• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.6
• /
• pp.3575-3579
• /
• 2013

Background: The 2518 A/G polymorphism in the MCP-1 gene has been extensively studied for association swith cancer; however, results from replication studies have been inconsistent. The aim of this investigation was to determine links with risk of cancer by meta-analysis. Methods: We searched Pubmed, Embase, CNKI, Weipu and Wanfang databases, covering all case-control studies until March, 2013. Statistical analyses were performed using the Revman 5.0 software. Results: A total of 11 case-control studies met our inclusion criteria, including 1,422 cases and 2,237 controls. The results indicated that the MCP-1 2518 gene polymorphism had no association with cancer risk overall (GG vs.GA+ AA: OR = 0.89, 95%CI = 0.61-1.28, P = 0.52). However, in the subgroup analysis by ethnicity, a decrease of cancer risk was found in Asian populations (GG vs.GA+ AA: OR = 0.79, 95%CI = 0.63-0.99, P = 0.04). Conclusion: This meta-analysis suggested that the 2518A/G polymorphism of MCP-1 gene is associated with risk of cancer among Asian, but not in Caucasian populations.

• Tuberculosis and Respiratory Diseases
• /
• v.82 no.1
• /
• pp.81-85
• /
• 2019

Background: Bronchoscopy is a useful diagnostic and therapeutic tool. However, the clinical use of high-flow nasal cannula (HFNC) in adults with acute respiratory failure for diagnostic and invasive procedures has not been well evaluated. We present our experiences of well-tolerated diagnostic bronchoscopy as well as cases of improved saturation in hypoxaemic patients after a therapeutic bronchoscopic procedure. Methods: We retrospectively reviewed data of hypoxaemic patients who had undergone bronchoscopy for diagnostic or therapeutic purposes from October 2015 to February 2017. Results: Ten patients (44-75 years of age) were enrolled. The clinical purposes of bronchoscopy were for diagnosis in seven patients and for intervention in three patients. For the diagnoses, we performed bronchoalveolar lavage in six patients. One patient underwent endobronchial ultrasonography with transbronchial needle aspiration of a lymph node to investigate tumour involvement. Patients who underwent bronchoscopy for therapeutic interventions had endobronchial mass or blood clot removal with cryotherapy for bleeding control. The mean saturation ($SpO_2$) of pre-bronchoscopy in room air was 84.1%. The lowest and highest mean saturation with HFNC during the procedure was 95% and 99.4, respectively. The mean saturation in room air post-bronchoscopy was 87.4%, which was 3.3% higher than the mean room air $SpO_2$ pre-bronchoscopy. Seven patients with diagnostic bronchoscopy had no hypoxic event. Three patients with interventional bronchoscopy showed improvement in saturation after the procedure. Bronchoscopy was well tolerated in all 10 cases. Conclusion: This study suggests that the use of HFNC in hypoxaemic patients during diagnostic and therapeutic bronchoscopy procedures has clinical effectiveness.

• Fisheries and Aquatic Sciences
• /
• v.4 no.2
• /
• pp.88-92
• /
• 2001

To examine effects of cadmium on the respiratory burst of kidney phagocytes and antioxidant defense in liver, juvenile red seabream Pagrus major were fed a cadmium-incorporated diet $(1g\;CdC1_2/kg\;diet)$. The respiratory burst activity measured by chemiluminescence (CL) was significantly reduced by oral intake of cadmium. Lipid peroxidation in liver expressed as thiobarbituric acid reactive substances (TBARS) was significantly higher in the fish fed a cadmium-incorporated diet than that of the fish fed a control diet both on Day 3 and Day 9. Liver Glutathione S-transferase (GST) activitiy was significantly increased both on Day 3 and Day 9 by feeding a cadmium-incorporated diet, when compared with the controls. From the present results, it can be concluded that oral intake of cadmium in red seabream is associated with marked reduction of respiratory burst capacity of kidney phagocytes which can elevate susceptibility of fish against infecting pathogens. Cadmium administration also elicits significant increment of lipid peroxidation in liver, and fish try to detoxify cadmium by increasing GST activity.

