• 대한의용생체공학회:의공학회지
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• 제33권1호
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• pp.1-7
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• 2012

Hemorrhagic shock is a common cause of death in emergency rooms. Early diagnosis of hemorrhagic shock makes it possible for physicians to treat patients successfully. Therefore, the purpose of this study was to select an optimal survival prediction model using physiological parameters for the two analyzed periods: two and five minutes before and after the bleeding end. We obtained heart rates, mean arterial pressures, respiration rates and temperatures from 45 rats. These physiological parameters were used for the training and testing data sets of survival prediction models using an artificial neural network (ANN) and support vector machine (SVM). We applied a 5-fold cross validation method to avoid over-fitting and to select the optimal survival prediction model. In conclusion, SVM model showed slightly better accuracy than ANN model for survival prediction during the entire analysis period.

• The Korean Journal of Ecology
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• 제24권6호
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• pp.335-339
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• 2001

The dynamic model was developed to simulate the photosynthetic rate of Phragmites communis stands in coastal ecosystem. The model was composed of the compartments of both climatic and biological variables. The former were photosynthetic photon flux density(PPFD), daily maximum- and minimum-temperature. The latter were combinations of the specific physiological responses of plant organs with the biomass of each organs. The PPFD and air temperature were calculated and using those values, gas exchange rate of each plant organ was calculated at every hour. The carbon budget was constructed using the modelled predictions. Analysis of annual productivity and fluxes showed that yearly gross population productivity, yearly population respiration and yearly net population productivity were 33.4, 21.3 and 12.1 $CO_2ton{\cdot}ha^{-2}{\cdot}yr^{-1}$, respectively. The final result was tested over two stands, produced promising predictions with regards to the levels of production attained. The model can be used to determine production potential under given climatic conditions and could even be applied to plant canopies with analogous biological characteristics.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2004년도 Proceedings of 2004 Korea-Japan Joint Seminar on Particle Image Velocimetry
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• pp.125-134
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• 2004

The improvement of artificial respiration method has brought about the decrease in mortality of pulmonary diseases patients. Various respiratory curative methods, inclusive of HFOV (High Frequency Oscillatory Ventilation), have been developed for more effectual and less harmful management of acute respiratory failure. However, the mechanism of gas transfer and diffusion in a bronchiole has not yet been clarified in detail. As a first approach to the problem, we measured oscillatory flows in a Y-shaped micro-channels as bronchiole model by micro Particle Image Velocimetry(micro PIV). In order to establish the fundamental technique of PIV measurements on oscillatory air flow in a micro-channel, we used about 500-nm-diameter incense smoke particles, a diode laser, a high speed camera including an objective lens, and a HFOV, which is effective technique for medical care of pulmonary disease patients, especially, infants. The bronchiole model size is that parent tube is $500\{mu}m$ width and $500\{mu}m$ depth, and daughter tubes are $450\{mu}m$ width and $500\{mu}m$ depth. From this study made on the phenomenon of fluid in micro size bronchus branch of a lung, we succeeded to get time series velocity distribution in a micro scale bronchial mode. The experimental results of velocity distribution changing with time obtained by micro PIV can give fundamental knowledge on oscillatory airflow in micro-channel.

• 대한의용생체공학회:의공학회지
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• 제33권3호
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• pp.148-154
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• 2012

Hemorrhagic shock is a primary cause of deaths resulting from injury in the world. Although many studies have tried to diagnose accurately hemorrhagic shock in the early stage, such attempts were not successful due to compensatory mechanisms of humans. The objective of this study was to construct a survival prediction model of rats in acute hemorrhagic shock using a random forest (RF) model. Heart rate (HR), mean arterial pressure (MAP), respiration rate (RR), lactate concentration (LC), and peripheral perfusion (PP) measured in rats were used as input variables for the RF model and its performance was compared with that of a logistic regression (LR) model. Before constructing the models, we performed 5-fold cross validation for RF variable selection, and forward stepwise variable selection for the LR model to examine which variables were important for the models. For the LR model, sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (ROC-AUC) were 0.83, 0.95, 0.88, and 0.96, respectively. For the RF models, sensitivity, specificity, accuracy, and AUC were 0.97, 0.95, 0.96, and 0.99, respectively. In conclusion, the RF model was superior to the LR model for survival prediction in the rat model.

