• Korean journal of food and cookery science
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• v.23 no.1 s.97
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• pp.1-8
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• 2007

Extraction conditions were optimized using response surface methodology for preparing high-quality, hot water extracts from cultivated Chrysanthemum indicum L. petals. A fractional factorial design was applied to investigate the effects of added sample ratio ($X_1$), extraction temperature ($X_2$) and extraction time ($X_3$) variables on extract properties, such as, soluble solid contents ($Y_1$), sugar content ($Y_2$), ?E ($Y_3$), turbidity ($Y_4$), total phenol ($Y_5$) and DPPH ($Y_6$). Second-order models were employed to generate a 3-dimensional response surface for dependent variables and their coefficients of determination ($R^2$) ranged from 0.8408${\sim}$0.9914. The range of optimum conditions at $80^{\circ}C$ extraction for maximize characteristics of hot water extracts was 2.3${\sim}$2.7 g and 9.2${\sim}$11.2 hr.

• International Journal of Highway Engineering
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• v.15 no.6
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• pp.69-78
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• 2013

PURPOSES : In this study blast furnace slag, an industrial byproduct, was used with an activating chemicals, $Ca(OH)_2$ and $Na_2SiO_3$ for carbon capture and sequestration as well as strength development. METHODS : This paper presents the optimized mixing design of Carbon-Capturing and Sequestering Activated Blast-Furnace Slag Mortar. Design of experiments in order to the optimized mixing design was applied and commercial program (MINITAB) was used. Statistical analysis was used to Box-Behnken (B-B) method in response surface analysis. RESULTS : The influencing factors of experimental are water ratio, Chemical admixture ratio and Curing temperature. In the results of response surface analysis, to obtain goal performance, the optimized mixing design for Carbon-Capturing and Sequestering Activated Blast-Furnace Slag Mortar were water ratio 40%, Chemical admixture ratio 58.78% and Curing temperature of $60^{\circ}C$. CONCLUSIONS : Compared with previous studies of this experiment is to some extent the optimal combination is expected to be reliable.

• Structural Engineering and Mechanics
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• v.47 no.1
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• pp.45-58
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• 2013

In structural reliability analysis, the response surface method is a powerful method to evaluate the probability of failure. However, the location of experimental points used to form a response surface function must be selected in a judicious way. It is necessary for the highly nonlinear limit state functions to consider the design point and the nonlinear trend of the limit state, because both of them influence the probability of failure. In this paper, in order to approximate the actual limit state more accurately, experimental points are selected close to the design point and the actual limit state, and consider the nonlinear trend of the limit state. Linear, quadratic and cubic polynomials without mixed terms are utilized to approximate the actual limit state. The direct Monte Carlo simulation on the approximated limit state is carried out to determine the probability of failure. Four examples are given to demonstrate the efficiency and the accuracy of the proposed method for both numerical and implicit limit states.

• Journal of Sensor Science and Technology
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• v.30 no.5
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• pp.326-330
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• 2021

Reactions between gold (Au) surface plasmon resonance (SPR) chips and bovine serum albumin (BSA) dissolved in solutions of different pH were investigated. The charge on the BSA depends on the pH of the solution in which it is dissolved. Thus, dissolving BSA in different pH solutions resulted in different charges of BSA. Among the BSA dissolved in solutions with pH 4.01, 7.4, and 10.01, the SPR response was the highest for BSA dissolved in the solution of pH 4.01. To eliminate the response variation owing to the difference in the refractive indices of the solutions, phosphate buffered saline (PBS) was injected into the system after the reaction of BSA with the Au SPR chip had happened. In this case too, the BSA dissolved in the solution with pH 4.01 exhibited the highest response. This may be attributed to the non-uniform distribution of ionic patches on the BSA, which can induce electrostatic attraction to the surface even though BSA has a positive charge at pH 4.01, and the absolute values of the net charge of BSA at pH 4.01 and 7.4 were very close.

• Integrative Medicine Research
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• v.6 no.4
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• pp.388-394
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• 2017

Background: The present study optimized ultrasound-assisted extraction conditions to maximize extraction yields of glycyrrhizic acid from licorice. Methods: The optimal extraction temperature ($X_1$), extraction time ($X_2$), and methanol concentration ($X_3$) were identified using response surface methodology (RSM). A central composite design (CCD) was used for experimental design and analysis of the results to obtain the optimal processing parameters. Results: Statistical analyses revealed that three variables and the quadratic of $X_1$, $X_2$, and $X_3$ had significant effects on the yields and were followed by significant interaction effects between the variables of $X_2$ and $X_3$ (p<0.01). A 3D response surface plot and contour plots derived from the mathematical models were applied to determine the optimal conditions. The optimum ultrasound-assisted extraction conditions were as follows: extraction temperature, $69^{\circ}C$; extraction time, 34?min; and methanol concentration, 57%. Under these conditions, the experimental yield of glycyrrhizic acid was 3.414%, which agreed closely with the predicted value (3.406%). Conclusion: The experimental values agreed with those predicted by RSM models, thus indicating the suitability of the model employed and the success of RSM in optimizing the extraction conditions.

