• Biotechnology and Bioprocess Engineering:BBE
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• 제5권4호
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• pp.219-226
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• 2000

The application of recombinant DNA technology to restructure metabolic net-work can change metabolite and protein products by altering the biosynthetic pathways in an organism. Although some success has been achieved, a more detailed and thorough investigation of this approach is certainly warranted since it is clear that such methods hold great potential based on the encouraging results obtained so far. In last decade, there have been tremendous advances in the field of glycobiology and the stage has been set for the biotechnological production of glycoproteins for therapeutic use. Today glycoproteins are one of the most important groups of pharmaceutical products. In this study the attempt was made to focus on identifying technologies that may have general application for modifying glycosylation pathway of the yeast cells in order to produce glycoproteins of therapeutic use. The carbohydrates of therapeutic recombinant glycoproteins play very important roles in determining their pharmacokinetic properties. A number of biological interactions and biological functions mediated by glycans are also being targeted for therapeutic manipulation in vivo. For a commercially viable production of therapeutic glycoproteins a metabolic engineering of a host cell is yet to be established.

• 대한예방한의학회지
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• 제9권2호
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• pp.17-41
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• 2005

Current Korean medical system is evaluated as inefficient and the government is planning a new medical development plan to provide guaranteed life-long medical service and more efficient medical system Korean medicine also needs to participate as the primary medical provider and strengthen public recognition. The needs for active participation are essential to prevent irrational medical policies and Korean medicine can exercise medical merits. When the doctors of Korean medicine are recognized as the primary medical provider, not only social rights are served but also provide medical service to less privileged sector of the society. This calls for the establishment of system for attending physician and public health doctor from Korean medicine. Another important issue is the establishment of public medical service at the government level. Doctors of Korean medicine should be posted at the national health center and other public hospitals. Revision of the current policies on Korean medicine must be made to yield concrete outcome of the public Korean medicine service as well as cooperation between the conventional allopathic medical community and the Korean medical community

• Biomolecules & Therapeutics
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• 제10권3호
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• pp.202-207
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• 2002

The hepato-protective activity of the GODEX (Hepadif-s capsule) has been studied in the rats against $CCl_4$-ethanol induced liver toxicity. The rats were oral1y treated with $CCl_4$ (corn oil/ $CCl_4$ 1:1, 1 mg/kg). And one week passes, $CCl_4$(0.4 mg/kg) administered two times a week for 7 weeks. The drugs have been administered every two days for 4 weeks after $CCl_4$ injection. The experimental groups have consisted of the GODEX (250 mg/kg), Hepadif (200 mg/kg), DDB complex (DDB 50 mg/kg and garlic oil powder 50 mg/kg), DDB (50 mg/kg), and vehicle control respectively. There was a significant decrement on the serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin in all treated groups. Specially, ALT level of GODEX and Hepadif only treated groups was decreased c1early. Also, serum albumin level was significantly enhanced in GODEX treated group compared with control and DDB treated groups. In histological results, hepatocellular vacuolar degeneration, lobular restructure and necrosis of bile duct were severely showed in control. But other treated groups showed centerilobular degeneration and mild hyper-plasia. Hepadif or DDB has a effects of the recovery on serum parameters and structure ill liver injury. When it was compared GODEX to Hepadif alone or DDB complex or DDB, it suggested to have the best activity of the liver recovery.

• 보건행정학회지
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• 제18권2호
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• pp.107-129
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• 2008

The purpose of this paper is to critically examine Korean government's efforts in policy making and implementation regarding the Korea National Health Insurance System in the past and suggest a new paradigm for future policy changes. The structural and political characteristics of the Korea National Health Insurance, where health care services are provided almost exclusively by the private providers and funding for health comes equally from public and private sources, imply persistent difficulties in the operation of the system This may partially explain why the Korean system has continually experienced conflicts among stakeholders whenever there was an attempt to change policy. In this paper, we discuss four cases to illustrate such difficulties and barriers. We propose that in order to address these challenges and reduce policy errors as well as unintended results, it is necessary to restructure policy making process from being oriented toward 'quantitative expansion' to 'qualitative maturity', from a 'linear thinking' to a 'system thinking', from taking a 'top-down' to a 'governance and participatory' decision making process.

• 정보처리학회논문지D
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• 제8D권1호
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• pp.54-61
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• 2001

소프트웨어 아키텍쳐는 설계 과정 동안 수정과 대체로 인해 변경될 수 있고, 소프트웨어 개발에 적합한 설계는 하나 이상 존재할 수 있으므로 개발자는 다양한 관점에서 설계된 아키텍쳐의 서로 다른 버전들을 유지 관리할 수 있는 방법과 아키텍쳐의 변경 요소들을 효율적으로 명세할 수 있는 방법이 필요하다. 본 논문에서는 기존에 이미 정의되어 있는 아키텍쳐와 이를 재사용하여 설계한 새로운 아키텍쳐를 통합한 구조의 소프트웨어 아키텍쳐로 재구성할 수 있는 방법과 재구성 아키텍쳐 명세에 필요한 명세 요소와 명세 구조에 대해 정의하고 있다. 제안된 통합 구조의 명세 방법은 아키텍쳐 설계 과정에서 다양한 개발자 관점에서 정의된 아키텍쳐들을 참조 및 재사용할 수 있는 방법을 제공한다.