• 한국포장학회지
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• 제19권2호
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• pp.61-65
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• 2013

Modified atmosphere (MA) of reduced $O_2$ and elevated $CO_2$ concentrations has been used for keeping the quality of fresh produce and extending the shelf life. As a way to attain the beneficial MA package around the produce, a gas diffusion tube or perforation can be attached onto the container and controlled on real time in its opening/closing responding to $O_2$ and $CO_2$ concentrations measured by gas sensors. The timely-controlled opening of the gas diffusion tube can work in harmony with the produce respiration and help to create the desired MA. By use of the mathematical modeling, the effect of tube dimension on the controlled container atmosphere was figured out in this study. Spinach and king oyster mushroom were used as typical commodities for designing the model container system (0.35 and 0.9 kg in 13 L, respectively) because of their respiration characteristics and the optimal MA condition ($O_2$ 7~10%/$CO_2$ 5~10% for spinach; $O_2$ 2~5%/$CO_2$ 10~15% for mushroom). With a control logic for the gas composition to stay as close as possible to optimum MA window without invading injurious low $O_2$ and/or high $CO_2$ concentrations, the atmosphere of the sensor-controlled container could stay at its lower $O_2$ boundary or upper $CO_2$ limit under certain tube dimensional conditions. There were found to be the ranges of the tube diameter and length allowing the beneficial MA. The desired range of the tube dimension for spinach consisted of combinations of larger diameter and shorter length in the window of 0.3~2 cm diameter and 0.2~10 cm length. Similarly, that for king oyster mushroom was combinations of larger diameter and shorter length in the window of 0.9~2 cm diameter and 0.2~3 cm in length. Clear picture on generally affordable tube dimension range may be formulated by further study on a wide variety of commodity and pack conditions.

• 한국포장학회지
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• 제20권1호
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• pp.1-6
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• 2014

신선 농산물의 필름포장은 적정의 저온저장 시에는 적정 변형기체조건 유지로 품질유지가 양호하나, 상대적으로 온도가 높은 판매유통단계에서는 적정조건의 유지가 어려워 품질손실이 발생한다. 저온저장과 판매유통단계에서 농산물 주위에 적정 변형기체(modified atmosphere, MA)조성을 유지하는 개별(1차)포장/2차 포장의 결합 및 해체 개념을 설계한 마스터 포장 시스템이 최근에 제안되고, 단감, 큰느타리 버섯, 밤, 딸기에 대해서 적용된 바 있다. 온도에 따라 다른 농산물의 호흡과 포장의 기체이동 현상의 상호관계를 이용한 마스터 포장 시스템의 개념을 체계화하고, 적정 MA 유지를 위한 설계변수의 조합을 살펴보았다. 바람직한 포장기체조성을 형성 유지할 수 있는 마스터 포장 시스템의 설계를 위한 수학적 모델이 제시되었다. 아울러 마스터 포장 시스템의 이점과 함께 적용을 위한 한계에 대해서 논의하였다. 마스터 포장 시스템의 적용 확대를 위한 미래의 연구방향을 제시하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1971-1972
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• 2008

Cardiopulmonary resuscitation(CPR) is an important clinical technique performing artificial ventilation and chest compression on a patient under emergent situation before arriving in hospital. Since the quality of CPR significantly affects the survival rate, it would be of great advantage to monitor respiration in real time during CPR. However, currently applied respiratory air flow transducers are difficult to apply with sensing elements in the middle of the flow axis. The present study developed a new turbulent air flow transducer conveniently applicable to CPR. Abrupt changes in diameter of the flow tube generated turbulence in air flow, thereby pressure difference was obtained to estimate the air flow rate, with no physical object on the flow plane. Expiration and inspiration were separated by the direction of the pressure difference, resulting in good symmetry. Pressure-flow relationship was tested on a quadratic model, which provided accurate enough estimation results. Therefore, the present turbulent air flow transducer seemed appropriate to monitor respiration during CPR.

