• The Korean Journal of Nuclear Medicine
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• v.13 no.1_2
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• pp.31-36
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• 1979

The TRH stimulation test was known as a highly diagnostic method in hypothalamopituitary disorders. To evaluate the location and the extension of the lesion, we estimated TSH response to TRH test in 27 patients. Correlation between volume of sella and TSH response was also studied. The results obtained were as follows: 1. In Sheehan's syndrome, TSH response after TRH test were not observed in all of 12 patients. 2. All 2 acromegaly patients showed normal TSH response. 3. In 4 cases of chromophobe adenoma, 2 cases showed no TSH response. In 2 responded cases, one patient whose tumor mass extended to suprasella region was hypothyroid state. 4. In craniopharyingioma 3 cases, the tumor which extended to intrasella showed hypothyroid and no TSH response. 5. Correlation between volume of sella and TSH response were valuable in 2 cases, but no diagnostic significance. 6. In diabetes inspidus, TSH response were all absent. 7. In primary amenorrhea, TSH response observed in 1 case, which conformed with isolated FSH deficiency.

• Restorative Dentistry and Endodontics
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• v.12 no.1
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• pp.149-153
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• 1986

Clinical analysis on early evidence of the pulp response to composite resin filling (27 cases) was made and reached to the results as follow; 1. Under age 40's early symptome was reported within the 1st, 2nd, 3rd and 4th week after composite filling evenly and age 50's reported after 4th week. 2. Sensitive response to cold were 11 cases, to warm 3 cases and to both (cold, warm) were 9 cases. 3. Tenderness to percussion and light pressure on apical area were 5 cases.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6663-6668
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• 2015

Background: Treatment failure in leukemia is due to either pharmacokinetic resistance or cell resistance to drugs. Materials and Methods: Gene expression of multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and low resistance protein (LRP) was assessed in 45 pediatric ALL cases and 7 healthy controls by real time PCR. The expression was scored as negative, weak, moderate and strong. Results: The male female ratio of cases was 2.75:1 and the mean age was 5.2 years. Some 26/45 (58%) were in standard risk, 17/45(38%) intermediate and 2/45 (4%) in high risk categorie, 42/45 (93%) being B-ALL and recurrent translocations being noted in 5/45 (11.0%). Rapid early response (RER) at day 14 was seen in 37/45 (82.3%) and slow early response (SER) in 8/45 (17.7%) cases. Positive expression of MDR-1, LRP and MRP was noted in 14/45 (31%), 15/45 (33%) and 27/45 (60%) cases and strong expression in 3/14 (21%), 11/27 (40.7%) and 8/15 (53.3%) cases respectively. Dual or more gene positivity was noted in 17/45 (38%) cases. 46.5 % (7/15) of LRP positive cases at day 14 were in RER as compared to 100% (30/30) of LRP negative cases (p<0.05). All 8 (100%) LRP positive cases in SER had strong LRP expression (p=<0.05). Moreover, only 53.3% of LRP positive cases were in haematological remission at day 30 as compared to 100% of LRP negative cases (p=<0.05). Conclusions: Our study indicated that increased LRP expression at diagnosis in pediatric ALL predicts poor response to early treatment and hence can be used as a prognostic marker. However, larger prospective studies with longer follow up are needed, to understand the clinical relevance of drug resistance proteins.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4117-4123
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• 2014

Background: To determine prognostic value of excision repair cross-complementation 1 (ERCC1) in patients with malignant pleural mesothelioma (MPM). Materials and Methods: The study included 60 patients with MPM who were diagnosed and treated in the Radiation Oncology Department of Kayseri Teaching Hospital and Medical Oncology Department of Erciyes University, Medicine School between 2005 and 2013. By using immunohistochemical methods, ERCC1 expression in biopsy specimens was evaluated. We retrospectively assessed whether there is a correlation between ERCC1 and response to anti-neoplastic therapy or survival. Results: There were 50 men and 10 women with median age of 62 years (range: 39-83). Histological type was epithelial mesothelioma in the majority of the cases (85%), most commonly presenting in stage four. Of the cases, 20 (33%) received radiotherapy, 60 (%100) received first-line chemotherapy and 15 (%25) received second-line chemotherapy. In the assessment after therapy, it was found that there was partial response in 12 cases (20%), stable disease in 19 cases (31.4%) and progression in 25 cases (41.7%). ERCC1 was positive in 43% of the cases. Mean OS was 11.7 months and mean DFS was 9.5 months in ERCC1-positive cases regardless of therapy, while they were 19.2 months and 17.1 months in ERCC1-negative cases, respectively. The difference was found to be significant (p<0.05). In univariate analysis, stage, comorbidity, response to treatment and ERCC1 expression were found to be significantly associated with OS (p=0.083; p=0.043; p=0.041; p=0.050). In multivariate analysis, response to treatment remained to be significant for OS (p=0.005). In univariate and multivariate analyses, response to treatment and ERCC1 were found to be significantly associated with DFS (p=0.049; p=0.041). Conclusions: ERCC1 was identified as poor prognostic factor in patients with MPM.

