• Clinical and Experimental Reproductive Medicine
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• 제14권2호
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• pp.101-108
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• 1987

In order to evaluate the consistency of the serum estradiol pattern and response and to determine the influence of number of ovary on them in repeat cycles in the same patient, 57 cycles in 24 patients who underwent in Vitro Fertilization-Embryo Transfer or Gamete Intrafallopian Transfer in Seoul National University Hospital. The patients were stimulated by follicular stimulating hormone and human menopausal gonadotropin and classified as high(${\geqq}$400 pg/ml) and low(<400 pg/ml) response group according to preovulatory estradiol concentration and classified as three estradiol patterns (A,G.B) according to Jones criteria. Seventeen(89.5%) of 19 patients in when a high response to ovulation induction in their first cycle showed a high response. 40%(2/5) of the second ovulation induction cycle were low response in the patient whose first cycle resulted resulted in a low response. Serum estradiol pattern in the first ovulation induction cycle tended to be repeated in the second cycle. Women with high response tended to be more likely to have A and G patterns and less likely to have a cancellation than those with low response. One-ovary patients were at higher risk for inadequate ovulation induction response.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 추계학술대회논문집
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• pp.755-762
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• 2004

In our country, when the replacement for individual components of equipment in nuclear power plants is required, establishment of individual criteria i.e. Required Response Spectra(RRS) of seismic test/analysis for the component is very difficult because of the absence of Test Response Spectra(TRS) for the individual component to be replaced, from the existing qualification documents. In this case, it is required to perform the structural analysis for the nuclear equipment including the components to be replaced. After the structural analysis, Analysis Response Spectra(ARS) at the point of the component shall be generated and used for seismic test of the component. However, as of today, no standard program authorized for the response spectra generation by using the structural analysis exists in korea. Because of above reason, the STAR-Egs computer program was developed by using the method which calculates directly the expected response spectrum(frequency vs. acceleration type) of the selected points in the nuclear equipment with input spectrum(Required Response Spectra, RRS), based on the dynamic characteristics of the Finite Element(FE) model that is equivalent to the nuclear equipment. The STAR-Egs controls ANSYS/I-DEAS commercial software and automatically extract modal parameters of the FE model. The STAR-Egs calculates response spectrum using the established algorithm based on the extracted modal parameters, too. Reliance on the calculation result of the STAR-Egs was verified through comparison output with the result of MATLAB commercial software based on the identical algorithm. Moreover, actual seismic testing was performed as per IEEE344-1987 for the purpose of program verification by comparison of the FE analysis results.

• 산업진흥연구
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• 제9권1호
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• pp.57-64
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• 2024

2015년 화학물질관리법 전면 개정에 따라 국내 유해화학물질 관리 패러다임이 사업장 단위에서 지역 단위로 변화하였다. 이에 2020년 지역화학사고대응계획이 수립되었으나 지자체마다 대응 범위와 기준에 대한 내용에서 조금씩 차이를 보이고 있다. 이에 본 연구는 각 지역내 수립된 화학사고대응계획을 비교 고찰함으로써 효과적인 화학사고 대응계획에 대한 시사점을 제공하고자 연구를 수행하였다. 이에 공개된 자료를 기반으로 시 단위 4개 지역의 사고 대비 현황, 화학사고 대응시스템, 주민 대피 대응 및 교육훈련의 3가지 차원에서 지역별 대응계획을 비교 분석하였다. 연구 결과, 지역별 사고 대비 및 사고 대응시스템에서는 차이가 크지 않으며, 각 지역별 사업장 특성에 연계한 대비체계는 논의가 부족했다. 또한, 주민을 위한 교육 및 훈련에서 지역간 차이가 존재했다. 앞으로 각 지자체는 지역 환경 특성에 맞는 대응 조직을 구성하고, 유관 기관 협력을 통해 민첩하고 효과적인 사고 대응을 위해 전략을 구상해야 할 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7331-7335
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• 2015

