• 대한물리의학회지
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• 제14권3호
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• pp.81-89
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• 2019

PURPOSE: To solve the problems of chronic obstructive pulmonary disease (COPD) patients complaining of muscle fatigue and having limited motor abilities, this study provided the clinical basic data for pulmonary rehabilitation by examining the effects of High Low-Frequency Neuromuscular Electrical Stimulation (NMES) on the respiratory muscle strength, quadriceps muscle activity, and life quality. METHODS: Samples were collected from 20 COPD patients and placed randomly in a low-frequency group (n=10) and high-frequency group (n=10). For a pretest, the respiratory muscle strength (MIP, MEP), quadriceps muscle activity (LF, VM, VL), and life quality (SGRQ) were measured. After applying NMES to each group for 30 minutes at a time, five times a week, for four weeks, a posttest was conducted in the same way as the pretest. RESULTS: Both groups showed significant differences in the respiratory muscle strength, quadriceps muscle activity, and quality of life within the groups and there were significant differences in the quadriceps muscle activity between the groups. CONCLUSION: The four-weeks NMES positively influenced the respiratory muscle strength and life quality by enhancing the function of the quadriceps and exercise tolerance. In particular, high-frequency(75 Hz) NMES was more effective than low-frequency (15 Hz) NMES. This result can be an alternative means to improve the physical functions of COPD patients clinically in the future.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권11호
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• pp.5527-5545
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• 2019

Through-wall ultra-wide band (UWB) radar has been considered as one of the preferred and non-contact technologies for the targets detection owing to the better time resolution and stronger penetration. The high time resolution is a result of a larger of bandwidth of the employed UWB pulses from the radar system, which is a useful tool to separate multiple targets in complex environment. The article emphasised on human subject localization and detection. Human subject usually can be detected via extracting the weak respiratory signals of human subjects remotely. Meanwhile, the range between the detection object and radar is also acquired from the 2D range-frequency matrix. However, it is a challenging task to extract human respiratory signals owing to the low signal to clutter ratio. To improve the feasibility of human respiratory signals detection, a new method is developed via analysing the standard deviation based kurtosis of the collected pulses, which are modulated by human respiratory movements in slow time. The range between radar and the detection target is estimated using joint time-frequency analysis (JTFA) of the analysed characteristics, which provides a novel preliminary signature for life detection. The breathing rates are obtained using the proposed accumulation method in time and frequency domain, respectively. The proposed method is validated and proved numerically and experimentally.

• Tuberculosis and Respiratory Diseases
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• 제72권4호
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• pp.367-373
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• 2012

Background: Chronic obstructive pulmonary disease (COPD) is now regarded as a heterogenous disease, with variable phenotypes. Acute exacerbation of COPD is a major event that alters the natural course of disease. The frequency of COPD exacerbation is variable among patients. We analyzed clinical features, according to the frequency of acute exacerbation in COPD. Methods: Sixty patients, who visited Gyeongsang National University Hospital from March 2010 to October 2010, were enrolled. Patients were divided into two groups, according to their frequency of acute exacerbation. Frequent exacerbator is defined as the patient who has two or more exacerbation per one year. We reviewed patients' medical records and investigated modified Medical Research Council (MMRC) dyspnea scale, smoking history and frequency of acute exacerbation. We also conducted pulmonary function test and 6-minute walking test, calculated body mass index, degree of airway obstruction and dyspnea and exercise capacity (BODE) index and measured CD146 cells in the peripheral blood. Results: The number of frequent exacerbators and infrequent exacerbators was 20 and 40, respectively. The frequent exacerbator group had more severe airway obstruction (forced expiratory volume in one second [$FEV_1$], 45% vs. 65.3%, p=0.001; $FEV_1$/forced vital capacity, 44.3% vs. 50.5%, p=0.046). MMRC dyspnea scale and BODE index were significantly higher in the frequent exacerbator group (1.8 vs. 1.1, p=0.016; 3.9 vs. 2.1, p=0.014, respectively). The fraction of CD146 cells significantly increased in the frequent exacerbator group (2.0 vs. 1.0, p<0.001). Conclusion: Frequent exacerbator had more severe airway obstruction and higher symptom score and BODE index. However, circulating endothelial cells measured by CD146 needed to be confirmed in the future.

