• Journal of Microbiology and Biotechnology
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• v.24 no.4
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• pp.577-583
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• 2014

Three major classes of retroviral restriction factors (APOBEC3G, Tetherin, and TRIM5${\alpha}$) have been identified in mammals. Restriction factors are cellular proteins that are able to limit viral replication by targeting specific steps of the viral life cycle. To evaluate which restriction factor is the most effective to inhibit the replication of porcine endogenous retroviruses (PERVs), the antiviral activity of each restriction factor was compared. In pseudotype assay, the antiviral activity of human tetherin against PERV pseudotype was slightly weaker than that of human APOBEC3G (hA3G). A combination of tetherin and hA3G was more potent than each individual restriction factor. We questioned whether a combination of tetherin and hA3G could also inhibit the spreading replication of PERV. In agreement with the pseudotype assay, two restriction factors inhibit infectious PERV replication in a spreading infection. In this study, hA3G could strongly inhibit the replication of PERV, but tetherin modestly restricted it. Based on these results, we concluded that a combination of tetherin and hA3G is the most effective way to restrict PERV. A combination of different restriction factors will encourage the development of a new approach to treat retroviral disease.

• BMB Reports
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• v.46 no.4
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• pp.181-187
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• 2013

Caloric restriction is the most reliable intervention to prevent age-related disorders and extend lifespan. The reduction of calories by 10-30% compared to an ad libitum diet is known to extend the longevity of various species from yeast to rodents. The underlying mechanisms by which the benefits of caloric restriction occur have not yet been clearly defined. However, many studies are being conducted in an attempt to elucidate these mechanisms, and there are indications that the benefits of caloric restriction are related to alteration of the metabolic rate and the accumulation of reactive oxygen species. During molecular signaling, insulin/insulin-like growth factor signaling, target of rapamycin pathway, adenosine monophosphate activated protein kinase signaling, and Sirtuin are focused as underlying pathways that mediate the benefits of caloric restriction. Here, we will review the current status of caloric restriction.

• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.2
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• pp.471-476
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• 1999

The effects of total dietary restriction(100% restriction of energy intake) on thiobarbituric acid reactive substance(TBARS) contents and intracellular antioxidant enzymes activities in the liver and kidney of young male Sprague Dawley rats were studied. The TBARS contents were reduced in both liver and kidney, up to 77% and 79% of the control rats, fed ad libitum, respectively at 7 days after dietary restriction . Superoxide dismutase(SOD) activities in the liver and kidney of rats were increased significantly by total dietary restriction. However, the activity of catalase in kidney was decreased 27% at 6 days after dietary restriction, but this enzyme activity did not change in liver. The changes of glutathione peroxidae(GSHPx) and catalase activities in the liver and kidney of rats with dietary restriction were not significant. These result suggested that dietary restriction reduce the free radical induced by tissue damage, as determined by TBARS content, in both the liver and kidney but the changes of activities of antioxidant enzymes may not be a contributory factor in reducing oxidative damage to tissue.

• Journal of Environmental Science International
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• v.18 no.4
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• pp.389-400
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• 2009

In this research, we measured the number of lanes, distance, disposition of apartment that are affecting the road traffic noise to evaluate the current condition of G city's road traffic noise. We decide on a basis regarding an apartment price formation factor, and the apartment current price and the results that compared. To have a point scale, we set the maximum road traffic noise at a 8 lane road for 5 points, give 4 points for a 6 lane road, which has a $2.1{\sim}2.5\;dB(A)$ difference compared to a 8 lane road, give 3 points for a 4 lane road, which has a $5.2{\sim}5.5\;dB(A)$ difference compared to a 8 lane road, and set 2 points for a 2 lane road and lower. If we set the standard floor plan as horizontal and a living room facing the roadside, the horizontal and living room facing the opposite side of the road is 1 point because it differs by 14.1 dB(A), and the vertical is 3 points since the difference is 5.3 dB(A). If we make grades by the distance, making standard the fifth floor with little soundproof effect from apartment to road, we observe a measurement below 2.9 dB(A) at a distance of less than 10 m and 5 dB(A), decreased at a distance of 20 m. Therefore, 4 points were given for less than 10m, 3 points for $10{\sim}20\;m$, 2 points for more than 20 m as we can apply the effect of a decay distance of line sound source and the decrease in noise effects of more than 6 dB(A), 1 point for more than 40m, and 0 points for more that 80 m since it is negligible. 28 apartments got 0 points because there is no effect of road traffic noise from other apartments, and 50 apartments where only the road at one side effect them got $5{\sim}10$ points. 4 apartments (17-2, 6-3, 10-4, 3-3) received over 20 points. 15 cases showed a difference between developer price and resale price, and 11 cases (73%) among them showed the same trend (price increases with a low road traffic noise restriction factor point) with the point of road traffic noise restriction factor. 4 cases demonstrated the opposite trend, showing price increases with a high restriction factor point. Among the 4 cases, case numbers 2,6 and 9 appear to be more affected by the location factor (business district) than the road traffic noise restriction factor, and case number 1 appears to be affected by the building factor (openness and direction).

