• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3213-3218
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• 2012

When patients with advanced breast cancer (ABC) are treated with neoadjuvant chemotherapy (NACT), efficacy is monitored by the extent of tumor shrinkage. Since their publication in 1981, World Health Organization (WHO) guidelines have been widely practiced in clinical trials and oncologic practice, for standardized tumor response evaluation. With advances in cancer treatment and tumor imaging, a simpler criterion based on one-dimensional rather than bi-dimensional (WHO) tumor measurement, named Response Evaluation Criteria in Solid Tumors (RECIST) was introduced in 2000. Both approaches have four response categories: complete response, partial response, stable disease and progressive disease (PD). Bi-dimensional measurement data of 151 patients with ABC were analysed with WHO and RECIST criteria to compare their response categories and inter criteria reproducibility by Kappa statistics. There was 94% concordance and 9/151 patients were recategorized with RECIST including 6/12 PD cases. RECIST therefore under-estimates and delays diagnosis of PD. This is undesirable because it may delay or negate switch over to alternate therapy. Analysis was repeated with a new criteria named RECIST-Breast (RECIST-B), with a lower threshold for PD (${\geq}10%$ rather than ${\geq}20%$ increase of RECIST). This showed higher concordance of 97% with WHO criteria and re-categorization of only 4/151 patients (1/12 PD cases). RECIST-B criteria therefore have advantages of both ease of measurement and calculations combined with excellent concordance with WHO criteria, providing a practical clinical tool for response evaluation and offering good comparison with past and current clinical trials of NACT using WHO guidelines.

• 식물병연구
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• 제12권3호
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• pp.231-234
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• 2006

오이 흰가루병(Sphaerotheca fusca)이 수량에 미치는 영향을 구명하고자 오이 잎 제거를 통한 시뮬레이션으로 적정 잎수에 관한 모의시험 및 발병도 조절에 따른 흰가루병이 수량에 미치는 영향과 경제적 피해허용수준을 검토하였다. 오이 잎 제거 수준과 수량과의 시뮬레이션 결과 봄작기에서는 오이 잎 수를 10매, 가을작기에서는 13매 정도를 유지하면 표준방제구와 큰 차이가 없었다. 오이 흰가루병 발병도가 증가할수록 수량이 감소하였으며, 특히 상품성 수량의 감소폭이 전체 수량의 감소폭보다 더 커서 상품성 수량에 큰 영향을 미쳤다. 오이 흰가루병 발병도와 수량과의 회귀식은 Y=-57.237x+6143.1, $R^2=0.9628$로 방제비용을 감안하여 수량 3% 지점의 발병도 17.6%를 경제적 피해 허용 수준으로 설정하였다. 오이 흰가루병 방제적기는 경제적 피해 허용수준과 시뮬레이션 결과를 종합할 때 흰가루병으로 발병된 잎이 $1{\sim}2$장일 때 방제를 시작해야 하는 시점으로 생각된다.

• 한국식품과학회지
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• 제30권3호
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• pp.509-516
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• 1998

조개추출물분말, 해물조미베이스, 라면분말수프, 정어리추출물분말 등 조미분말식품에 대한 TL 검지방법의 적용가능성을 확인하였다. 이들 시료의 방사선 조사선량과 TL response 간의 $R^2$는0.5966 이상을 보여 주었고, 특히 라면수프는 0.9500 이상의 상관계수를 보이면서 방사선 조사선량이 증가할수록 TL intensity도 증가하였다. 따라서 라면수프 시료를 대상으로 re-irradiation step에 의한 TL response의 검증을 실시하였고, 미지시료의 검지에 필요한 역치(threshold value)를 측정하였다. 이때 비조사 시료의 역치는 최고 1.37 이하였고, 감마선 조사시료(2.5 kGy) 역치는 최저 6.06 이상이였다. 그리고 1.37과 6.06 사이의 역치를 나타내는 미지시료는 재조사하여 방사선 조사유무를 검지하였고, 검지시료의 호기성 전세균의 수를 측정함으로써 검지 결과를 검증하였다. Blind test의 일환으로 실시한 미지시료 검지실험에서는 본 실험에서 설정한 역치의 적용으로 총 167개 시료(감마선 82, 전자선 85)의 방사선 조사유무를 정확하게 확인할 수 있었다. 방사선 조사선량을 예측하기 위하여 3가지 예측모델식을 설정하고 조사선량을 예측하여 본 결과, 2차회귀식이 가장 적합하였으나 실제 조사선량과는 상당한 오차를 보였다.

