• 정보보호학회논문지
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• 제15권4호
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• pp.83-92
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• 2005

Koga와 Sakurai에 의해 제안된 D-OCSP-KIS는 USP Responder의 인증서 수를 줄여줄 뿐만 아니라 클라이언트에게 OCSP Responder의 인증서 상태 검증도 제공하여 주며 통신량, 계산량 그리고 클라이언트의 메모리량을 줄일 수 있는 효율적인 방법이지만 몇 가지 문제점도 가지고 있다. 공격자가 한 시간 주기(예, 1일)에서 OCSP Responder의 세션 개인키를 획득하였다면 OCSP Responder가 인식하지 못하는 경우, 한 시간주기 동안에 OCSP Responder를 사칭할 수 있다. 그리고 그는 가로챈 해쉬값을 이용하여 클라이언트에게 잘못된 응답을 보낼 수 있어 E-commerce상의 서버와 사용자는 심각한 혼란과 손해를 입을 수 있다. 아울러 해쉬 체인의 계산과 배포는 CA에게 부하가 될 수 있다. 따라서 본 논문에서는 D-OCSP-KIS에서 OCSP Responder의 세션 개인키의 노출과 해쉬값의 악용을 검출할 수 있는 방법을 제안하고자 한다. 이 방법에서 각 해쉬값은 OCSP Responder의 인증서 검증을 위해 한번씩만 사용이 되며 CA에서의 해쉬 체인을 위한 부하가 각 OCSP Responder로 분산되어진다.

• 한국컴퓨터정보학회논문지
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• 제11권1호
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• pp.35-44
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• 2006

E-commerce와 E-business가 급격히 발전함에 따라 인증서의 사용이 증가하고 있다. 인증서 검증은 E-commerce에서 가장 먼저 이루어져야 하며 OCSP Responder는 OCSP를 이용하여 클라이언트에게 CSI를 제공해주게 된다. 인터넷을 기반으로 하는 E-commerce가 급속히 발전함에 따라 많은 클라이언트들이 OCSP Responder에게 CSI요청을 하게 되었으며 OCSP Responder에 대한 로드가 증가하게 되고 과부하 상태에 이르게 될 수 있다. 따라서 이를 해결하기 위하여 D-OCSP가 도입되었으며 CA에 의해 발행되는 CRL은 각 OCSP Responder로 배포되어야 한다. CRL은 폐지된 인증서에 대한 많은 정보를 포함하고 있어 배포 시에 정보 유출의 가능성이 있으므로 무결성뿐만 아니라 기밀성도 유지되어야 한다. 따라서 본 논문에서는 CRL을 무결성과 기밀성을 유지하면서 각 OCSP Responder에게 배포할 수 있는 방법을 제안하고자 한다. 이 방법은 각 OCSP Responder들이 동시에 CSI서비스를 제공할 수 있도록 해준다.

• Journal of Korean Neurosurgical Society
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• 제63권5호
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• pp.539-549
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• 2020

The efficacy of P2Y12 reaction unit (PRU) of VerifyNow still remains as a controversial issue in neurointervention. So we investigated the usefulness of PRU of VerifyNow to predict the peri-procedural thromboembolic events (TE) and hemorrhagic events (HE). And we evaluated the safety of modified dual antiplatelet therapy (DAPT) or triple antiplatelet therapy (TAPT) for clopidogrel hyporesponders. We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science and Scopus on August 19 2018. Data was collected the 1) incidence of TE between clopidogrel responder and clopidogrel hypo-responder, 2) incidence of HE between clopidogrel hyper-responder and clopidogrel responder and hypo-responder, and 3) incidence of TE and HE between modified DAPT or TAPT and standard DAPT in clopidogrel hypo-responder. High cut-off value of PRU was defined as PRU >40% or <220. Fifteen studies were enrolled. Clopidogrel responder showed lower incidence of TE than hypo-responder (risk ratio [RR], 0.32; 95% confidence interval [CI], 0.17-0.61; p<0.001). With the high cut-off value of PRU, clopidogrel responder showed more lower incidence of TE than hypo-responder (RR, 0.11; 95% CI, 0.02-0.45; p=0.002). The incidence of periprocedural HE have higher on clopidogrel hyper-responder than clopidogrel responder and hypo-responder (RR, 4.26; 95% CI, 1.10-16.44; p=0.04; I²=66%). The incidence of periprocedural TE after changing regimen of DAPT for clopidogrel hypo-responder have a tendency to reduce, but there was no significant difference between modified DAPT or TAPT group and standard DAPT group (p>0.05). The incidence of periprocedural HE after changing regimen of DAPT for clopidogrel hypo-responder was no significant difference between modified DAPT or TAPT group and standard DAPT group (p>0.05). PRU is a useful tool as a predictor of peri-procedural TE or HE on neurointervention. PRU has a threshold effect of cut-off value to predict the peri-procedural TE. Modified DAPT or TAPT to prevent TE in clopidogrel hypo-responders could not reduce the incidence of TE. We should investigate the further research about modification of regiment on neurointervention.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.662-674
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• 2018

