• 한국항공우주학회지
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• 제31권4호
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• pp.99-104
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• 2003

본 논문은 헬리콥터 로터 시스템 설계시 고려해야 할 구조동역학 분야와 차세대 저진동 블레이드를 설계하는 과정을 소개하였다. 일반적으로 로터 시스템 설계시 허브 하중 최소화, 지상공진 방지 및 저진동 특성 등을 만족하도록 고유 진동수 범위를 정하게 된다. 먼저 로터 시스템에 대한 회전수별 고유 진동수 도표를 통해 로터 회전 속도와 공진영역이 생기지 않도록 설계하며 다음으로 동체에 전달되는 진동 하중 크기를 예측하기 위해 회전시 블레이드에서 발생되는 하중을 허브 중심의 비회전계 좌표축 성분으로 전환한다. 헬리콥터 전진 비행속도에 따라 동체에 전달되는 하중 크기를 구하고 동체를 강체로 모델링하여 조종속에서 발생되는 가속도를 계산함으로써 저진동 특성을 예측하였다. 본 설계기법은 현재 수행중인 차세대 로터 시스템 개발에 적용되고 있으며 향후 국내 개발 로터 시스템에 유용하게 적용될 것이다.

• Journal of Korean Neurosurgical Society
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• 제61권4호
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• pp.427-433
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• 2018

Obsessive compulsive disorder is a debilitating condition characterized by recurrent obsessive thoughts and compulsive reactions. A great portion of the obsessive compulsive disorder (OCD) patients are managed successfully with psychiatric treatment such as selective serotonin-reuptake inhibitor and cognitive behavioral psychotherapy, but more than 10% of patients are remained as non-responder who needs neurosurgical treatments. These patients are potential candidates for the neurosurgical management. There had been various kind of operation, lesioning such as leucotomy or cingulotomy or capsulotomy or limbic leucotomy, and with advent of stereotaxic approach and technical advances, deep brain stimulation was more chosen by neurosurgeon due to its characteristic of reversibility and adjustability. Gamma knife radiosurgery are also applied to make lesion targeting based on magnetic resonance (MR) imaging, but the complication of adverse radiation effect is not predictable. In the neurosurgical field, MR guided focused ultrasound has advantage of less invasiveness, real-time monitored procedure which is now growing to attempt to apply for various brain disorder. In this review, the neurosurgical treatment modalities for the treatment of OCD will be briefly reviewed and the current state of MR guided focused ultrasound for OCD will be suggested.

• 대한방사선기술학회지:방사선기술과학
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• 제15권2호
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• pp.37-47
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• 1992

Magnetic Resonance Imaging(MRI) is one of the most expensive and sophisticated diagnostic tool and has been hailed as the most exciting event in medical imaging "since the introduction of X-rays", but a major disadvantage, high cost, is coming into focus especially in our country. To determine the status of distribution of MR imagers in Korea and to serve as a basic material for an efficient utilization of this Imaging machine, a retrospective survey of nationwide and regional(3 hospitals in Pusan) installations was performed. The results were as follows : 1. As of April 30, 1991, a total of 33 MRI units(24 for superconducting, 6 for permanent and 3 for resistive units) were set up and operated. 91% of the units were distributed in big cities with no one installation in 7 provinces among 12 provinces in our country. 85% of the units were imported. 2. Although 42.4% of the units were operated in Seoul, Taejeon had the best condition for the distribution of this imaging machine per population, hospital, and bed in Korea. 3. In Pusan : a) 5 units were operated with all superconducting magnet and medium magnetic field in type of machine. b) 80.1 % of the examinations were central nervous system(CNS). c) MRI examination occupied 1.4% of all radiographic examinations and the patients referred from other hospitals were composed of 23.4%% of all patients. 4. The average days under operating of MRI unit a week in Puasn were higher(5.5) than that of Seoul(4.5), but the average number of examinations and hours a week and a day, respectively(33, 8.4), was less than that of Seoul(57, 12.9). 5. The patients with positive MRI findings in a hospital(B) in Pusan was 74.5% on an average.