• Restorative Dentistry and Endodontics
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• 제16권2호
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• pp.85-98
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• 1991

The aim of this study was to investigate the effect of low - power laser used in the medical field for various purposes to suppress pain responses evoked by noxious electrical or mechanical stimuli. After both inferior alveolar nerves and the left anterior digastric muscle of cats under general anesthesia were exposed, a recording electrode for the jaw opening reflex was inserted into the anterior digastric muscle. The right inferior alveolar nerve was dissected under a surgical microscope until the response of the functional single nerve could be evoked by the electrical stimulation of the dental pulp or oral mucosa. The electrical stimulus was applied with a rectangular pulse of 10 ms duration for measuring the threshold intensity of a single nerve fiber in the inferior alveolar nerve which responds to stimulation of dental pulp and oral mucosa. Then a pulse of 1 ms duration was applied for determination of conduction velocity. A noxious mechanical stimulus to the oral mucosa was applied by clamping the receptive field with an arterial clamp. The Ga-As diodide laser(wave length, 904 nm ; frequency, 1,000 Hz) was irradiated to the prepared tooth cavity, inferior alveolar nerve and oral mucosa as a pulse wave of 2 mW for 6 minutes. This was followed by a continuous wave of 15 mW for 3 minutes. The action potential of the nerve and EMG of the digastric muscle evoked by the noxious electrical stimulus and nerve response to noxious mechanical stimulus were compared at intervals of before, immediately after, and at 5, 10, 20, 40, 60 minutes after laser irradiation. The results were as follows: The conduction velocity of the intrapulpal $A{\delta}$- nerve fiber recorded from the inferior alveolar nerve before irradiation had a mean value of $6.68{\pm}2.07m/sec$. The laser irradiation did not affect the conduction velocity of the AS - nerve fiber and did not change the threshold intensity or amplitude of the action potential either. The EMG of the digastric muscle evoked by noxious electrical stimulation to the tooth was not changed by the laser irradiation, whether in latency, threshold intensity or amplitude. The laser irradiated to the receptive field of the oral mucosa which was subjected to noxious stimuli did not affect the amplitude of the action potential or the frequency either.

• 한국정보전자통신기술학회논문지
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• 제9권5호
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• pp.445-450
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• 2016

In this paper we study the effect of chaos in nonuniform instability with optical fiber based IoT networks. The transient response of optically controlled fiber has also described. Nonlinear optical fiber effects especially fiber scattering in networks has emerged as the essential means active optical devices. The paradigm instability in fiber Internet serves as a test for fundamental study of chaos and its suppression and exploitation in practical application in optical communication. This paper attempts to present a survey and some of our research findings on the nature of chaotic effect on Internet based optical communication. The transient response in optical fiber has been evaluated theoretically by calculating the variation of the scattering function. The lines has used under open ended termination containing optically induced region. The scattered optical waves in a fiber used in optic communications are temporally unstable above certain threshold intensity.

• Current Photovoltaic Research
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• 제5권3호
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• pp.100-104
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• 2017

This paper analyzes the correlation between Net Benefit Test (NBT) and System marginal price (SMP), which has a significant impact on the allocation of demand response (DR) resources in resource scheduling and commitment (RSC) process, based on the performance data of the demand resource market which has been established in 2014. Demand resources compete with generation resources in the RSC process, and it is prescribed to use demand resources only when net benefit occurs. Analysis result shows that the larger the SMP than the Net Benefit Threshold Price (NBTP), the more the winning bid of demand response resource was. It is interpreted that the introduction of NBT in DR market is justified. The demand resource market has been steadily growing. It is required to expand the scope of resources up to the small-sized DR, and to expand the functionalities of demand resources not only in the current energy market but also in the reserve market in the future. In order for that, institutional improvements are required.

