• BMB Reports
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• 제42권11호
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• pp.737-742
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• 2009

Hypoxia-inducible factor-$1{\alpha}/{\beta}$ (HIF-$1{\alpha}/{\beta}$) is a heterodimeric transcriptional activator that mediates gene expression in response to hypoxia. HIF-$1{\alpha}$ has been noted as an effective therapeutic target for ischemic diseases such as myocardiac infarction, stroke and cancer. By using a yeast two-hybrid system and a random peptide library, we found a 16-mer peptide named F29 that directly interacts with the bHLH-PAS domain of HIF-$1{\alpha}$. We found that F29 facilitates the interaction of the HIF-$1{\alpha/\beta}$ heterodimer with its target DNA sequence, hypoxia-responsive element (HRE). The transient transfection of an F29-expressing plasmid increases the expression of both an HRE-driven luciferase gene and the endogenous HIF-1 target gene, vascular endothelial growth factor (VEGF). Taken together, we conclude that F29 increases the DNA-binding ability of HIF-$1{\alpha}$, leading to increased expression of its target gene VEGF. Our results suggest that F29 can be a lead compound that directly targets HIF-$1{\alpha}$ and increases its activity.

• 한국작물학회지
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• 제27권4호
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• pp.439-451
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• 1982

In fact, rice cultivation technique from 1962 to 1970 was very slight, but this technique from 1970 to now was remarkably developed in Korea, it was due to development of high fretilizer responsive and lodging resistant variety, Tongil; ie. Ind. ${\times}$ Japonica remote-cross rice variety. The main factors of this development is as follow: Firstly the most farmer (more than 90%) used newly developed seedling growth method; polyethylene film covered protected nursery bed. Secondly date of transplanting (middle or late part. of May) was earlier 10-15days than before 1970. Thirdly new varieties were highly lodging resistant at high fertilizer level $(N-P_2O_5-K_2O:15-9-11 kg/l0a)$. However, this level is 50% increased one than it for Japonica varieties. At forth planting density increased up to 75-80 hills per $3.3m^2$. Added to these factors, farm labor shortage and wage increase due to economic development gave a chance for introduction of transplanting machine to farmer in 1977. It's use increased for 100, 800 ha in 1981. The most of farmers are using herbicides and weed control system dependoing on wood composition has been established and disseminated to farmer.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.785-791
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• 2005

Reconfigurability of machine tools is one of the critical factors to realize the responsive manufacturing systems to satisfy the mass-customization production. This paper presents the methods to model and simulate the machine tools on Internet in response to change in the machining requirements. Specifically, a set of module combination rules and a modeling method of the structure of machine tools using connectivity graph are developed. In response to the user requirements, kinematic relations and structures of machine tools can be derived using the module combination rules and connectivity graph relationships. Internet-based simulator of machine tools is implemented and presented. The developed machine tool simulator can be used to verify the structure of machine tools derived from the user requirements.

• Journal of Electrical Engineering and Technology
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• 제12권6호
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• pp.2127-2137
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• 2017

A virtual power plant (VPP) is a system that virtually integrates power resources based on the VPP participating customer (VPC) unit and operates as a power plant. When VPP operators manage resources to maximize their benefits, load reduction instructions may focus on more responsive VPCs, or those producing high profitability, by using VPC resources with high operation efficiency. VPCs may thus encounter imbalance problems during operation. This imbalance in operation time would bring more participation for some VPCs, causing potential degradation of their resources. Such an operation strategy would be not preferable for VPP operators in managing the relationship with VPCs. This issue impedes both continual VPC participation and economical and reliable VPP operation in the long term. An operation algorithm is therefore proposed that considers the operation time of VPC generators for mandatory reduction of power resource consumption. The algorithm is based on constraints of daily and annual operation times when VPP operators of local generators perform capacity-market power transactions. The algorithm maximizes the operator benefit through VPP operations. The algorithm implements a penalty parameter for imbalances in operation times spent by VPC generators in fulfilling their obligations. An evaluation was conducted on VPP operational effects by applying the algorithm to the Korean power market.

• 대한의용생체공학회:의공학회지
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• 제14권1호
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• pp.41-50
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• 1993

This paper proposes an adaptive technique for the cardiac output regulation of a pendulum type electromechanical TAH. This techinque, which consists of two RLSE's and two PASTC' 5, performs Its controllability over the TAIB so that the m(RAP) and m(LAP) values re- main close to their desired values under she assumption that the variation of m(RAP) and m (LAP) are dominated by the variation of C.0. and the difference between the left and right ventricular output, respectively. To evaluate the performance of the proposed control system, a simulation is performed by using a human model which contains physiologic, drug and treatment, artificial heart and noise models. As a result, dual adaptive controller showed that abnormal m(LAP) and m(RAP) could be recovered to the normal range within 10minute and maintained desired value in steady state. The operation of this controller prored to be robust in spite of the rapid variation of human status.