• Physical Therapy Rehabilitation Science
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• 제12권3호
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• pp.251-258
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• 2023

Objective: The practice of breathing exercises involves altering the depth and frequency of respiration. Strengthening respiratory muscles plays a crucial role in maintaining overall health and well-being. The efficiency of the respiratory system affects not only physical activity but also various physiological processes including cardiovascular health, lung function, and cognitive abilities. The study evaluated the reliability of the developed device for inspiratory/expiratory training using pressure sensors and Bluetooth connectivity with a smartphone application. Design: Design & development research Methods: The research methodology involved connecting a custom-made respiratory sensor to an IMT-PEP BIC Breath device. Various pressure conditions were measured, and statistical analyses were performed to assess reliability and consistency. Results showed high Intraclass Coefficient Correlation (ICC) values for both inspiratory and expiratory pressures, indicating strong test-retest reliability. The device was designed for ease of use and wireless monitoring through a smartphone app. Results: This study conducted at expiratory pressure confirmed the proper operation of the IMT/PEP breathing trainer at the specified pressure setting in the product. The pressure sensor demonstrated high test-retest reliability with an ICC value of 0.999 for both expiratory and inspiratory pressure measurements. Conclusions: The developed respiratory training device measured and monitored inspiratory and expiratory pressures, demonstrating its reliability for respiratory training. The system could be utilized to record training frequency and intensity, providing potential benefits for patients requiring respiratory interventions. Further research is needed to assess the full potential of the device in diverse populations and applications.

• Tuberculosis and Respiratory Diseases
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• 제75권1호
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• pp.1-8
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• 2013

Several papers on respiratory and critical care published from March 2012 to February 2013 were reviewed. From these, this study selected and summarized ten articles, in which the findings were notable, new, and interesting: effects of high-frequency oscillation ventilation on acute respiratory distress syndrome (ARDS); safety and efficacy of hydroxyethyl starch as a resuscitation fluid; long-term psychological impairments after ARDS; safety and efficacy of dexmedetomidine for sedation; B-type natriuretic peptide-guided fluid management during weaning from mechanical ventilation; adding of daily sedation interruptions to protocolized sedations for mechanical ventilation; unassisted tracheostomy collar of weaning from prolonged mechanical ventilations; and effects of nighttime intensivist staffing on the hospital mortality rates.

• 대한통합의학회지
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• 제6권2호
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• pp.17-23
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• 2018

Purpose : The purpose of this study was to investigate whether the respiratory cycle and posture can modulate the autonomic nervous system. Methods : Thirty-two healthy men and women, aged 20-30 years, were enrolled in this study. We conducted 2-second and 6-second respiratory cycle with the subjects in standing, sitting, and supine positions, respectively. Their heart rate variability was measured in each position for both cycle lengths. Results : The low frequency/high frequency (LF/HF) ratio is derived from heart rate variability. In the 2-second respiratory cycles, the LF/HF ratios were highest in standing, sitting, and supine position in descending order. There was a significant difference in heart rate between standing and sitting positions (P<.005). In addition, there was a significant difference in heart rate between standing and supine position (P<.000). In the 6-second respiratory cycles, the LF/HF ratios were again highest in a standing, sitting, and supine position in descending order. However, posture was not found to make a significant difference in this case. Conclusion : Respiratory cycle and posture effectively modulated the autonomic nervous system. Further studies of the clinical application of these results should be conducted.

• Clinical and Experimental Pediatrics
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• 제48권12호
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• pp.1310-1316
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• 2005

Mechanical ventilation in children has some differences compared to in neonates or in adults. The indication of mechanical ventilation can be classified into two groups, hypercapnic respiratory failure and hypoxemic respiratory failure. The strategies of mechanical ventilation should be different in these two groups. In hypercapnic respiratory failure, volume target ventilation with constant flow is favorable and pressure target ventilation with constant pressure is preferred in hypoxemic respiratory failure. For oxygenation, fraction of inspired oxygen($FiO_2$) and mean airway pressure(MAP) can be adjusted. MAP is more important than FiO2. Positive end expiratory pressure(PEEP) is the most potent determinant of MAP. The optimal relationship of $FiO_2$ and PEEP is PEEP≒$FiO_2{\times}20$. For ventilation, minute volume of ventilation(MV) product of tidal volume(TV) and ventilation frequency is the most important factor. TV has an maximum value up to 15 mL/kg to avoid the volutrauma, so ventilation frequency is more important. The time constant(TC) in children is usually 0.15-0.2. Adequate inspiratory time is 3TC, and expiratory time should be more than 5TC. In some severe respiratory failure, to get 8TC for one cycle is impossible because of higher frequency. In such case, permissive hypercapnia can be considered. The strategy of mechanical ventilation should be adjusted gradually even in the same patient according to the status of the patient. Mechanical ventilators and ventilation modes are progressing with advances in engineering. But the most important thing in mechanical ventilation is profound understanding about the basic pulmonary mechanics and classic ventilation modes.