Purpose: Group 2 innate lymphoid cells (ILC2s) have been implicated in the pathogenesis of allergic disease. However, the effect of allergen-specific immunotherapy (AIT) on ILCs remains to be clarified. The aim of this study was to evaluate the levels of ILC subsets in allergic rhinitis (AR) patients in response to house dust mite (HDM)-specific immunotherapy. Methods: We enrolled 37 AR patients undergoing AIT (16 responders and 11 non-responders) for 2 years, 35 HDM AR patients and 28 healthy subjects. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry to identify ILC subsets. Stimulation of ILC2s with recombinant allergen-specific protein was used to determine ILC2's activation (CD69 expression). Results: Responder AIT patients and healthy subjects had a decreased frequency of circulating ILC2s compared to non-responder AIT and AR patients. Conversely, ILC1s from responder AIT patients and healthy subjects showed increased frequency compared to non-responder AIT and AR patients. The frequency of ILC3s natural cytotoxicity receptor $(NCR)^+$ and $NCR^-$ in responder AIT patients was significantly lower compared to AR patients and healthy subjects. The ILC1: ILC2 proportion in responder AIT patients was similar to that of healthy subjects. PBMCs from patients who were responders to AIT had a significantly lower expression of the activation marker CD69 on ILC2s in response to allergen re-stimulation compared to AR patients, but no difference compared to non-responder AIT patients and healthy subjects. Conclusions: We propose that AIT might affect ILC responses. The activation of ILC2s was reduced in AR patients treated with AIT. Our results indicate that a relative ILC1/ILC2 skewed response is a possible key to successful AIT.

• Journal of Korean Neurosurgical Society
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• 제54권5호
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• pp.437-440
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• 2013

The cerebrospinal fluid tap test (CSFTT) is recommended as a key step in the diagnosis of idiopathic normal pressure hydrocephalus (iNPH). While there is no generally accepted evaluation period for ascertaining a CSFTT responder, a substantial number of patients are evaluated only once within 24 hours of the test for improvement in gait. We report an iNPH patient with a favorable response to shunt surgery, who was first judged a non-responder by this standard, though subsequently was judged a responder in virtue of repetitively testing gait over 7 days. A 68-year-old man presented with progressive impairment of gait, balance, and memory. He was diagnosed as iNPH with an Evans' ratio of 0.35. At first hospitalization, change in gait was evaluated 24 hours after the CSFTT. He didn't show any significant improvement and was judged as a non-responder. However, at the second CSFTT, we repetitively tested his change in gait over seven days. Forty-eight hours after the tap, he showed significant improvement in his gait. He was then confirmed as a responder. After the operation, the gait difficulties were almost fully resolved. Further studies developing the standard procedure of the CSFTT should be considered.

• Clinical and Experimental Reproductive Medicine
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• 제14권2호
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• pp.109-118
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• 1987

Ninety-one patients with irreparable tubal disease underwent in Vitro Fertilization-Embryo Transfer (IVF-ET) in Seoul National University Hospital. Ovulation was stimulated in 104 cycles by human menopausal gonadotropin (HMG) or follicular stimulating hormone (FSH)/human chorionic gonadotropin (HCG). The patients were classified as high (>900 pg/ml), intermediate (400-900 pg/ml), or low (<400pg/ml) responder according to preovulatory $E_2$ response and four $E_2$ patterns were found. The overall pregnancy rate per cycle in this consecutive series was 11.5% (n=12). The number of preovulatory oocytes per cycle was higher significantly in intermediate and high responder group than in low responder group (P<0.01), While the number of immature oocytes per cycle significantly higher in low responder group than high and intermediate responder group (P<0.01). The pregnancy rate in each responder group was not signigicant. According to the $E_2$ pattern of response, there was no significant difference in number of the immature and preovulatory oocytes recovery per cycle. There was a apparently direct relationship between the preovulatory $E_2$ pattern and pre gnancy rate was noted.

• Korean Journal of Acupuncture
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• 제21권1호
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• pp.41-50
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• 2004

Objectives : This study was designed to investigate the differences of effects in smoking cessation after acupuncture treatment and we hypothesized that the discrepancies might be caused by individual genetic differences. Methods : Acupuncture treatment was given to the subjects three times a week for the 231 healthy male Korean smokers without personal or familial history of psychiatric or neurological illness. We evaluated for differentiate responder and non-responder who showed more than 50% decrease in the cigarette consumption or the desire for smoking were regarded as responder, and less than 25% decrease in the cigarette consumption or the desire for smoking were regarded as non-responder, respectively. Allele and genotype frequencies of the Taq1 A polymorphism of dopamine D2 receptor (DRD2) gene were compared in 231male smokers. Chai-square analyses were performed to test for an interactive effect between the DRD2 Taq1 A allele. Results : The allele frequencies and genotype distributions of DRD2 gene among the smokers (n = 231) showed significant the differences in their genotype distributions. The responder and non-responder showed the difference in genotype distribution with a prevalence of A1 allele. A slightly positive association of DRD2 Taq1 A1 genotypes with smoking was observed. Conclusions : This experiment results indicate that the present of DRD2 allele genotype showing significant difference in the genotype distributions between responders and non-responders could be explained by the difference in the genetic effect of DRD2 A1 allele.