• 한국지열·수열에너지학회논문집
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• 제6권2호
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• pp.15-22
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• 2010

The natural refrigerants have used into HVAC equipments because the CFCs and HFCs have some environmental problems like high ODP and GWP. The carbon dioxide has small effect on the environmental problem but also good thermodynamics properties. In this study, the simulation study on the performance and characteristics of a $CO_2$ gascooler and evaporator using a fin-tube and microchannel heat exchanger has been conducted. Besides, the comparison of performance with operating condition was carried out in order to apply to the $CO_2$ heat pump system. As a result, the front sizes of a gascooler and evaporator using a microchannel were decreased by 63% and 58%, respectively, compared to those using a fin-tube. The performance of the fin-tube gascooler and evaporator were more responsive to the variation of operating conditions compared to that of microchannel. The pressure drop of a fin-tube heat exchanger was higher than that of a microchannel one.

• KIEAE Journal
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• 제3권1호
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• pp.45-56
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• 2003

New and innovative technologies for utilizing daylight in buildings have been developed for saving energies and improving visual environments. This study describes the most up-to date information available about the application and evaluation of advanced daylighting systems to enhance daylighting in non-residential buildings from IEA's Task 21. IEA's Task 21 consists on 4 subtasks such as "Performance Evaluation of Daylighting Systems(subtask A)", "Daylighting Responsive Controls(subtask B)", "Daylighting Design Tools(subtask C)" and "Case Studies(subtask D)". For the study, the configurations and characteristics of IEA's advanced daylighting systems are comparatively analyzed. As results, innovative daylighting systems are designed to redirect sunlight or skylight to areas which it is required without glare. These systems use optical devices that initiate reflection or refraction of sunlight and skylight. And they can be designed to actively track the sun or passively control the direction of sunlight and skylight. The comprehensive overview of innovative daylighting systems presented in this study helps designer to understand the advantages of daylighting in building and choose a suitable system for building in the earliest stage of the design process.

• 한국병원경영학회지
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• 제9권3호
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• pp.18-48
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• 2004

Health policies in many countries have come under critical scrutiny in recent years. This is because of increasing national health expenditures. Also many persons in health sector have been the perception that resources allocated to health services are not always deployed in an optimal fashion. And they believe that the scope of resources in health services is limited, there is need to search for ways of using existing resources more efficiently. A further concern has been the desire to ensure access to healthcare of various groups on an equitable basis. In some European countries this has been linked to a wish to enhance patient choice and to make service providers more responsive to consumers, while Korea integrated health insurance funds into single fund in 2000. Many European countries are under considerable pressure to review and restructure their health care systems. There are several reasons of pressure to reform. There are demographic changes, pattern of disease change, advances in medical sciences will also give rise to new demands within the health services, public expectations of health services are rising as those who use services demand higher standards of care. These circumstances require the change of health care delivery system based on hierarchical regionalism, which was basis of health care delivery since 1920s. Korea is also under similarly pressure to restructure our own health care systems. We will have good learning from OECD experiences. In this paper we reviewed and compared among OECD countries' various experiences.

• Journal of Korean Biological Nursing Science
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• 제10권2호
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• pp.184-193
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• 2008

Purpose: Anxiety and depression are the concepts that commonly used as an emotional approach in the nursing researches and most of researches have been used questionnaires as a marker of anxiety and depression. There were few researches using physiological markers in measuring anxiety and depression. Methods: Journals published between 1950 and 2007 that include depression and anxiety measuring through physiological markers were reviewed. Results: As in the case of the hypothlamus-pituitary-adrenal axis system, it appeared that cortisol, epinephrine, and norepinephrine belonged to the category of hormones which were responsive to anxiety and depression. Plasma norepinephrine was a marker of the anxiety whereas plasma cortisol was a marker of the depression. The anxiety and depression were correlated with immune and taste, but it considered as an outcome variable not a physiological marker. Conclusion: Catecholamine and cortisol reflect anxiety and depression state. Our findings suggest that further researches are needed to distinguish between markers and outcomes of depression and anxiety using physiological markers.

• 한국실내디자인학회논문집
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• 제13권6호
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• pp.123-131
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• 2004

The hospitals built In the seventies and eighties have gone through many different extensions and renovations. However, as there had been no prior projections of the future extensions, irrational processes in terms of interdepartmental functional relocations and space availability have recurred. As well, areas and departments are located in several wings, which bring about a decrease in interdepartmental functional linkage, causing a lot of confusion and trouble in hospital management. Through this research we acquire concluding remarks. 1) To restore functional linkage in the whole hospital, strategy of interdepartmental relocation with the clinic-in-the clinic concept is the measure to minimize the problems of the increase in interdepartmental functional linkage since the clinic-in-the clinic concepts minimize circulation and maximizes efficiency of hospital management by making all the dispersed wings as professional as possible. 2) The measure of smooth circulation in order to resolve the problems of patients' difficulty in identifying directions and in decrease in staff's work performance, which arises from the extensions without considering the traffic systems of the whole hospital involves introduction of linear circulation systems in which connections between departments or areas can be made centering main axes of circulation. It is also a responsive measure to enhance the functional linkage between buildings and efficiency of patient's ease in identification of directions.