• Korean Journal of Child Studies
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• v.36 no.5
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• pp.173-188
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• 2015

The main purpose of this study was to investigate the effects of a mother's big five personality factors and playfulness on maternal parenting behavior. The participants consisted of 270 mothers with young children, aged 3-6 years old. The subjects completed questionnaires on IPIP(International Personality Item Pool), PAS(Playfulness Scale for Adults) and Parenting Behavior. The results were as follows. First, regarding the relationships of the mother'personality and parenting behavior, higher levels of neuroticism(N) in the mothers resulted in lower levels of warmth acceptance(W A) in parenting behavior. Higher levels of extroversion(E), openness(O), agreeableness(A), and conscientiousness(C) resulted in higher levels of W A. In terms of the relationships of the mother's playfulness and parenting behavior, higher levels of playfulness resulted in higher levels of W A. and lower levels of permissiveness nonintervention(P N) and rejection restriction(R R). Second, N, E, C, and a maternal sense of humor had an effect in W A. C was found to have an effect in P N and N was observed to have an effect in R R.

• Journal of Preventive Medicine and Public Health
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• v.52 no.5
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• pp.281-291
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• 2019

Objectives: The validity of instruments measuring socioeconomic position (SEP) has been a major area of concern in research on cardiovascular health disparities. The purpose of this systematic review is to identify the current status of the methods used to measure SEP in research on cardiovascular health disparities in Korea and to provide directions for future research. Methods: Relevant articles were obtained through electronic database searches with manual searches of reference lists and no restriction on the date of publication. SEP indicators were categorized into compositional, contextual, composite, and life-course measures. Results: Forty-eight studies published from 2003 to 2018 satisfied the review criteria. Studies utilizing compositional measures mainly relied on a limited number of SEP parameters. In addition, these measures hardly addressed the time-varying and subjective features of SEP. Finding valid contextual measures at the organizational, community, and societal levels that are appropriate to Korea's context remains a challenge, and these are rarely modeled simultaneously. Studies have rarely focused on composite and life-course measures. Conclusions: Future studies should develop and utilize valid compositional and contextual measures and appraise social patterns that vary across time, place, and culture using such measures. Studies should also consider multilevel influences, adding a focus on the interactions between different levels of intertwined SEP factors to advance the design of research. More attention should be given to composite and life-course measures.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.3
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• pp.309-319
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• 2019

Phytochemicals which exist in various plants and fungi are non-nutritive compounds that exert numerous beneficial bioactive actions for animals. In recent years following the restriction of antibiotics, phytochemicals have been regarded as a primal selection when dealing with the challenges during the producing process in the poultry industry. The selected fast-growing broiler breed was more fragile when confronting the stressors in their growing environments. The disruption of oxidative balance that impairs the production performance in birds may somehow be linked to the immune system since oxidative stress and inflammatory damage are multi-stage processes. This review firstly discusses the individual influence of oxidative stress and inflammation on the poultry industry. Next, studies related to the application of phytochemicals or botanical compounds with the significance of their antioxidant and immunomodulatory abilities are reviewed. Furthermore, we bring up nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor kappa B ($NF-{\kappa}B$) for they are respectively the key transcription factors involved in oxidative stress and inflammation for elucidating the underlying signal transduction pathways. Finally, by the discussion about several reports using phytochemicals to regulate these transcription factors leading to the improvement of oxidative status, heme oxygenase-1 gene is found crucial for Nrf2-mediated $NF-{\kappa}B$ inhibition.

• Research in Community and Public Health Nursing
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• v.33 no.1
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• pp.63-73
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• 2022

Purpose: The purpose of this study was to identify the predictors influencing fear of falling in community-dwelling elderly women with mild cognitive impairment (MCI). Methods: A secondary data analysis was performed using data of 65 years or older elderly women with MCI participating in the 7th Korea Longitudinal Study of Ageing of the Korea Employment Information Service. The study subjects included 368 elderly women with MCI. For data analysis, descriptive statistics and logistic regression with complex samples were performed using IBM SPSS ver. 23.0. Results: 89.9% of the elderly women with MCI had fear of falling. There were significant factors such as religion (OR=8.85, 95% CI: 3.39~23.15), restriction of activity (OR=6.84, 95% CI: 2.14~21.90), depression (OR=0.75, 95% CI: 0.62~0.90), and MMSE (OR=1.30, 95% CI: 1.03~1.63), predicting fear of falling in community-dwelling elderly women with MCI. Conclusion: Differentiated strategies should be developed for elderly women with MCI to decrease fear of falling and prevent falls with understanding of contributing factors. This study will provide fundamental information on programming and a policy proposal related to fear of falling for elderly women with MCI.