• The Journal of the Korean bone and joint tumor society
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• v.3 no.1
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• pp.1-8
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• 1997

Osteosarcoma is the most common primary bony malignancy and its survivorship has been progressed markedly through refined chemotherapy and surgery. But still there are many non-responders and analysis of prognostic factors may be helpful for them. Two hundred and sixty-six patients were enlisted between Mar, 1985 and Sep. 1994. Among them our inclusion criteria were: 1)primary, nonmetastatic classical osteosarcoma 2)extremity in location 3)no prior treatment at other institute and completed neoadjuvant chemotherapy and surgery according to our protocol. One hundred and eleven cases were eligible. Analyzed factors were:age, sex, location, tumor size, and pathologic response. Statistical methods were log-rank test for univariate and Cox's test for multivariate analysis. Male to female ratio was 69:42 with an average age of 17.2 years. Locations of tumor were distal femur 59, proximal tibia 29, and proximal humerus 8. Tumor size were measured by its maximal diameter and 48 cases were above 10cm and 47 cases were below 10cm. For pathologic response, 57 cases showed more than 90% and 54 cases were less than that. Limb salvage procedure was 101 cases and amputation was 10 cases and their local recurrence rate were 3.6%. Average follow-up period was 24(9-78.2) months and their final status was CDF 86, AWD 8, NED 5, and DOD 12 cases. In univariate study: type of operation(p=0.005), tumor size(p=0.005), and pathologic response(p=0.02) were significant variables. Pathologic response(p=0.03) and type of operation(p=0.01) were meaningful prognostic factors on multivariate analysis. But the latter result was interpreted as a bias, so pathologic response remained as a sole meaningful prognostic factor. More aggressive chemotherapy will be needed to improve the survival.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2061-2067
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• 2014

Background: It has been demonstrated that neutrophil:lymphocyte (NLR) and platelet:lymphocyte (PLR) ratios are associated with prognosis in cancer patients. The aim of this study was to investigate whether pretreatment white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, basophil and eosinophil counts, LDH level, NLR and PLR are associated with prognosis in patients with malignant pleural mesothelioma (MPM). Materials and Methods: We retrospectively reviewed files of 50 patients who were managed with a diagnosis of MPM between 2005 and 2010. Demographic and clinical characteristics, treatments, response to treatment and prognostic factors were evaluated, along with relationships between pretreatment blood parameters and prognosis. Results: Overall, 38 men and 12 women were included to the study. Mean age was $61.5{\pm}9.4$ years (range: 39-83 years). There was advanced disease in 86% (n=43) and the histological type was epithelial mesothelioma in the majority (82%). Of the cases, 17 (34%) received radiotherapy, while 42 cases underwent first- and second-line chemotherapy, with cisplatin plus pemetrexed as the most commonly used regimen. In the assessment after therapy, it was found that there was complete response in 4 cases (8%), partial response in 10 cases (20%), stable disease in 17 cases (34%) and progression in 19 cases (38%). Median follow-up was 10 months (range: 10 day-30 months). Median overall survival was found to be 20.7 months while median progression-free survival as 10 months. In univariate and multivariate analyses, it was found that factors significantly affecting overall survival included stage (p=0.030), response to treatment (p=0.026) and monocyte count (p=0.004), while factors affecting disease-free survival included NLR (p=0.018), response to treatment (p=0.001), and PLR score (p=0.003). Conclusions: Overall and disease-free survival was found to be better in cases with a WBC count<8.000, platelet count<300,000, and low NLR and PLR scores in malignant pleural mesothelioma.

