Information about retinal blood vessels can be used in grading disease severity or as part of the process of automated diagnosis of diseases with ocular menifestations. In this paper, we address the problem of detecting retinal blood vessels and optic disk (papilla) in eye-fundus images. We introduce an algorithm for feature extraction based on Fuzzy Clustering algorithm (fuzzy c-means). A method of finding the optic disk (papilla) is proposed in the eye-fundus images. Additionally, the inrormations such as position and area of the optic disk are extracted. The results are compared to those obtained from other methods. The automatic detection of retinal blood vessels and optic disk in the eye-rundus images could help physicians in diagnosing ocular diseases.

• Proceedings of the KOSOMBE Conference
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• v.1993 no.11
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• pp.27-30
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• 1993

Information about retinal blood vessels can be used in grading disease severity or as part of the process of automated diagnosis of diseases with ocular menifestations. In this paper, we address the problem of detecting retinal blood vessels and optic disk (papilla) in Eye-fundus images. We introduce an algorithm for feature extraction based on Fuzzy festering(FCM). The results ore compared to those obtained with other methods. The automatic detection of retinal blood vessels and optic disk in the Eye-fundus images could help physicians in diagnosing ocular diseases.

• Journal of Veterinary Clinics
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• v.24 no.2
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• pp.154-159
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• 2007

The objective of this retrospective study was to investigate the prevalence of retinal diseases in dogs presented to the Veterinary Medical Teaching Hospital, Seoul National University from April 2004 to December 2005. Sixty-five dogs (120 eyes) with retinal diseases involving blindness were included in this study. Age, breed, and gender data for all breeds were collected from medical records documenting vision loss. Generalized progressive retinal atrophy (gPRA) was the most common manifestation. Other prevalent findings included sudden acquired retinal degeneration (SARD) and retinal detachment (RD). Bilateral gPRA was found in 32 dogs with a female-to-male ratio of 1 : 1. The mean $age{\pm}SD$ of all dogs in this group was $4.66{\pm}2.30$ years with a range of 3 to 12 years. Breeds with highest prevalence of gPRA were Miniature Schnauzer (24/32, $mean{\pm}SD$ age: $3.79{\pm}0.78$ yr) and Poodle (2/32, $6.50{\pm}0.71$ yr). Twelve dogs (24 eyes) were diagnosed with SARD bilateraly, ranging from 3 to 13 years of age ($mean{\pm}SD:\;6.91{\pm}2.61$ yr). There were no abnormalities in fundus of 11 dogs at presentation. Electroretinography (ERG) without anesthesia was performed in 7 dogs, and all response was totally extinguished. Retinal detachment was identified in 21 dogs (32 eyes): 11 bilateral and 10 unilateral (7 right eye, 3 left eye). The most common breed was Shih Tzu (15/21, $mean{\pm}SD$ age: $4.39{\pm}3.24$ yr). Four other breeds comprised the remaining 6 cases (8 eyes). The everall mean age of the group was: $4.18{\pm}2.89$ years (range 0.8 to 14 years) with a female-to-male ratio of 1 : 1.1 (10 females, and 11 males).

• Journal of Korea Multimedia Society
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• v.23 no.12
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• pp.1476-1485
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• 2020

Segmenting OCT retinal images into layers is important to diagnose and understand the progression of retinal diseases or identify potential symptoms. The task of manually identifying these layers is a difficult task that requires a lot of time and effort even for medical professionals, and therefore, various studies are being conducted to automate this using deep learning technologies. In this paper, we use cGAN-based neural network to automatically segmenting OCT retinal images into seven terrain-type regions defined by six layer boundaries. The network is composed of a Segnet-based generator model and a discriminator model. We also proposed a dynamic programming algorithm for refining the outputs of the network. We performed experiments using public OCT image data set and compared its performance with the Segnet-only version of the network. The experimental results show that the cGAN-based network outperforms Segnet-only version.

