• Tuberculosis and Respiratory Diseases
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• 제82권1호
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• pp.35-41
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• 2019

Background: Pulmonary tuberculosis can result in anatomical sequelae, and cause airflow limitation. However, there are no treatment guidelines for patients with a tuberculosis-destroyed lung. Recently, indacaterol effectiveness in chronic obstructive pulmonary disease (COPD) patients with Tuberculosis history (INFINITY) study revealed indacaterol provided bronchodilation and symptom improvement in COPD patients with a tuberculosis-destroyed lung. Methods: We conducted a post-hoc subgroup analysis of the randomized controlled trial, the INFINITY study, to determine factors associated with indacaterol response in a tuberculosis-destroyed lung with airflow limitation. Data from 68 patients treated with inhaled indacaterol, were extracted and analyzed. Factors associated with the response of forced expiratory volume in one second ($FEV_1$) to indacaterol treatment, were determined using linear regression analysis. Results: Of 62 patients included, 68% were male, and 52% had history of cigarette smoking. Patients revealed mean $FEV_1$ of 50.5% of predicted value with mean improvement of 81.3 mL in $FEV_1$ after indacaterol treatment for 8 weeks. Linear regression analysis revealed factors associated with response of $FEV_1$ to indacaterol included a short duration of smoking history, and high short-acting bronchodilator response. When patients with history of smoking were excluded, factors associated with response of $FEV_1$ to indacaterol included high short-acting bronchodilator response, and poor health-related quality of life score as measured by St. George's Respiratory Questionnaire for COPD. Conclusion: In a tuberculosis-destroyed lung with airflow limitation, short-acting bronchodilator response and smoking history can play a critical role in predicting outcomes of indacaterol treatment.

• Earthquakes and Structures
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• 제10권6호
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• pp.1347-1367
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• 2016

The purpose of this work is to investigate the seismic behavior of St. Titus Church in Heraklion, Crete, Greece as well as the need of its seismic retrofitting. A numerical model of the Church is constructed using shell finite elements and it is then seismically examined using response spectrum and linear time-history analyses. Effects of soil-structure interaction have been also taken into account. The Church without retrofit is expected to exhibit extensive tensile failures and many compressive ones. Aiming to maintain the architectural character of the structure as well as to increase its seismic resistance, a retrofitting procedure involving injection of cement grout in conjunction with reinforced concrete jacketing to the internal side of the masonry walls is proposed. A numerical implementation of the proposed seismic retrofitting is performed and its effect is evaluated by response spectrum and linear time-history analyses. From the results of these analyses, it is shown that compressive failures are eliminated while only few tensile failures of local character take place.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2006년도 학술발표회 논문집
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• pp.637-644
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• 2006

Acceleration time history used in the seismic analysis of nuclear porter plant structure should envelop a target power spectral density (PSD) function in addition to design response spectrum. Current regulation guide defines the target PSD function only for the U.S. URC RG 1.60 Design Response Spectrum. This paper proposes a technical scheme to obtain the target PSD function compatible with generally defined design response spectrum. The scheme includes the methodology for design-spectrum compatible motion history in order to minimize the variation of the derived target PSD function. The PSD calculation procedure follows simple and practical methods allowed within regulation. Effectiveness of the proposed scheme is identified through an example problem. The design response spectrum In the example is based on U.S. NRC RG 1.60 but amplifies the spectral acceleration amplitudes above 9Hz. The target PSD function with little variation can be constructed with the reduced time history ensemble.

• Structural Engineering and Mechanics
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• 제41권5호
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• pp.675-689
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• 2012

Most connections of steel structures exhibit flexible behaviour under cyclic loading. The flexible connections can be assumed as nonlinear rotational springs attached to the ends of each beam. The nonlinear behaviour of the connections can be considered by suitable moment-rotation relationship. Time-history analysis by direct integration method can be used as a powerful technique to determine the nonlinear dynamic response of the structure. In conventional numerical integration, the response is evaluated for a series of short time increments. The limitations on the size of time intervals can be removed by using Chen and Robinson improved time history analysis method, in which the integrated displacements are used as the new variables in integrated equation of motion. The proposed method permits longer time intervals and reduces the computational works. In this paper the nonlinearity behaviour of the structure is summarized on the connections, and the step by step improved time-history analysis is used to calculate the dynamic response of the structure. Several numerical calculations which indicate the applicability and advantages of the proposed methodology are presented. These calculations illustrate the importance of the effect of the nonlinear behaviour of the flexible connections in the calculation of the dynamic response of steel frames.