Background: Concurrent chemoradiation with three weekly high dose cisplatin is the non-surgical standard of care for the treatment of locally advanced head and neck cancers. Although this treatment regime is efficacious, it has high acute toxicity, which leads not only to increased treatment cost, but also to increased overall treatment time. Hence, the current study was undertaken to evaluate the acute toxicity and tumor response in head and neck cancer patients treated with concurrent chemoradiation using $40mg/m^2$ weekly cisplatin, which has been our institutional practice. Materials and Methods: This single institution retrospective study included data for 287 head and neck cancer patients treated with concurrent chemoradiation from 2012 to 2014. Results: The mean age of the patients was 48.8 years. The most common site of involvement was oral cavity. Most of the study patients presented with advanced stage disease. The mean overall treatment time was 56.9 days. Some 67.2% had overall complete response to treatment as documented till 90 days from the start of treatment. According to the Radiation Therapy Oncology Group (RTOG) acute radiation morbidity scoring criteria, mucositis was seen in 95.1% of the patients. Dermatitis and emesis were observed in 81.9% and 98.6%, respectively. Regarding haematological toxicity, 48.8% and 29.6% suffered from anaemia and leukopenia, respectively, during treatment. Acute kidney injury was assessed using the Common Terminology Criteria for Adverse Events (CTCAE), and was found in 18.8% of the patients. Conclusions: Concurrent chemoradiotherapy with weekly cisplatin is an effective treatment regime for head and neck cancers with reasonable toxicity which can be used in developing countries, where cost of treatment is so important.

• 한국의류산업학회지
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• 제11권4호
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• pp.537-548
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• 2009

Consumers' price related response in the clothing purchase decision-making process includes their expectation of price, price perception, attitude toward price and consequent behaviors. The purposes of this research are to systematically organize consumers' price related responses in the clothing purchase decision-making process, and to explain the effect of price on their purchasing. The qualitative research including shopping observation and in-depth interview was conducted. The result identified stages that showed different price related responses in clothing purchase decision-making process, and clarified each stage's characteristics. In the internal search stage, consumers recalled price information from memory and had a specific expectation about the price. This set a direction for the external search. In the external search stage, consumers selected brands or stores by a non-compensatory evaluating with an expectation of the price, and narrowed these down to several determinant alternatives by actively evaluating the products. In case a sufficient amount of price information was not recalled, the consumer established reference price through the external search. Finally, in the purchasing stage, consumers evaluated the determinant alternatives based on their compensatory evaluation. When perception of price was negative, consumers evaluate price combined with the higher criteria of clothing benefits, such as symbolic value and usability. The research is expected to contribute to predicting consumers' responses to price, and to establishing an effective pricing strategy.

• Journal of Korean Neurosurgical Society
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• 제52권6호
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• pp.517-522
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• 2012

Objective : Meningiomas represent 18-20% of all intracranial tumors and have a 20-50% 10-year recurrence rate, despite aggressive surgery and irradiation. Hydroxyurea, an inhibitor of ribonucleotide reductase, is known to inhibit meningioma cells by induction of apoptosis. We report the long-term follow-up result of hydroxyurea therapy in the patients with recurrent meningiomas. Methods : Thirteen patients with recurrent WHO grade I or II meningioma were treated with hydroxyurea (1000 $mg/m^2/day$ orally divided twice per day) from June 1998 to February 2012. Nine female and 4 male, ranging in age from 32 to 83 years (median age 61.7 years), were included. Follow-up assessment included physical examination, computed tomography, and magnetic resonance imaging (MRI). Standard neuro-oncological response criteria (Macdonald criteria) were used to evaluate the follow-up MRI scans. The treatment was continued until there was objective disease progression or onset of unmanageable toxicity. Results : Ten of the 13 patients (76.9%) showed stable disease after treatment, with time to progression ranging from 8 to 128 months (median 72.4 months; 6 patients still accruing time). However, there was no complete response or partial response in any patients. Three patients had progressive disease after 88, 89, 36 months, respectively. There was no severe (Grade III-IV) blood systemic disorders and no episodes of non-hematological side effects. Conclusion : This study showed that hydroxyurea is a modestly active agent against recurrent meningiomas and can induce long-term stabilization of disease in some patients. We think that hydroxyurea treatment is well tolerated and convenient, and could be considered as an alternative treatment option in patients with recurrent meningiomas prior to reoperation or radiotherapy.