• Journal of the Korea Institute of Military Science and Technology
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• v.26 no.3
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• pp.205-213
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• 2023

An optimal design of a simple beam-shaped flexure hinge mount supporting an optical mirror is presented. An optical mirror assembly is an opto-mechanically coupled system as the optical and mechanical behaviors interact. This side-supporting mount is flexible in the radial direction and rigid for the remaining degrees of freedom to support the mirror without transferring thermal load. Through thermo-elastic, optical and eigenvalue analysis, opto-mechanical performance was predicted to establish the objective functions for optimization. The key design parameters for this flexure are the thickness and length. To find the optimal values of design parameters, response surface analysis was performed using the design of experiment based on nested FCD. Optimal design candidates were derived from the response surface analysis, and the optimal design shape was confirmed through Opto-mechanical performance validation analysis.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.17 no.1
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• pp.21-28
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• 2008

The final polishing process is based on slurry, pad, conditioner, equipment. Therefore, the concept of wafer final polishing is also necessary for repeatability of results between polished wafers. In this study, the machining conditions have a pressure, table speed, machining time and slurry ratio. This research investigated the surface characteristics that apply variable machining conditions and response surface methodology was used to obtain more flexible and optimumal condition base on Taguchi method. On the base of estimated response surface curvature from the equation and results of Taguchi method, combined design of experiment was considered to lead to optimumal condition. Finally, polished wafer was obtained mirror like surface.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.05a
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• pp.452-456
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• 2004

A study on gust loads alleviation using aircraft control surface was performed. Aeroservoelastic model including control surface controller was formulated and validated by comparing the results of continuous turbulence response analysis with those of MSC/NASTRAN. Optimal control with output feedback was adopted for designing the control surface controller, and the effects of gust loads alleviation was validated by performing the numerical simulation for the controller designed.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.1
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• pp.29-35
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• 2014

This paper aims to obtain the effect of lightweight on Radius rod. The response surface method used in the paper is the statistical method. Optimization method is performed with the Radius rod using the lightweight material. Structural analysis is executed by using the ANSYS program to find static and dynamic responses. From this study result, it is verified that the response surface method has the advantage of optimum value in comparison with other optimization methods. The analysis is also performed by response surface method to derive optimal design values. Steel model and aluminium initial model are obtained by finite element analysis to clarify design criteria and the results are compared with three models each other. The weights can be reduced by optimal design analysis results of these models similar to those of existing products. The quantitative goals in this study can also attained through results of fatigue analyses. The reliability on optimal design of Radius rod can be improved by use of structural and fatigue analysis results.

• Computers and Concrete
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• v.3 no.1
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• pp.1-15
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• 2006

The seismic safety of reinforced concrete containment building can be evaluated by probabilistic analysis considering randomness of earthquake, which is more rational than deterministic analysis. In the safety assessment of earthquake-resistant structures by the deterministic theory, it is not easy to consider the effects of random variables but the reliability theory and random vibration theory are useful to assess the seismic safety with considering random effects. The reliability assessment of reinforced concrete containment building subjected to earthquake load includes the structural analysis considering random variables such as load, resistance and analysis method, the definition of limit states and the reliability analysis. The reliability analysis procedure requires much time and labor and also needs to get the high confidence in results. In this study, random vibration analysis of containment building is performed with random variables as earthquake load, concrete compressive strength, modal damping ratio. The seismic responses of critical elements of structure are approximated at the most probable failure point by the response surface method. The response surface method helps to figure out the quantitative characteristics of structural response variability. And the limit state is defined as the failure surface of concrete under multi-axial stress, finally the limit state probability of failure can be obtained simply by first-order second moment method. The reliability analysis for the multiaxial strength limit state and the uniaxial strength limit state is performed and the results are compared with each other. This study concludes that the multiaxial failure criterion is a likely limit state to predict concrete failure strength under combined state of stresses and the reliability analysis results are compatible with the fact that the maximum compressive strength of concrete under biaxial compression state increases.