• Tuberculosis and Respiratory Diseases
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• 제74권2호
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• pp.63-69
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• 2013

Background: Aiming to improve outcome of lung transplantation (LTx) patients, we reviewed risk factors and treatment practices for the LTx recipients who experienced respiratory infection in the late post-LTx period (>1 month after LTx). Methods: We analyzed the clinical data of 48 recipients and donors from 61 LTx, who experienced late respiratory infections. Late respiratory infections were classified according to the etiology, time of occurrence, and frequency of donor-to-host transmission or colonization of the recipient prior to transplantation. Results: During the period of observation, 42 episodes of respiratory infections occurred. The organisms most frequently involved were gram (-) bacteria: Acinetobacter baumannii (n=13, 31.0%), Pseudomonas aeruginosa (n=7, 16.7%), and Klebsiella pneumoniae (n=4, 10.0%). Among the 42 episodes recorded, 14 occurred in the late post-LTx period. These were bacterial (n=6, 42.9%), fungal (n=2, 14.3%), viral (n=4, 28.5%), and mycobacterial (n=2, 14.3%) infections. Of 6 bacterial infections, 2 were from multidrug-resistant (MDR) A. baumannii and one from each of MDR P. aeruginosa, extended spectrum ${\beta}$-lactamase (+) K. pneumoniae, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae. Infection-related death occurred in 6 of the 14 episodes (43%). Conclusion: Although the frequency of respiratory infection decreased sharply in the late post-LTx period, respiratory infection was still a major cause of mortality. Gram (-) MDR bacteria were the agents most commonly identified in these infections.

• ETRI Journal
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• 제37권4호
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• pp.824-832
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• 2015

Heart sounds are the main obstacle in lung sound analysis. To tackle this obstacle, we propose a diagnosis algorithm that uses singular spectrum analysis (SSA) and frequency features of heart and lung sounds. In particular, we introduce a frequency coefficient that shows the frequency difference between heart and lung sounds. The proposed algorithm is applied to a synthetic mixture of heart and lung sounds. The results show that heart sounds can be extracted successfully and localizations for the first and second heart sounds are remarkably performed. An error analysis of the localization results shows that the proposed algorithm has fewer errors compared to the SSA method, which is one of the most powerful methods in the localization of heart sounds. The presented algorithm is also applied in the cases of recorded respiratory sounds from the chest walls of five healthy subjects. The efficiency of the algorithm in extracting heart sounds from the recorded breathing sounds is verified with power spectral density evaluations and listening. Most studies have used only normal respiratory sounds, whereas we additionally use abnormal breathing sounds to validate the strength of our achievements.

• 대한물리의학회지
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• 제18권3호
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• pp.85-97
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• 2023

PURPOSE: This study analyzed the effectiveness of respiratory exercise in stroke patients conducted in Korea over the past 10 years (2012-2023). METHODS: Using the RISS, KCI, KISS, and NDSL databases, previous studies on stroke and respiratory exercise were searched, and relevant articles were collected following the PRISMA guidelines. Twelve articles were selected, and the quality of the studies was evaluated using the PEDro scale. RESULTS: Twelve studies were selected, and the qualitative evaluation of these studies showed that five articles received a score of six out of 10, while five articles received a score of five. The remaining two articles received scores of four and three, respectively. The intervention duration for respiratory exercise ranged from 20 to 30 minutes per session, with a frequency of three to five sessions per week, conducted over a period of three to eight weeks. These results indicated that respiratory exercise effectively improved the respiratory function, physical function, and respiratory muscle activation in stroke patients. CONCLUSION: Respiratory exercise was reported to have a positive affect the respiratory function, physical activity, and respiratory muscle activation in stroke patients.