• Asian-Australasian Journal of Animal Sciences
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• 제18권1호
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• pp.8-12
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• 2005

Response in a modified reciprocal recurrent selection scheme for egg production was evaluated considering variable family sizes and genetic correlation between purebred and crossbred half sisters. The criteria of selection of purebred breeders included pullet's own performance, purebred full and half sisters and crossbred half sister's performance. Heritability of egg production of crossbreds (aggregate genotype) and purebred's was assumed to be 0.2 and genetic correlation between purebred and crossbred half sisters ($r_{pc}$) as 0.1, 0.2, 0.3, 0.4, 0.5, 1.0, -0.1, -0.2, -0.3, -0.4, -0.5 and -1.0. Number of dams per sire to produce purebred and crossbred progenies assumed to be 5, 6, 7, 8, while number of purebred female progeny ($N_p$) and crossbred progeny ($N_c$) per dam were considered to be 3, 4, 5 and 6 in each case. Considering phenotypic variance as unity, selection indices were constructed for different combinations of dams and progeny for each value of $r_{pc}$. Following selection index theory, response in crossbred and purebred for egg production was computed. Results indicated that response in crossbreds depended mainly on crossbred family size and also on magnitude of$r_{pc}$ irrespective of its direction, and response was greater with large crossbred family size than the purebred families. Correlated response in purebreds depends both on magnitude and direction of $r_{pc}$ and was expected to be greater with large purebred family size only. Inclusion of purebred information increased the accuracy of selection for crossbred response for higher magnitude of$r_{pc}$ irrespective of its direction. Present results indicate that desirable response in both crossbred and purebred performance is a function of $r_{pc}$ and family sizes. The ratio of crossbred and purebred family sizes can be optimized depending on the objective of improving the performance of crossbreds and/or of purebreds.

• 한국생활과학회지
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• 제10권1호
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• pp.101-111
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• 2001

The purpose of this study was to investigate using and evaluative criteria for purchasing of sleepwear in winter. Subjects were 523 males and females aged from twenties to fifties, living in Chongju and Taejon. For data analysis, frequency, descriptive analysis, t-test, and F-test were used. The results are as follows. First, the ownership of sleepwear was sweat suits with zippered top, pajamas, T-shirts/pants, underwear, and nightgown in order. The mean of using sweat suits was used the highest, and subjects used more home wear than sleepwear in winter. Second, the using or sleepwear had a significant difference in cold-sensitiveness and body types. Cold-sensitive group used sweat suit and T-shirts/pants more than cold-insensitive group. Also, groups who are thin wore sweat suit the most while groups who are corpulent, used underwear the most when they slept. Third, subjects, who are married women and use bed, used nightgown, but pajamas were used by groups who are older, married, and professional. Sweat suits and T-shirts/pants were used the most by single aged twenties. Forth, consumers considered the wearing comfort when they purchased sleepwear for winter, and they evaluated washing/management, fabric, design/style, economic, service, brand, and others' response in order, for judging the quality of sleepwear. Also, the evaluative criteria had a significant difference in demographic variables such as sex, occupation, and marital state. These results implied that sleepwear would be needed for winter in terms of behavioral temperature regulation. Especially, cold-sensitive and thin group would wear knitted and two-piece sleepwear for thermal comfort when they sleep in winter. Also, Using and evaluative criteria of sleepwear would be different in demographic characteristics. For winter, sleepwear should be develop based on physiologic as well as demographic variables.