• Neonatal Medicine
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• v.17 no.1
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• pp.53-63
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• 2010

Purpose : Extrauterine growth restriction (EUGR) in preterm infants is a major problem in neonatal intensive care units (NICUs) and it has been related to long-term growth deficit and neurodevelopmental issues. The aim of this study was to investigate the frequency of and risk factors for EUGR. Methods : The study subjects consisted of very low birth weight (VLBW) infants with a gestational age $\leq$32 weeks that were born at the Seoul National University Children's Hospital between November 2005 and April 2009. EUGR was defined as weight for gestation, lower than the 10th percentile on discharge. Results : The frequency of EUGR was 67% (n=111/166). By multiple logistic regression, the presence of small for gestational age (SGA) was the greatest predictor of EUGR, birth weight and daily weight gain during the first 28 days were independent predictors of EUGR. Risk factors for EUGR in non-SGA infants were evaluated because 56% (64/114) of non-SGA infants developed EUGR at discharge. Daily weight gain in the first 28 days was also decreased in EUGR group and independently predicted the risk of EUGR in the non-SGA group. Conclusion : EUGR was a common problem in the NICU. SGA was the most significant predictive factor of the EUGR. Half of the non-SGA infants also developed EUGR, revealing poor weight gain in the early days was as an important predictor. These results support the importance of early nutritional intervention for weight gain which have lagged behind other modern therapeutic interventions when the infant is clinically unstable.

• Journal of Korean society of Dental Hygiene
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• v.11 no.6
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• pp.1005-1016
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• 2011

Objectives : The purpose of this study was to examine the awareness of mothers on their children's oral health and their concern for that by socio-demographic characteristics and the relationship of their awareness of methods of dental-caries prevention to their practice of the methods. Methods : The subjects in this study were 337 guardians of preschoolers at kindergartens and daycare centers. A self-administered survey was conducted from April 25 to May 27, 2011, and the collected data were analyzed by the statistical package SPSS 18.0. Results : 1.Self-rated concern for children's oral health, 87.7 percent and 12.1 percent replied, "So-so." Whether they were working or not and whether they were mainly responsible for child rearing made significant differences to that(p<.05). 2. As to subjective awareness of their children's oral health, the largest group of the mothers answered "So-so." (44.9%) The second replied that their children were in good oral health(40.5%), and the third group in poor oral health(14.2%). 3. The relationship between self-rated concern for their children's oral health and awareness of methods of caries prevention, statistically significant differences were found according to toothbrushing education and sealant(p<.05). There were no statistically significant differences in practice, but application of fluoride was the least. 4. The relationship between self-rated awareness for their children's oral health and awareness of the preventive methods of caries, there were statistically significant gaps in awareness of toothbrushing education(p<.05). In practice, statistically significant gaps were found in practice of toothbrushing education and sugar-intake restriction(p<.01). 5. In regard to the correlation between awareness and practice of the preventive methods of caries, awareness of all the factors involving toothbrushing education, sealant, application of fluoride and restriction of sugar intake had a significant positive correlation to practice of them. Better awareness led to better practice. Conclusions : In order to ensure children's successful oral health care, more authentic education of how to prevent dental caries should be offered by experts such as dental hygienists and dentists. Especially, detailed information on application of fluoride, restriction of sugar intake and pit and sealant should be provided for mothers to help their children to stay away from dental caries.