• 한국항공우주학회지
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• 제41권6호
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• pp.495-501
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• 2013

한국형 기동헬기는 블레이드 가진주파수를 회피하고 지상 운용에서 로터와 기체의 동적 특성이 연계되어 나타나는 불안정성이 없도록 설계되었다. 이러한 설계 목적을 위해 진동 해석과 지상공진 해석을 수행하여 기체와 주로터의 동적 특성을 분석하였다. 이후 훨타워 시험을 통해 주로터의 동적특성을 확인하였으며 지상진동시험을 통해 기체의 동적 특성을 확인하였다. 지상진동시험은 지상 및 비행 운용 조건이 고려된 시험체 구성과 시험 조건을 적용하여 수행되었다. 본 논문에서는 한국형 기동헬기에 적용된 지상진동시험 방법 및 분석 기법을 보이고 해석 모델 보정기법과 보정된 해석 결과를 제시한다.

• 한국소음진동공학회논문집
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• 제27권2호
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• pp.155-161
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• 2017

When a military vehicle is driven on a cross-country road, the occupants are exposed to vibration at a body resonance. In case that the exposure continues for too long period, the attention ability of the occupant could be affected by the vibration exposure. In the study, it was experimentally tried to find if there is a correlation between degradation of attention and vibration exposure. Two kinds of test among various psychological attention tests were employed, which were selected with considering a situation of carrying out military mission on vehicle. At the result, the searching test for controlled attention showed significant degradation in the accuracy and performance time in case of exposure at the vibration. And the attention degradation appeared to be greater when the vibration exposure increases. The dual task test for divided attention showed the difference between vibration and non-vibration condition, but showed it is insignificant for the attention to degrade by increasing exposure time.

• 한국자기공명학회논문지
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• 제3권2호
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• pp.100-108
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• 1999

Cop protein is the transcription repressor protein in rolling circle replication plasmid. With antisense RNA, Cop protein controls the copy number of plasmid. Cop family proteins have been found in various plasmids. Among Cop family proteins, Cop studied in this paper consists of 55 amino acids (Mw. 6,400), and was known to have trimer structure. Since no structural facts are elucidated, we have carried out preliminary experiments aimed at the elucidation of its three dimensional structure. The secondary structure of Cop is studied by CD and NMR. To solve the aggregation of Cop at high concentration, we tested various detergents and salts. The addition of detergents and salts could not solve the aggregation problem. However, we found that concentration is important in solving the aggregation problem. We knew that 0.18mM in 50mM potassium phosphate without any other ingredients is maximum concentration not to aggregate. Wa also investigated the pH dependence of Cop protein, and knew that Cop protein is more stable in acid state. At various temperatures, 15N-1H HSQC spectra were measured in order to find the optimal experimental condition. To enhance the peak resolution, 3D NOESY-HSQC spectrum is acquired. Since there are NOE peaks in the NH-NH region, we knew that Cop protein has $\alpha$-helical content, which was also confirmed by CD.

• 한국자기공명학회논문지
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• 제16권1호
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• pp.34-45
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• 2012

Melanocortin-4 receptor (MC4R) subtype is associated with obese humans. Especially, in a patient with severe early-onset obesity, novel heterozygous mutation in the MC4R gene was detected, resulting in an exchange of aspartic acid to asparagine in $90^{th}$ amino acid residue located in the predicted second trans-membrane domain (TM2). Mutations in the melanocortin-4 receptor (MC4R) gene are the most frequent monogenic causes of severe obesity which have been described as heterozygous with loss of function. In order to compare structure difference between MC4R wild type (MC4R-TM2-wt) and mutant (MC4R-TM2-D90N), we designed both MC4R-TM2-wt and MC4R-TM2-D90N construct in pET 21b vector. In this study, we optimized high-yield purification procedure for recombinant TM2-D90N. Eluted recombinant protein was resolubilized under urea condition for thrombin cleavage reaction and we conducted the high-performance liquid chromatography (HPLC) with reverse phase column under 1% acetonitrile, 0.01% TFA buffer solution. The molecular size of purified target peptide was confirmed by Tricine-SDS page analysis. To characterize MC4R-TM2-D90N, we have performed $^{15}N$-isotope labeling of peptide using M9 media and purified labeled target peptide for hetero-nuclear NMR spectroscopy.