• Restorative Dentistry and Endodontics
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• v.4 no.1
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• pp.11-16
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• 1978

This experimental study was made to investigate the effect of the "Hi-Pol" composite resin on the human dental pulp. 38 cavities of healthy permanent teeth were divided into 5 groups which were used as experimental materials. Group 1: Zinc Oxide-Euginol paste was applied to the cavities as controls $\cdots\;\cdots8$ cases Group 2: "Hi-Pol"*filling with Dycal** base $\cdots\;\cdots9$ cases Group 3: "Hi-Pol" filling without Dycal base $\cdots\;\cdots9$ cases Groud 4: Adaptic*** filling with Dycal base $\cdots\;\cdots6$ cases Group 5: Adaptic filling without Dycal base $\cdots\;\cdots6$ cases The treated teeth were extracted after 1 week, 2 weeks, 3 weeks and 4 weeks and processed for histological study. The results obtained from this experimental study were as follows; 1. The controls applied zinc oxide-eugenol showed the minimal pulp response and group 3 and group 5 showed the most severe pulp response. 2. In group 3 and group 5, the severity of pulp response increased in intensity according to the time elapsed. 3. In group 2 and group 4, the mild pulp response was found in earlier stage and the repairing process could be observed in later stage. * Boo-Pyung Co., Korea ** L. D. Caulk Co., Milford, Del. 19963 *** Johnson and Johnson Co., New Brunswick, NJ 08903.

• The Korean Journal of Emergency Medical Services
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• v.22 no.3
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• pp.177-187
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• 2018

Purpose: The purpose of the study was to investigate the causes of non-transport in 119 ambulance services and to describe the difference in response time according to the reason for non-transport. Methods: This study analyzed 42,415 non-transport cases out of 123,158 cases using prehospital care reports in a metropolitan city. The Kruskal-Wallis test and the Wilcoxon-Mann-Whitney test were used to 6,857 cases for which time was recorded. Results: Non-transportation in 20${\bigcirc}{\bigcirc}$ comprised 33.1% of all ambulance services. The reason for non-transport were other reasons (25.5%), cancellation (23.8%), and moving to other vehicles (21.7%). There were differences in ambulance service times according to the reasons for non-transport. The activation interval was the longest (2.68 minutes) in the absence of the patient, and the response interval was the shortest (4.96 minutes) among the cancelled case. The total interval was the shortest time (21.97 minutes) in the cancellation cases and the longest time among the death cases (32.23 minutes). Conclusion: It is important to suggest the direction of development of emergency services by identifying the reasons for non-transport by ambulance services and describing the response time according to the reason for non-transport.

• Nuclear Engineering and Technology
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• v.48 no.3
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• pp.831-839
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• 2016

Seismic qualification by test is widely used as a way to show the integrity and functionality of equipment that is related to the overall safety of nuclear power plants. Another means of seismic qualification is by direct integration analysis. Both approaches require a series of time histories as an input. However, in most cases, the possibility of using real earthquake data is limited. Thus, artificial time histories are widely used instead. In many cases, however, response spectra are given. Thus, most of the artificial time histories are generated from the given response spectra. Obtaining the response spectrum from a given time history is straightforward. However, the procedure for generating artificial time histories from a given response spectrum is difficult and complex to understand. Thus, this paper presents a simple time-domain method for generating a time history from a given response spectrum; the method was shown to satisfy conditions derived from nuclear regulatory guidance.

• International Journal of Naval Architecture and Ocean Engineering
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• v.11 no.2
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• pp.923-938
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• 2019

Surge motion of top-end platform induced by periodic wave makes marine flexible riser encounter equivalent sheared-oscillatory flow, under which the Vortex-induced Vibration (VIV) response will be more complicated than pure sheared flow or oscillatory flow cases. Based on a time domain force-decomposition model, the VIV response characteristics under sheared-oscillatory flows are investigated numerically in this paper. Firstly, the adopted numerical model is validated well against laboratory experiments under sheared flow and oscillatory flow. Then, 20 sheared-oscillatory flow cases with different oscillation periods and top maximum current velocities are designed and simulated. Under long and short oscillation period cases, the structural response presents several similar features owing to the instantaneous sheared flow profile at each moment, but it also has some different patterns because of the differently varying flow field. Finally, the effects and essential mechanism of oscillation period and top maximum current velocity on VIV response are discussed systematically.