• Journal of the Korean housing association
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• v.27 no.1
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• pp.41-50
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• 2016

This study aims to draw the factors of support and restriction as children play in the outdoor space through their participation. The 135 students (fifth- and sixth- graders) participated in the research using the mapping method included the daily diagram and the open-ended questionnaire. As the research results, the park, the school yard, the playground and the rest space were emerged as play spaces with high utilization rate. Through the analysis of play spaces based on children's perception, the physical and social-psychological factors are drawn as the factors of support and restriction. Some physical factors such as the location are relevant to social-psychological factors such as the friend and the danger. In conclusion, the physical factors which support or restrict children's activities have to be considered with the socialpsychological factors. And the result from children's experience and perception should be basis of providing appropriate spaces for children who are actual users of play spaces.

• Proceedings of the Microbiological Society of Korea Conference
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• 2008.05a
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• pp.72-73
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• 2008

• Journal of Nutrition and Health
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• v.36 no.9
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• pp.924-932
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• 2003

In middle-aged men, abdominal obesity has been an important risk factor of coronary artery disease (CAD) as well as a predictor of hypertension, dyslipidemia, insulin resistance and glucose intolerance. Particularly, risks from abdominal obesity increase when adipose tissue accumulates in visceral compartment. Many studies showed that weight reduction by caloric restriction improves abdominal obesity and reduces lots of cardiovascular risk factors. Testosterone treatment also results in a significant decrease in visceral fat area and normalizes endocrine metabolism. However there is no study that compare the effect of caloric restriction with that of testosterone treatment. The purpose of this study is to investigate the effect of caloric restriction and that of testosterone treatment on body fat distribution, serum lipids and glucose metabolism in male patients with CAD. Forty five middle-aged overweight-obese men with CAD participated in 12 weeks' program. They were matched with age, body weight, body mass index (BMI) and divided into three groups : control group (n = 15) , caloric restriction group (-300 kcal/day, n = 15) and testosterone treatment group (testosterone undecanoate tablets, n = 15) . After 12 weeks, control group did not have any changes in anthropometries, lipid profile, body fat distribution, glucose metabolism and hormonal status. Expectedly, caloric restriction group showed decreases in body weight, BMI, waist to hip ratio, ％ body fat. Ten percentage of total cholesterol and 23% of triglyceride in serum were also decreased. In body fat distribution, total fat areas at both L1 and L4 levels were significantly reduced in this group without reduction in muscle of thigh and calf. However, testosterone treatment group did not have any significant changes in body weight, ％ body fat, serum lipid profile and abdominal fat distribution. In conclusion, weight reduction by caloric restriction is more beneficial in body fat distribution and serum lipid level than testosterone treatment in overweight male patients with CAD. This result suggests that modest weight reduction is possible to help decrease risk factors of CAD.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.8
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• pp.485-493
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• 2019

The purpose of this study is to gain basic information to manage the free choice activities of kindergarten by investigating the teachers' perception of restriction rules. The subjects of the study were 200 kindergarten teachers who worked in J province. The instrument used for this study was a questionnaire that focused on teachers' perception about the restriction rules for the free choice activities. The results of this study were as follows. First, the teachers considered restriction rules in the art center as the most important factor. Second, the teachers recognized that limiting the number of players in a same center is the most important thing among the three restriction rules. Third, the teachers' perception regarding the necessity of restriction rules is as follows. The rule of restricting the number of players is needed to prevent too many players focusing in a certain center. The rule of restricting play time is necessary to encourage children to play in various centers, and the rule of restricting play space is crucial to solidify the educational purpose that every interest center has. The meaning and the necessity of the restriction rules on children's free choice activities were further discussed as connected with children's right to play.

• Journal of Korean society of Dental Hygiene
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• v.1 no.1
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• pp.53-62
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• 2001

The purpose of this study was to measure of dental impact on daily lining among workers. The number of subjects were 1.457 workes. To predict the oral health of workers, we used the measurement of dental impact on daily living. Using methodology was self-questionnaire which included the perceived oral health status, and performance, appearance, pain, eating restriction and discomfort. The associations between the performance factors and perceived oral health status, pain, eating restriction and discomfort, the results were as follows: 1. There were consisted of 48.3% of female. 63.1% of smokers. 92.3% of lower than 30years and 99.4% of graduating high school. 2. Measurement of daily impact on daily living were classified into the following 6 categories. Facter analysis for validity was carried out for corroboration. 3. Association between performance factors and other factors(pain, eating restriction and discomfort) were evaluated by multiple regression was significant(44%, p<0.01).

• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.1
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• pp.23-46
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• 2005

Background and purpose: Maek Kyoung(脈經) is a book written, compiled, and edited by Wang Hui circa 3 A.D. This book is the first technical book devoted to the diagnostics. These are very important data but never make a special study and translate. so I hope this treatise can be great help to understand diagnosis study. Methods: Maek Kyoung(脈經) consists of ten volumes, and the third volume consists of the five chapters, including inter-generation and inter-restriction of the five viscera and the six entrails and prognosis of diseases. This treatise is made up of principal, notes, study and conclusion, we tried to make a translation faithful to the original. Results and Conclusion: Chapter 3 refers to five things. The first is relation between spleen and stomach, the second is how to diagnose diseases by using intergneration and inter-restriction of five elements, the third is roles of spleen that has an influence on four viscera through four seasons, the forth is the fact that quantity of gastroqi decides prognosis of diseases, and the fifth is that climate change has influence on the seriousness of diseases. Chapter 4 refers to four things. The first is relation between lung and large intestines, the second is ordinary and extraordinary pulse condition of lung, the third is that pulse condition including its speed, and the forth is how to diagnose diseases by using intergneration and inter-restriction of five elements and climate change.