• Journal of Korean Neurosurgical Society
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• 제40권2호
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• pp.74-78
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• 2006

Objective : We examined the incidence of fenestration in the proximal segment of the anterior cerebral artery[ACA] and reviewed its clinical significance. Methods : Cerebral angiography was performed in 843 patients and magnetic resonance angiography[MRA] in 1,787; all patients had, or were suspected to have, cerebrovascular disease. We subsequently reviewed the angiography and MRA data. Results : Fourteen patients [six men and eight women, $35{\sim}81$ years of age, median age = 67 years] had proximal ACA fenestrations. Three of the 843 patients [0.36%] undergoing cerebral angiography had fenestrations of proximal ACA as did eleven of the 1,787 MRA patients [0.62%]. Seven fenestrations were located on the right side and seven fenestrations were located on the left side. The fenestrated ACA in one patient was associated with a saccular aneurysm at its proximal end. None of the 120 patients who underwent both conventional cerebral angiography and cranial MRA showed fenestration of proximal ACA. Conclusion : Although fenestration of ACA has little clinical significance, knowledge and recognition of this condition is important in the interpretation of cerebral images, especially during neurosurgical procedures.

• 제어로봇시스템학회논문지
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• 제18권6호
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• pp.546-554
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• 2012

This paper suggests a design method of an improved phase control loop for tracking resonant frequency of solid type precision resonant gyroscope. In general, a low cost MEMS gyroscope adapts the automatic gain control loops by taking a velocity feedback configuration. This control technique for controlling the resonance amplitude shows a stable performance. But in terms of resonant frequency tracking, this technique shows an unreliable performance due to phase errors because the AGC method cannot provide an active phase control capability. For the resonance control loop design of a solid type precision resonant gyroscope, this paper presents a phase domain control loop based on linear PLL (Phase Locked Loop). In particular, phase control loop is exploited using a higher order PLL loop filter by extending the first order active PI (Proportion-Integral) filter. For the verification of the proposed loop design, a hemispherical resonant gyroscope is considered. Numerical simulation result demonstrates that the control loop shows a robust performance against initial resonant frequency gap between resonator and voltage control oscillator. Also it is verified that the designed loop achieves a stable oscillation even under the initial frequency gap condition of about 25 Hz, which amounts to about 1% of the natural frequency of a conventional resonant gyroscope.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2001년도 춘계학술대회 논문집
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• pp.135-139
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• 2001

This paper describes a string resonator that is used for the interrogation system of a Fiber Bragg Grating(FBG) strain sensor. The strain on the fiber piece is calculated from the measured frequency based on that the natural frequency of a string is a function of the applied absolute strain. Existing research considered a fiber as a string, but a fiber is not a string in the strict sense due to its bending stiffness, thus the fiber should be modeled as a beam accompanied with an axial force. In the vibration modeling, the relationship between the strain and the natural frequency is derived, and then the resonance condition is described in terms of both the phase and the mode shape for sustaining resonant motion. Several experiments verify the effectiveness of the proposed model of the fiber. The performance of the string resonator is analyzed by measuring the frequency change according to the applied strains in the dynamic range of 1100$\mu\varepsilon$ referred to the displacement from capacitance sensor. From the experimental results, the implemented string resonator provides the accuracy of $\pm$3$\mu\varepsilon$, the quasi-static resolution of ~0.1$\mu\varepsilon$(rms) which amount to be $\pm$0.17$\mu\textrm{m}$ and ~6nm respectively, in case of fiber length of 56mm. For a dynamic strain, it can provide the accuracy of ~3$\mu\varepsilon$ until the frequency comes to 8Hz. As a consequence, the string resonator proposed for FBG sensor provides the high accuracy and the high resolution in strain measurement, and also it is expecting to be used, for the application, to not only strain but also displacement measuring device.