• Communications for Statistical Applications and Methods
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• 제23권6호
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• pp.531-541
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• 2016

Cerebral atrophy affects the brain and is a common feature of patients with mild cognitive impairment or Alzheimer's diseases. It is evaluated by the radiologist or reader based on patient's history, age and the space between the brain and the skull as indicated by magnetic resonance (MR) images. A total of 70 patients were scanned in the supine and prone positions before three radiologist assessed their atrophy level. This study examined the radiologist's assessment of the cerebral atrophy level using a graded response model of item response theory (IRT). A graded response model (GRM) is fitted to our data and then item-fit and person-fit statistics are evaluated to assess the fitted model. Our analysis found that the cerebral atrophy level is better discriminated by readers in the prone position because all item slopes were greater than 2 at this position, versus the supine position where all the slope parameters were less than 1. However, the thresholds are very similar for the first reader and are quite different for the second and third readers because the scanning position affects readers differently as the category threshold estimates vary considerably between the readers..

• Nuclear Engineering and Technology
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• 제52권5호
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• pp.1079-1092
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• 2020

A parametric study of several parameters relevant to design safety on the spent nuclear fuel (SNF) rod response under a drop accident is presented. In the view of the complexity of interactions between the independent safety-related parameters, a factorial design of experiment is employed as an efficient method to investigate the main effects and the interactions between them. A detailed single full-length fuel rod is used with consideration of post-irradiated fuel conditions under horizontal and vertical free-drops onto an unyielding surface using finite-element analysis. Critical drop heights and critical g-loads that yield the threshold plastic strain in the cladding are numerically estimated to evaluate the fuel rod structural resistance to impact load. The combinatory effects of four uncertain parameters (pellet-cladding interfacial bonding, material properties, spacer grid stiffness, rod internal pressure) and the interactions between them on the fuel rod response are investigated. The principal finding of this research showed that the effects of above-mentioned parameters on the load-carrying capacity of fuel rod are significantly different. This study could help to prioritize the importance of data in managing and studying the structural integrity of the SNF.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 G
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• pp.2956-2958
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• 1999

The classical solution to the noise removal problem is the Wiener filter, which utilizes the second-order statistics of the Fourier decomposition. We discuss a Bayesian formalism which gives rise to a type of wavelet threshold estimation in non-parametric regression. A prior distribution is imposed on the wavelet coefficients of the unknown response function, designed to capture the sparseness of wavelet expansion common to most application. For the prior specified, the posterior median yields a thresholding procedure

• 한국음향학회지
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• 제23권6호
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• pp.446-453
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• 2004

본 논문에서는 잡음에 의해 열화된 오디오 신호를 가변 임계값을 이용한 적응 지각 필터를 사용하여 음질을 개선하는 알고리즘을 제안한다. 제안된 적응 지각 필터는 신호 구간마다 달라지는 신호의 세기와 잡음의 영향 정도를 고려하여 임계값을 가변적으로 조정함으로써 잔여 잡음을 효과적으로 제어하는 방식으로 지각적으로 개선된 음질의 신호를 얻을 수 있다 제안한 방식은 잡음에 의해 열화된 오디오 신호를 주파수 영역으로 변환한 후 임계 대역 기반의 임계 대역 에너지 (Critical intensity energy)와 마스킹 영향이 고려된 청각 자극 에너지 (Excitation energy)를 계산한 다음, 지각 필터를 기반으로 한 적응 지각 필터 알고리즘으로 각 단계별 지각 필터 응답을 임계값으로 이용하여 가변 임계값이 재조정되는 단계를 결정하게 된다. 신호의 구간별 에너지 크기에 의한 잡음에 의해 열화된 정도의 차이를 가변 임계값을 이용하여 고려함으로써 잔여 잡음의 효과적인 제어가 가능하게 된다. 제안한 방법은 다양한 신호대 잡음비에서 열화된 오디오 신호를 입력으로 사용하였다. 입력 신호대 잡음비가 15dB, 20dB, 25dB와 30dB의 각각의 경우에 대하여 잡음대 마스킹비 (Noise-to-mask ratio, NMR)와 청감 테스트 (Mean opinion score, MOS Test)를 시행하였다. 그 결과, 잡음대 마스킹비의 개선 측면에서 각각의 경우에 대해 17.4dB, 15.3dB, 12.8dB, 9.8dB의 개선을 확인할 수 있었고, 청감 테스트의 개선 측면에서는 각각 2.9, 2.5, 2.3, 1.7의 개선된 음질을 확인할 수 있었다.