• Title/Summary/Keyword: Restricted Randomization

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A Comparative Study of Restricted Randomization Methods in Clinicla Trials

  • Huh, Myung-Hoe
    • Journal of the Korean Statistical Society
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    • v.14 no.1
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    • pp.48-55
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    • 1985
  • In clinical trials subjects are avalible sequentially and must be assigned to treatments immediately. Completely randomized procedure for the allocation of treatments to each subject may result in severe imbalance among the number of subjects in treatment groups, especially for small experiments or interim analyses of large experiments. In this study, restricted randomization methods such as biased coin designs (Efron, 1971), permuted block design, and truncated binomial design are compared to teh completely randomized design in the presence of selection and/or accidential bias by Monte Carlo simulations.

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Analysis of Measurement Precisions Using Measurement Experimental Design for Split Plot (단일분할법 측정 실험계획을 이용한 정밀측정도 분석)

  • Choi, Sung-Woon;You, Jung-Sang
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.32 no.4
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    • pp.223-227
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    • 2009
  • The study presents two measurement split-plot models with a restricted randomization to save cost and time. Split-plot models are used to handle HTCM (Hard To Control Measurement) factors such as high temperature and long-time catalyst control. The models developed are represented by the processes for estimating the measurement precisions, that is, gauge R&R. The study also introduces three-step procedures to indentify resolution, improve R&R reduction, and evaluate the precision effect.