• KIEAE Journal
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• 제10권2호
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• pp.39-48
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• 2010

PAJU Book City Plan was designed to integrate two concepts of "Publishing Productive City" and "Ecological City" with the goal of "bringing of human being and nature together". This research on the post occupancy evaluation on PAJU Book City has two aims; One is to define how people, mainly working there rather than living, recognize the city and the other is to identify the problems resulted from the first phase of planning process and to suggest feasible solutions at the same time. It would be desirable that the outcome of this research should be used as data sources to improve the second phase of the plan. The evaluation criteria were created by the pre-survey on the basis of previous researches and "Pa Ju publishing city architectural design guide book (1999)". With those criteria, on-site questionnaire was conducted among people who work in PAJU Book City and stratified sampling was used for the proper sampling. The result is as follows; the visual-aesthetic criteria had positive response, which also closely related to a city satisfaction. Considering this result, construction type, circumferential environment of the building and a place of building form were found appropriate. The evaluation on the physical-ecological criteria was relatively low. Respondents were unsatisfied with green space and required better ecological waterway and more roadside tree. As green space was given a lot of weight in satisfaction survey, more green urban areas should be planned in the next phase. The evaluation on the social-behavior criteria got the lowest score. Particularly, the accessibility and convenient facilities were remarkably low. Nonetheless, the self-conceit about PAJU Book City was highly evaluated and played a crucial role in a city satisfaction. In order to achieve the goal, physical beauty, characteristics as a publication city as well as an ecologically sustainable city should be main agenda in the second phase of Paju Book City Plan. Consequently, it is important to strike a balance between the external environment and image media in order that PAJU Book City should be re-born as a culture city.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2009년도 춘계학술대회 논문집
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• pp.423-423
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• 2009

미진동 제어라는 분야에 대한 연구는 반도체 산업이 초고도화 및 초정밀화가 진전되고 있는 최근에 들어와 학계보다는 전문 반도체와 TFT-LCD의 미진동제어 관련 엔지니어 그룹과 정밀 장비 제작사를 중심으로 이루어져왔다. 고집적 생산 제품을 가공 및 검사하기 위해서는 가공 선폭 이상의 분해 성능을 가진 고정밀도의 생산 및 검사 장비가 필요하다. 이런 고정밀도 생산 및 검사장비는 내외부로부터 입력되는 진동에 민감한 영향을 받는다. 초기 반도체 산업을 주도한 미국을 중심으로 일부 학자와 반도체 진동 제어를 수행하는 전문연구소에서 작성한 BBN-Criteria는 정밀장비의 용도나 분해능 별로 정리된 진동허용규제치를 지침서로 사용하여 왔다. 그러나 장비의 엄밀한 주파수 특성 및 정밀도 측면에서 불확실한 영역부분을 가지고 있기 때문에 미소한 진동을 제어하는 구조 설계자 관점에서는 불충분한 자료이다. 그리고 주파수 분해능을 가진 진동허용규제치를 제시하는 것이 바람직하지만 대부분의 제작사에서는 그렇지 못하고 있다. 그런 이유에는 장비 개개의 진동허용규제치가 다른 고가의 장비 전량에 대하여 시험을 수행해야 하는 점, 가진(加振)특성, 중량, 크기 등의 진동실험 자체에 어려움 때문이다. 또한 진동실험시 가진주파수의 분해능의 결려에 따른 장비의 동적 특성이 고려되지 않은 불확실한 영역 부분을 포함한 진동허용규제치를 제시함으로서 불확실한 영역부분의 진동 하한치를 진동허용규제치의 상한치로 결정하는 문제로 인하여 진동허용규제치가 더욱 가혹하게 제시되어 건물 구조 설계와 방진의 어려움을 가중시킬 여지가 있다. 본 논문에서는 이런 어려움 등을 회피하는 방법으로 주파수응답함수(Frequency Response Function, FRF)를 이용하여 정밀장비의 진동허용규제치를 결정하는 간편하면서도 더욱 정밀한 새로운 방법을 모색하였다.