• Journal of Korean Physical Therapy Science
• /
• v.21 no.1
• /
• pp.79-84
• /
• 2014

Background : This study is for respiratory muscle activity and chest expansion through practice abdominal breathing exercises. Methods : The subjects were consisted normal 30 persons(15 males and 15 females). The control group to 15 people to compare group and 15 people for the abdominal breathing exercise group through lip retraction movement of the therapist with the resistance of mediated abdominal breathing exercises. For 8 weeks EMG was used to know the changes in respiratory muscle. We also found out the changes in chest expansion. And the t-test was conducted to analyze among the compared group, the abdominal breathing group the differences between before and after the experiment. Results : On the changes in respiratory muscle muscular activity in the transverse abdominis have shown significant results(p<.05), and the change in chest expansion was no significant(p>.05). Conclusion : Various breathing exercises in future research on intervention programs can be studied to promote the public if the functional status is considered to be of much help.

• Tuberculosis and Respiratory Diseases
• /
• v.80 no.1
• /
• pp.21-26
• /
• 2017

It is well established that health care workers (HCWs) have a considerably higher risk of occupationally acquired tuberculosis (TB). To reduce the transmission of TB to HCWs and patients, TB infection control programs should be implemented in health care settings. The first and most important level of all protection and control programs is administrative control. Its goals are to prevent HCWs, other staff, and patients from being exposed to TB, and to reduce the transmission of infection by ensuring rapid diagnosis and treatment of affected individuals. Administrative control measures recommended by the United States Centers for Disease Control and Prevention and the World Health Organization include prompt identification of people with TB symptoms, isolation of infectious patients, control of the spread of the pathogen, and minimization of time spent in health care facilities. Another key component of measures undertaken is the baseline and serial screening for latent TB infection in HCWs who are at risk of exposure to TB. Although the interferon-gamma release assay has some advantages over the tuberculin skin test, the former has serious limitations, mostly due to its high conversion rate.

• Tuberculosis and Respiratory Diseases
• /
• v.43 no.5
• /
• pp.728-735
• /
• 1996

Background : Recognition and ingestion of opsonized microorganisms by neutrophils induces the burst of oxidative metabolic activity. Products of the respiratory burst activity provide powerful oxygen dependent killing mechanism. Measurement of respiratory burst activity has been a major indicator of the functional capacity of neutrophils. We determined the respiratory burst activity of neutrophils in patients with pneumonia and observed the changes during the clinical course of pneumonia. Methods: The EDTA blood was drawn from 24 normal controls and same numbers of pneumonia patients. The respiratory burst activity(with the production of $H_2O_2$ which changes nonfluorescent DCF-DA to green fluorescent DCF) in the non-stimulated state and the stimulated state with fMLP and PMA of neutrophils was measured by flowcytometry at day 1, 3, 5, 7 and 9 of admission. Results: The respiratory burst activity of neutrophils was mildly increased by stimulation with fMLP. But there was no statistical significance between normal control and patients with pneumonia. The respiratory burst activity of neutrophils was markedly increased by stimulation with PMA in both groups. There was a significant difference in response to PMA between normal control and patients with pneumonia. The production of hydrogen peroxide from neutrophils was decreased during early course of pneumonia and it was recuperated gradually to normal level in 9 days. Conclusion : Hydrogen peroxide production from neutrophils was suppressed during early course of pneumonia and restored after treatment. It is suggested that the production of oxygen radical in response to PMA stimulation from each neutrophils is decreased rather than increased during the early course of pneumonia.

• Journal of the Korean Society of Physical Medicine
• /
• v.6 no.4
• /
• pp.381-389
• /
• 2011

Purpose : The purpose of this study was to compare the respiratory function in the different body position of the stroke patients. Methods : Twenty patients with stroke patients group(M:12, F:8) and twenty control group(M:12, F:8) were participated in experiment. Strokes patients group and control group were assessed according to position changes(supine position, $45^{\circ}$ sitting position, $90^{\circ}$ sitting position) using pulmonary function(vital capacity, inspiratory capacity, tidal volume, expiratory reserve volume, inspiratory reserve volume). Results : These findings suggest that supine position in stroke group and control group were significant difference in IC, VC, IRV, ERV(p<.05). $45^{\circ}$ lean sitting position in stroke group and control group were significant difference in IC, VC, ERV(p<.05). 90 sitting position in stroke group and control group were significant difference in VC, IRV, ERV(p<.05). In comparison of two groups, strokes group was more low pulmonary function than normal group. Conclusion : This study showed pulmonary function was more high normal groups than stroke groups. And $90^{\circ}$ sitting position was high pulmonary function than supine position, $45^{\circ}$ lean sitting position. Thus it indicates that the functions will be suggest the objective data of patients with strokes for respiratory function.