• Smart Structures and Systems
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• 제6권4호
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• pp.363-372
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• 2010

Accurate peak response estimation of a seismically excited structure with frictional damping system (FDS) is very difficult since the structure with FDS shows nonlinear behavior dependent on the structural period, loading characteristics, and relative magnitude between the frictional force and the excitation load. Previous studies have estimated the peak response of the structure with FDS by replacing a nonlinear system with an equivalent linear one or by employing the response spectrum obtained based on nonlinear time history and statistical analysis. In case that earthquake excitation is defined probabilistically, corresponding response of the structure with FDS becomes to have probabilistic distribution. In this study, nonlinear time history analyses were performed for the structure with FDS subjected to artificial earthquake excitation generated using Kanai-Tajimi filter. An equation for the probability density function (PDF) of the displacement response is proposed by adapting the PDF of the normal distribution. Coefficients of the proposed PDF are obtained by regression of the statistical distribution of the time history responses. Finally, the correlation between the resulting PDFs and statistical response distribution is investigated.

• Earthquakes and Structures
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• 제20권4호
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• pp.405-415
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• 2021

Following the dynamic property analysis and elaboration, linear response spectrum analysis (RSA) and response history analysis (RHA) were conducted on a representative hyperbolic cooling towers (HCT) in present study. The seismic responses in tower shell were illustrated in detail, including the internal force amplitude, modal contribution, influence from damping ratio, comparison of results got from RSA and RHA and especially the latitude distributions of internal forces. The results show that the eigenmodes could be classified in a new method into four types according to their mode shapes and only the lateral bending modes and vertical stretching modes are meaningful for horizontal and vertical earthquake correspondingly. The bending modes and seismic deformation display the same feature which is global lateral bending accompanied by minute circular flow displacement of section. This feature also decides the latitude distributions of internal forces as sine or cosine. Moreover, the following method is also proposed for approximate estimation of internal force amplitudes without time-consuming response history analysis: getting the response spectrums of the selected ground accelerations and then comparing values of response spectrums at the natural period of first lateral bending mode because it is always prime dominant for horizontal seismic responses.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2003년도 가을 학술발표회 논문집
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• pp.608-612
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• 2003

In the seismic response analysis, the artificial earthquake time history is generated to do the exact seismic analysis for the complex structural system like as containment building. In the present study the several simulated earthquakes are generated by use of SIMQKE program and the time history dynamic analysis of containment building is performed. Also, the seismic responses are statistically analyzed. The seismic response uncertainty arisen from the simulation of earthquakes is one of major uncertainties and the statistical description is needed to account for the random nature of earthquake.

• 한국공간구조학회논문집
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• 제19권2호
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• pp.51-61
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• 2019

The objective of this study is to analysis the seismic response of 200m spanned honeycomb lattice domes under horizontal and up-down ground motion of El Centro earthquake. For the analysis of seismic response of the honeycomb lattice domes by rise/span ratio, the time history analysis is used for the estimation of the dynamic response. The low rise lattice dome is less deformed and less stressed than the high rise lattice dome for the earthquake ground motion. The 3-dimensional earthquake response is not significantly different the dynamic response of one directional ground motion. The earthquake response of domes with LRB isolation system is significantly reduced for the asymmetric vertical deformation and the horizontal and vertical accelerations.

• 한국지진공학회논문집
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• 제24권6호
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• pp.267-275
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• 2020

In the event of an earthquake, non-structural components require seismic performance to ensure evacuation routes and to protect lives from falling non-structural components. Accordingly, the seismic design code proposes horizontal force for the design and evaluation of non-structural components. Ground motion observed on each floor is affected by a building's eigen vibration mode. Therefore, the earthquake damage of non-structural components is determined by the characteristics of the non-structural component system and the vibration characteristics of the building. Floor response spectra in the seismic design code are estimated through time history analysis using seismic waves. However, it is difficult to use floor response spectra as a design criterion because of user-specific uncertainties of time history analysis. In addition, considering the response characteristics of high-rise buildings to long-period ground motions, the safety factor of the proposed horizontal force may be low. Therefore, this study carried out the horizontal force review proposed in the seismic design code through dynamic analysis and evaluated the floor response of seismic waves considering buildings and predominant periods of seismic waves.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2007년도 정기 학술대회 논문집
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• pp.639-644
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• 2007

The accurate peak response estimation of a seismically excited structure with frictional damping system(FDS) is very difficult since the structure with FDS shows nonlinear behavior dependent on the structural period, loading characteristics, and relative magnitude between the frictional force and the excitation load. Previous studies have estimated that by replacing a nonlinear system with an equivalent linear one or by employing the response spectrum obtained based on nonlinear time history and statistical analysis. In the case that on earthquake load is defined with probabilistic characteristics, the corresponding response of the structure with FDS has probabilistic distribution. In this study, nonlinear time history analyses were performed for the structure with FDS subjected to artificial earthquake loads generated using Kanai-Tajimi filter. An equation for the probability density function (PDF) of the displacement response is proposed by adapting the PDF of the normal distribution. Finally, coefficients of the proposed PDF is obtained by regression analysis of the statistical distribution of the time history responses. Finally, the correlation between PDFs and statistical response distribution is presented.