• 대한의생명과학회지
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• 제11권2호
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• pp.129-134
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• 2005

Three different deconvolution techniques for quantifying cerebral blood flow (CBF) from whole brain $T2^{\ast}-weighted$ bolus tracking images were implemented (parametric Fourier transform P-FT, parametric single value decomposition P-SVD and nonparametric single value decomposition NP-SVD). The techniques were tested on 206 regions from 38 hyperacute stroke patients. In the P-FT and P-SVD techniques, the tissue and arterial concentration time curves were fit to a gamma variate function and the resulting CBF values correlated very well $(CBF_{P-FT}\;=\;1.02{\cdot}CBF_{p-SVD},\;r^2\;=\;0.96)$. The NP-SVD CBF values correlated well with the P-FT CBF values only when a sufficient number of time series volumes were acquired to minimize tracer time curve truncation $(CBF_{P-FT}\;=\;0.92{\cdot}CBF_{NP-SVD},\;r^2\;=\;0.88)$. The correlation between the fitted CBV and the unfitted CBV values was also maximized in regions with minimal tracer time curve truncation $(CBV_{fit}\;=\;1.00{\cdot}CBV_{ Unfit},\;^r^2\;=\;0.89)$. When a sufficient number of time series volumes could not be acquired (due to scanner limitations) to avoid tracer time curve truncation, the P-FT and P-SVD techniques gave more reliable estimates of CBF than the NP-SVD technique.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 1996년도 특별강연 및 추계학술발표 개요집
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• pp.139-141
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• 1996

Among various welding parameters, the welding current which is inversely proportional to the tip-to-workpiece distance in GMAW is an essential parameter to monitor the GMAW process of horizontal fillet joints. For the case of weld defect such as overlap in horizontal fillet welding, therefore, the signal processing for process monitoring or automatic seam tracking should be modified by considering the weld pool surface geometry including the corresponding weld defect. In other words, the adequate signal processing algorithm is indispensible to improve the performance of the arc sensor. However, arc sensor algorithm already developed usually focus on weld seam tracing but do not considering the weld qualities. In this paper, various experiments were carried out to investigate the tendencies of the weld defects when weaving motion is added, and the experimental method based on 2$^n$ factorial design was proposed for deriving the mathematical model between the leg length and the various welding conditions. Moreover, a signal processing method based on the artificial neural network(Adaptive Resonance Theory) was proposed far discriminating the current signal of sound weld beads from that of weld beads with overlap. Finally, the algorithm for weld seam tracking combined with the mathematical modeling and the signal processing method was carried out to track the weld line in conjunction with the improvement of the weld qualities. The reliability of the proposed algorithms were evaluated through various experiments, which showed that the proposed algorithms could be effectively used for arc welding automation.

• 한국소음진동공학회논문집
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• 제23권1호
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• pp.84-91
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• 2013

Ultrasonic flip-chip bonding needs a precise bonding tool which delivers ultrasonic energy into chip bumps effectively to use the selected resonance mode and frequency of the horn structure. The bonding tool is excited at the resonance frequency and the input and output ports should locate at the anti-nodal points of the resonance mode. In this study, we propose new design method with topology optimization for ultrasonic bonding tools. The SIMP(solid isotropic material with penalization) method is used to formulate topology optimization and OC(optimal criteria) algorithm is adopted for the update scheme. MAC(modal assurance criterion) tracking is used for the target frequency and mode. We fabricate two prototypes of ultrasonic tools which are based on 3D optimization models after reviewing 2D and 3D topology optimization results. The prototypes are satisfied with the ultrasonic frequency and vibration amplitude as the ultrasonic bonding tools.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.130.5-130
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• 2001

This paper presents a discrete-time sliding mode control method for linear time-invariant systems with matched uncertainties. In this paper, we suggest a method of adding a command generator using input shaping filter to a discrete-time sliding mode controller. We design the number of steps required to reach the sliding layer and the magnitude of a control input, respectively using the shaping filter. Therefore we can minimize the excitation of the resonance mode and increase the tracking performance of a system. Simulation results are included to show its effectiveness.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회.한국자기공명학회 2005년도 공동학술대회
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• pp.67-67
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• 2005

• International Journal of Stem Cells
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• 제16권1호
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• pp.93-107
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• 2023

Background and Objectives: Chronic periodontitis can lead to alveolar bone resorption and eventually tooth loss. Stem cells from exfoliated deciduous teeth (SHED) are appropriate bone regeneration seed cells. To track the survival, migration, and differentiation of the transplanted SHED, we used super paramagnetic iron oxide particles (SPIO) Molday ION Rhodamine-B (MIRB) to label and monitor the transplanted cells while repairing periodontal bone defects. Methods and Results: We determined an appropriate dose of MIRB for labeling SHED by examining the growth and osteogenic differentiation of labeled SHED. Finally, SHED was labeled with 25 ㎍ Fe/ml MIRB before being transplanted into rats. Magnetic resonance imaging was used to track SHED survival and migration in vivo due to a low-intensity signal artifact caused by MIRB. HE and immunohistochemical analyses revealed that both MIRB-labeled and unlabeled SHED could promote periodontal bone regeneration. The colocalization of hNUC and MIRB demonstrated that SHED transplanted into rats could survive in vivo. Furthermore, some MIRB-positive cells expressed the osteoblast and osteocyte markers OCN and DMP1, respectively. Enzyme-linked immunosorbent assay revealed that SHED could secrete protein factors, such as IGF-1, OCN, ALP, IL-4, VEGF, and bFGF, which promote bone regeneration. Immunofluorescence staining revealed that the transplanted SHED was surrounded by a large number of host-derived Runx2- and Col II-positive cells that played important roles in the bone healing process. Conclusions: SHED could promote periodontal bone regeneration in rats, and the survival of SHED could be tracked in vivo by labeling them with MIRB. SHED are likely to promote bone healing through both direct differentiation and paracrine mechanisms.

