• Radiation Oncology Journal
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• v.29 no.2
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• pp.63-70
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• 2011

Purpose: To evaluate the extent of pain response and objective response to palliative radiotherapy (RT) for bone metastases from hepatocellular carcinoma according to RT dose. Materials and Methods: From January 2007 to June 2010, palliative RT was conducted for 103 patients (223 sites) with bone metastases from hepatocellular carcinoma. Treatment sites were divided into the high RT dose and low RT dose groups by biologically effective dose (BED) of 39 $Gy_{10}$. Pain responses were evaluated using the numeric rating scale. Pain scores before and after RT were compared and categorized into 'Decreased', 'No change' and 'Increased'. Radiological objective responses were categorized into complete response, partial response, stable disease and progression using modified RECIST (Response Evaluation Criteria In Solid Tumors) criteria; the factors predicting patients' survival were analyzed. Results: The median follow-up period was 6 months (range, 0 to 46 months), and the radiologic responses existed in 67 RT sites (66.3%) and 44 sites (89.8%) in the high and low RT dose group, respectively. A dose-response relationship was found in relation to RT dose (p=0.02). Pain responses were 75% and 65% in the high and low RT dose groups, respectively. However, no statistical difference in pain response was found between the two groups (p=0.24). There were no differences in the toxicity profiles between the high and low RT dose groups. Median survival from the time of bone metastases diagnosis was 11 months (range, 0 to 46 months). The Child-Pugh classification at the time of palliative RT was the only significant predictive factor for patient survival after RT. Median survival time was 14 months under Child-Pugh A and 2 months under Child-Pugh B and C. Conclusion: The rate of radiologic objective response was higher in the high RT dose group. Palliative AT with a high dose would provide an improvement in patient quality of life through enhanced tumor response, especially in patients with proper liver function.

• Clinical and Experimental Reproductive Medicine
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• v.14 no.2
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• pp.101-108
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• 1987

In order to evaluate the consistency of the serum estradiol pattern and response and to determine the influence of number of ovary on them in repeat cycles in the same patient, 57 cycles in 24 patients who underwent in Vitro Fertilization-Embryo Transfer or Gamete Intrafallopian Transfer in Seoul National University Hospital. The patients were stimulated by follicular stimulating hormone and human menopausal gonadotropin and classified as high(${\geqq}$400 pg/ml) and low(<400 pg/ml) response group according to preovulatory estradiol concentration and classified as three estradiol patterns (A,G.B) according to Jones criteria. Seventeen(89.5%) of 19 patients in when a high response to ovulation induction in their first cycle showed a high response. 40%(2/5) of the second ovulation induction cycle were low response in the patient whose first cycle resulted resulted in a low response. Serum estradiol pattern in the first ovulation induction cycle tended to be repeated in the second cycle. Women with high response tended to be more likely to have A and G patterns and less likely to have a cancellation than those with low response. One-ovary patients were at higher risk for inadequate ovulation induction response.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.755-762
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• 2004

In our country, when the replacement for individual components of equipment in nuclear power plants is required, establishment of individual criteria i.e. Required Response Spectra(RRS) of seismic test/analysis for the component is very difficult because of the absence of Test Response Spectra(TRS) for the individual component to be replaced, from the existing qualification documents. In this case, it is required to perform the structural analysis for the nuclear equipment including the components to be replaced. After the structural analysis, Analysis Response Spectra(ARS) at the point of the component shall be generated and used for seismic test of the component. However, as of today, no standard program authorized for the response spectra generation by using the structural analysis exists in korea. Because of above reason, the STAR-Egs computer program was developed by using the method which calculates directly the expected response spectrum(frequency vs. acceleration type) of the selected points in the nuclear equipment with input spectrum(Required Response Spectra, RRS), based on the dynamic characteristics of the Finite Element(FE) model that is equivalent to the nuclear equipment. The STAR-Egs controls ANSYS/I-DEAS commercial software and automatically extract modal parameters of the FE model. The STAR-Egs calculates response spectrum using the established algorithm based on the extracted modal parameters, too. Reliance on the calculation result of the STAR-Egs was verified through comparison output with the result of MATLAB commercial software based on the identical algorithm. Moreover, actual seismic testing was performed as per IEEE344-1987 for the purpose of program verification by comparison of the FE analysis results.