• Journal of Ginseng Research
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• 제45권4호
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• pp.473-481
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• 2021

Background: Mitochondrial dysfunction is one of the significant reasons for Alzheimer's disease (AD). Ginsenosides, natural molecules extracted from Panax ginseng, have been demonstrated to exert essential neuroprotective functions, which can ascribe to its anti-oxidative effect, enhancing central metabolism and improving mitochondrial function. However, a comprehensive analysis of cellular mitochondrial bioenergetics after ginsenoside treatment under Aβ-oxidative stress is missing. Methods: The antioxidant activities of ginsenoside Rb₁, Rd, Re, Rg₁ were compared by measuring the cell survival and reactive oxygen species (ROS) formation. Next, the protective effects of ginsenosides of mitochondrial bioenergetics were examined by measuring oxygen consumption rate (OCR) in PC12 cells under Aβ-oxidative stress with an extracellular flux analyzer. Meanwhile, mitochondrial membrane potential (MMP) and mitochondrial dynamics were evaluated by confocal laser scanning microscopy. Results: Ginsenoside Rg₁ possessed the strongest anti-oxidative property, and which therefore provided the best protective function to PC12 cells under the Aβ oxidative stress by increasing ATP production to 3 folds, spare capacity to 2 folds, maximal respiration to 2 folds and non-mitochondrial respiration to 1.5 folds, as compared to Aβ cell model. Furthermore, ginsenoside Rg1 enhanced MMP and mitochondrial interconnectivity, and simultaneously reduced mitochondrial circularity. Conclusion: In the present study, these results demonstrated that ginsenoside Rg₁ could be the best natural compound, as compared with other ginsenosides, by modulating the OCR of cultured PC12 cells during oxidative phosphorylation, in regulating MMP and in improving mitochondria dynamics under Aβ-induced oxidative stress.

• The Korean Journal of Ecology
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• 제27권4호
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• pp.245-256
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• 2004

Simple Biosphere model 2(SiB2)는 전구기후모형 (global climate model)의 지표면모형으로서 토양-식생-대기 사이의 에너지, 물 및 이산화탄소 교환을 모의한다. 특히 광합성-기공전도 하부모형을 포함하고 있어, 식물군락의 광합성과 기공개폐기작을 근거로 하여 이산화탄소 동화량 및 물의 증산량을 계산한다. 따라서 SiB2 수치실험 결과를 통해, 육상생태계에 있어서의 이산화탄소 순환, 물수지, 그리고 환경과 식물군락간의 상호관계를 분석할 수 있다. 본 종설은 일례로서 개량된 SiB2-Paddy를 이용하여, 다양한 식생 및 토지 이용을 보이는 태국 챠오플라야강 유역의 하천유출량 변화에 관한 연구를 소개한다. 이는 SiB2 수치실험결과가 지표면 식생의 차이에 따른 유출량의 변화를 예측 가능하며, 이를 통하여 육상생태계에 있어서 식생이 갖는 기능적인 측면을 연구하는데 적합한 모형임을 알 수 있었다. 그러나 SiB2모형을 이용하여 더욱 정확도 높은 육상 생태계 모의를 위해서는 토양호흡, 엽면적지수, 식물군락간 경쟁 그리고 뿌리의 분포를 고려한 토양수분 등을 모의할 수 있는 하부모형의 도입이 필요하다.

• 한국농림기상학회지
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• 제22권4호
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• pp.233-238
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• 2020

식물의 생리적 과정과 환경 요인 간 상호작용에 바탕을 둔 프로세스 모형은 작물 생육 및 생산성 예측을 위한 좋은 도구이다. 탄소 획득과 바이오매스 증가는 프로세스 모형 개발의 주요 구성요소로서, 작물모형 내에서 광합성 과정의 이해 및 통합에 중요한 역할을 한다. 본 연구는 1980년 Farquhar 등에 의해 제안된 C3 식물 잎의 광합성 모델인 FvCB 모형의 양파에 대한 적용 가능성 평가 및 적합한 모수 추정을 목표로 수행되었다. 이를 위해 온도구배하우스에서 재배된 조생종 양파 품종인 '싱싱볼'과 '썬더볼'의 광합성 측정 결과를 바탕으로 Vcmax, Jmax, TPU 및 Rd 값을 추정하였다. 본 연구에서 개발된 양파의 기체교환 모형은 다양한 환경 조건에서 양파의 광합성 반응 예측 및 설명에 유용하게 활용될 것으로 기대된다.