• Journal of Korean Society of Coastal and Ocean Engineers
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• v.31 no.6
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• pp.351-355
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• 2019

Load resistance factors for the limit state design of vertical caisson breakwaters are presented. Reliability analysis of 16 breakwaters in nationwide ports was conducted to calculate the partial safety factors and they were converted into load and resistance factors. The final load resistance factor was calibrated by applying the optimization technique to the individually calculated load resistance factors. Finally, the breakwater was redesigned using the optimal load resistance factor and verified whether the target level was met. The load resistance factor according to the change of the target reliability level is presented to facilitate the limit state design of breakwater.

• Journal of the Korean GEO-environmental Society
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• v.16 no.6
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• pp.5-11
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• 2015

Recently the necessity of developing the Load and Resistance Factor Design (LRFD) for shallow foundation has been raised to implement to the domestic design codes related to geotechnical engineering since the limit state design is requested as international technical standard for the foundation of structures. In this study, applicability of LRFD for shallow foundation on weathered soils was investigated and resistance factor for this case was proposed. The quantitative analyses on the uncertainty and resistance bias for shallow foundation on weathered soil ground were performed by collecting the statistical data about domestic case studies for design and construction of shallow foundation. Reliability analyses for shallow foundation were first performed using FDA (First-order Design value Approach) method. Resistance factors were calibrated using the load factors obtained from the specifications of shallow foundations on weathered soil ground. The influence of the load factors developed in this study on the resistance factors were discussed by comparing with the resistance factor obtained from using AASHTO load factors.

• Tuberculosis and Respiratory Diseases
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• v.75 no.5
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• pp.188-198
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• 2013

Over the past decade, several kinase inhibitors have been approved based on their clinical benefit in cancer patients. Unfortunately, in many cases, patients develop resistance to these agents via secondary mutations and alternative mechanisms. To date, several major mechanisms of acquired resistance, such as secondary mutation of the epidermal growth factor receptor (EGFR) gene, amplification of the MET gene and overexpression of hepatocyte growth factor, have been reported. This review describes the recent findings on the mechanisms of primary and acquired resistance to EGFR tyrosine kinase inhibitors and acquired resistance to anaplastic lymphoma kinase inhibitors, primarily focusing on non-small cell lung carcinoma.

• International Journal of Concrete Structures and Materials
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• v.10 no.sup3
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• pp.109-121
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• 2016

Recently, as the use of high-performance materials and complex composite methods has increased, the need for advanced design specifications for steel-concrete composite structures has grown. In this study, various design provisions for ultimate flexural strengths of composite beams were reviewed. Design provisions reviewed included the load and resistance factor design method of AISC 360-10 and the partial factor methods of KSSC-KCI, Eurocode 4 and JSCE 2009. The design moment strengths of composite beams were calculated according to each design specification and the variation of the calculated strengths with design variables was investigated. Furthermore, the relationships between the deformation capacity and resistance factor for flexure were examined quantitatively. Results showed that the design strength and resistance factor for flexure of composite beams were substantially affected by the design formats and variables.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.03a
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• pp.427-434
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• 2010

Load Resistance Factor Design method is used increasingly in geotechnical design world widely and resistance factors for drilled shafts are suggested by AASHTO. However, these resistance factors are determined for intact rock conditions, by comparison most of bedrocks in Korea are weathered condition, so that applying the AASHTO resistance factors is not reasonable. Thus, this study suggests the proper resistance factors for design of drilled shaft in Korea. The 22 cases of pile load test data from 8 sites were chosen and reliability-based approach is used to analyze the data. Reliability analysis was performed by First Order Second Moment Method (FOSM) applying 4 bearing capacity equations. As a result, when the Factor of Safety(FOS) were selected as 3.0, the target reliability index($\beta_c$) were evaluated about 2.01~2.30. Resistance factors and load factors are determined from optimization based on above results. The resistance factors ranged between 0.48 and 0.56 and load factor for dead load and live load are evaluated approximately 1.25 and 1.75 respectively. However, when the target reliability are considered as 3.0, the resistance factors are evaluated as approximately 50% of results when the target reliability index were 2.0.

• Journal of the Korea Concrete Institute
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• v.12 no.2
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• pp.21-30
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• 2000

In the Ultimate Strength Design, the design strength of a member is determined by multiplying the strength reduction factor to the nominal strength. This concept may be a reasonable approach, however it can not consider failure modes appropriately. Moreover, column design strength diagram show an abrupt change at a low level of axial load, which does not seem to be reasonable. This research compares the design strength determined by the strength resistance factors. As the material resistance factors for flexure and compression, 0.65 and 0.90 are proposed for concrete and steel, respectively. The design strength calculation process by applying material resistance factors addresses failure modes more effectively than by applying member strength reduction factor, and provides more resnable design strength for reinforced concrete flexural and compression members.

• 한국신재생에너지학회:학술대회논문집
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• 2008.05a
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• pp.428-430
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• 2008

Dye-sensitized solar cell has many internal resistant components such as Pt counter electrode, $TiO_2$/dye/electrolyte, charge diffusion, sheet resistance of TCO. Among these, the resistance about the counter electrode can be reduced by increasing the roughness factor of Pt counter electrode. This causes the increase of fill factor and improvement of efficiency. And the amount of light reflection on the counter electrode also increases as the roughness factor goes up. In our experiment, we suggest a new deposition structure of Pt thin film that is a stepped-type structure. The more step lines are in the counter electrode, the more roughness factor is. As a result, we get the improvement of fill factor and efficiency by controlling the roughness factor of counter electrode.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.6
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• pp.458-464
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• 2020

Calibration of load-resistance factors for the limit state design of perforated caisson breakwaters are presented. Reliability analysis of 12 breakwaters in nationwide ports was conducted. Then, partial safety factors and load-resistance factors were sequentially calculated according to target reliability index. Load resistance factors were optimized to give one set of factor for limit state design of breakwater. The breakwaters were redesigned by using the optimal load resistance factor and verified whether reliability indices larger than the target value. Finally, some load-resistance factors were proposed by changing target reliability index.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.33 no.6
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• pp.293-297
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• 2021

Calibration of load-resistance factors for the limit state design of front covered caisson breakwaters were presented. Reliability analysis of the breakwaters which are constructed in Korean coast was conducted. Then, partial safety factors and load-resistance factors were sequentially calculated according to target reliability index. Load resistance factors were optimized to give one set of factor for limit state design of breakwater. The breakwaters were redesigned by using the optimal load resistance factor and verified whether reliability indices larger than the target value. Finally, load-resistance factors were compared with foreign country's code for verification.

• Tuberculosis and Respiratory Diseases
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• v.79 no.4
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• pp.248-256
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• 2016

Somatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine kinase inhibitors are now the standard first line treatment for advanced disease. They have led to a doubling of progression-free survival and an increase in overall survival by more than 2 years. However, emergence of resistant clones has become the primary cause for treatment failure, and has created a new challenge in the daily management of patients with EGFR mutations. Identification of mechanisms leading to inhibitor resistance has led to new therapeutic modalities, some of which have now been adapted for patients with unsuccessful tyrosine kinase inhibitor treatment. In this review, we describe mechanisms of tyrosine kinase inhibitor resistance and the available strategies to overcoming resistance.