• Industry Promotion Research
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• v.9 no.1
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• pp.57-64
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• 2024

In 2015, the paradigm of hazardous chemical substance management in Korea shifted from the workplace to the regional level due to the complete revision of the Chemicals Control Act. Although regional chemical accident response plans were established in 2020, there were slight differences in the scope and criteria of each local government. Therefore, this study compared and analyzed chemical accident response plans established in four different regions to provide insights into effective chemical accident response plans. Based on publicly available information, the current status of accident preparedness, chemical accident response systems, and resident evacuation response and education/training were compared and analyzed. The results showed that there were not significant differences in the accident preparedness and response systems between the regions. However, there was a lack of discussion on the preparedness system linked to the characteristics of each workplace in each region. Additionally, there were differences in education and training for residents between regions. In the future, each local government needs to establish a response organization that fits the characteristics of their region and develop strategies for agile and effective accident response through cooperation with relevant agencies.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7331-7335
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• 2015

Background: Concurrent chemoradiation with three weekly high dose cisplatin is the non-surgical standard of care for the treatment of locally advanced head and neck cancers. Although this treatment regime is efficacious, it has high acute toxicity, which leads not only to increased treatment cost, but also to increased overall treatment time. Hence, the current study was undertaken to evaluate the acute toxicity and tumor response in head and neck cancer patients treated with concurrent chemoradiation using $40mg/m^2$ weekly cisplatin, which has been our institutional practice. Materials and Methods: This single institution retrospective study included data for 287 head and neck cancer patients treated with concurrent chemoradiation from 2012 to 2014. Results: The mean age of the patients was 48.8 years. The most common site of involvement was oral cavity. Most of the study patients presented with advanced stage disease. The mean overall treatment time was 56.9 days. Some 67.2% had overall complete response to treatment as documented till 90 days from the start of treatment. According to the Radiation Therapy Oncology Group (RTOG) acute radiation morbidity scoring criteria, mucositis was seen in 95.1% of the patients. Dermatitis and emesis were observed in 81.9% and 98.6%, respectively. Regarding haematological toxicity, 48.8% and 29.6% suffered from anaemia and leukopenia, respectively, during treatment. Acute kidney injury was assessed using the Common Terminology Criteria for Adverse Events (CTCAE), and was found in 18.8% of the patients. Conclusions: Concurrent chemoradiotherapy with weekly cisplatin is an effective treatment regime for head and neck cancers with reasonable toxicity which can be used in developing countries, where cost of treatment is so important.

• Fashion & Textile Research Journal
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• v.11 no.4
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• pp.537-548
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• 2009

Consumers' price related response in the clothing purchase decision-making process includes their expectation of price, price perception, attitude toward price and consequent behaviors. The purposes of this research are to systematically organize consumers' price related responses in the clothing purchase decision-making process, and to explain the effect of price on their purchasing. The qualitative research including shopping observation and in-depth interview was conducted. The result identified stages that showed different price related responses in clothing purchase decision-making process, and clarified each stage's characteristics. In the internal search stage, consumers recalled price information from memory and had a specific expectation about the price. This set a direction for the external search. In the external search stage, consumers selected brands or stores by a non-compensatory evaluating with an expectation of the price, and narrowed these down to several determinant alternatives by actively evaluating the products. In case a sufficient amount of price information was not recalled, the consumer established reference price through the external search. Finally, in the purchasing stage, consumers evaluated the determinant alternatives based on their compensatory evaluation. When perception of price was negative, consumers evaluate price combined with the higher criteria of clothing benefits, such as symbolic value and usability. The research is expected to contribute to predicting consumers' responses to price, and to establishing an effective pricing strategy.

• Journal of Korean Neurosurgical Society
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• v.52 no.6
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• pp.517-522
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• 2012

Objective : Meningiomas represent 18-20% of all intracranial tumors and have a 20-50% 10-year recurrence rate, despite aggressive surgery and irradiation. Hydroxyurea, an inhibitor of ribonucleotide reductase, is known to inhibit meningioma cells by induction of apoptosis. We report the long-term follow-up result of hydroxyurea therapy in the patients with recurrent meningiomas. Methods : Thirteen patients with recurrent WHO grade I or II meningioma were treated with hydroxyurea (1000 $mg/m^2/day$ orally divided twice per day) from June 1998 to February 2012. Nine female and 4 male, ranging in age from 32 to 83 years (median age 61.7 years), were included. Follow-up assessment included physical examination, computed tomography, and magnetic resonance imaging (MRI). Standard neuro-oncological response criteria (Macdonald criteria) were used to evaluate the follow-up MRI scans. The treatment was continued until there was objective disease progression or onset of unmanageable toxicity. Results : Ten of the 13 patients (76.9%) showed stable disease after treatment, with time to progression ranging from 8 to 128 months (median 72.4 months; 6 patients still accruing time). However, there was no complete response or partial response in any patients. Three patients had progressive disease after 88, 89, 36 months, respectively. There was no severe (Grade III-IV) blood systemic disorders and no episodes of non-hematological side effects. Conclusion : This study showed that hydroxyurea is a modestly active agent against recurrent meningiomas and can induce long-term stabilization of disease in some patients. We think that hydroxyurea treatment is well tolerated and convenient, and could be considered as an alternative treatment option in patients with recurrent meningiomas prior to reoperation or radiotherapy.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.1
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• pp.8-12
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• 2005