• Journal of Microbiology and Biotechnology
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• v.33 no.9
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• pp.1213-1227
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• 2023

Fetal growth restriction (FGR) is a prevalent obstetric condition. This study aimed to investigate the role of Toll-like receptor 9 (TLR9) in regulating the inflammatory response and gut microbiota structure in FGR. An FGR animal model was established in rats, and ODN1668 and hydroxychloroquine (HCQ) were administered. Changes in gut microbiota structure were assessed using 16S rRNA sequencing, and fecal microbiota transplantation (FMT) was conducted. HTR-8/Svneo cells were treated with ODN1668 and HCQ to evaluate cell growth. Histopathological analysis was performed, and relative factor levels were measured. The results showed that FGR rats exhibited elevated levels of TLR9 and myeloid differentiating primary response gene 88 (MyD88). In vitro experiments demonstrated that TLR9 inhibited trophoblast cell proliferation and invasion. TLR9 upregulated lipopolysaccharide (LPS), LPS-binding protein (LBP), interleukin (IL)-1β and tumor necrosis factor (TNF)-α while downregulating IL-10. TLR9 activated the TARF3-TBK1-IRF3 signaling pathway. In vivo experiments showed HCQ reduced inflammation in FGR rats, and the relative cytokine expression followed a similar trend to that observed in vitro. TLR9 stimulated neutrophil activation. HCQ in FGR rats resulted in changes in the abundance of Eubacterium_coprostanoligenes_group at the family level and the abundance of Eubacterium_coprostanoligenes_group and Bacteroides at the genus level. TLR9 and associated inflammatory factors were correlated with Bacteroides, Prevotella, Streptococcus, and Prevotellaceae_Ga6A1_group. FMT from FGR rats interfered with the therapeutic effects of HCQ. In conclusion, our findings suggest that TLR9 regulates the inflammatory response and gut microbiota structure in FGR, providing new insights into the pathogenesis of FGR and suggesting potential therapeutic interventions.

• Biomedical Science Letters
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• v.14 no.4
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• pp.275-281
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• 2008

Plasma fibrinogen is risk factor of vascular disease including stroke, ischemic heart disease, atherosclerosis and thrombosis. Many studies have confirmed that high plasma fibrinogen levels are related with age, obesity, cholesterol, alcohol consumption, and genotype. This study was carried out to investigate the effect of fibrinogen genotype and other characteristics on the plasma fibrinogen levels in the elderly Koreans. For this study the blood samples were collected from 178 healthy elderly Koreans (102 males and 76 females, $55{\sim}80$ year olds). The blood samples were analyzed by smoking status, cholesterol levels, genotype, age, exercise, drinking, and gender. The plasma fibrinogen was assayed by clotting method, cholesterol being assayed by cholesterol oxidase method. The $\beta$-fibrinogen genotype was detected by PCR of relevant region and digestion with Alu I. The alleres with the restriction site and the non cleavable alleres were designated $A_1$ and $A_2$. In conclusion, genotype $A_1A_2$ and exercise are increased and associated with plasma fibrinogen levels. But, there were no significant differences by smoking, gender, age, drinking and cholesterol.

• BMB Reports
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• v.38 no.2
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• pp.191-197
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• 2005

Although the human genome has been nearly completely sequenced, the functions and the roles of the vast majority of the genes, and the influences of single nucleotide polymorphisms (SNPs) in these genes are not entirely known. A modified mutation detection method was developed for large-scale cloning of the possible SNPs between tumor and normal cells for facilitating the identification of genetic factors that associated with cancer formation and progression. The method involves hybridization of restriction enzyme-cut chromosomal DNA, cleavage and modification of the sites of differences by enzymes, and differential cloning of sequence variations with a designed vector. Experimental validations of the presence and location of sequence variations in the isolated clones by PCR and DNA sequencing support the capability of this method in identifying sequence differences between tumor cells and normal cells.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2001.10a
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• pp.283-285
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• 2001

The most work-space invest much time and labor for optimal arrangement. The work-plates of the work-space should be arranged, processed and assembled under the restricted work space. The optimal arrangement under the terms of a restriction arrange the maximum work-plates in appointed work-space. It's the central aim. The work-plates arrangement scheduling of the most work-space are achieved through the experience of the planner. Like this, if the work-plates arrangement is worked by hand, there spend much time for the training planner. And the burden of the personnel expenses occur for using the master worker, also there are dangerous factors to be able to bring the bottleneck circumstance for the process planning, because the quick work planning does not accomplish. With such problems, the biggest problem is inferior the value of the plan. For solved the such problem of hand-operating, some work-spaces developed and used the work-plate arrangement scheduling system for the special quality of themselves. This paper make research into a plan to develop the work-plate arrangement scheduling system efficiently.