• International Journal of Korean Welding Society
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• 제1권1호
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• pp.23-30
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• 2001

Among the various welding conditions, the welding current that is inversely proportional to the tip-to-work-piece distance is an essential parameter as to monitor the GMAW process and to implement the welding automation. Considering the weld pool surface geometry including weld defects, it should modify the signal processing method for automatic seam tracking in horizontal fillet welding. To meet the above necessities, a mathematical model related with the weld pool geometry was proposed as in a conjunction with the two-dimensional heat flow analysis of the horizontal fillet welding. The signal processing method based on the artificial neural network (Adaptive Resonance Theory) was proposed for discriminating the sound weld pool surface from that with the weld defects. The reliability of the numerical model and the signal processing method proposed were evaluated through the experiments of which showed that they are effective for predicting the weld bead shape with or without the weld defects in a horizontal fillet welding.

• Journal of Power Electronics
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• 제16권6호
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• pp.2202-2211
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• 2016

In certain applications, such as IPT-based EV charger (IPTEC), any variation in alignment and distance between pickup and charger primary leads to a change in leakage and magnetic impedance magnitudes. The power transmission capacity is not always at the maximum level because of these variations. This study proposes a new low-cost tracking method that achieves the Maximum Inductive Power Transmission Capacity (MIPTC). Furthermore, in the proposed method, the exchange of information between load and source is not required. For an application such as IPTEC, the load detected by the IPTEC varies continuously with time because of the change in state of the charge. This load variation causes a significant variation in IPT resonant circuit voltage gain. However, the optimized charging output voltage should be kept constant. From the analysis of the behavior of the IPT circuit at different working frequencies and load conditions, a MIPTC operation point that is independent of load condition can be identified. Finally, the experimental results of a developed prototype IPT circuit test show the performance of the proposed method.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집A
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• pp.477-482
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• 2001

To realize higher track density of HDD, the servo bandwidth should be higher, however, is limited by the mechanical resonances of the arm, coil of the VCM and ball bearing pivot. The dual-stage actuator systems have been suggested as a possible solution. For the dual-stage actuator systems based on the suspension, the suspension resonance frequencies in the radial access direction are important factors to increase a servo bandwidth, however the improvement of these frequencies may affect the shock resistance performance and spring constant. The slider's flying stability can be deteriorated by the change of a vertical stiffness. In this work, we have investigated a suspension design scheme possessing a milliactuator for dual-stage actuator systems and also achieved higher mechanical characteristics. Design parameters are deduced by finite element analysis with sensitivity function. It is confirmed that the proposed suspension with the milliactuator has the capability of fine tracking motion, due to its hinge structure on the spring region, and achieves higher mechanical resonance frequencies in the radial access direction with a high-shock resistance and a low-spring constant.

• Journal of mucopolysaccharidosis and rare diseases
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• 제4권1호
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• pp.21-25
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• 2018

Fabry disease is a hereditary lysosomal storage disorder caused by the reduction or absence of lysosomal enzyme alpha-galactosidase A and the accumulation of glycosphingolipids, such as globotriaosylceramide (Gb3), in various organs, including the heart. The prevention of cardiac involvement in Fabry disease can only be achieved by enzyme replacement therapy (ERT), and the method of assessing the efficacy of ERT should be confirmed. Changes in the electrocardiogram, such as the shortening of PQ interval, prolongation of QTc and repolarization abnormalities as well as left ventricular hypertrophy in voltage criteria, can be used to identify Fabry disease patients; however, the usefulness of electrocardiograms for evaluating the efficacy of ERT is limited. The assessment of left ventricular hypertrophy using echocardiography has been established to evaluate the efficacy of ERT during long-term period. A new technique involving speckled tracking method might be useful for detecting early cardiac dysfunction and identifying the effect of ERT for a relatively short period. The estimation of left ventricular hypertrophy using cardiac magnetic resonance (CMR) is also useful for assessing the efficacy of ERT. Identifying late gadolinium enhancement in CMR may affect the effectiveness of ERT, and the new technique of T1 mapping might be useful for monitoring the accumulation of Gb3 during ERT. Histopathology in cardiac biopsy specimens is another potentially useful method for identifying the accumulation of GB3; however, the use of histopathology to evaluate of the efficacy of ERT is limited because of the invasive nature of an endomyocardial biopsy.