Response in a modified reciprocal recurrent selection scheme for egg production was evaluated considering variable family sizes and genetic correlation between purebred and crossbred half sisters. The criteria of selection of purebred breeders included pullet's own performance, purebred full and half sisters and crossbred half sister's performance. Heritability of egg production of crossbreds (aggregate genotype) and purebred's was assumed to be 0.2 and genetic correlation between purebred and crossbred half sisters ($r_{pc}$) as 0.1, 0.2, 0.3, 0.4, 0.5, 1.0, -0.1, -0.2, -0.3, -0.4, -0.5 and -1.0. Number of dams per sire to produce purebred and crossbred progenies assumed to be 5, 6, 7, 8, while number of purebred female progeny ($N_p$) and crossbred progeny ($N_c$) per dam were considered to be 3, 4, 5 and 6 in each case. Considering phenotypic variance as unity, selection indices were constructed for different combinations of dams and progeny for each value of $r_{pc}$. Following selection index theory, response in crossbred and purebred for egg production was computed. Results indicated that response in crossbreds depended mainly on crossbred family size and also on magnitude of$r_{pc}$ irrespective of its direction, and response was greater with large crossbred family size than the purebred families. Correlated response in purebreds depends both on magnitude and direction of $r_{pc}$ and was expected to be greater with large purebred family size only. Inclusion of purebred information increased the accuracy of selection for crossbred response for higher magnitude of$r_{pc}$ irrespective of its direction. Present results indicate that desirable response in both crossbred and purebred performance is a function of $r_{pc}$ and family sizes. The ratio of crossbred and purebred family sizes can be optimized depending on the objective of improving the performance of crossbreds and/or of purebreds.

• Korean Journal of Human Ecology
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• v.10 no.1
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• pp.101-111
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• 2001

The purpose of this study was to investigate using and evaluative criteria for purchasing of sleepwear in winter. Subjects were 523 males and females aged from twenties to fifties, living in Chongju and Taejon. For data analysis, frequency, descriptive analysis, t-test, and F-test were used. The results are as follows. First, the ownership of sleepwear was sweat suits with zippered top, pajamas, T-shirts/pants, underwear, and nightgown in order. The mean of using sweat suits was used the highest, and subjects used more home wear than sleepwear in winter. Second, the using or sleepwear had a significant difference in cold-sensitiveness and body types. Cold-sensitive group used sweat suit and T-shirts/pants more than cold-insensitive group. Also, groups who are thin wore sweat suit the most while groups who are corpulent, used underwear the most when they slept. Third, subjects, who are married women and use bed, used nightgown, but pajamas were used by groups who are older, married, and professional. Sweat suits and T-shirts/pants were used the most by single aged twenties. Forth, consumers considered the wearing comfort when they purchased sleepwear for winter, and they evaluated washing/management, fabric, design/style, economic, service, brand, and others' response in order, for judging the quality of sleepwear. Also, the evaluative criteria had a significant difference in demographic variables such as sex, occupation, and marital state. These results implied that sleepwear would be needed for winter in terms of behavioral temperature regulation. Especially, cold-sensitive and thin group would wear knitted and two-piece sleepwear for thermal comfort when they sleep in winter. Also, Using and evaluative criteria of sleepwear would be different in demographic characteristics. For winter, sleepwear should be develop based on physiologic as well as demographic variables.

• KIEAE Journal
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• v.10 no.2
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• pp.39-48
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• 2010

PAJU Book City Plan was designed to integrate two concepts of "Publishing Productive City" and "Ecological City" with the goal of "bringing of human being and nature together". This research on the post occupancy evaluation on PAJU Book City has two aims; One is to define how people, mainly working there rather than living, recognize the city and the other is to identify the problems resulted from the first phase of planning process and to suggest feasible solutions at the same time. It would be desirable that the outcome of this research should be used as data sources to improve the second phase of the plan. The evaluation criteria were created by the pre-survey on the basis of previous researches and "Pa Ju publishing city architectural design guide book (1999)". With those criteria, on-site questionnaire was conducted among people who work in PAJU Book City and stratified sampling was used for the proper sampling. The result is as follows; the visual-aesthetic criteria had positive response, which also closely related to a city satisfaction. Considering this result, construction type, circumferential environment of the building and a place of building form were found appropriate. The evaluation on the physical-ecological criteria was relatively low. Respondents were unsatisfied with green space and required better ecological waterway and more roadside tree. As green space was given a lot of weight in satisfaction survey, more green urban areas should be planned in the next phase. The evaluation on the social-behavior criteria got the lowest score. Particularly, the accessibility and convenient facilities were remarkably low. Nonetheless, the self-conceit about PAJU Book City was highly evaluated and played a crucial role in a city satisfaction. In order to achieve the goal, physical beauty, characteristics as a publication city as well as an ecologically sustainable city should be main agenda in the second phase of Paju Book City Plan. Consequently, it is important to strike a balance between the external environment and image media in order that PAJU Book City should be re-born as a culture city.