• Journal of Microbiology and Biotechnology
• /
• v.29 no.12
• /
• pp.2006-2013
• /
• 2019

The isolation of respiratory viruses, especially from clinical specimens, often shows poor efficiency with classical cell culture methods. The lack of suitable methods to generate virus particles inhibits the development of diagnostic assays, treatments, and vaccines. We compared three inoculation methods, classical cell culture, the addition of a JAK2 inhibitor AZD1480, and centrifugation-enhanced inoculation (CEI), to replicate human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV). In addition, a combined method using AZD1480 treatment and CEI was used on throat swabs to verify that this method could increase virus isolation efficiency from human clinical specimens. Both CEI and AZD1480 treatment increased HRSV and HMPV genome replication. Also, the combined method using CEI and AZD1480 treatment enhanced virus proliferation synergistically. The combined method is particularly suited for the isolation of interferon-sensitive or slowly growing viruses from human clinical specimens.

• CELLMED
• /
• v.3 no.2
• /
• pp.13.1-13.6
• /
• 2013

The objective of the current study was to find out the effect of Integrated Amrita Meditation Technique (IAM) on blood pressure (BP), heart rate (HR), respiratory rate (RR) and IgA. One hundred and fifty subjects were randomized into three groups IAM, Progressive Muscle Relaxation (PMR) and Control. Baseline values were collected before giving the training for all the subjects and the IAM and PMR groups were given training in the respective techniques. BP, HR, RR and IgA were recorded manually at 0 h, 48 h, 2 months and 8 months after the first visit. HR was found to be reduced in the IAM group 48 h onwards and the fall sustained till 8 months (p < 0.05). IAM group showed significant drop when compared to the PMR group and control group in all the subsequent visits (p < 0.05). RR decreased significantly in the IAM group in the third and fourth visits (p < 0.05). RR of IAM showed significant decrease when compared to PMR and control from the third visit onwards. IgA showed significant increase in comparison with PMR and control in the third and fourth visits. BP did not show any difference in any of the visits. There was subject dropout from randomization to completion of the study, in all the three groups. The significant decrease in HR and RR and increase in IgA in the IAM group when compared to the PMR and control group shows the efficacy of the technique in reducing the physiological stress indicators for up to 8 months.

• Journal of the Korean Society of Physical Medicine
• /
• v.10 no.1
• /
• pp.15-21
• /
• 2015

PURPOSE: This study compared the effects of chest expansion resistance exercise (CERE) and breathing retraining (BRT) on stroke patients' chest expansion and maximal inspiratory pressure(MIP), thereby intending to present an effective intervention method for enhancing their respiratory functions. METHODS: The subjects were 30 stroke patients and randomly and equally assigned to a CERE group (10), a BRT group (10), and a control group (10). The intervention was applied to each group five times per week, 30 minutes per each time, for six weeks. A tapeline was used to measure upper and lower chest expansion and MIP prior to and after the intervention and the results were compared. RESULTS: After the intervention, the upper and lower chest expansion was considerable in the CERE group (p<.01), significant in the BRT group (p<.05) but was not significant in the control group (p>.05). According to the post-hoc test result, the upper and lower chest of the CERE group and the BRT group significantly expanded compared to that of the control group (p<.05) and the upper and lower chest of the CERE group statistically significantly expanded relative to that of the BRT group (p<.05). According to the MIP evaluation result, the CERE group saw considerable improvement (p<.01) and the BRT group underwent significant changes (p<.05), but there were no significant changes in the control group (p>.05). The post-hoc test result was that the CERE group and the BRT group saw significant improvement compared to the control group (p<.05) and the CERE group experienced statistically significant enhancement relative to the BRT group (p<.05). CONCLUSION: As an intervention for respiratory function improvement, CERE is considered effective for strengthening respiratory muscles and promoting chest expansion through manual resistance by a therapist.