• Clinical and Experimental Pediatrics
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• v.65 no.3
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• pp.115-126
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• 2022

Retinopathy of prematurity (ROP) is among the most common causes of childhood blindness. Three phases of ROP epidemics have been observed worldwide since ROP was first described in the 1940s. Despite advances in neonatal care, the occurrence of ROP and associated visual impairment has been increasing somewhere on Earth and remains difficult to control. Conventional treatment options for preventing ROP progression include retinal ablation using cryotherapy or laser therapy. With the emergence of anti-vascular endothelial growth factor (anti-VEGF) treatment for ocular diseases, the efficacy and safety of anti-VEGF therapy for ROP have recently been actively discussed. In the advanced stage of ROP with retinal detachment, surgical treatment including scleral buckling or vitrectomy is needed to maintain or induce retinal attachment. At this stage, the visual outcome is usually poor despite successful anatomical retinal attachment. Therefore, preventing ROP progression by timely screening examinations and treatment remains the most important part of ROP management.

• Clinical and Experimental Reproductive Medicine
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• v.38 no.4
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• pp.216-221
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• 2011

Objective: To differentiate the human embryonic stem cells (hESCs) into the retinal pigment epithelium (RPE) in the defined culture condition and determine its therapeutic potential for the treatment of retinal degenerative diseases. Methods: The embryoid bodies were formed from hESCs and attached on the matrigel coated culture dishes. The neural structures consisting neural precursors were selected and expanded to form rosette structures. The mechanically isolated neural rosettes were differentiated into pigmented cells in the media comprised of N2 and B27. Expression profiles of markers related to RPE development were analyzed by reverse transcription-polymerase chain reaction and immunostaining. Dissociated putative RPE cells ($10^5$ cells/5 ${\mu}L$) were transplanted into the subretinal space of rat retinal degeneration model induced by intravenous sodium iodate injection. Animals were sacrificed at 1, 2, and 4 weeks after transplantation, and immnohistochemistry study was performed to verify the survival of the transplanted cells. Results: The putative RPE cells derived from hESC showed characteristics of the human RPE cells morphologically and expressed molecular markers and associated with RPE fate. Grafted RPE cells were found to survive in the subretinal space up to 4 weeks after transplantation, and the expression of RPE markers was confirmed with immunohistochemistry. Conclusion: Transplanted RPE cells derived from hESC in the defined culture condition successfully survived and migrated within subretinal space of rat retinal degeneration model. These results support the feasibility of the hESC derived RPE cells for cell-based therapies for retinal degenerative disease.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.2
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• pp.26-44
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• 2023

Objectives : This study was designed to examine and analyze the recent trend of Korean medicine research on retinal and optic nerve diseases, which is increasing. Methods : This study examines papers related to diseases occurring in the retina and optic nerve that were published in Korean journals of Korean medicine, and analyzes the results of research so far by classifying them by year, journal, disease type and type of paper. Results : 1. Since it was first published in 1995, a total of 17 articles have been published until 2018, with 2 articles(11.1%) each in 1997, 2014 and 2018, and 1 article(5.6%) each in other years. 2. The number of searched journals was 17 paper; 4 review articles, 1 original articles, 12 case reports. 3. Distribution of journals; the percentage of Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology ranked the highest(41.2%). 4. Classification of 12 case reports into three categories; 7 retinal diseases, 3 optic nerve diseases, 2 other diseases. Conclusions : Currently, researches on retinal and optic nerve involvement in the Korean medicine journals have been conducted mainly through case reports. In the future, more clinical research and case reports are necessary to give practical application to patients.

• Childhood Kidney Diseases
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• v.5 no.2
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• pp.210-212
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• 2001

Retinal detachment is a rare disease in children but cases of serous retinal detachment due to use of systemic corticosteroids have been reported in and out country Rhematogenous retinal detachment has developed in a child with oral and steroid pulse therapy due to nephrotic syndrome. He was treated with laser and buckling in right and left eye respectively. Currently he is under observation through the out patient department. (J. Korean Soc Pediatr Nephrol 2001 ; 5 : 210-12)