• International Journal of Contents
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• 제7권2호
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• pp.32-35
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• 2011

This research would be the first step toward in the long processes of proton technology industrial cluster development by focusing on the region's readiness and acceptability of the proton technology project. As is shown in our questionnaire survey, the top priorities needed to consider for the Proton Technology project are found to be job creation (mean 3.74), regional economic development (mean 3.72), industry infrastructure(3.54), institution for science and education(3.53), economic inequalities(3.33), tourism industry revitalization(3.20). For public servants top priorities in order found to be regional economic development, job creation, industry infrastructure, institution for science and education, economic inequalities, tourism industry revitalization. Universities' priorities in order found to be job creation, regional economic development, institution for science and education, industry infrastructure, economic inequalities, tourism industry revitalization. The mean reliability score for the each party was found to be mayor((3.04), citizens(2.99), province(2.97), private corporation(2.96), and universities((2.93). Of particular note, the mean score except the mayor were all below median (3.00). province(3.24), city council member(3.20), public employees (3.09), private corporation(3.03), nonprofit organization (2.97), mass media (2.96), citizens(2.96), and universities(2.89). The universities and colleges also should revise their strategic plans and thus restructure their internal academic programs, and must develop their own collaborative programs with Proton Engineering Frontier Project, related industries, city, and other government units. Not only educating, training, and providing top-notched man powers to the proton technology industries will be one of their primary missions.

• 자원ㆍ환경경제연구
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• 제10권2호
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• pp.135-159
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• 2001

This study analyses the energy consumption increase by using a physical production index (PPI) based decomposition method. The energy efficiency of the Korean industry deteriorated to a large extent in the 1992 to 1997 period. This outcome, however, does not contradict the result of a previous study that the physical energy intensities (measured by energy use per production unit) decreased in four Korean energy intensive industries such as steel, cement, petrochemical and pulp and paper in the same period. Although the physical energy intensities in four industries considered decreased significantly, the energy efficiency of the Korean industry deteriorated because the increase in the value-added production was smaller than that in the physical production except for the steel industry. This outcome suggests that the reduction in the physical energy intensity alone will not result in reducing the economic energy intensity, thereby reducing the increase in the energy consumption of the Korean industry. Therefore, it necessitates to restructure the Korean industry towards a higher value-added production and to strengthen energy efficiency improvement efforts in the Korean industry. As the overinvestment in the energy intensive industries caused a deep price fall of Korean products and a reduction of the value added of the Korean industry and with it an increase in the economic energy intensity, a decrease in this intensity will highly depend on reducing the overcapacity in the energy intensive industries which was partly responsible for the currency and economic crisis of 1997.

• Journal of Electrical Engineering and Technology
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• 제13권2호
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• pp.568-579
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• 2018

Virtual power plants can be regarded as systems that have entered the network after restructure of power systems. In fact, these plants are a set of consumers capable of consuming and generating power. In response to widespread implementation of plug-in hybrid electric vehicles, further investigation of energy management in this type of power plants seems to be of great value. In effect, these vehicles are able to receive and inject power from/into the network. Hence, study of the effects of these vehicles on management of virtual power plants seems to be illuminative. In this paper, management of power consumption/generation in virtual power plants has been investigated in the presence of hybrid electric vehicles. The objective function of virtual power plants problem management is to minimize the overall costs including not only the costs of energy production in power generation units, fuels, and degradation of batteries of vehicles, but also the costs of purchasing electricity from the network. Furthermore, the constraints on the operational of plants, loads and hybrid vehicles, level of penalty for greenhouse gas emissions ($CO_2$ and $NO_x$) produced by power plants and vehicles, and demand response to the immediate price of market have all been attended to in the present study. GAMS/Cplex software system and sample power system have been employed to pursue computer implementation and simulation.

• 문화기술의 융합
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• 제4권1호
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• pp.279-284
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• 2018

최근 개인화에 대한 관심이 높아지면서 교육에서도 학생 개개인에게 맞는 학습 콘텐츠를 제공하고자 하는 요구가 높아지고 있다. 특히, 온라인 교육이 대중화되면서 기존 오프라인 교육에서의 획일적인 교육에서 벗어나 학생의 개인 학습 성취도에 따라 학생 수준에 맞는 콘텐츠로 재구성하여 전달할 수 있게 되었다. 이에 본 논문에서는 동적 프로파일 기반으로 학생 로그 정보를 분석하여 순서 변경, 구성 확장, 구성 축소가 가능한 학습 콘텐츠를 재구성하는 서비스를 제안한다. 이를 위해 본 논문에서는 학생 정보와 콘텐츠 정보를 메타데이터로 기록하여 동적으로 프로파일을 생성, 반영하여 학생 상황인지를 통해 학습 콘텐츠를 재구성하는 엔진을 설계하였다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제29권5호
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• pp.289-294
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• 2002

다층신경회로망 구조의 재구성은 회로망의 일반화 능력이나 효율성의 관점에서 중요한 문제로 연구되어왔다. 본 논문에서는 신경회로망에 학습된 은닉 지식들을 추출하여 조합함으로써 신경회로망의 구조를 재구성하는 새로운 방법을 제안한다. 먼저, 각 노드별로 학습된 대표적인 지역 규칙을 추출하여 각 노드의 불필요한 연결구조들을 제거한 후, 이들의 논리적인 조합을 통하여 중복 또는 상충되는 노드와 연결구조를 제거한다. 이렇게 학습된 지식을 분석하여 노드와 연결구조를 재구성한 신경회로망은 처음의 신경회로망에 비하여 월등히 감소된 구조 복잡도를 가지며 일반적으로 더 우수한 일반화 능력을 가지게 됨을 실험결과로서 제시하였다.