• 대순사상논총
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• 제34집
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• pp.1-26
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• 2020

九天應元雷聲普化天尊在臺灣道教中, 被奉為雷部至上之神 ; 在韓國大巡真理會中, 卻是其宗教信仰的至上神。而九天應元雷聲普化天尊也因為在兩個宗教中具有相同名稱, 不禁讓人想知道, 在不同宗教卻出現相同名稱的神祇, 兩者之間是否指的是同一位神?亦或是兩者之間是否具有一定的關聯性?九天應元雷聲普化天尊在兩個宗教中, 所負含的意義為何?諸如此類的相關問題, 有必要先進行基礎性的釐清。而宗教經典即是釐清基礎性問題的基石。宗教經典對於具有該宗教情愫的人而言, 通常具有一定的神聖性, 權威性與教化性, 這些宗教經典的特性, 經常可由經典中人物的話語或經文字句中看出端倪, 因此, 本文亦試圖從兩宗教的經典中開始著手研究。本文從韓國大巡真理會與道教正一派的兩部關於「九天應元雷聲普化天尊」之經典 《典經》 與 《玉樞寶經》 著手, 探究兩部經典中, 解析 關於九天應元雷聲普化天尊, 在兩部經典中的神聖形象, 權威形象與教化形象, 並對九天應元雷聲普化天尊在兩部經典中的形象進行比較, 試圖探究兩者異同性。本文基於釐清「九天應元雷聲普化天尊在兩宗教中的異同」的終極目標下, 於本文中先進行第一步的經典分析探究。本文內容大致分為四大部分, 第一部分為, 探究兩部經典的內涵, 包含經典的由來, 內涵與價值。第二部分為, 兩部經典中九天應元雷聲普化天尊之三種經典形象, 包含神聖形象, 權為形象與教化形象。第三部分為, 兩部經典中九天應元雷聲普化天尊之三種經典形象比較。最後, 以兩教間的發展演化, 歷史關係, 為兩部經典中的九天應元雷聲普化天尊之存在價值做些許論述。

• 대한핵의학회지
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• 제12권1호
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• pp.9-16
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• 1978

It has been suggested that plasma renin activity (PRA) and its response to volume depletion may be abnormal in that it shows little or exaggerated change in patients with chronic renal failure and hypertension. Intravenous furosemide stimulation test was performed in 46 control subjects and 51 patients with chronic renal failure and/or malignant hypertension in order to evaluate PRA response. In contrast to the consistent increase in PRA in control subjects (from $2.5{\pm}1.95\;to\;4.5{\pm}2.51ng/ml/hr$), no consistent increase was observed in patients with chronic renal failure, especially in those who showed favorable response to antihypertensive therapy (from $2.5{\pm}2.21\;to\;2.9{\pm}2.46ng/ml/hr$). But poor responder to antihypertensive treatment showed considerably higher PRA before and after furosemide stimulation (from $4.9{\pm}1.96\;to\;6.4{\pm}1.71ng/ml/hr$) than the responder group did. Moreover, this group seemed to retain the ability to increase PRA in response to intravenous furosemide stimulation. Thus it became apparent that responder group was unable to increase PRA normally in response to furosemide as well as volume depletion, while poor responder seemed to retain that ability. Thus intravenous furosemode may serve as a convenient way to differenfiate those who might be benefited by conservative antihypertensive measures from those who would require more drastic measures such as bilateral nephrectomy for their optimal blood pressure control.

• 생물정신의학
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• 제18권1호
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• pp.36-45
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• 2011

Objectives : Though a proportion of Alzheimer's disease(AD) patients treated with donepezil have shown positive response on cognition, but the responders' characteristics are still uncertain. This study attempts to identify whether a single oral dose of donepezil(5mg) can change cognition and the relationship between single dose responder items and long-term responder are examined. Methods : Twenty-three AD patients for single donepezil challenge study group and eleven AD patients for controls were participated in the study. Seven days after baseline study for neuropsychological test and EEG, same studies were rechecked after donepezil medication in study group. In donepezil study groups, 12 weeks after donepezil medication, neuropsychological test and EEG were rechecked. Results : After single donepezil challenge, forward digit span, Rey-Osterrieth Complex Figure Test copy, SVLT delayed recall were significantly improved, and beta spectra power in anterior, theta spectra power in posterior field were significantly decreased. According to linear regression analysis, forward digit span after single donepezil challenge was significantly positive correlated with long-term responders. Conclusions : This study suggests that single donepezil medication can significantly change cognitive functions and EEG in AD patients. Among these responsive items, forward digit span was significantly correlated with long-term responder.